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  • 1
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    Mutation analyses in pedigrees and sporadic cases of ethnic Han Chinese Kallmann syndrome patients
    SAGE Publications ; 2015
    In:  Experimental Biology and Medicine Vol. 240, No. 11 ( 2015-11), p. 1480-1489
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 240, No. 11 ( 2015-11), p. 1480-1489
    Abstract: Kallmann syndrome, a form of idiopathic hypogonadotropic hypogonadism, is characterized by developmental abnormalities of the reproductive system and abnormal olfaction. Despite association of certain genes with idiopathic hypogonadotropic hypogonadism, the genetic inheritance and expression are complex and incompletely known. In the present study, seven Kallmann syndrome pedigrees in an ethnic Han Chinese population were screened for genetic mutations. The exons and intron–exon boundaries of 19 idiopathic hypogonadotropic hypogonadism (idiopathic hypogonadotropic hypogonadism)-related genes in seven Chinese Kallmann syndrome pedigrees were sequenced. Detected mutations were also tested in 70 sporadic Kallmann syndrome cases and 200 Chinese healthy controls. In pedigrees 1, 2, and 7, the secondary sex characteristics were poorly developed and the patients’ sense of smell was severely or completely lost. We detected a genetic mutation in five of the seven pedigrees: homozygous KAL1 p.R191ter (pedigree 1); homozygous KAL1 p.C13ter (pedigree 2; a novel mutation); heterozygous FGFR1 p.R250W (pedigree 3); and homozygous PROKR2 p.Y113H (pedigrees 4 and 5). No genetic change of the assayed genes was detected in pedigrees 6 and 7. Among the 70 sporadic cases, we detected one homozygous and one heterozygous PROKR2 p.Y113H mutation. This mutation was also detected heterozygously in 2/200 normal controls and its pathogenicity is likely questionable. The genetics and genotype–phenotype relationships in Kallmann syndrome are complicated. Classical monogenic inheritance does not explain the full range of genetic inheritance of Kallmann syndrome patients. Because of stochastic nature of genetic mutations, exome analyses of Kallmann syndrome patients may provide novel insights.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370215587531
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2020856-X
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  • 2
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    Prognostic Nutritional Index as a Novel Predictor of Long-Term Prognosis in Patients with Coronary Artery Disease After Percutaneous Coronary Intervention
    SAGE Publications ; 2022
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 28 ( 2022-01), p. 107602962211032-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962211032-
    Abstract: The Prognostic Nutritional Index (PNI) has been reported to be correlated with long-term outcomes after gastrointestinal tumor surgery. However, to our knowledge, only a few studies have shown that the PNI is related to cardiovascular diseases. Therefore, we aimed to assess the association between the PNI and long-term outcomes in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Methods This was retrospective observational study. A total of 3561 patients with CAD after PCI were retrospectively enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The patients (3519) were divided into three groups according to PNI tertiles: the first tertile (PNI  〈  47.12, n = 1173), the second tertile (47.12 ≤ PNI  〈  51.50, n = 1185), and the third tertile (PNI ≥ 51.50, n = 1161). The mean follow-up time was 37.59 ± 22.24 months. The primary endpoint long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM).Secondary endpoints were major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs). Result In our study, the incidences of ACM in the first, second, and third tertiles were 3.8%, 1.8% and 1.4%, respectively ( P  〈  0.001). The incidences of CM occurring in the first, second, and third tertiles were 1.7%, 3.1% and 2.1%, respectively ( P  〈  0.001).There was statistically significant different in primary endpoints incidence. MACEs occurred in 139 patients (11.8%) in the first tertile, 121 patients(11.1%) in the second tertile and 123 patients(10.8%) in the third tertile( P = 0.691). MACCEs occurred in 183 patients (15.6%) in the first tertile, 174 patients(14.7%) in the second tertile and 160 patients(13.85%) in the third tertile( P = 0.463).There was no statistically significant different in secondary endpoints incidence. Kaplan–Meier analyses showed that elevated PNI was significantly related to long-term CM (log rank, P   〈  0.001) and long-term ACM (log-rank, P   〈  0.001). Cox regression analyses suggested that compared with the patients in the first tertile, the risk of ACM was decreased to 60.9% (HR = 0.609, 95% CI: 0.398–0.932, P = 0.029) in the second tertile and 40.3%(HR = 0.403, 95% CI: 0.279–0.766, P = 0.003) in the third tertile, while the risk of CM was decreased to 58.8%(HR = 0.588, 95% CI: 0.321–0.969, P = 0.038) in the second tertile and 46.6%(HR = 0.466, 95% CI: 0.250–0.870, P = 0.017) in the third tertile. Multivariate Cox regression analyses showed that the PNI was an independent predictor of long-term ACM and CM. Conclusion Our finding shown that PNI is an independent predictor in CAD patients after PCI，the higher the PNI, the less occurring adverse event. Therefore，PNI may be an new biomarker to predict long-term outcome of CAD patients after PCI.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296221103271
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 3
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    Optimal inspection and replacement strategy for 145 kV gas-insulated switchgear
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability Vol. 236, No. 2 ( 2022-04), p. 339-347
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability, SAGE Publications, Vol. 236, No. 2 ( 2022-04), p. 339-347
    Abstract: We deal with an optimization problem of planning a maintenance strategy for 145 kV gas-insulated switchgear and apply reliability-centered maintenance approach to find an efficient and effective strategy. In a three-step sequential process, we use failure mode effects and criticality analysis to define the critical failure modes that cause the major failures of 145 kV gas-insulated switchgear, select the maintenance significant items to remove the major failure modes, and finally apply logic tree analysis to assign the appropriate maintenance task to each critical failure modes in the system. We then compare the assigned maintenance tasks with existing tasks in the installation, operation, and maintenance manuals developed in the system design and development phase. The assigned maintenance tasks in this study are compared with those in the system design and development phase by simulation, and a simple heuristic method is proposed to find optimal solutions.
    Type of Medium: Online Resource
    ISSN: 1748-006X , 1748-0078
    URL: Article
    DOI: 10.1177/1748006X19893540
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 4
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    A Correlation Between Monocyte to Lymphocyte Ratio and Long-Term Prognosis in Patients With Coronary Artery Disease After PCI
    SAGE Publications ; 2021
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 27 ( 2021-01-01), p. 107602962199971-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 27 ( 2021-01-01), p. 107602962199971-
    Abstract: Monocyte to lymphocyte ratio (MLR) has been confirmed as a novel marker of poor prognosis in patients with coronary heart disease (CAD). However, the prognosis value of MLR for patients with CAD after percutaneous coronary intervention (PCI) needs further studies. In present study, we aimed to investigate the correlation between MLR and long-term prognosis in patients with CAD after PCI. A total of 3,461 patients with CAD after PCI at the First Affiliated Hospital of Zhengzhou University were included in the analysis. According to the cutoff value of MLR, all of the patients were divided into 2 groups: the low-MLR group ( 〈 0.34, n = 2338) and the high-MLR group (≥0.34, n = 1123). Kaplan–Meier curve was performed to compare the long-term outcome. Multivariate COX regression analysis was used to assess the independent predictors for all-cause mortality, cardiac mortality and MACCEs. Multivariate COX regression analysis showed that the high MLR group had significantly increased all-cause mortality (ACM) [hazard ratio (HR) = 1.366, 95% confidence interval (CI): 1.366-3.650, p = 0.001] and cardiac mortality (CM) (HR = 2.379, 95%CI: 1.611-3,511, p 〈 0.001) compared to the low MLR group. And high MLR was also found to be highly associated with major adverse cardiovascular and cerebrovascular events (MACCEs) (HR = 1.227, 95%CI: 1.003-1.500, p = 0.047) in patients with CAD undergoing PCI. MLR was an independent predictor of ACM, CM and MACCEs in CAD patients who underwent PCI.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029621999717
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 5
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    Increased Medial Meniscal Slope Is Associated With Greater Risk of Ramp Lesion in Noncontact Anterior Cruciate Ligament Injury
    SAGE Publications ; 2016
