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  • 1
    Online Resource
    Online Resource
    Experimental Study of the Performance of Air Source Heat Pump Systems Assisted by Low-Temperature Solar-Heated Water
    SAGE Publications ; 2013
    In:  Advances in Mechanical Engineering Vol. 5 ( 2013-01), p. 843013-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 5 ( 2013-01), p. 843013-
    Abstract: Due to the low temperatures, the heating efficiency of air source heat pump systems during the winter is very low. To address this problem, a low-temperature solar hot water system was added to a basic air source heat pump system. Several parameters were tested and analyzed. The heat collection efficiency of the solar collector was analyzed under low-temperature conditions. The factors that affect the performance of the heat pumps, such as the fluid temperature, pressure, and energy savings, were analyzed for cases where the solar energy auxiliary heat pump and the air source heat pump are used independently. The optimal heating temperature and the changes in the fluid temperature were determined. The influence of the compression ratio and the coefficient of performance (COP) were investigated theoretically. The results revealed the parameters that are important to the performance of the system. Several measures for improving the COP of the heat pump units are provided for other applications and future research.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1155/2013/843013
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2501620-9
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  • 2
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    Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients
    SAGE Publications ; 2022
    In:  Lupus Vol. 31, No. 14 ( 2022-12), p. 1735-1743
    Details
    In: Lupus, SAGE Publications, Vol. 31, No. 14 ( 2022-12), p. 1735-1743
    Abstract: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. Methods Initially, 1000 participants (500 SLE cases and 500 controls) were recruited for the case–control study. Then, 429 cases who received GCs were followed through 12 weeks to explore GCs efficacy, depression, anxiety, and HRQoL. We selected the iMLDR technique for genotyping: RPEL1: rs4917385 (G/T) and miR-1307: rs7911488 (A/G). Results The minor G allele of rs7911488 reduced the risk of SLE ( p = .024). Four haplotypes consisting of rs4917385 and rs7911488 were associated with SLE susceptibility ( p 〈 .025). Both rs4917385 and rs7911488 were associated with anxiety symptoms and physical function (PF) in SLE patients ( p 〈 .025). The rs4917385 was associated with depression and its improvement. No statistical significance was found between RPEL1 and miR-1307 gene polymorphisms with GCs efficacy. Meanwhile, additive interaction analysis showed a significant association between RPEL1 and miR-1307 gene polymorphisms with tea consumption in anxiety. Conclusion RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population. Additionally, the two polymorphisms were possibly associated with depression, anxiety, and HRQoL in Chinese SLE population.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/09612033221131182
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2008035-9
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  • 3
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    Prediction of Poor Prognosis of HCC by Early Warning Model for Co-Expression of miRNA and mRNA Based on Bioinformatics Analysis
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303382095935-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303382095935-
    Abstract: Hepatocellular Carcinoma (HCC) has the highest mortality rate worldwide with the intractability of its extremely complicated pathogenesis and unclear mechanism. The limited survival highlights the need for the further detection of prognosis for HCC. MicroRNAs (miRNAs) and messenger RNAs (mRNAs) have been identified as regulatory factors and target genes in human cancers, while some studies also found post-transcriptional modification plays a crucial role in the occurrence and development of HCC. The present study aimed to elucidate the prognostic significance of miRNA and mRNA models in HCC. Methods: Data were obtained from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Gene Expression Omnibus (GEO) databases. The miRNA and mRNA expressions were tested by the Wilcoxon and used funrich software to predict mRNA that might be related to miRNA. Then we determined the intersection with overlapped mRNA and miRNA Venn diagram, and screened out hub gene by using Degree algorithm in Cytoscape software. The COX models, with TCGA data as the training set and ICGC data as the test set, were constructed. All patients were divided into high-risk and low-risk groups. Data on overall survival of different groups were collected and analyzed by Kaplan-Meier method, and independent risk factors affecting prognosis were assessed by Cox analysis. Results: The miRNA and mRNA polygenic risk model showed a good true positive rate. Kaplan-Meier curve and Cox analysis suggested that the high-risk group was associated with poor prognosis, and the risk score could be used as an independent risk factor for HCC. Conclusion: Tumor risk models constructed in this study could effectively predict the prognosis of patients, which is expected to provide a reference for the prognostic stratification and treatment strategy development of HCC.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033820959353
