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  • SAGE Publications  (4)
  • 1
    Online Resource
    Online Resource
    Nanobody Conjugates for Targeted Cancer Therapy and Imaging
    SAGE Publications ; 2021
    In:  Technology in Cancer Research & Treatment Vol. 20 ( 2021-01-01), p. 153303382110101-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 20 ( 2021-01-01), p. 153303382110101-
    Abstract: Conventional antibody-based targeted cancer therapy is one of the most promising avenues of successful cancer treatment, with the potential to reduce toxic side effects to healthy cells surrounding tumor cells. However, the full potential of antibodies is severely limited due to their large size, low stability, slow clearance, and high immunogenicity. Alternatively, recently discovered nanobodies, which are the smallest naturally occurring antigen-binding format, have shown great potential for addressing these limitations. Bioconjugation of nanobodies to functional groups such as toxins, enzymes, radionucleotides, and fluorophores can improve the efficacy and potency of nanobodies, enhance their in vivo pharmacokinetics, and expand the range of potential applications. Herein, we review the superior characteristics of nanobodies in comparison to conventional antibodies and provide insight into recent developments in nanobody conjugates for targeted cancer therapy and imaging.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338211010117
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Sound absorption properties of multi-layer structural composite materials based on waste corn husk fibers
    SAGE Publications ; 2020
    In:  Journal of Engineered Fibers and Fabrics Vol. 15 ( 2020-01), p. 155892502091086-
    Details
    In: Journal of Engineered Fibers and Fabrics, SAGE Publications, Vol. 15 ( 2020-01), p. 155892502091086-
    Abstract: In order to find a reasonable way to use the waste corn husk, waste degummed corn husk fibers were used as reinforcing material in one type of composite material. And polylactic acid particles were used as matrix material. The composite materials were prepared by mixing and hot-pressing process, and they were processed into the micro-slit panel. Then, the multi-layer structural sound absorption composite materials were prepared sequentially by micro-slit panel, air cavity, and flax felt. Finally, the sound absorption properties of the multi-layer structural composite materials were studied by changing flax felt thickness, air cavity depth, slit rate, and thickness of micro-slit panel. As the flax felt thickness varied from 0 to 10 mm in 5 mm increments, the peak of sound absorption coefficient shifted to low frequency. The sound absorption coefficient in the low frequency was improved with the air cavity depth varied from 0 to 10 mm in 5 mm increments. With the slit rate increased from 3% to 7% in 2% increments, the peak of sound absorption coefficient shifted to high frequency. With the thickness of micro-slit panel increased from 2 to 6 mm in 2 mm increments, the sound absorption bandwidth was broaden, and the peak of sound absorption coefficient was increased and shifted to low frequency. Results showed that the highest sound absorption coefficient of the multi-layer structural composite materials was about 1 under the optimal process conditions.
    Type of Medium: Online Resource
    ISSN: 1558-9250 , 1558-9250
    URL: Article
    DOI: 10.1177/1558925020910861
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2393988-6
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  • 3
    Online Resource
    Online Resource
    Celastrol alleviates LPS-induced inflammation in BMDMs and acute lung injury in mice via inhibition of p-38 MAPK/MK2 signaling
    SAGE Publications ; 2021
    In:  European Journal of Inflammation Vol. 19 ( 2021-01), p. 205873922110205-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 19 ( 2021-01), p. 205873922110205-
    Abstract: Celastrol is a compound extracted from a medicinal plant Tripterygium wilfordii which has a broad-spectrum anti-inflammatory effect in traditional medicine. However, the effect of celastrol on acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is still unknown. Methods: We reported that celastrol alleviated LPS-induced acute lung injury by H & E staining, MPO activity and the expression of cytokines in broncho-alveolar lavage fluid. The effect of celastrol on bone marrow-derived macrophages (BMDMs) after LPS treatment was measured by ELISA and Western blotting. Results: In vivo, celastrol reduced the LPS-induced lung edema and MPO activity of lung tissue. Furthermore, the production of inflammatory cytokines IL-6, TNF-α, and KC in bronchoalveolar lavage was reduced. In vitro, upon treatment of LPS, celastrol dose-dependently inhibited the expression of iNOS in BMDMs. Meanwhile, the expression of IL-6, TNF-α, and KC in BMDMs were also inhibited by celastrol treatment. Furthermore, we found that celastrol attenuated the phosphorylation of p38 MAPK and MK2, and inhibited the interaction between p38 MAPK and MK2. Conclusion: Our data indicate that celastrol has an anti-inflammatory effect on LPS-induced inflammatory response in vivo and in vitro, suggesting celastrol is a promising compound for the treatment of ALI and ARDS.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/20587392211020569
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2584683-8
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  • 4
    Online Resource
    Online Resource
    Associations Between Bicycling for Transportation and Cardiometabolic Risk Factors Among Minneapolis–Saint Paul Area Commuters: A Cross-Sectional Study in Working-Age Adults
    SAGE Publications ; 2018
    In:  American Journal of Health Promotion Vol. 32, No. 3 ( 2018-03), p. 631-637
    Details
    In: American Journal of Health Promotion, SAGE Publications, Vol. 32, No. 3 ( 2018-03), p. 631-637
    Abstract: This study describes the association between frequency of bicycling for active transportation and modifiable cardiometabolic risk factors in the Minneapolis–Saint Paul (MSP) metropolitan area. Design: We conducted an online survey from a convenience sample of likely bicycle commuters. Setting: Participants were e-mailed invitations including a link to the online survey. Participants: Participants (n = 1450, 15.6% response rate) were residents of the 7-county MSP metropolitan area aged 20 to 64 years. Measures: Participants reported frequency of commute and destination cycling from April to September and October to March, prevalent cardiometabolic risk factors, and demographic covariates. Analysis: We performed logistic regressions for associations between average weekly transportation bicycling and self-reported prevalent obesity, high blood pressure, high cholesterol, low high-density lipoprotein cholesterol, and high triglycerides. We used Poisson regression for the count of cardiometabolic risk factors. All models were adjusted for age, sex, race, smoking, alcohol consumption, and other physical activity, with random intercepts by zip code. Results: Self-reported bicycling frequency is associated with significantly lower odds of prevalent obesity, hypertension, and high triglycerides. Three bicycling trips per week is associated with 20% fewer (95% confidence interval: 12%-28%) cardiometabolic risk factors. Conclusion: Bicycling frequency is inversely associated with cardiometabolic risk factors. These results provide empirical support for the promotion of active transportation as public health policy.
    Type of Medium: Online Resource
    ISSN: 0890-1171 , 2168-6602
    URL: Article
    DOI: 10.1177/0890117117710735
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2134271-4
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