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  • SAGE Publications  (21)
  • 1
    Online Resource
    Online Resource
    Application of telehealth intervention in Parkinson’s disease: A systematic review and meta-analysis
    SAGE Publications ; 2020
    In:  Journal of Telemedicine and Telecare Vol. 26, No. 1-2 ( 2020-01), p. 3-13
    Details
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 26, No. 1-2 ( 2020-01), p. 3-13
    Abstract: Telehealth intervention has been proposed as a sustainable and innovative intervention approach to Parkinson’s disease (PD) patients, but there are still conflicting results in the literature about its effect. This study aimed to evaluate the efficacy of telehealth intervention for PD patients. Methods PubMed, EMBASE, CENTRAL and China National Knowledge Infrastructure (CNKI) were searched from the inception to June 2018 for randomized controlled trials (RCTs) and cohort studies, without language restrictions. When feasible, data were statistically pooled for meta-analysis using Review Manager 5.3. Otherwise, narrative summaries were used. Results Twenty-one studies were included. With respect to PD severity, compared with usual care, telehealth intervention was beneficial in lowering motor impairment of PD patients significantly (mean difference (MD) = –2.27, 95% confidence interval (95% CI) −4.25 to −0.29, p = 0.02), rather than mental status (MD = –0.98, 95% CI −2.61 to 0.65, p = 0.24), activities of daily living (MD = –1.51, 95% CI −4.91 to 1.89, p = 0.38) and motor complications (MD = –0.36, 95% CI −1.31 to 0.59, p = 0.46). Telehealth intervention did not lead to significant reduction in quality of life (standardized mean difference (SMD) = 0.04, 95% CI −0.20 to 0.28, p = 0.76), depression (SMD = –0.12, 95% CI −0.37 to 0.13, p = 0.34), cognition (MD = 0.37, 95% CI −0.34 to 1.09, p = 0.31) and balance (MD = 0.09, 95% CI −2.49 to 2.66, p = 0.95). Discussion Telehealth intervention is an effective option for individuals with PD to improve their motor impairment. Further well-designed studies are warranted to confirm our findings.
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    URL: Article
    DOI: 10.1177/1357633X18792805
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2007700-2
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  • 2
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    Online Resource
    On the causation correlation of maritime accidents based on data mining techniques
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability, SAGE Publications
    Abstract: A great deal of valuable information included in maritime accident reports needs to be excavated to contribute to accident prevention or risk defence. In the present study, data mining technologies are applied to explore the potential causation correlations among the risk factors associated with maritime accidents. A collection of 285 accident reports is subjected to database analysis by using text mining technology to extract keywords, and the critical factors are then determined with reference to objective reports. The FP-Growth (frequent pattern growth) algorithm is then applied to identify the association rules hidden in the causations leading accidents, and the strength level of the identified association rules is evaluated quantitatively. The results show that the data mining technologies are applicable for identifying correlations hidden among factors contributing to maritime accidents. In addition, single factors do not significantly lead to accidents, while the integration of factors can easily cause accidents even under the condition of a good navigation environment. Therefore, stakeholders involved in maritime activities are advised to systematically assess risk factors, and prevent maritime accidents by interrupting the correlations among the factors.
    Type of Medium: Online Resource
    ISSN: 1748-006X , 1748-0078
    URL: Article
    DOI: 10.1177/1748006X221131717
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2246471-2
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  • 3
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    Online Resource
    Structure-Cardiac Activity Relationship of C 19 -Diterpenoid Alkaloids
    SAGE Publications ; 2012
    In:  Natural Product Communications Vol. 7, No. 6 ( 2012-06), p. 1934578X1200700-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 7, No. 6 ( 2012-06), p. 1934578X1200700-
    Abstract: Thirty three C 19 -diterpenoid alkaloids, twenty-two prepared from known C 19 -diterpenoid alkaloids and eleven isolated from Aconitum and Delphinium spp. were evaluated for their cardiac activity in the isolated bullfrog heart assay. Among them, eleven compounds exhibited cardiac activity, with average rate of amplitude increase in the range of 16-118%. Compound 7, mesaconine (17), hypaconine (25), and beiwutinine (26) exhibited strong cardiac activities relative to the reference drug. The structure-activity relationship data acquired indicated that an α-hydroxyl group at C-15, a hydroxyl group at C-8, an α-methoxyl or hydroxyl group at C-1, and a secondary amine or N-methyl group in ring A are important structure features necessary for the cardiac activities of the aconitine-type C 19 -diterpenoid alkaloids without any ester groups. In addition, an α-hydroxyl group at C-3 is also helpful for the cardiac activity of these alkaloids.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1200700606
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 4
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    Further Studies on Structure-Cardiac Activity Relationships of Diterpenoid Alkaloids
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 12 ( 2015-12), p. 1934578X1501001-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 12 ( 2015-12), p. 1934578X1501001-