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 4
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    Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture
    SAGE Publications ; 2011
    In:  Molecular Pain Vol. 7 ( 2011-01-01), p. 1744-8069-7-98-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 7 ( 2011-01-01), p. 1744-8069-7-98-
    Abstract: Electroacupuncture (EA) can produce analgesia by increasing the β-endorphin level and activation of peripheral μ-opioid receptors in inflamed tissues. Endogenous cannabinoids and peripheral cannabinoid CB2 receptors (CB2Rs) are also involved in the antinociceptive effect of EA on inflammatory pain. However, little is known about how peripheral CB2Rs interact with the endogenous opioid system at the inflammatory site and how this interaction contributes to the antinociceptive effect of EA on inflammatory pain. In this study, we determined the role of peripheral CB2Rs in the effects of EA on the expression of β-endorphin in inflamed skin tissues and inflammatory pain. Results: Inflammatory pain was induced by injection of complete Freund's adjuvant into the left hindpaw of rats. Thermal hyperalgesia was tested with a radiant heat stimulus, and mechanical allodynia was quantified using von Frey filaments. The mRNA level of POMC and protein level of β-endorphin were quantified by real-time PCR and Western blotting, respectively. The β-endorphin-containing keratinocytes and immune cells in the inflamed skin tissues were detected by double-immunofluorescence labeling. The CB2R agonist AM1241 or EA significantly reduced thermal hyperalgesia and mechanical allodynia, whereas the selective μ-opioid receptor antagonist β-funaltrexamine significantly attenuated the antinociceptive effect produced by them. AM1241 or EA significantly increased the mRNA level of POMC and the protein level of β-endorphin in inflamed skin tissues, and these effects were significantly attenuated by pretreatment with the CB2R antagonist AM630. AM1241 or EA also significantly increased the percentage of β-endorphin-immunoreactive keratinocytes, macrophages, and T-lymphocytes in inflamed skin tissues, and these effects were blocked by AM630. Conclusions: EA and CB2R stimulation reduce inflammatory pain through activation of μ-opioid receptors. EA increases endogenous opioid expression in keratinocytes and infiltrating immune cells at the inflammatory site through CB2R activation.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1186/1744-8069-7-98
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2174252-2
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  • 5
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    A Survey of how Occupational Therapy Fieldwork Influences Future Professional Preference
    SAGE Publications ; 2013
    In:  Hong Kong Journal of Occupational Therapy Vol. 23, No. 2 ( 2013-12), p. 62-68
    Details
    In: Hong Kong Journal of Occupational Therapy, SAGE Publications, Vol. 23, No. 2 ( 2013-12), p. 62-68
    Abstract: Although fieldwork experience plays an important role in an occupational therapy (OT) student's choice of future area of practice, studies on the influences of fieldwork on the preference of practice areas remain limited. The goal of the study was to further understand how OT students choose their future areas of practice. Methods: A questionnaire, “The preferred future practice areas of occupational therapy students”, was created by systematic review of the relevant literature and collection of opinions from occupational therapists, students, and faculty. In total, 152 OT students undergoing their Level II fieldwork participated in the survey. Reliability tests, factor analysis tests, and discrimination analysis were carried out. Results The questionnaire demonstrated good to moderate reliability and validity. The factorial analysis indicated that the most influential factors for the preference of future practice areas of senior occupational therapy students are as follows: fieldwork experiences with clinical supervisors, fieldwork experiences with peers, social factors, college courses, and pressure from future work. The discrimination analysis revealed that social factors and college courses are the best factors for discriminating the variable “Choosing physical dysfunction, paediatric, or psychiatric OT as the most preferred future practice area.” Conclusion The choice of future area of practice is proved to be influenced by the experience in fieldwork for OT students. The psychometric properties of the questionnaire used in this study are supported, and it is recommended for use in future studies.
