In:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 45, No. 6 ( 2008-11), p. 593-597
Abstract:
The principle of the erythrocyte sedimentation rate (ESR) as assessed by TEST 1 is different from that of Westergren-based methods. This could result in different influences on the tests by paraproteins. Methods We investigated the effect of paraproteins on ESR readings by TEST 1 ( y) and the StarrSed ( x), a Westergren-based method, in 142 patients with paraproteinaemia. Agreement (Passing-Bablok) and bias (Bland–Altman) between methods was investigated and compared with that of a control population. Results A poor agreement between the two methods was found in patients with a paraprotein ( y = 0.67 x + 3.3) in comparison with that of the control population ( y = 0.96 x + 0.2). Large differences between methods were present when ESR readings were 〉 40 mm/hour, but clinical interpretation was similar in 90% of cases. Linear regression showed a concentration dependent influence of paraproteins on ESR readings by the StarrSed, especially for immunoglobulin class IgM. Conclusion ESR readings by TEST 1 result in similar clinical interpretation for most subjects, but readings are less influenced by the presence of a paraprotein than those of a Westergren-based method.
Type of Medium:
Online Resource
ISSN:
0004-5632
,
1758-1001
DOI:
10.1258/acb.2008.008062
Language:
English
Publisher:
SAGE Publications
Publication Date:
2008
detail.hit.zdb_id:
2041298-8
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