    Abstract: The cardiac effect of thirty-eight diterpenoid alkaloids was evaluated on the isolated bullfrog heart model. Among them, twelve compounds exhibited appreciable cardiac activity, with compounds 3 and 35 being more active than the reference drug lanatoside. The structure-cardiac activity relationships of the diterpenoid alkaloids were summarized based on our present and previous studies [2]: i) 1α-OMe or 1α-OH, 8-OH, 14-OH, and NH (or NMe) are key structural features important for the cardiac effect of the aconitine-type C 19 -diterpenoid alkaloids without any esters. C 18 -diterpenoid alkaloids, lycoctonine-type C 19 -diterpenoid alkaloids, and the veatchine- and denudatine-type C 20 -diterpenoid alkaloids did not show any cardiac activity; ii) the presence of 3α-OH is beneficial to the cardiac activity; iii) the effect on the cardiac action of 6α-OMe, 13-OH, 15α-OH, and 16-demethoxy or a double bond between C-15 and C-16 depends on the substituent pattern on the nitrogen atom.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501001216
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 5
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    The Efficacy and Safety of Transcutaneous Acupoint Interferential Current Stimulation for Cancer Pain Patients With Opioid-Induced Constipation: A Prospective Randomized Controlled Study
    SAGE Publications ; 2018
    In:  Integrative Cancer Therapies Vol. 17, No. 2 ( 2018-06), p. 437-443
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 17, No. 2 ( 2018-06), p. 437-443
    Abstract: Introduction. Opioid-induced constipation (OIC) is a principal complication secondary to analgesic therapy for cancer pain patients who suffer moderate to severe pain. In this study, we observe the efficacy and safety of transcutaneous acupoint interferential current (IFC) stimulation in those patients with OIC. Methods. A total of 198 patients were randomly allocated to the IFC group and control group in a 1:1 ratio. Finally, 98 patients in the IFC group received 14 sessions administered over 2 weeks, whereas 100 patients in the control group took lactulose orally during the same period. Observation items were documented at management stage and at follow-up stage according to Cleveland Constipation Scales (CCS), pain Numeric Rating Scales (NRS) and Patient Assessment of Constipation Quality of Life (PAC-QoL). Results. The total curative effects of the IFC group and the control group were indistinguishable (76.5% vs 70.0%, P = .299). Regarding CCS and PAC-QoL scores, no significant difference was observed between the 2 groups during the management time and at the follow-up stage of week 3 ( P 〉 .05, respectively), but groups were distinguished at the follow-up stage of week 4 ( P 〈 .001 and P = .031, respectively). The pain NRS decreased significantly at management stage week 2 and follow-up stage week 3 and week 4 ( P = .013, P = .041, P = .011, respectively). Conclusions. Transcutaneous acupoint IFC therapy over acupoints of Tianshu (ST25) and Zhongwan (RN12) may improve constipation and quality of life in cancer patients receiving opiates; further studies are worthwhile.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735417734910
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2101248-9
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  • 6
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    Overexpression of HDJ-2 Protects Astrocytes from Ischemia-Like Injury and Reduces Redistribution of Ubiquitin Staining in Vitro
    SAGE Publications ; 2003
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 23, No. 10 ( 2003-10), p. 1113-1116
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 23, No. 10 ( 2003-10), p. 1113-1116
    Abstract: HDJ-2, a member of the HSP40 family, functions as a cochaperone to promote protein folding both by binding to unfolded polypeptides and by regulating the activity of HSP70. This study tested whether HDJ-2 overexpression alone could provide significant protection from ischemia-like injury. Primary mouse astrocyte cultures were infected with an HDJ-2 encoding retroviral vector or control retrovirus lacking HDJ-2. Expression of HDJ-2 was confirmed by immunohistochemical staining and immunoblotting. Injury paradigms to mimic ischemia were glucose deprivation (GD) for 24 hours and oxygen-glucose deprivation (OGD) for 8 hours. Cell death was determined by trypan blue exclusion and cell counting. Overexpression of HDJ-2 alone significantly reduced astrocyte injury after both GD and OGD, independent of an elevation in HSP70. To further search for the mechanism of HDJ-2 protection, cultured astrocytes allowed to recover 16 hours after 8 hours GD were labeled with a monoclonal antiubiquitin antibody that recognizes both free ubiquitin and ubiquitinated proteins. The immunolabeling pattern changed from a relatively even distribution in both nuclei and cytoplasm in control cells to heterogeneous aggregates and marked reduction of nuclear staining in most of the cells after GD. When HDJ-2 was overexpressed, the number of cells with evidence of protein aggregation was significantly reduced. Thus, blocking protein aggregation may be an important mechanism by which HDJ-2 protects cells from damage.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1097/01.WCB.0000088765.02615.FE
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2039456-1
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  • 7
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    Predictors of perirenal haematoma post-percutaneous ultrasound-guided renal biopsy
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 11 ( 2021-11), p. 030006052110583-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 11 ( 2021-11), p. 030006052110583-
