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  • 1
    Online Resource
    Online Resource
    Intravenous Ribavirin for Hantavirus Pulmonary Syndrome: Safety and Tolerance during 1 Year of Open-Label Experience
    SAGE Publications ; 1999
    In:  Antiviral Therapy Vol. 4, No. 4 ( 1999-05), p. 211-219
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 4, No. 4 ( 1999-05), p. 211-219
    Abstract: Intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (HPS) in the United States between 4 June 1993 and 1 September 1994. Therapy was initiated prior to laboratory confirmation of hantavirus infection because most deaths from HPS occur within 48 h of hospitalization. Thirty patients with confirmed HPS, 105 patients without HPS and 5 patients without adequate diagnostic testing for HPS were enrolled. This observational study arguably provides the most complete information available on ribavirin-associated adverse effects. Although ribavirin was generally well tolerated, 71% of recipients became anaemic and 19% underwent transfusion. An apparent excess of hyperamylasaemia/pancreatitis was either therapy-associated or due to enrolment bias. The 30 enrolled HPS patients had a case–fatality rate of 47% (14/30). It is not possible to assess efficacy with this study design. However, comparison of survival curves for the 30 enrolled HPS patients and 34 patients who developed HPS during the same time period but were not enrolled did not suggest an appreciable drug effect. A randomized, placebo-controlled trial that enrols patients during the prodrome phase would be necessary to assess the efficacy and further define the safety of intravenous ribavirin for HPS.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965359900400404
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1999
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  • 2
    Online Resource
    Online Resource
    Absence of Expression of c-sis and Transforming Growth Factor-β mRNA in Malignant Fibrous Histiocytoma
    SAGE Publications ; 1993
    In:  International Journal of Surgical Pathology Vol. 1, No. 2 ( 1993-10), p. 117-121
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 1, No. 2 ( 1993-10), p. 117-121
    Abstract: Total RNA was extracted from five malignant fibrous histiocytomas and two benign fibrohistiocytic lesions and assayed for mRNA expressions for transforming growth factor beta (TGF-β) and c-sis by Northern blot analysis. Production of both of these has been associated with cells of monocyte-macrophage lineage, and these factors have been shown to be important in physiologic mesenchymal cell proliferation. No mRNA expression of either TGF-β or c-sis was identified in any of the fibrohistiocytic tumor samples. The lack of expression of TGF-β and c-sis may be consistent with a nonhistiocytic origin of malignant fibrous histiocytoma, or may reflect transformation- associated loss of the normal molecular mechanisms of mesenchymal proliferation. The absence of c-sis mRNA expression can be reconciled with the prior immunohisto chemical demonstration of platelet-derived growth factor in tumor cells of malignant fibrous histiocytoma. Int J Surg Pathol(2):117-122, 1993
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/106689699300100205
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1993
    detail.hit.zdb_id: 2070102-0
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  • 3
    Online Resource
    Online Resource
    Recruiting: A Comparative Study of the Recruiting Practices of State Police Agencies
    SAGE Publications ; 2006
    In:  International Journal of Police Science & Management Vol. 8, No. 1 ( 2006-03), p. 52-66
    Details
    In: International Journal of Police Science & Management, SAGE Publications, Vol. 8, No. 1 ( 2006-03), p. 52-66
    Abstract: This study focused on recruiting practices in state police organisations. A survey was mailed to the 49 state police agencies and state highway patrols in the United States. Numerous advertising and recruiting methods were employed by the responding departments. Traditional advertising methods were seen by respondents as relatively ineffectual and aggressive face-to-face recruiting efforts at job fairs and community gatherings were deemed more effective. The use of internet websites also showed promise for increasing the number of viable candidates.
