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  • 1
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    Online Resource
    BMDS: A Collection of R Functions for Bayesian Multidimensional Scaling
    SAGE Publications ; 2009
    In:  Applied Psychological Measurement Vol. 33, No. 7 ( 2009-10), p. 570-571
    Details
    In: Applied Psychological Measurement, SAGE Publications, Vol. 33, No. 7 ( 2009-10), p. 570-571
    Type of Medium: Online Resource
    ISSN: 0146-6216 , 1552-3497
    URL: Article
    DOI: 10.1177/0146621608321761
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 224215-1
    detail.hit.zdb_id: 2002941-X
    SSG: 5,2
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  • 2
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    Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture
    SAGE Publications ; 2023
    In:  Global Spine Journal
    Details
    In: Global Spine Journal, SAGE Publications
    Abstract: Retrospective multicenter study. Objective The purpose of this study was to compare the prognosis of elderly patients with injuries related to cervical diffuse idiopathic skeletal hyperostosis (cDISH) to matched control for each group, with and without fractures. Methods The current multicenter study was a retrospective analysis of 140 patients aged 65 years or older with cDISH-related cervical spine injuries; 106 fractures and 34 spinal cord injuries without fracture were identified. Propensity score–matched cohorts from 1363 patients without cDISH were generated and compared. Logistic regression analysis was performed to determine the risk of early mortality for patients with cDISH-related injury. Results Patients with cDISH-related injuries with fracture did not differ significantly in the incidence of each complication and ambulation or severity of paralysis compared to matched controls. In patients with cDISH-related injury without fracture, those who were nonambulatory at discharge comprised 55% vs 34% of controls, indicating significantly poorer ambulation in those with cDISH-related injuries ( P = .023). There was no significant difference in the incidence of complications and ambulation or paralysis severity at 6 months as compared with controls. Fourteen patients died within 3 months. Logistic regression analysis identified complete paralysis (odds ratio [OR] 36.99) and age (OR 1.24) as significant risk factors for mortality. Conclusions The current study showed no significant differences in the incidence of complications, ambulation outcomes between patients with cDISH-related injury with fracture and matched controls, and that the ambulation at discharge for patients with cDISH-related injury without fractures were significantly inferior to those of matched controls.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682231186757
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 3
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    Incidence, predictors, and etiology of subsequent ischemic stroke within one year after transient ischemic attack
    SAGE Publications ; 2017
    In:  International Journal of Stroke Vol. 12, No. 1 ( 2017-01), p. 84-89
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 12, No. 1 ( 2017-01), p. 84-89
    Abstract: Incidence and predictors of ischemic stroke in patients with transient ischemic attack (TIA) have not been fully clarified outside Europe and North America. Aims We undertook the present prospective, multicenter study to clarify the incidence, predictors, and etiology of ischemic stroke within one year of TIA onset in Japan. Methods The study subjects were patients within seven days of TIA onset who were enrolled in a prospective register from 57 hospitals between June 2011 and December 2013. The primary endpoint was occurrence of ischemic stroke. Results Of 1365 consecutive patients, 1245 were followed for one year after TIA onset; 101 (8.1%) experienced ischemic stroke during follow-up. The leading subtype of ischemic stroke was small-vessel occlusion (SVO) followed by large-artery atherosclerosis (LAA) attributable to intracranial artery diseases. When dividing ischemic stroke events between those occurring within the first 90 days after TIA onset and those occurring after the first 90 days, the leading subtype of ischemic stroke within the first 90 days after TIA onset was SVO, followed by LAA attributable to intracranial artery diseases. In comparison, the subtypes most commonly seen beyond the first 90 days after TIA onset were cardioembolic and LAA attributable to intracranial artery disease. The one-year risk of ischemic stroke increased significantly as ABCD 2 score increased, at 6.2% for 0–3 points, 7.2% for 4–5 points, and 11.6% for 6–7 points. Conclusions The one-year ischemic stroke risk after TIA was about 8% and was associated with the ABCD 2 score. The most common subtype of subsequent ischemic stroke was SVO.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493016669884
