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  • 1
    Online Resource
    Online Resource
    Implantation of an Atelocollagen Sponge with Autologous Bone Marrow—Derived Mesenchymal Stromal Cells for Treatment of Vocal Fold Scarring in a Canine Model
    SAGE Publications ; 2011
    In:  Annals of Otology, Rhinology & Laryngology Vol. 120, No. 6 ( 2011-06), p. 401-408
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 120, No. 6 ( 2011-06), p. 401-408
    Abstract: Vocal fold scarring remains a therapeutic challenge. A new regenerative approach is needed to restore disorganized extracellular matrix. Tissue regeneration requires appropriate cells and a scaffold. Bone marrow–derived mesenchymal stromal cells (BMSCs) are multipotent and secrete many kinds of growth factors to regenerate tissues. Atelocollagen sponges have many large pores that permit cell entry. The present study was performed to evaluate whether implantation of an atelocollagen sponge plus BMSCs is effective for the treatment of vocal fold scarring. Methods: Twelve beagles underwent implantation of an atelocollagen sponge or of an atelocollagen sponge with autologous BMSCs (1.0 × 10 6 cells) in the subepithelial pockets of scarred vocal folds. Six months after the operation, vibratory examinations and histologic examinations were performed. Results: Mucosal vibrations improved significantly for the atelocollagen sponge–implanted vocal folds. Histologic analyses revealed favorable restoration of the extracellular matrix in the lamina propria. Increased distribution of hyaluronic acid and decreased dense collagen deposition were also noted. These improvements were enhanced by implantation of BMSCs. Conclusions: Implantation of atelocollagen sponges with autologous BMSCs into scarred vocal folds significantly increased hyaluronic acid distribution and decreased dense collagen deposition in the lamina propria, leading to better mucosal vibration.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348941112000610
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
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  • 2
    Online Resource
    Online Resource
    Non-contrast-enhanced MR portography and hepatic venography with time-spatial labeling inversion pulses: comparison at 1.5 Tesla and 3 Tesla
    SAGE Publications ; 2015
    In:  Acta Radiologica Open Vol. 4, No. 5 ( 2015-05-01), p. 205846011558411-
    Details
    In: Acta Radiologica Open, SAGE Publications, Vol. 4, No. 5 ( 2015-05-01), p. 205846011558411-
    Abstract: A 3 Tesla (3 T) magnetic resonance (MR) scanner is a promising tool for upper abdominal MR angiography. However, there is no report focused on the image quality of non-contrast-enhanced MR portography and hepatic venography at 3 T. Purpose To compare and evaluate images of non-contrast-enhanced MR portography and hepatic venography with time-spatial labeling inversion pulses (Time-SLIP) at 1.5 Tesla (1.5 T) and 3 T. Material and Methods Twenty-five healthy volunteers were examined using respiratory-triggered three-dimensional balanced steady-state free-precession (bSSFP) with Time-SLIP. For portography, we used one tagging pulse (selective inversion recovery) and one non-selective inversion recovery pulse; for venography, two tagging pulses were used. The relative signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were quantified, and the quality of visualization was evaluated. Results The CNRs of the main portal vein, right portal vein, and left portal vein at 3 T were better than at 1.5 T. The image quality scores for the portal branches of segment 4, 5, and 8 were significantly higher at 3 T than at 1.5 T. The CNR of the right hepatic vein (RHV) at 3 T was significantly lower than at 1.5 T. The image quality scores of RHV and the middle hepatic vein were higher at 1.5 T than at 3 T. For RHV visualization, the difference was statistically significant. Conclusion Non-contrast-enhanced MR portography with Time-SLIP at 3 T significantly improved visualization of the peripheral branch in healthy volunteers compared with1.5 T. Non-contrast-enhanced MR hepatic venography at 1.5 T was better than at 3 T.