    Type of Medium: Online Resource
    ISSN: 1461-3557 , 1478-1603
    URL: Article
    DOI: 10.1350/ijps.2006.8.1.52
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2112649-5
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  • 4
    Online Resource
    Online Resource
    PAVDRN: Computer Model for Predicting Water Film Thickness and Potential for Hydroplaning on New and Reconditioned Pavements
    SAGE Publications ; 1997
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 1599, No. 1 ( 1997-01), p. 128-131
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 1599, No. 1 ( 1997-01), p. 128-131
    Abstract: PAVDRN is a computer model that determines the speed at which hydroplaning will be initiated on a section of highway pavement. It is intended to be used by highway engineers before final geometric design to (a) indicate the location of the worst incidence of hydroplaning that is likely to occur on a given section and (b) to rapidly assess different geometric configurations of a section and pavement materials to select a design that will minimize hydroplaning potential. The model is based upon a one-dimensional, steady-state form of the kinematic wave equation. This equation is used in conjunction with relationships for Manning's n that account for the nature of the shallow flow over highway pavements. Ultimately, water-film thickness along a maximum flowpath length is used in empirical expressions to determine the speed at which hydroplaning is likely to occur along this path. The path is determined by analyzing the geometry of the pavement section. Five different geometric sections can be analyzed: ( a) tangent section, ( b) superelevated curve, ( c) transition section, ( d) vertical crest curve, and ( e) vertical sag curve. The user interface was written in Microsoft Visual Basic Version 3.0. It uses context-sensitive help screens. The algorithms for water-film thickness and hydroplaning potential were written in FORTRAN 77.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/1599-16
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
    detail.hit.zdb_id: 2403378-9
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  • 5
    Online Resource
    Online Resource
    Air Combat Maneuvering Performance Measurement
    SAGE Publications ; 1979
    In:  Proceedings of the Human Factors Society Annual Meeting Vol. 23, No. 1 ( 1979-10), p. 324-328
    Details
    In: Proceedings of the Human Factors Society Annual Meeting, SAGE Publications, Vol. 23, No. 1 ( 1979-10), p. 324-328
    Abstract: Due to the complex, dynamic and fast-moving nature of the air combat task, performance assessment during air-to-air combat provides many unique measurement problems. A combined analytical and empirical technical approach was used to develop a candidate measurement structure and algorithm for the measurement of pilot performance during one-versus-one air combat maneuvering. Nearly all of 28 candidate measures were found to discriminate between high and low skilled pilots during free engagements on the Simulator for Air-to-Air Combat. Discriminant analyses provided a measurement algorithm consisting of 13 measures which accounted for 51% of the variance in the performance data and which predicted membership in high or low skill groups with 92% accuracy.
    Type of Medium: Online Resource
    ISSN: 0163-5182
    URL: Article
    DOI: 10.1177/107118137902300183
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1979
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  • 6
    Online Resource
    Online Resource
    Image Analysis Algorithms for Immunohistochemical Assessment of Cell Death Events and Fibrosis in Tissue Sections
    SAGE Publications ; 2009
    In:  Journal of Histochemistry & Cytochemistry Vol. 57, No. 7 ( 2009-07), p. 649-663
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 57, No. 7 ( 2009-07), p. 649-663
    Abstract: Cell death is of broad physiological and pathological importance, making quantification of biochemical events associated with cell demise a high priority for experimental pathology. Fibrosis is a common consequence of tissue injury involving necrotic cell death. Using tissue specimens from experimental mouse models of traumatic brain injury, cardiac fibrosis, and cancer, as well as human tumor specimens assembled in tissue microarray (TMA) format, we undertook computer-assisted quantification of specific immunohistochemical and histological parameters that characterize processes associated with cell death. In this study, we demonstrated the utility of image analysis algorithms for color deconvolution, colocalization, and nuclear morphometry to characterize cell death events in tissue specimens: (a) subjected to immunostaining for detecting cleaved caspase-3, cleaved poly(ADP-ribose)-polymerase, cleaved lamin-A, phosphorylated histone H2AX, and Bcl-2; (b) analyzed by terminal deoxyribonucleotidyl transferase–mediated dUTP nick end labeling assay to detect DNA fragmentation; and (c) evaluated with Masson's trichrome staining. We developed novel algorithm-based scoring methods and validated them using TMAs as a high-throughput format. The proposed computer-assisted scoring methods for digital images by brightfield microscopy permit linear quantification of immunohistochemical and histochemical stainings. Examples are provided of digital image analysis performed in automated or semiautomated fashion for successful quantification of molecular events associated with cell death in tissue sections. (J Histochem Cytochem 57:649–663, 2009)
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/jhc.2009.952812
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 1421306-0
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  • 7
    Online Resource
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    Temporal and Spatial Profile of Bid Cleavage after Experimental Traumatic Brain Injury
    SAGE Publications ; 2002
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 22, No. 8 ( 2002-08), p. 951-958
