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  • SAGE Publications  (32)
  • 1
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    Online Resource
    Increased Signal Transducer and Activator of Transcription 3 (STAT3) and Decreased Cyclin D1 in Recurrent Astrocytic Tumours Compared with Paired Primary Astrocytic Tumours
    SAGE Publications ; 2011
    In:  Journal of International Medical Research Vol. 39, No. 6 ( 2011-12), p. 2103-2109
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 39, No. 6 ( 2011-12), p. 2103-2109
    Abstract: This study compared the levels of signal transducer and activator of transcription 3 (STAT3) and cyclin D1 protein in paired primary and recurrent astrocytic tumours, and analysed their correlation with clinicopathological and treatment factors. A total of 48 samples from 24 patients who had undergone surgical removal of primary and recurrent astrocytic tumours were analysed. Levels of STAT3 and cyclin D1 protein were detected using immunohistochemistry. Increased STAT3 and decreased cyclin D1 levels were observed in recurrent astrocytic tumours compared with their paired primary tumours. There was a significant correlation between higher levels of STAT3 protein and shorter progression-free survival in primary tumours after surgery ( r = 0.417), and a significant correlation between decreased cyclin D1 protein levels and radiotherapy in recurrent tumours ( r = 0.468). It was concluded that increased STAT3 and decreased cyclin D1 protein levels may contribute to the recurrence of astrocytic tumours. Detection of STAT3 may be useful in predicting progression-free survival in primary astrocytic tumours after surgery. In addition, radiotherapy may decrease cyclin D1 levels in astrocytic tumours, but the nature of this association requires further investigation.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323001103900606
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2082422-1
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  • 2
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    Application of thromboelastography in comparing coagulation difference of rivaroxaban and enoxaparin for thromboprophylaxis after total hip arthroplasty
    SAGE Publications ; 2021
    In:  Journal of Orthopaedic Surgery Vol. 29, No. 3 ( 2021-09), p. 230949902110426-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 29, No. 3 ( 2021-09), p. 230949902110426-
    Abstract: Purpose: The purpose of this study was to compare the coagulation difference in patients with either rivaroxaban or enoxaparin as thromboprophylaxis after total hip arthroplasty (THA) regarding thromboelastography (TEG) and routine coagulation tests. Patients and methods: Two hundred and twenty-eight patients undergoing primary THA were recruited in this study. They were divided into two groups according to a computer-generated random sequence. Patients in the rivaroxaban group received 10 mg of rivaroxaban orally once daily. Patients in the enoxaparin group received 4000 AxaIU (0.4 mL) of enoxaparin subcutaneously once daily. Rivaroxaban and enoxaparin were started 6–8 h after surgery. The administration of the anticoagulant prophylaxis was lasted for a minimum of 14 days. TEG and routine coagulation tests were performed on the day before the operation and 1 day and 7 days after the operation. Results: No difference was observed in the incidence of deep vein thrombosis (DVT) or pulmonary embolism (PE) between the two groups. There was no significant difference with regard to prothrombin time (PT), activated partial thromboplastin time (PTT), international normalized ratio (INR), and thrombin time (TT) between the two groups. However, while considering TEG, R time of the rivaroxaban group was significantly higher than that of the enoxaparin group ( p = 0.003), whereas the maximum amplitude (MA) ( p = 0.036) value and coagulation index (CI) ( p = 0.002) value were significantly lower than those of the enoxaparin group. Conclusion: With regard to TEG analysis, there was coagulation difference in patients with rivaroxaban and those with enoxaparin as thromboprophylaxis after THA. Under recommended dose of rivaroxaban and enoxaparin, patients undergoing THA were in hypercoagulability on 7days postoperative.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/23094990211042674
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2128854-9
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  • 3
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    Effects analysis of thermo-mechanical loads on classified damage characteristics with the equivalent cylinder head model
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 237, No. 9 ( 2023-07), p. 2185-2195
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 237, No. 9 ( 2023-07), p. 2185-2195
    Abstract: As a vulnerable part of diesel engine, cylinder head is periodically subjected to the thermo-mechanical coupling loads. While due to the restriction of complex structures and working conditions, it makes the damage mechanism of thermo-mechanical coupling still unclear. In this research, thermo-mechanical responses are predicted successfully by load spectrums and the Sehitoglu theory. Then the effects of working loads on classified damage characteristics are analyzed with the equivalent cylinder head model. The results show that the deviations of temperature and stress are, respectively, within 10°C and 30 MPa, and it verifies the effectiveness of simulated component. Operating speed takes the greatest effect on the thermo-mechanical characteristics, and bolt force and gas pressure are negatively correlated with the responses of stress and strain. Fatigue life and damage are determined by the values of working loads. The effect of temperature load is the most dominant, MechDam and OxidDam increase substantially when operating speed exceeds 3500 r/min. The research will provide a theoretical reference for engineering design and optimization of cylinder head.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/09544100221149239