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2211666-7
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  • 4
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    Branch atheromatous disease diagnosed as embolic stroke of undetermined source: A sub-analysis of NAVIGATE ESUS
    SAGE Publications ; 2019
    In:  International Journal of Stroke Vol. 14, No. 9 ( 2019-12), p. 915-922
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 14, No. 9 ( 2019-12), p. 915-922
    Abstract: Branch atheromatous disease (BAD) is distinctive from large and small arterial diseases, which is single subcortical infarction larger than lacunar stroke in the territories of deep perforators without relevant arterial stenosis. BAD meets the current criteria of embolic stroke of undetermined source. We performed an exploratory analysis of BAD in patients recruited to NAVIGATE embolic stroke of undetermined source, a randomized controlled trial to compare rivaroxaban and aspirin in embolic stroke of undetermined source patients. Methods and results Among 3972 stroke patients in cerebral hemispheres with intracranial arterial imaging, 502 (12.6%) patients met the criteria for BAD. BAD was associated with younger age (years; OR: 0.97, 95% CI: 0.96–0.98), race (Asian; OR: 1.78, 95% CI: 1.44–2.21), region (Eastern Europe; OR: 2.49, 95% CI: 1.87–3.32), and higher National Institute of Health Stroke Scale (OR: 1.17, 95% CI: 1.12–1.22) at randomization. During follow-up, stroke or systemic embolism (2.5%/year vs. 6.2%/year, p = 0.0022), stroke (2.1%/year vs. 6.2%/year, p = 0.0008), and ischemic stroke (2.1%/year vs. 5.9%/year, p = 0.0013) occurred less frequently in BAD than non-BAD patients. There were no differences in annual rates of stroke or systemic embolism (2.5%/year vs. 2.5%/year, HR: 1.01, 95% CI: 0.33–3.14) or major bleeding (1.3%/year vs. 0.8%/year, HR: 1.51, 95% CI: 0.25–9.05) between rivaroxaban and aspirin groups among BAD patients. Conclusions BAD was relatively common, especially in Asian and from Eastern Europe among embolic stroke of undetermined source patients. Stroke severity was higher at randomization but recurrence of stroke was fewer in BAD than non-BAD patients. The efficacy and safety of rivaroxaban and aspirin did not differ among BAD patients.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493019852177
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 5
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    Direct Phlebography for Visualization of the Deep Veins in the Lower Extremities
    SAGE Publications ; 1992
    In:  Vascular Surgery Vol. 26, No. 7 ( 1992-09), p. 529-537
    Details
    In: Vascular Surgery, SAGE Publications, Vol. 26, No. 7 ( 1992-09), p. 529-537
    Abstract: A new method of phlebography, which the authors have named "direct phlebography," was developed as a means of obtaining accurate information on the deep vein system, as well as on the communicating veins in the lower extremities. This method consists of two techniques: one is a retrograde insertion of a catheter into the deep veins and the other is a direct injection of the contrast medium into the deep veins. For these techniques, use of a thin, soft guidewire and catheter; injection of a low-osmolar contrast medium; and systemic administration of heparin are important. In cases of varix cruris, the deep veins and the insufficient communicating veins were clearly visualized by this method. In cases of deep vein thrombosis, a "narrowed" but patent common or superficial femoral vein was detected, which had often been diagnosed as "occluded" by conventional ascending phlebography. The deep femoral vein was usually patent. The authors have used this method in 54 limbs, but no serious complications such as venous valve injury, severe extravasation, or thrombus formation have been encountered so far, except for a small extravasation in 1 patient with superficial femoral vein thrombosis. This new method, used to visualize the deep vein system directly, is thought to provide correct and useful information about the lesions in the deep vein system of the lower extremities.
