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  • 1
    In: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, SAGE Publications, Vol. 9 ( 2016-01), p. CMAMD.S29844-
    Abstract: Osteoarthritis (OA) might affect chondrocyte culture characteristics and complement expression. Therefore, this study addressed the interrelation between macroscopical and microscopical structure, complement expression, and chondrocyte culture characteristics in non-OA and OA cartilage. Femoral head cartilage samples harvested from patients with femoral neck fractures (FNFs) and OA were analyzed for macroscopical alterations using an in-house scoring system, graded histologically (Mankin score), and immunolabeled for complement regulatory proteins (CRPs) and receptors. Morphology of monolayer cultured chondrocytes isolated from a subset of samples was assessed. The macroscopical score distinguished the FNF and OA cartilage samples and correlated significantly with the histological results. Chondrocyte phenotype from FNF or OA cartilage differed. Complement receptor C5aR, CRPs CD55 and CD59, and weakly receptor C3AR were detected in the investigated FNF and OA cartilage, except for CD46, which was detected in only two of the five investigated donors. The in-house score also allows inexperienced observers to distinguish non-OA and OA cartilage for experimental purposes.
    Type of Medium: Online Resource
    ISSN: 1179-5441 , 1179-5441
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2590933-2
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  InnovAiT: Education and inspiration for general practice Vol. 16, No. 8 ( 2023-08), p. 375-380
    In: InnovAiT: Education and inspiration for general practice, SAGE Publications, Vol. 16, No. 8 ( 2023-08), p. 375-380
    Abstract: Neck lumps are a common presenting complaint in primary care. They can cause a significant amount of concern for patients, due to their visibility around the head and neck. There is a plethora of causes for lumps in the neck, some of which need to be investigated urgently. In this article, we suggest a method for identifying the likely cause of a neck lump, introduce possible management strategies and cover red flag signs and symptoms to prompt urgent onward referral for investigation. The differential diagnosis of a lump in the neck may seem intimidating, but a thorough, systematic approach to history and examination narrows this list and directs appropriate investigation. If malignancy is suspected, a 2-week fast track referral should be made, without waiting for results of investigations in the community. These may be requested simultaneously with referral, according to local policy.
    Type of Medium: Online Resource
    ISSN: 1755-7380 , 1755-7399
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2416002-7
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 1983
    In:  Proceedings of the Human Factors Society Annual Meeting Vol. 27, No. 12 ( 1983-10), p. 996-1000
    In: Proceedings of the Human Factors Society Annual Meeting, SAGE Publications, Vol. 27, No. 12 ( 1983-10), p. 996-1000
    Abstract: Several methods are presented for breaking linkages among global optical flow and texture variables in order to assess their usefulness in experiments requiring observers to distinguish change in speed or heading of simulated self motion from events representing constant speed or level flight. Results of a series of studies testing for sensitivity to flow acceleration or deceleration, flow-pattern expansion variables, and the distribution of optical texture density are presented. Theoretical implications for determining the metrics of visual self-motion information, and practical relevance for pilot and flight simulator evaluation and for low-level, high-speed flight are discussed.
    Type of Medium: Online Resource
    ISSN: 0163-5182
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1983
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  InnovAiT: Education and inspiration for general practice Vol. 16, No. 10 ( 2023-10), p. 490-497
    In: InnovAiT: Education and inspiration for general practice, SAGE Publications, Vol. 16, No. 10 ( 2023-10), p. 490-497
    Abstract: Swallowing is a complex interplay of nerves, muscles and protective reflexes which involves both involuntary and voluntary phases. Difficulty swallowing can occur due to a variety of underlying pathologies, but can broadly be differentiated into high (oropharyngeal) and low (oesophageal) dysphagia. Using case scenarios this article will highlight common dysphagia presentations encountered in general practice and their appropriate history, examination, investigation and management.
    Type of Medium: Online Resource
    ISSN: 1755-7380 , 1755-7399
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2416002-7
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  • 5
    In: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, SAGE Publications, Vol. 9 ( 2016-01), p. CMAMD.S41352-
    Type of Medium: Online Resource
    ISSN: 1179-5441 , 1179-5441
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2590933-2
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Quarterly Journal of Experimental Psychology Vol. 70, No. 3 ( 2017-03), p. 444-460
    In: Quarterly Journal of Experimental Psychology, SAGE Publications, Vol. 70, No. 3 ( 2017-03), p. 444-460
    Abstract: Perceptual attention in healthy participants is characterized by two biases, one operating in the horizontal plane, which draws attention leftward, and the other operating in the vertical plane, which draws attention upward. Given that these biases are reliably found in the same individual, and appear similar at a surface level, a number of researchers have investigated the relationship between horizontal and vertical attentional biases. To date, these investigations have failed to find an association, and this may be due to the fact that one-dimensional vertical and horizontal stimuli were presented separately rather than being measured from a single, two-dimensional stimulus. Across three experiments, two dimensional stimuli were presented, and participants marked the centre of the stimuli. In addition, the shapes of the stimuli were manipulated to determine whether this produced the same modulation of the two biases. Across 13 stimuli and three experiments there were no correlations between the vertical and horizontal biases. In addition, manipulations of stimulus shape, which affected biases in one dimension, did not affect biases in the other dimension. There were, however, consistent correlations between the degree of bias within each dimension across the different stimuli. This study has produced converging evidence that horizontal and vertical biases in spatial judgments rely on separate cognitive mechanisms. To account for these results we discuss a model whereby horizontal asymmetries rely more on space-based mechanisms whereas vertical asymmetries rely more on object-based mechanisms.
    Type of Medium: Online Resource
    ISSN: 1747-0218 , 1747-0226
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2225936-3
    SSG: 5,2
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  Quarterly Journal of Experimental Psychology Vol. 68, No. 1 ( 2015-01), p. 10-18
    In: Quarterly Journal of Experimental Psychology, SAGE Publications, Vol. 68, No. 1 ( 2015-01), p. 10-18
    Abstract: Many studies use multiexperiment designs where experiments are carried out at different times of semester. When comparing between experiments, the data may be confounded by between-participants effects related to motivation. Research indicates that course-credit participants who engage in research early in semester have different personality and performance characteristics compared to those tested late in semester. This study examined whether the semester effect is caused by internal (inherent motivation of the participant) or external (looming exams, essays) factors. To do this, sustained attention and intrinsic/extrinsic motivation was measured in groups of course-credit ( n = 40) and paid ( n = 40) participants early and late in semester. While there was no difference in sustained attention between the groups early in semester, the course-credit group performed significantly worse late in semester. The course-credit group also showed a significant decrease in intrinsic motivation with time whereas the paid participants showed no change. Because changes were not seen for both groups, the semester difference cannot be due to external factors. Instead, the data demonstrate that course-credit participants who engage early have high sustained attention and intrinsic motivation compared to their late counterparts, who leave their participation to the last minute. Researchers who use multiexperimental designs across semester need to control for these effects—perhaps by using paid participants who do not vary across semester.
    Type of Medium: Online Resource
    ISSN: 1747-0218 , 1747-0226
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2225936-3
    SSG: 5,2
    Location Call Number Limitation Availability
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