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2032759-6
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  • 4
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    Effect of Chemical Thromboprophylaxis on the Rate of Venous Thromboembolism After Treatment of Foot and Ankle Fractures
    SAGE Publications ; 2016
    In:  Foot & Ankle International Vol. 37, No. 11 ( 2016-11), p. 1218-1224
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 37, No. 11 ( 2016-11), p. 1218-1224
    Abstract: Venous thromboembolism (VTE) is a well-documented complication in patients with lower limb fractures, but management guidelines for its prevention in isolated foot and ankle fracture patients are conflicting. The aim of this study was to conduct a multicenter, prospective cohort study to define the prevalence of VTE in patients with isolated foot and ankle fractures and determine whether routine prophylaxis is necessary in these patients. Methods: In a double-blind, placebo-controlled study, consecutive patients in 3 hospitals who met our criteria were enrolled. After randomization, patients received either thromboprophylaxis with low-molecular-weight heparin units (LMWH group) or placebo (placebo group) for a period of 2 weeks. All patients underwent routine ultrasonography 1 day preoperatively, 1 week postoperatively, and 1 month postoperatively. Demographic parameters were then collected and compared. Results: Of the 814 patients who met our criteria, 19 patients (2.3%, 95% confidence interval [CI], 0%-31.9%) were found to have objectively confirmed VTE, but none of the patients were symptomatic. Of the 411 patients in the LMWH group, 2 developed VTEs preoperatively and 4 postoperatively; of the 403 patients in the placebo group, 5 developed VTEs preoperatively and 8 postoperatively. The overall incidence of asymptomatic postoperative deep vein thrombosis (DVT) was 0.98% (95% CI 0%-20.3%) in the LMWH group and 2.01% (95% CI 0%-29.5%) in the placebo group without significant difference. Advanced age (odds ratio [OR] 1.050, 95% CI 1.014-1.088, P = .007) and high body mass index (OR 1.201, 95% CI 1.034-1.395, P = .016) were identified as risk factors in predicting occurrence of DVT. No fatal pulmonary emboli or major bleeding complication occurred in either group. Conclusion: Routine anticoagulant prophylaxis was not found to be necessary for patients with foot and ankle fractures, although further investigation with a properly powered study design is required to definitively determine which foot and ankle patients are best served by anticoagulation and which ones are not. Level of Evidence: Level II, prospective comparative study.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100716658953
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2129503-7
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  • 5
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    Efficacy of Recombinant Human Thrombopoietin for the Treatment of Secondary Failure of Platelet Recovery After Allogeneic HSCT
    SAGE Publications ; 2022
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 28 ( 2022-01), p. 107602962110680-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962110680-
    Abstract: Secondary failure of platelet recovery (SFPR) is a life-threatening complication that may affect up to 20% of patients after allogeneic hematopoietic stem cell transplantation (HSCT). In this study, to evaluate the efficacy of recombinant human thrombopoietin (rhTPO), we retrospectively analyzed 29 patients who received continuous rhTPO for the treatment of SFPR. Overall response and complete response were observed in 24 (82.8%) patients and 10 (34.5%) patients, at a median time of 21.5 days (range, 3-41 days) and 39.5 days (range, 7-53 days) after initiation of rhTPO treatment, respectively. Among the responders, the probability of keeping overall response and complete response at 1 year after response was 77.3% and 80.0%, respectively. In multivariate analysis, higher CD34 + cells (≥3 × 10 6 /kg) infused during HSCT (HR: 7.22, 95% CI: 1.53-34.04, P = 0.01) and decreased ferritin after rhTPO treatment (HR: 6.16, 95% CI: 1.18-32.15, P = 0.03) were indicated to associate with complete response to rhTPO. Importantly, rhTPO was well tolerated in all patients without side effects urging withdrawal and clinical intervention. The results of this study suggest that rhTPO may be a safe and effective treatment for SFPR.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296211068037
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2230591-9
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  • 6
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    Double-Limb Graft Versus Single-Limb Graft Medial Patellofemoral Ligament Reconstruction for Recurrent Patellar Dislocation: A Meta-analysis of Randomized Controlled Trials and Cohort Studies
    SAGE Publications ; 2023
    In:  The American Journal of Sports Medicine Vol. 51, No. 12 ( 2023-10), p. 3313-3324
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 51, No. 12 ( 2023-10), p. 3313-3324