    Type of Medium: Online Resource
    ISSN: 1569-1861 , 1876-4398
    URL: Article
    DOI: 10.1016/j.hkjot.2013.09.003
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2202253-3
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  • 6
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    Proteomic analysis of serum proteins in acute ischemic stroke patients treated with acupuncture
    SAGE Publications ; 2011
    In:  Experimental Biology and Medicine Vol. 236, No. 3 ( 2011-03), p. 325-333
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 236, No. 3 ( 2011-03), p. 325-333
    Abstract: In the present study, we have investigated the effects of acupuncture on (1) serum protein expression that might have a beneficial effect on stroke patients and (2) the strength of limb muscles in stroke patients. A total of 35 acute ischemic stroke (IS) patients were divided into two groups, one receiving drug treatment alone and the other receiving electroacupuncture (EA) and drug treatment. EA treatment was performed on eight acupuncture points once a day for 10 consecutive days. Serum proteins were detected using a proteomics method based on two-dimensional gel electrophoresis, and the specificity of proteins was confirmed by Western blotting. Changes of limb muscle strength were measured using a modified Medical Research Council grading scale. After EA, SerpinG1 protein expression in serum was down-regulated while the expressions of gelsolin, complement component I, C3, C4B and beta-2-glycoprotein I proteins were up-regulated in patients. The changes of serum protein expression were further confirmed by Western blotting in a majority of the cases. The muscle strength of limbs was increased after EA in 18 patients. EA appears to be effective in regulating differential expression of multiple serum proteins involved in stroke, and also in enhancement of muscle strength recovery in acute IS patients despite an individual variation.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2011.010041
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020856-X
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  • 7
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    Combined texture analysis of dynamic contrast-enhanced MRI with histogram analysis of diffusion kurtosis imaging for predicting IDH mutational status in gliomas
    SAGE Publications ; 2023
    In:  Acta Radiologica Vol. 64, No. 9 ( 2023-09), p. 2552-2560
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 64, No. 9 ( 2023-09), p. 2552-2560
    Abstract: Non-invasive detection of isocitrate dehydrogenase (IDH) mutational status in gliomas is clinically meaningful for molecular stratification of glioma; however, it remains challenging. Purpose To investigate the usefulness of texture analysis (TA) of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and histogram analysis of diffusion kurtosis imaging (DKI) maps for evaluating IDH mutational status in gliomas. Material and Methods This retrospective study enrolled 84 patients with histologically confirmed gliomas, comprising IDH-mutant (n = 34) and IDH-wildtype (n = 50). TA was performed for the quantitative parameters derived by DCE-MRI. Histogram analysis was performed for the quantitative parameters derived by DKI. Unpaired Student's t-test was used to identify IDH-mutant and IDH-wildtype gliomas. Logistic regression and receiver operating characteristic (ROC) curve analyses were used to compare the diagnostic performance of each parameter and their combination for predicting the IDH mutational status in gliomas. Results Significant statistical differences in the TA of DCE-MRI and histogram analysis of DKI were observed between IDH-mutant and IDH-wildtype gliomas (all P  〈  0.05). Using multivariable logistic regression, the entropy of K trans , skewness of V e , and K app−90th had higher prediction potential for IDH mutations with areas under the ROC curve (AUC) of 0.915, 0.735, and 0.830, respectively. A combination of these analyses for the identification of IDH mutation improved the AUC to 0.978, with a sensitivity and specificity of 94.1% and 96.0%, respectively, which was higher than the single analysis ( P  〈  0.05). Conclusion Integrating the TA of DCE-MRI and histogram analysis of DKI may help to predict the IDH mutational status.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/02841851231180291
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024579-8
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  • 8
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    Celiac Artery Stenting in the Treatment of Intestinal Ischemia Due to the Sacrifice of the Dominant Inferior Mesenteric Artery During Endovascular Aortic Repair
    SAGE Publications ; 2016
    In:  Vascular and Endovascular Surgery Vol. 50, No. 6 ( 2016-08), p. 446-450
    Details
    In: Vascular and Endovascular Surgery, SAGE Publications, Vol. 50, No. 6 ( 2016-08), p. 446-450
    Abstract: A 42-year-old man had intestinal ischemia 7 weeks after endovascular abdominal aortic aneurysm repair due to sacrifice of the inferior mesenteric artery, which had compensated for the intestinal blood supply because of the total occlusion of the superior mesenteric artery (SMA) and severe stenosis of the celiac artery (CA). He was diagnosed in the active phase of Takayasu arteritis, and an emergency endovascular treatment was performed. After the SMA failed to be recanalized, a stent was successfully placed into the CA; this choice was made based on the preexisting collaterals between them. The symptoms were relieved shortly after the operation. The Kirk arcade, the Barkow arcade, and the enlarged pancreaticoduodenal arcade were visualized on the follow-up computed tomography angiography. Based on this case, a short review of celiomesenteric and intermesenteric collateral circulations is presented.