    Abstract: To perform a prospective study to determine the risk factors associated with perirenal haematoma development after percutaneous renal biopsy (PRB). Methods This multivariate prospective study collected demographic and clinical data from all consecutive adult patients that underwent real-time ultrasound-guided PRB of native kidneys. All biopsies were performed by two well-trained ultrasound physicians using 16G biopsy needles. Routine renal ultrasounds were performed within 12–24 h after biopsies in order to observe post-biopsy perirenal haematoma formation. Patients were stratified based on the occurrence of post-biopsy haematoma development. Results This prospective study enrolled 218 patients and stratified them into a haematoma group ( n = 126) and a non-haematoma group ( n = 92). Binary logistic regression analysis identified female patients (odds ratio [OR] 1.990; 95% confidence interval [CI] 1.125, 3.521), patients with a body mass index (BMI) ≥28 kg/m 2 (OR 2.660; 95% CI 1.097, 6.449) and patients with immediate post-biopsy active bleeding (IPAB) (OR 2.572; 95% CI 1.422, 4.655) as being more likely to have perirenal haematoma after real-time ultrasound guided PRB of native kidneys. Conclusion Female sex, a BMI ≥28 kg/m 2 and IPAB were risk factors for perirenal haematoma after real-time ultrasound-guided PRB of native kidneys.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211058377
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 8
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    Online Resource
    Astrocytic Induction of Matrix Metalloproteinase-9 and Edema in Brain Hemorrhage
    SAGE Publications ; 2007
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 27, No. 3 ( 2007-03), p. 460-468
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 27, No. 3 ( 2007-03), p. 460-468
    Abstract: We tested the hypothesis that astrocytic matrix metalloproteinase-9 (MMP-9) mediates hemorrhagic brain edema. In a clinical case of hemorrhagic stroke, MMP-9 co-localized with astrocytes and neurons in peri-hematoma areas. In a mouse model where blood was injected into striatum, MMP-9 was colocalized with astrocytes surrounding the hemorrhagic lesion. Because MMP-9 is present in blood as well as brain, we compared four groups of wild type (WT) and MMP-9 knockout (KO) mice: WT blood injected into WT brain, KO blood into KO brain, WT blood into KO brain, and KO blood into WT brain. Gel zymography showed that MMP-9 was elevated in WT hemorrhagic brain tissue but absent from KO hemorrhagic brain tissue. Edematous water content was elevated when WT blood was injected into WT brain. However, edema was ameliorated when MMP-9 was absent in either blood or brain or both. To further assess the mechanisms involved in astrocytic induction of MMP-9, we next examined primary mouse astrocyte cultures. Exposure to hemoglobin rapidly upregulated MMP-9 in conditioned media within 1 to 24 h. Hemoglobin-induced MMP-9 was reduced by the free radical scavenger U83836E. Taken together, these data suggest that although there are large amounts of MMP-9 in blood, hemoglobin-induced oxidative stress can trigger MMP-9 in astrocytes and these parenchymal sources of matrix degradation may also be an important factor in the pathogenesis of hemorrhagic brain edema.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/sj.jcbfm.9600354
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2039456-1
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  • 9
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    Tissue-Type Plasminogen Activator has Paradoxical Roles in Focal Cerebral Ischemic Injury by Thrombotic Middle Cerebral Artery Occlusion with Mild or Severe Photochemical Damage in Mice
    SAGE Publications ; 2002
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 22, No. 6 ( 2002-06), p. 648-651
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 22, No. 6 ( 2002-06), p. 648-651
    Abstract: The role of endogenous tissue-type plasminogen activator (tPA) in focal cerebral ischemic injury (FCII) after middle cerebral artery occlusion was studied using tPA gene-deficient (KO) mice and their wild-type (WT) littermates. The middle cerebral artery was occluded by thrombi induced by three different intensities of photochemical damage, a method that was newly introduced in mice. In both WT and KO mice, the intensity-dependent increase of FCII size was observed. The FCII size in tPA WT mice was smaller than in KO mice in cases of mild damage, whereas the FCII size was larger in WT mice than in KO mice in cases of severe damage. There was no difference in FCII size between WT and KO mice in cases of moderate damage. The number of microthrombi also increased with damage intensity in both WT and KO mice, but was less in WT mice at all intensities of damage. The results support the validity of the model of thrombotic occlusion by photochemical damage in mice, and suggest that endogenous tPA protects FCII through thrombolytic action on transient occlusion of middle cerebral artery with mild damage, but deteriorates on persistent occlusion with severe damage.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1097/00004647-200206000-00002
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2039456-1
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  • 10
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    Experimental investigation of steel-concrete composite beams with different degrees of shear connection under monotonic and fatigue loads
    SAGE Publications ; 2018
    In:  Advances in Structural Engineering Vol. 21, No. 2 ( 2018-01), p. 227-240
    Details
    In: Advances in Structural Engineering, SAGE Publications, Vol. 21, No. 2 ( 2018-01), p. 227-240
    Type of Medium: Online Resource
    ISSN: 1369-4332 , 2048-4011
    URL: Article
    DOI: 10.1177/1369433217717121
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2026561-X
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