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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2014
    In:  Cancer Growth and Metastasis Vol. 7 ( 2014-01), p. CGM.S11285-
    In: Cancer Growth and Metastasis, SAGE Publications, Vol. 7 ( 2014-01), p. CGM.S11285-
    Abstract: The presence of abnormal cells with malignant potential or neoplastic characteristics is a relatively common phenomenon. The interaction of these abnormal cells with their microenvironment is essential for tumor development, protection from the body's immune or defence mechanisms, later progression and the development of life-threatening or metastatic disease. The tumor microenvironment is a collective term that includes the tumor's surrounding and supportive stroma, the different effectors of the immune system, blood platelets, hormones and other humoral factors. A better understanding of the interplay between the tumor cells and its microenvironment can provide efficient tools for cancer management, as well as better prevention, screening and risk assessment protocols.
    Type of Medium: Online Resource
    ISSN: 1179-0644 , 1179-0644
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2594639-0
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  Journal of Thermoplastic Composite Materials Vol. 28, No. 6 ( 2015-06), p. 863-878
    In: Journal of Thermoplastic Composite Materials, SAGE Publications, Vol. 28, No. 6 ( 2015-06), p. 863-878
    Abstract: The effect of β-hydroxynaphthoic acid (β-HNA) addition on electrical and mechanical properties of multiwalled carbon nanotubes (MWCNTs)–polystyrene (PS) composite at a fixed amount of MWCNTs (0.85 wt%) are delineated. Obtained electrical, mechanical, morphological, and Fourier transform infrared results showed that addition of β-HNA up to 1 wt% to MWCNTs-PS composite enhanced the dispersion of MWCNTs in the neat PS, formation of MWCNTs-PS network, relative permittivity, dielectric loss, and the electrical conductivity increased by about three orders of magnitude for the prepared composite. Dielectric relaxation results showed that at the domain frequency range, the relaxation process below 1.0 wt% β-HNA was mostly due to polymer molecular relaxation process, while at 1.0 wt% β-HNA, the composite relaxation behavior was mostly due to charge conductivity relaxation. Mechanical results showed that addition of β-HNA to composite system up to 1.0 wt% increased the elastic modulus, yield stress, and tensile strength of the composites by about 12.2, 17.1, and 10.0%, respectively, which indicated that the addition of β-HNA to composite system improved MWCNTs dispersion in PS matrix and enhanced the interfacial bond in the β-HNA-MWCNTs-PS network.
    Type of Medium: Online Resource
    ISSN: 0892-7057 , 1530-7980
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2098671-3
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  • 3
    In: Journal of Oncology Pharmacy Practice, SAGE Publications, Vol. 27, No. 4 ( 2021-06), p. 907-910
    Abstract: Daratumumab is used in the treatment of relapsed multiple myeloma. Daratumumab infusion-related reactions can occur with the highest incidence on the first infusion. Methods A retrospective review of all daratumumab infusions used as part of the DVd and DRd regimens for relapsed multiple myeloma was undertaken. The review of infusion-related reactions was conducted by reviewing the treatment room nursing note on the days that daratumumab was administered. If the patient experienced an infusion-related reaction, then the data captured included if the full dose was administered. Results Daratumumab infusion-related reactions occurred most frequently on the first dose. The rates of infusion-related reactions using a split dose approach for daratumumab administration were lower than that reported in clinical trials. All of the infusion-related reactions were managed with appropriate interventions in the outpatient setting. The adoption of rapid infusion daratumumab beginning with cycle 2 of DVd and DRd was well tolerated. Conclusions Our experience of daratumumab infusions using a split dose approach was associated with an infusion-related reaction rate in 28% of patients on cycle 1, day 1 of DVd and DRd regimens. All patients were able to complete full doses of daratumumab by utilizing split dose. The rates of daratumumab infusion-related reactions are highest on the first infusion. In addition, our adoption of rapid infusion daratumumab was safe.
    Type of Medium: Online Resource
    ISSN: 1078-1552 , 1477-092X
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2026590-6
    SSG: 15,3
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