    Abstract: The medial patellofemoral ligament (MPFL) is the most important stabilizer of lateral dislocation of the patella. Single-limb (SL) and double-limb (DL) graft MPFL reconstructions have been increasingly used to treat recurrent patellar dislocations, but the clinical efficacy of SL versus DL graft MPFL reconstructions remains controversial owing to the inconsistent conclusions of previous studies. Purpose: This study aimed to compare the clinical outcomes of SL and DL graft MPFL reconstructions for patients with recurrent patellar dislocation by conducting a meta-analysis of randomized controlled trials and cohort studies. Study Design: Meta-analysis; Level of evidence, 3. Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched for relevant studies. The retrieval time was up to July 25, 2022. Two evaluators independently screened the literature, extracted data, and assessed the methodological quality of the enrolled studies. Meta-analysis was conducted using RevMan 5.4 software. Results: A total of 4 randomized controlled trials and 3 cohort studies with 451 patients were included. The joint stability and functional scores in both groups improved significantly from baseline. When compared with SL graft reconstruction, DL graft reconstruction provided reduced recurrent instability ( P = .01), anterior patella–related pain ( P = .02), and patellar lateral shift rate ( P = .02). Regarding functional recovery, patients undergoing DL graft reconstruction presented better scores on the Kujala ( P 〈 .001), Tegner ( P = .009), and International Knee Documentation Committee (IKDC) ( P 〈 .001) but similar Lysholm scores as compared with SL graft reconstruction. No statistically significant difference was found between the techniques in the reduction of the patellar tilt angle, complications other than anterior patella–related pain, or postoperative pain. Conclusion: When compared with SL graft MPFL reconstruction, DL graft MPFL reconstruction yielded better outcomes in terms of postoperative recurrent instability, anterior patella–related pain, patellar lateral shift rate, Kujala score, Tegner score, and IKDC score. The amount of high-quality evidence is insufficient, so this conclusion should be interpreted with caution.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/03635465221130448
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2063945-4
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  • 7
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    Interobserver Variations in Target Delineation in Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinoma and its Impact on Target Dose Coverage
    SAGE Publications ; 2023
    In:  Technology in Cancer Research & Treatment Vol. 22 ( 2023-01), p. 153303382311695-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 22 ( 2023-01), p. 153303382311695-
    Abstract: To investigate the differences between physicians in target delineation in intensity-modulated radiation therapy for nasopharyngeal carcinoma as well as their impact on target dose coverage. Methods Ninety-nine in-hospital patients were randomly selected for retrospective analysis, and the target volumes were delineated by 2 physicians. The target volumes were integrated with the original plans, and the differential parameters, including the Dice similarity coefficient (DSC), Hausdorff distance (HD), and Jaccard similarity coefficient (JSC) were recorded. The dose–volume parameters to evaluate target dose coverage were analyzed by superimposing the same original plan to the 2 sets of images on which the target volumes were contoured by the 2 physicians. The significance of differences in target volumes and dose coverage were evaluated using statistical analysis. Results The target dose coverage for different sets of target volumes showed statistically significant differences, while the similarity metrics to evaluate geometric target volume differences did not. More specifically, for PGTVnx, the median DSC, JSC, and HD were 0.85, 0.74, and 11.73, respectively; for PCTV1, the median values were 0.87, 0.77, and 11.78, respectively; for PCTV2, the median values were 0.90, 0.82, and 16.12, respectively. For patients in stages T3-4, DSC, and JSC were reduced but HD was increased compared to those in stages T1-2. Dosimetric analysis indicated that, for the target volumes, significant differences between the 2 physicians were found in D95, D99, and V100 for all the target volumes (ie, PGTVnx, PCTV1, and PCTV2) across the whole group of patients, as well as in patients with disease stages T3-4 and T1-2. Conclusions The target volumes delineated by the 2 physicians had a high similarity, but the maximal distances between the outer contours of the 2 sets were significantly different. In patients with advanced T stages, significant differences in dose distributions were found, stemming from the deviations of target delineation.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338231169592
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 8
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    Optimized Node Deployment Algorithm and Parameter Investigation in a Mobile Sensor Network for Robotic Systems
    SAGE Publications ; 2015
    In:  International Journal of Advanced Robotic Systems Vol. 12, No. 10 ( 2015-10-01), p. 152-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 12, No. 10 ( 2015-10-01), p. 152-