    Type of Medium: Online Resource
    ISSN: 2058-4601 , 2058-4601
    URL: Article
    DOI: 10.1177/2058460115584110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
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  • 3
    Online Resource
    Online Resource
    Non-contrast-enhanced MR hepatic arteriography with time-spatial labeling inversion pulses: comparison of imaging with flow-in and modified flow-out methods
    SAGE Publications ; 2017
    In:  Acta Radiologica Vol. 58, No. 7 ( 2017-07), p. 786-791
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 58, No. 7 ( 2017-07), p. 786-791
    Abstract: In non-contrast-enhanced magnetic resonance (MR) arteriography, the flow-out method using a selective tagging pulse with a long inversion time (TI) and a non-selective inversion recovery pulse with a short TI (the modified flow-out method) might further contribute to the suppression of background signal and facilitate improved visualization of the hepatic artery. However, no report has focused on the image quality of non-contrast-enhanced MR arteriography using the modified flow-out method. Purpose To compare the flow-in method with the modified flow-out method and to determine which method better visualizes the hepatic artery. Material and Methods Twenty-seven healthy volunteers were examined using respiratory-triggered three-dimensional true steady-state free-precession MR with two selective inversion recovery pulses (the flow-in method) or with one tagging pulse and one non-selective inversion recovery pulse (the modified flow-out method). Results Artery-to-liver contrast was significantly increased in the modified flow-out method relative to the flow-in method ( P  〈  0.05). In all analyses of vessel visibility, non-contrast-enhanced MR arteriography using the modified flow-out method exhibited higher scores than with the flow-in method. With respect to overall image quality, the modified flow-out method was significantly better than the flow-in method ( P  〈  0.01). Conclusion The modified flow-out method for non-contrast-enhanced MR angiography is a promising technique for visualizing the hepatic artery.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185116674500
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2024579-8
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  • 4
    Online Resource
    Online Resource
    Atelocollagen Sponge as a Stem Cell Implantation Scaffold for the Treatment of Scarred Vocal Folds
    SAGE Publications ; 2009
    In:  Annals of Otology, Rhinology & Laryngology Vol. 118, No. 11 ( 2009-11), p. 805-810
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 118, No. 11 ( 2009-11), p. 805-810
    Abstract: Treatment of vocal fold scarring remains a therapeutic challenge. Our group previously reported the efficacy of treating injured vocal folds by implantation of bone marrow–derived stromal cells containing mesenchymal stem cells. Appropriate scaffolding is necessary for the stem cell implant to achieve optimal results. Terudermis is an atelocollagen sponge derived from calf dermis. It has large pores that permit cellular entry and is degraded in vivo. These characteristics suggest that this material may be a good candidate for use as scaffolding for implantation of cells. The present in vitro study investigated the feasibility of using Terudermis as such a scaffold. Methods Bone marrow–derived stromal cells were obtained from GFP (green fluorescent protein) mouse femurs. The cells were seeded into Terudermis and incubated for 5 days. Their survival, proliferation, and expression of extracellular matrix were examined. Results Bone marrow–derived stromal cells adhered to Terudermis and underwent significant proliferation. Immunohistochemical examination demonstrated that adherent cells were positive for expression of vimentin, desmin, fibronectin, and fsp1 and negative for beta III tubulin. These findings indicate that these cells were mesodermal cells and attached to the atelocollagen fibers biologically. Conclusions The data suggest that Terudermis may have potential as stem cell implantation scaffolding for the treatment of scarred vocal folds.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348940911801110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
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  • 5
    Online Resource
    Online Resource
    Survival Outcomes of Retreatment with Trastuzumab and Cytotoxic Chemotherapy for HER2-Positive Recurrent Patients With Breast Cancer Who Had Been Treated with Neo/adjuvant Trastuzumab Plus Multidrug Chemotherapy: A Japanese Multicenter Observational Study
    SAGE Publications ; 2018
    In:  Breast Cancer: Basic and Clinical Research Vol. 12 ( 2018-01-01), p. 117822341878624-
    Details
    In: Breast Cancer: Basic and Clinical Research, SAGE Publications, Vol. 12 ( 2018-01-01), p. 117822341878624-
    Abstract: There are little data on the usefulness of trastuzumab (TZM) retreatment as the first-line treatment for patients with HER2 (human epidermal growth factor receptor 2)–positive breast cancer recurrence after perioperative treatment with TZM. Aim: To clarify the outcome and safety of TZM retreatment in patients with recurrent HER2-positive breast cancer. Method: An observational study was conducted on patients who relapsed after primary systemic therapy with TZM using the central registration system. The primary end point was progression-free survival (PFS). Secondary end points consisted of the response rate, overall survival (OS), and safety. Result: In total, 34 patients were registered between July 2009 and June 2012. The median follow-up time was 23.7 months (2-24 months). The 1- and 2-year PFS rates were 46.9% (95% confidence interval (95% CI): 29.2%-62.9%) and 29.8% (95% CI: 15.0%-46.3%), respectively (median 10.6 months). The median PFS time for patients receiving TZM combined with CTx was 13.9 months. The 1-and 2-year OR rates were 93.9 (95% CI: 77.9%-98.4%) and 84.8% (95% CI: 67.4%-93.4%). Trastuzumab-induced grade 3/4 adverse events were not observed. Conclusions: This study suggests that the PFS and OS in Japanese patients who relapsed after perioperative TZM therapy improved or were similar to those in previous reports. Differences in patient backgrounds and treatments must be considered when interpreting the results. Trastuzumab should be used combination with CTx and/or HTx for retreatment. Retreatment with TZM is safe. Trial registration: UMIN000002738.