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 22, No. 8 ( 2002-08), p. 951-958
    Abstract: Apoptosis plays an essential role in the cascade of CNS cell degeneration after traumatic brain injury. However, the underlying mechanisms are poorly understood. The authors examined the temporal profile and cell subtype distribution of the proapoptotic protein Bid from 6 hours to 7 days after cortical impact injury in the rat. Increased protein levels of tBid were seen in the cortex ipsilateral to the injury site from 6 hours to 3 days after trauma. Immunohistologic examinations revealed expression of tBid in neurons, astrocytes, and oligodendrocytes from 6 hours to 3 days after impact injury, and concurrent assessment of DNA damage using TUNEL identified tBid-immunopositive cells with apoptoticlike morphology in the traumatized cortex. Moreover, Bid cleavage and activation of caspase-8 and caspase-9 occurred at similar time points and in similar brain regions (i.e., cortical layers 2 to 5) after impact injury. In contrast, there was no evidence of caspase-8 or caspase-9 processing or Bid cleavage in the ipsilateral hippocampus, contralateral cortex, and hippocampus up to 7 days after the injury. The results provide the first evidence of Bid cleavage in the traumatized cortex after experimental traumatic brain injury in vivo, and demonstrate that tBid is expressed in neurons and glial cells. Further, findings indicate that cleavage of Bid may be associated with the activation of the initiator caspase-8 and caspase-9. Finally, these data support the hypothesis that cleavage of Bid contributes to the apoptotic degeneration of different CNS cells in the injured cortex.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1097/00004647-200208000-00006
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2039456-1
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  • 8
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    Online Resource
    Measuring Complexity: A Confirmatory Factor Analysis Approach
    SAGE Publications ; 2017
    In:  Journal of Contemporary Criminal Justice Vol. 33, No. 4 ( 2017-11), p. 380-391
    Details
    In: Journal of Contemporary Criminal Justice, SAGE Publications, Vol. 33, No. 4 ( 2017-11), p. 380-391
    Abstract: This study examines complexity as a measure of support for organizational redirection. This study considers whether 16 items (culture, mission, values, decentralization, policies and procedures, administrative reporting practices, weapons, contract, pay, benefits, patrol boundaries, equalization of workload, size of boundaries, communications, 10-codes, and car numbers) appropriately characterized a suppressed measure of complexity related to complex organizational change, a police department merger. The current study utilizes data collected from 390 sworn officers from two merged law enforcement agencies in Kentucky. The results of the structural equation model analysis supported the view that four factors (mission, logistics, benefits, and policy) fashion an underlying construct for measuring complexity related to organizational change/redirection. The implications of these findings are also considered.
    Type of Medium: Online Resource
    ISSN: 1043-9862 , 1552-5406
    URL: Article
    DOI: 10.1177/1043986217724531
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2027876-7
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  • 9
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    Online Resource
    Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine
    SAGE Publications ; 2011
    In:  Experimental Biology and Medicine Vol. 236, No. 2 ( 2011-02), p. 247-251
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 236, No. 2 ( 2011-02), p. 247-251
    Abstract: We report here a series of new inhibitors of the X-linked inhibitor of apoptosis protein (XIAP protein) based on the SMAC-tetrapeptide AVPI. The structural novelty of these molecules is the presence of the proline mimetic exo-2-azabicyclo[2.2.1]heptane-3-carboxylic acid, leading to analogs with similar activity to the natural ligand peptide. The structure–activity relationship and computational docking studies support the convenience of this unnatural amino acid as a building block to develop new peptides or small molecules targeting the XIAP-BIR3 domain.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2010.010284
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020856-X
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  • 10
    Online Resource
    Online Resource
    Epa, Collaborative Rule Making, and the Small Communities Outreach Project For Environmental Issues : A Three-State Experience
    SAGE Publications ; 2002
    In:  Public Works Management & Policy Vol. 7, No. 2 ( 2002-10), p. 87-97
    Details
    In: Public Works Management & Policy, SAGE Publications, Vol. 7, No. 2 ( 2002-10), p. 87-97
    Abstract: In an era of increased attention paid to the impact of federal regulation on citizens and small business entities, the Small Communities Outreach Project for Environmental Issues (SCOPe) is a collaborative attempt between the U.S. Environmental Protection Agency (EPA) and the National Association of Schools of Public Affairs and Administration to facilitate communication between small communities and local government officials and EPA. The authors report on the activities of SCOPe designed to elicit comment on EPA’s proposed groundwater rule. They contend that SCOPe is an effective model of communication between EPA and small community officials and is particularly adept at capturing the “state of the world” of small communities through qualitative data. Finally, the authors analyze the activities of SCOPe in terms of its utility in the federal rule-making process.
    Type of Medium: Online Resource
    ISSN: 1087-724X , 1552-7549
    URL: Article
    DOI: 10.1177/108772402236951
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2070370-3
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