    Abstract: Mobile sensor networks are an important part of modern robotics systems and are widely used in robotics applications. Therefore, sensor deployment is a key issue in current robotics systems research. Since it is one of the most popular deployment methods, in recent years the virtual force algorithm has been studied in detail by many scientists. In this paper, we focus on the virtual force algorithm and present a corresponding parameter investigation for mobile sensor deployment. We introduce an optimized virtual force algorithm based on the exchange force, in which a new shielding rule grounded in Delaunay triangulation is adopted. The algorithm employs a new performance metric called ‘pair-correlation diversion', designed to evaluate the uniformity and topology of the sensor distribution. We also discuss the implementation of the algorithm's computation and analyse the influence of experimental parameters on the algorithm. Our results indicate that the area ratio, φ s , and the exchange force constant, G, influence the final performance of the sensor deployment in terms of the coverage rate, the convergence time and topology uniformity. Using simulations, we were able to verify the effectiveness of our algorithm and we obtained an optimal region for the (φ s , G)-parameter space which, in the future, could be utilized as an aid for experiments in robotic sensor deployment.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.5772/61443
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2202393-8
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  • 9
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    Design and experiment of automatic transplanting device for potted tomato seedlings
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 233, No. 3 ( 2019-02), p. 1045-1054
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 233, No. 3 ( 2019-02), p. 1045-1054
    Abstract: In this study, an automatic machine for transplanting potted tomato seedlings was designed, based on the analysis of physical characteristics of the main varieties of tomato seedlings. The machine is composed of a horizontal and vertical seedling supply mechanism, a picking mechanism composed with a gear-rod component, a planting part featured with an eccentric-disk parallelogram duckbilled mechanism, and a control system. The control system included position sensors, stepper motor, variable-frequency motor and program controller. The force condition for successful picking potted tomato seedlings was studied by analyzing the force and motion during the taking procedure with the use of analytical graphic method. Combined with the parameters of physical characteristics of tomato seedlings, the key parameters of the machine was determined, which included L 1  = 105 mm as the distance between the point of the gripper needles and the center of rotation, L 0  = 18 mm as the initial opening distance between the two gripper needles, and s = 40 mm as the distance between the two gripper needles when they were at the upper hinge point of the clamping hands. The key structure and the parameters of the seedlings-taking part were determined by theoretical calculation according to the position of the seedling during taking and dropping procedure, and the requirement of the motion. The machine was tested by using the potted tomato seedlings. The result showed that the seedling picking rate was 92.35%–86.61%, and the leakage rate was 12.57%–18.03%, when the transplanting speed was between 60 and 90 seedlings per minute. The result demonstrated that the machine was feasible to transplant the potted tomato seedlings efficiently.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406218762954
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024890-8
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  • 10
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    Endovascular Aortic Repair With Castor Single-Branched Stent-Graft in Treatment of Acute Type B Aortic Syndrome and Aberrant Right Subclavian Artery
    SAGE Publications ; 2021
    In:  Vascular and Endovascular Surgery Vol. 55, No. 6 ( 2021-08), p. 551-559
    Details
    In: Vascular and Endovascular Surgery, SAGE Publications, Vol. 55, No. 6 ( 2021-08), p. 551-559
    Abstract: In this retrospective study, we presented the results of Castor single-branched stent-graft in a small series of patients with acute type B aortic syndrome and aberrant right subclavian artery (ARSA). Methods: Between January 2019 and November 2019, 5 patients were diagnosed with acute type B aortic syndrome and ARSA (4 patients with intramural hematoma and ARSA, 1 patient with type B aortic dissection and ARSA). All the patients underwent thoracic endovascular aortic repair (TEVAR) using Castor single-branched stent-graft. In-hospital and 3-month outcomes were collected. Results: The mean operative time was 116 ± 20.43 minutes (range 90-145). All the TEVAR procedures were successfully performed without conversion to open surgery (100% success rate). All the ARSAs of the 5 patients were revascularized in situ by Castor single-branched stent-grafts. No deaths and complications were observed in the 3-month follow-up. The maximal diameters of diseased aortas in the 4 patients with IMH decreased 3 months after TEVAR. The false lumen in the graft-covered segment was completely thrombosed in the patient with type B aortic dissection. Conclusions: Castor single-branched stent-graft may be a good choice in treatment of acute type B aortic syndrome and aberrant right subclavian artery.
    Type of Medium: Online Resource
    ISSN: 1538-5744 , 1938-9116
    URL: Article
    DOI: 10.1177/15385744211005664
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2095223-5
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