    In:  The American Journal of Sports Medicine Vol. 44, No. 8 ( 2016-08), p. 2039-2046
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 44, No. 8 ( 2016-08), p. 2039-2046
    Abstract: A special type of meniscal lesion involving the peripheral attachment of the posterior horn of the medial meniscus (PHMM), termed ramp lesion, is commonly associated with anterior cruciate ligament (ACL) injury. However, no study has investigated its anatomic risk factors. Recently, increased meniscal slope has been identified as an independent anatomic risk factor for noncontact ACL injury. Hypothesis: Increased medial meniscal slope (MMS) as measured on magnetic resonance imaging (MRI) will correlate with greater risk of concomitant ramp lesion in noncontact ACL injury. Study Design: Case-control study; Level of evidence, 3. Methods: From January 2011 to December 2013, a total of 1012 consecutive patients were diagnosed as having noncontact ACL injuries and underwent primary ACL reconstructions. Among them, 160 patients were arthroscopically verified to have concomitant ramp lesions. Study exclusion criteria included partial ACL rupture, multiligamentous injury, associated medial/lateral meniscal lesions other than ramp lesion, skeletal immaturity, general joint laxity, severe malalignment of the lower extremity, history of knee surgery, lack of available preoperative MRI, and history of trauma to the proximal tibia. This left 53 patients in the study group (ACL + ramp group), who were matched in a 1:1 fashion to 53 control participants (isolated ACL group) who were arthroscopically verified to have isolated complete ACL injury during the same study period. Patients were matched by age, sex, and time from injury to surgery (TFI). Patients from the matched control group were selected by applying the same exclusion criteria as mentioned above. The MMS and medial posterior tibial slope (MPTS) were measured on the preoperative MRI in a blinded fashion. Predictors of ramp lesion, including MMS, MPTS, body mass index, pivot-shift test grade, and KT-1000 arthrometer side-to-side difference, were assessed by multivariable conditional logistic regression analysis. Results: The mean MMS in the study group was 3.5°, which was significantly larger than that in the control group (2.0°; P 〈 .001). In addition, increased MMS was significantly (odds ratio [OR], 5.180; 95% CI, 1.814-32.957; P 〈 .001) associated with concomitant ramp lesion in noncontact ACL injury, especially for those with a TFI of ≥6 months (OR, 13.819; 95% CI, 2.251-49.585; P 〈 .001). However, no significant association was identified between MPTS and concomitant ramp lesion. Conclusion: Increased MMS was identified to be an independent anatomic risk factor of concomitant ramp lesions in noncontact ACL injuries, particularly for those with a TFI ≥6 months. This may provide additional information for counseling patients who have increased MMS on the greater risk of secondary PHMM lesions if their ACL-deficient knee joints are not well stabilized initially.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546516640516
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2063945-4
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  • 6
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    Interaction Between Season of Birth and COMT Val158Met (rs4680) in ADHD in a Large Sample of Chinese Han Participants
    SAGE Publications ; 2018
    In:  Journal of Attention Disorders Vol. 22, No. 9 ( 2018-07), p. 886-895
    Details
    In: Journal of Attention Disorders, SAGE Publications, Vol. 22, No. 9 ( 2018-07), p. 886-895
    Abstract: Objective: To investigate the interaction between catechol-O-methyltransferase gene (COMT) Val108/158Met (rs4680) and season of birth (SOB) on ADHD and its symptoms. Method: We conducted transmission disequilibrium tests (TDTs) in 976 trios, then further performed the above analyses in subgroups according to SOB. Quantitative analyses were performed for ADHD symptoms evaluated by ADHD Rating Scale–IV in 1,530 ADHD cases. Results: Overall, there was no association between COMT and ADHD. After stratification, we found an increased transmission of the Val allele in the trios born in spring, while a decreased transmission was observed in the autumn months. We also observed a significant interaction between Val108/158Met and SOB on ADHD symptoms. Among those born in spring, Met carriers had milder ADHD symptoms compared with Val homozygotes, whereas opposite association was found in those born in autumn. Conclusion: Our study provided evidence for the modifying effect of SOB on the association between COMT and ADHD along with its symptoms.