    Type of Medium: Online Resource
    ISSN: 0042-2835
    URL: Article
    DOI: 10.1177/153857449202600703
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1992
    detail.hit.zdb_id: 2095223-5
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  • 6
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    Effects of Auditory Imagery on the Detection of a Pure Tone in White Noise: Experimental Evidence of the Auditory Perky Effect
    SAGE Publications ; 1992
    In:  Perceptual and Motor Skills Vol. 74, No. 2 ( 1992-04), p. 443-448
    Details
    In: Perceptual and Motor Skills, SAGE Publications, Vol. 74, No. 2 ( 1992-04), p. 443-448
    Abstract: The purpose of this study was to examine whether the auditory image of a pure tone facilitates or interferes with the auditory perception of the pure tone. The masked threshold of a pure tone in white noise with and without the image of a pure tone was compared. It was shown that, in contrast to Farah and Smith's (1983) finding of facilitation, imagery interfered with the detection of the pure tone only when the frequency of the imagined tone and the detected tone was the same. This interference was interpreted as showing the assimilation of the signal tone into imagery, i.e., the effect described by Perky in 1910, occurred in the auditory modality. An explanation of the differences between findings of interference and facilitation is offered.
    Type of Medium: Online Resource
    ISSN: 0031-5125 , 1558-688X
    URL: Article
    DOI: 10.2466/pms.1992.74.2.443
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1992
    detail.hit.zdb_id: 2066876-4
    SSG: 5,2
    SSG: 7,11
    SSG: 31
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  • 7
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    Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Neurological Disorders Vol. 13 ( 2020-01), p. 175628642090420-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 13 ( 2020-01), p. 175628642090420-
    Abstract: Eculizumab is a humanized monoclonal antibody that targets complement protein C5 and inhibits terminal complement-mediated damage at the neuromuscular junction. Recently, the REGAIN study showed that eculizumab was effective and well tolerated in patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG). However, there is no consensus regarding which kind of patients with gMG are selected to preferentially receive eculizumab. Methods: Between January and December 2018, we followed 1388 patients with MG at seven hospitals located in Tokyo and Chiba. We evaluated the clinical features of MG and the patients’ quality of life. Clinical status and severity were determined by the recommendations of the Myasthenia Gravis Foundation of America. Results: Of 1388 patients with MG, 12 (0.9%) patients received eculizumab. A total of 11 patients who were anti-acetylcholine receptor antibody-positive with refractory gMG (M:F = 3:8) completed the 26-week treatment with eculizumab. The disease subtypes represented included five cases of early onset MG, one of late-onset MG, and five of thymoma-associated MG. Overall, seven patients had experienced myasthenic crisis. The mean quantitative MG score ranged from 18.6 at baseline to 9.1 at week 26 ( p = 0.008). Similarly, the mean MG activities of daily living score ranged from 10.8 at baseline to 4.2 at week 26 ( p = 0.002). There were marked improvements in all patients’ quality of life status. Overall, seven patients were able to reduce the dose of prednisolone at week 26. All but one patient did not require additional rescue treatment. Overall, one patient with early onset MG could not continue the eculizumab treatment due to nausea and vertigo. Conclusion: We demonstrate that eculizumab provided remarkable benefits for refractory gMG in practical real-world experience as well as in the REGAIN study. Patients with refractory gMG with myasthenia crisis and thymoma-associated MG are suitable for eculizumab administration.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/1756286420904207
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 8
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    Clinical Effect of Encephabol (Pyritinol) in the Treatment of Cerebrovascular Disorders
    SAGE Publications ; 1980
    In:  Journal of International Medical Research Vol. 8, No. 2 ( 1980-03), p. 118-126
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 8, No. 2 ( 1980-03), p. 118-126
    Abstract: The results of a series of multicentre, controlled, double-blind trials of the clinical efficacy of Encephabol compared with placebo in patients with a variety of cerebrovascular disorders are reported.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/030006058000800203
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1980
    detail.hit.zdb_id: 2082422-1
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  • 9