    Type of Medium: Online Resource
    ISSN: 1538-5744 , 1938-9116
    URL: Article
    DOI: 10.1177/1538574416665988
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2095223-5
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  • 9
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    Characterization of Axon Formation in the Embryonic Stem Cell-Derived Motoneuron
    SAGE Publications ; 2011
    In:  Cell Transplantation Vol. 20, No. 4 ( 2011-05), p. 493-502
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 20, No. 4 ( 2011-05), p. 493-502
    Abstract: The developing neural cell must form a highly organized architecture to properly receive and transmit nerve signals. Neural formation from embryonic stem (ES) cells provides a novel system for studying axonogenesis, which are orchestrated by polarity-regulating molecules. Here the ES-derived motoneurons, identified by HB9 promoter-driven green fluorescent protein (GFP) expression, showed characteristics of motoneuron-specific gene expression. In the majority of motoneurons, one of the bilateral neurites developed into an axon that featured with axonal markers, including Tau 1, vesicle acetylcholine transporter, and synaptophysin. Interestingly, one third of the motoneurons developed bi-axonal processes but no multiple axonal GFP cell was found. The neuronal polarity-regulating proteins, including the phosphorylated AKT and ERK, were compartmentalized into both of the bilateral axonal tips. Importantly, this aberrant axon morphology was still present after the engraftment of GFP + neurons into the spinal cord, suggesting that even a mature neural environment fails to provide a proper niche to guide normal axon formation. These findings underscore the necessity for evaluating the morphogenesis and functionality of neurons before the clinical trials using ES or somatic stem cells.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368910X536464
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020466-8
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  • 10
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    Prediction of overall survival after radical gastrectomy using nomograms created by tumor markers
    SAGE Publications ; 2023
    In:  Journal of Investigative Medicine
    Details
    In: Journal of Investigative Medicine, SAGE Publications
    Abstract: Prediction of prognosis after radical resection of gastric cancer has not been well established. Therefore, we aimed to establish a prognostic model based on a new score system of patients with gastric cancer. A total of 1235 patients who underwent curative gastrectomy at our hospital from October 2015 to April 2017 were included in this study. Univariate and multivariate analyses were used to screen for prognostic risk factors. Construction of the nomogram was based on Cox proportional hazard regression models. The construction of the new score models was analyzed by the receiver operating characteristic curve (ROC curve), calibration curve, and decision curve. Multivariate analysis showed that tumor size, T, N, carcinoembryonic antigen, CA125, and CA19-9 were independent prognostic factors. The new score model had a greater AUC (The area under the ROC curve) than other systems, and the C-index of the nomogram was highly reliable for evaluating the survival of patients with gastric cancer. Based on the tumor markers and other clinical indicators, we developed a precise model to predict the prognosis of patients with gastric cancer after radical surgery. This score system can be helpful to both surgeons and patients.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1177/10815589231179927
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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