    Type of Medium: Online Resource
    ISSN: 1178-2234 , 1178-2234
    URL: Article
    DOI: 10.1177/1178223418786243
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2423804-1
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  • 6
    Online Resource
    Online Resource
    Atelocollagen Sponge as a Stem Cell Implantation Scaffold for the Treatment of Scarred Vocal Folds
    SAGE Publications ; 2010
    In:  Annals of Otology, Rhinology & Laryngology Vol. 119, No. 11 ( 2010-11), p. 805-810
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 119, No. 11 ( 2010-11), p. 805-810
    Abstract: Treatment of vocal fold scarring remains a therapeutic challenge. Our group previously reported the efficacy of treating injured vocal folds by implantation of bone marrow—derived stromal cells containing mesenchymal stem cells. Appropriate scaffolding is necessary for the stem cell implant to achieve optimal results. Terudermis is an atelocollagen sponge derived from calf dermis. It has large pores that permit cellular entry and is degraded in vivo. These characteristics suggest that this material may be a good candidate for use as scaffolding for implantation of cells. The present in vitro study investigated the feasibility of using Terudermis as such a scaffold. Methods: Bone marrow—derived stromal cells were obtained from GFP (green fluorescent protein) mouse femurs. The cells were seeded into Terudermis and incubated for 5 days. Their survival, proliferation, and expression of extracellular matrix were examined. Results: Bone marrow—derived stromal cells adhered to Terudermis and underwent significant proliferation. Immunohistochemical examination demonstrated that adherent cells were positive for expression of vimentin, desmin, fibronectin, and fsp1 and negative for beta III tubulin. These findings indicate that these cells were mesodermal cells and attached to the atelocollagen fibers biologically. Conclusions: The data suggest that Terudermis may have potential as stem cell implantation scaffolding for the treatment of scarred vocal folds.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348941011901110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
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  • 7
    Online Resource
    Online Resource
    Non-contrast-enhanced hepatic MR arteriography with balanced steady-state free-precession and time spatial labeling inversion pulse: optimization of the inversion time at 3 Tesla
    SAGE Publications ; 2015
    In:  Acta Radiologica Open Vol. 4, No. 12 ( 2015-12-01), p. 205846011561642-
    Details
    In: Acta Radiologica Open, SAGE Publications, Vol. 4, No. 12 ( 2015-12-01), p. 205846011561642-
    Abstract: A 3 Tesla (3 T) magnetic resonance (MR) scanner is a promising tool for upper abdominal angiography. However, no report has focused on the contrast behavior of non-contrast-enhanced hepatic MR arteriography at 3 T. Purpose To establish the optimal inversion time (TI) for favorable selective visualization of the hepatic arteries on non-contrast-enhanced MR arteriography with time spatial labeling inversion pulse (Time-SLIP) at 3 T. Material and Methods Twenty-five healthy volunteers were examined using respiratory-triggered three-dimensional balanced steady-state free-precession combined with Time-SLIP. According to the difference in the TI, five image groups (A, B, C, D, and E, from 1200 to 2000 ms, increasing at 200-ms intervals) were performed and compared to detect the optimal TI for hepatic artery visualization. The relative Cv-l (vessel-to-liver contrast) was quantified. For qualitative evaluation, the vessel visualization quality and order of the depicted hepatic artery branches were evaluated. Results In group C (TI of 1600 ms), the Cv-l showed the highest probably due to a favorable balance between the hepatic vessel signal and signal recovery of the surrounding tissue. Regarding qualitative assessment, in group C, the mean image quality score of all hepatic arteries and mean maximal visible order of the hepatic artery branches were the highest. However, there was no significant difference between these results. Conclusion Non-contrast-enhanced hepatic MR arteriography with Time-SLIP at 3 T enabled the selective visualization of hepatic arteries at a TI of 1600 ms with an optimal balance between Cv-l and peripheral hepatic artery visualization.
    Type of Medium: Online Resource
    ISSN: 2058-4601 , 2058-4601
    URL: Article
    DOI: 10.1177/2058460115616427
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
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