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    Small vessel occlusion is a high-risk etiology for early recurrent stroke after transient ischemic attack
    SAGE Publications ; 2019
    In:  International Journal of Stroke Vol. 14, No. 9 ( 2019-12), p. 871-877
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 14, No. 9 ( 2019-12), p. 871-877
    Abstract: Recent prospective registration studies of transient ischemic attack in Western countries demonstrated that large artery atherosclerosis is the highest risk etiology for early stroke recurrence under urgent evaluation and treatment. On the other hand, some limited transient ischemic attack studies from East Asian countries showed transient ischemic attack patients due to small vessel occlusion were at a higher early stroke risk. Aims We aimed to assess the risk for early stroke in small vessel occlusion-transient ischemic attack patients in a Japanese large transient ischemic attack registry. Methods We analyzed the data of a prospective Japanese transient ischemic attack registry including 1320 transient ischemic attack patients within seven days after onset. Small vessel occlusion-transient ischemic attack was defined as the presence of lacunar transient ischemic attack syndrome, without other etiologies. The outcome measure was recurrent stroke within 30 days after transient ischemic attack. The predictors of 30-day recurrent stroke were estimated using the Cox proportional hazards model. Results The study population had a mean age of 69 ± 12 years and 470 were women. Recurrent stroke was observed in 61 patients (4.6%), and the highest rate was observed with small vessel occlusion-transient ischemic attack (7.8%), followed by large artery atherosclerosis (5.4%). In multivariate analysis, recurrent stroke was independently associated with small vessel occlusion-transient ischemic attack (hazard ratio (HR): 2.01, 95% confidence interval (CI): 1.19–3.35), higher systolic blood pressure (HR: 1.18, 95% CI: 1.08–1.28), and presentation within 3 h after onset (HR: 2.21, 95% CI: 1.27–4.04). Furthermore, small vessel occlusion-transient ischemic attack with acute small deep infarct on diffusion-weighted imaging was a stronger predictor of recurrent stroke (HR: 4.87, 95% CI: 2.09–10.0). Conclusion Small vessel occlusion-transient ischemic attack, especially with acute small deep infarct, had a higher early stroke risk compared with other etiologies in Japanese transient ischemic attack patients who received early management.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493019840931
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 10
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    Intensive blood pressure lowering with nicardipine and outcomes after intracerebral hemorrhage: An individual participant data systematic review
    SAGE Publications ; 2022
    In:  International Journal of Stroke Vol. 17, No. 5 ( 2022-06), p. 494-505
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 17, No. 5 ( 2022-06), p. 494-505
    Abstract: Nicardipine has strong, rapidly acting antihypertensive activity. The effects of acute systolic blood pressure levels achieved with intravenous nicardipine after onset of intracerebral hemorrhage on clinical outcomes were determined. Methods A systematic review and individual participant data analysis of articles before 1 October 2020 identified on PubMed were performed (PROSPERO: CRD42020213857). Prospective studies involving hyperacute intracerebral hemorrhage adults treated with intravenous nicardipine whose outcome was assessed using the modified Rankin Scale were eligible. Outcomes included death or disability at 90 days, defined as the modified Rankin Scale score of 4–6, and hematoma expansion, defined as an increase ≥6 mL from baseline to 24-h computed tomography. Summary of review Three studies met the eligibility criteria. For 1265 patients enrolled (age 62.6 ± 13.0 years, 484 women), death or disability occurred in 38.2% and hematoma expansion occurred in 17.4%. Mean hourly systolic blood pressure during the initial 24 h was positively associated with death or disability (adjusted odds ratio (aOR) 1.12, 95% confidence interval (CI) 1.00–1.26 per 10 mmHg) and hematoma expansion (1.16, 1.02–1.32). Mean hourly systolic blood pressure from 1 h to any timepoint during the initial 24 h was positively associated with death or disability. Later achievement of systolic blood pressure to ≤140 mmHg increased the risk of death or disability (aOR 1.02, 95% CI 1.00–1.05 per hour). Conclusions Rapid lowering of systolic blood pressure by continuous administration of intravenous nicardipine during the initial 24 h in hyperacute intracerebral hemorrhage was associated with lower risks of hematoma expansion and 90-day death or disability without increasing serious adverse events.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930211044635
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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