    Type of Medium: Online Resource
    ISSN: 1087-0547 , 1557-1246
    URL: Article
    DOI: 10.1177/1087054715608441
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2188086-4
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  • 7
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    Risk Factors Associated With Grade 3 Pivot Shift After Acute Anterior Cruciate Ligament Injuries
    SAGE Publications ; 2016
    In:  The American Journal of Sports Medicine Vol. 44, No. 2 ( 2016-02), p. 362-369
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 44, No. 2 ( 2016-02), p. 362-369
    Abstract: Recent literature has demonstrated that involvement in pivoting sports at the time of injury, increased posterior-inferior tibial slope (PITS), anterolateral capsular ligament (ALCL) disruptions, and combined lateral meniscal lesions all contribute to a higher grade of pivot shift after acute anterior cruciate ligament (ACL) injuries. Purpose: To identify risk factors associated with grade 3 pivot shift after acute ACL injuries. Study Design: Case-control study; Level of evidence, 3. Methods: A database of patients undergoing primary ACL reconstruction from 2009 to 2015 after acute ACL injuries was retrospectively reviewed. A total of 30 patients (30 knees) with grade 3 pivot shift were identified as the study group. Moreover, 30 patients (30 knees) with grade 1 and 30 patients (30 knees) with grade 2 pivot shift were randomly chosen as the 2 control groups. All pivot-shift tests were performed with the patients under anesthesia. Predictors of grade 3 pivot shift that were explored included patient age, sex, time from injury to surgery, pivoting sports involvement at the time of injury, lateral PITS, medial PITS, ALCL disruptions, preoperative KT-1000 arthrometer side-to-side difference, and combined lateral or medial meniscal lesions. Comparisons were performed between the study group and the 2 control groups. Univariable and multivariable logistic regressions were used to identify independent risk factors that were associated with grade 3 pivot shift. Results: Univariable and multivariable logistic regressions between the study group and the 2 control groups showed that pivoting sports involvement at the time of injury (odds ratio 1 [OR 1 ; grade 3 vs grade 1 pivot shift with grade 1 = reference], 11.88; 95% CI, 1.94-149.91; OR 2 [grade 3 vs grade 2 pivot shift with grade 2 = reference], 3.41; 95% CI, 1.92-22.60), abnormal degree of lateral PITS (OR 1 , 14.41; 95% CI, 1.69-174.78; OR 2 , 6.41; 95% CI, 1.48-47.70), ALCL disruptions (OR 1 , 8.28; 95% CI, 1.71-117.14; OR 2 , 4.96; 95% CI, 1.07-28.75), and combined lateral meniscal lesions (OR 1 , 27.56; 95% CI, 5.48-240.52; OR 2 , 5.83; 95% CI, 1.21-38.56) were independent risk factors of grade 3 pivot shift after acute ACL injuries. Conclusion: For acute ACL injuries, the best set of predictors of grade 3 pivot shift were pivoting sports involvement at the time of injury, abnormal lateral PITS, ALCL disruptions, and combined lateral meniscal lesions. These results may provide additional information for counseling patients on residual laxity and risks for graft rerupture after ACL reconstruction.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546515613069
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2063945-4
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  • 8
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    The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI
    SAGE Publications ; 2022
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 28 ( 2022-01), p. 107602962211133-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962211133-
    Abstract: Previous evidences have been proved that age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and ejection fraction are tightly associated with the long-term outcomes in patients suffered from coronary artery disease (CAD). Therefore, the present study aimed to assess the prognosis value of age, NT-proBNP, and ejection fraction (ABEF) score in CAD patients who underwent percutaneous coronary intervention (PCI). Methods Observational cohort methodology was used in this study which enrolled totally 3561 patients. And the patients were followed up regularly for 37.59 ± 22.24 months. Patients were classed into three groups based on the tertiles of ABEF sore: first tertile ( 〈 5.06, n = 831), second tertile (5.06-6.25, n = 839), and third tertile (≥ 6.25, n = 834). The ABEF score was calculated as follows: age (years)/ejection fraction (%) + NT-proBNP (NT-proBNP 〈 177pg/mL was 1, 177≤NT-proBNP≥524pg/mL was 2 and NT-proBNP  〉  524pg/mL is 3). The association between ABEF score and adverse prognosis, including all-cause death (ACD), cardiac death (CD), major adverse cardiovascular events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs), in patients who underwent PCI was analyzed. Results According to the risk category of ABEF score, the incidences of ACD ( P  〈  .001), CD ( P  〈  .001) and MACCEs ( P = .021) among the three groups showed significant differences. Multivariate Cox regression analysis suggested that the respective risks of ACD and CD were increased 3.013 folds (hazard risk [HR] = 4.013 [95% confidence interval [CI] : 1.922-8.378], P  〈  .001) and 4.922 folds ([HR] = 5.922 [95% [CI] : 2.253-15.566], P  〈  .001) in the third tertile compared with those in the first tertile. Kaplan-Meier survival analyses showed that the cumulative risks of ACD,CD and MACCEs in patients with the high ABEF score tended to increase. Conclusion The present study indicated ABEF score was a novel biomarker suitable for predicting adverse prognosis in patients after PCI, which may be used for early recognition and risk stratification.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296221113345
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 9
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    Compatibilization of irradiated HDPE
    SAGE Publications ; 2016
    In:  Journal of Thermoplastic Composite Materials Vol. 29, No. 7 ( 2016-07), p. 904-912
    Details
    In: Journal of Thermoplastic Composite Materials, SAGE Publications, Vol. 29, No. 7 ( 2016-07), p. 904-912
    Abstract: The C–O, C=O, and C(=O)O groups were introduced onto high-density polyethylene (HDPE) chains by ultraviolet irradiation in air and the groups’ content increased with increase in the irradiation time. When they irradiated for 16 h, gels were formed in the irradiated HDPE, and the content of the gels increased with increase in the irradiation time. Compared with HDPE, the crystal form of the irradiated HDPE did not change and still retained the orthorhombic structure, and its melting temperature decreased, while its crystallinity increased. The irradiated HDPE was added in HDPE/CaCO 3 composites as a compatibilizer, and HDPE/irradiated HDPE/CaCO 3 composites were obtained. Compared with those in HDPE/CaCO 3 composites, the dispersion of the CaCO 3 and interfacial interaction between CaCO 3 and HDPE matrix in HDPE/irradiated HDPE/CaCO 3 composites improved due to compatibilization of the irradiated HDPE, and its mechanical properties (especially impact strength), thus, showed remarkable enhancement. With increase in irradiation time, the tensile strength of HDPE/irradiated HDPE/CaCO 3 composites enhanced and its impact strength increased during irradiation time of 16 h and then decreased slightly. In the same irradiation time, the tensile strength and impact strength of HDPE/irradiated HDPE/CaCO 3 composites increased with increase in the content of the irradiated HDPE.
    Type of Medium: Online Resource
    ISSN: 0892-7057 , 1530-7980
    URL: Article
    DOI: 10.1177/0892705714551238
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2098671-3
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  • 10
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    The influence of a nanoparticle gel loaded with siRNA-cyclooxygenase on flexor tendon healing: an in vivo animal study
    SAGE Publications ; 2022
    In:  Journal of Hand Surgery (European Volume) Vol. 47, No. 10 ( 2022-11), p. 1064-1070
    Details
    In: Journal of Hand Surgery (European Volume), SAGE Publications, Vol. 47, No. 10 ( 2022-11), p. 1064-1070
    Abstract: We investigated the influence of cyclooxygenase (COX)-1 and COX-2 siRNAs delivered through a nanoparticle-gel system on the strength of flexor tendon repairs. Sixteen flexor digitorum profundus (FDP) tendons of chicken toes were transected, repaired and wrapped with gels to evaluate gel adherence. We found that the gel adhered to the tendon surface firmly. Next, 56 tendons were used in a first set of in vivo experiments to compare the therapeutic effects of different doses of COX siRNAs. Another 15 tendons were added in a second set to further assess the effects of a dosage of 12 μg. After 4 weeks, the mean strength of the repaired tendons increased most notably in the toes treated with 12 μg COX siRNAs, and the number of samples with low strength ( 〈 35 N) was significantly smaller than in the group without molecular treatment. We conclude that COX-1 and COX-2 siRNAs delivered through a nanoparticle-gel system increased the healing strength of the repaired tendons.
    Type of Medium: Online Resource
    ISSN: 1753-1934 , 2043-6289
    URL: Article
    DOI: 10.1177/17531934221109709
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2270603-3
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