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  • 1
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    Online Resource
    Naturalistic, Prospective Study of Glaucoma and Ocular Hypertension Treatment in France: Strategies, Clinical Outcomes, and Costs at 2 Years
    SAGE Publications ; 2005
    In:  European Journal of Ophthalmology Vol. 15, No. 5 ( 2005-09), p. 562-580
    Details
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 15, No. 5 ( 2005-09), p. 562-580
    Abstract: To prospectively observe second-line treatment strategies, their clinical outcomes, and treatment costs in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) in France. Methods Second-line patients were recruited from September 14, 1998, to December 20, 2000, in 37 centers and were followed for up to 2 years. Outcomes were numbers of and reasons for treatment changes, changes in clinical parameters (intraocular pressure (IOP) levels, visual field defects, and optic nerve excavation), and direct medical costs associated with glaucoma management. This article reports results of the final analysis of 2-year follow-up data for patients with at least two contacts with a study ophthalmologist. Results Data were analyzed for 346 patients and 672 treated eyes. Monotherapy was used as first-line therapy in 92.0% of eyes. Second-line treatment was initiated an average of 2.8±0.2 years after diagnosis, primarily due to insufficient IOP control (60.3%) and adverse drug reactions (18.3%). Relative risk (RR) (95% CI) for adverse drug reactions (ADR) under monotherapy was 1.00 (1.00–1.00) under beta blockers (n=116) versus 0.40 (0.16–0.64) under latanoprost (n=21), 2.30 under carbonic anhydrase inhibitors (n=29), and 2.90 under adrenergics (n=38); RR for ADR under combination therapy was 1.00 (1.00–1.00) for unfixed combinations without latanoprost (n=66) versus 0.11 (0.00–0.22) for unfixed combinations of latanoprost + timolol (n=3). Cardiac or pulmonary problems have been reported in 26.9% of patients. Persistency on initial therapy was 62.5% (95% CI 53.0–72.0) for latanoprost monotherapy versus 41.1% (34.8–47.4) for beta-blocker monotherapy and 43.6% (26.6–60.6) for the latanoprost + timolol combination versus 29.8% (15.2–44.4) for combination therapies that did not include latanoprost. Average daily cost for latanoprost monotherapy was similar to that for patients who failed beta-blocker monotherapy: latanoprost + timolol did not cost more than therapeutic combinations without latanoprost. Conclusions Insufficient IOP control and adverse drug reactions are the two main reasons for changing first-line treatment in patients with POAG or OH. After 2 years, second-line treatment with latanoprost, as monotherapy or combined with timolol, provides superior safety and persistency to treatment at an acceptable cost.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.1177/112067210501500507
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 1475018-1
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  • 2
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    Immunogold labeling of luciferase in the luminous bacterium Vibrio harveyi after fast-freeze fixation and different freeze-substitution and embedding procedures.
    SAGE Publications ; 1989
    In:  Journal of Histochemistry & Cytochemistry Vol. 37, No. 5 ( 1989-05), p. 663-674
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 37, No. 5 ( 1989-05), p. 663-674
    Abstract: We studied the ultrastructural localization of luciferase on sections of the bioluminescent bacterium Vibrio harveyi by indirect immunogold staining, using a polyclonal antiluciferase antibody and the usual control tests, after chemical fixation or fast-freeze fixation (FFF) followed by different freeze-substitution (FS) procedures and embedding in either Epon or LR White. After liquid fixation with glutaraldehyde and paraformaldehyde and LR White embedding, labeling occurred over the cytoplasm but not over the condensed nucleoid. Epon embedding almost abolished it. FFF-FS considerably improved the morphological preservation and revealed cytoplasmic "patches" with a complex ultrastructure in Epon sections. The preservation was always less good in LR White. The patches were densely labeled, even in Epon sections, after FS in acetone. However, labeling intensity was 3.7 times greater in LR White than in Epon. With both resins, labeling diminished similarly when fixative agents were present in the FS medium. The localization of luciferase in the cytoplasm and particularly in the patches is discussed.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1177/37.5.2703702
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1989
    detail.hit.zdb_id: 1421306-0
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  • 3
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    How Many Participants Do I Need to Test an Interaction? Conducting an Appropriate Power Analysis and Achieving Sufficient Power to Detect an Interaction
    SAGE Publications ; 2023
    In:  Advances in Methods and Practices in Psychological Science Vol. 6, No. 3 ( 2023-07)
    Details
    In: Advances in Methods and Practices in Psychological Science, SAGE Publications, Vol. 6, No. 3 ( 2023-07)
    Abstract: Power analysis for first-order interactions poses two challenges: (a) Conducting an appropriate power analysis is difficult because the typical expected effect size of an interaction depends on its shape, and (b) achieving sufficient power is difficult because interactions are often modest in size. This article consists of three parts. In the first part, we address the first challenge. We first use a fictional study to explain the difference between power analyses for interactions and main effects. Then, we introduce an intuitive taxonomy of 12 types of interactions based on the shape of the interaction (reversed, fully attenuated, partially attenuated) and the size of the simple slopes (median, smaller, larger), and we offer mathematically derived sample-size recommendations to detect each interaction with a power of .80/.90/.95 (for two-tailed tests in between-participants designs). In the second part, we address the second challenge. We first describe a preregistered metastudy (159 studies from recent articles in influential psychology journals) showing that the median power to detect interactions of a typical size is .18. Then, we use simulations (≈900,000,000 data sets) to generate power curves for the 12 types of interactions and test three approaches to increase power without increasing sample size: (a) preregistering one-tailed tests (+21% gain), (b) using a mixed design (+75% gain), and (c) preregistering contrast analysis for a fully attenuated interaction (+62% gain). In the third part, we introduce INT×Power ( www.intxpower.com ), a web application that enables users to draw their interaction and determine the sample size needed to reach the power of their choice with the option of using/combining these approaches.
    Type of Medium: Online Resource
    ISSN: 2515-2459 , 2515-2467
    URL: Article
    DOI: 10.1177/25152459231178728
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2904847-3
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  • 4
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    Many Labs 2: Investigating Variation in Replicability Across Samples and Settings
    SAGE Publications ; 2018
    In:  Advances in Methods and Practices in Psychological Science Vol. 1, No. 4 ( 2018-12), p. 443-490
    Details
    In: Advances in Methods and Practices in Psychological Science, SAGE Publications, Vol. 1, No. 4 ( 2018-12), p. 443-490
    Abstract: We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance ( p 〈 .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion ( p 〈 .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely high-powered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small ( 〈 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.
    Type of Medium: Online Resource
    ISSN: 2515-2459 , 2515-2467
    URL: Article
    DOI: 10.1177/2515245918810225
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2904847-3
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  • 5
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    A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group
    SAGE Publications ; 2021
    In:  Lupus Vol. 30, No. 4 ( 2021-04), p. 630-640
    Details
    In: Lupus, SAGE Publications, Vol. 30, No. 4 ( 2021-04), p. 630-640
    Abstract: Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203320988586
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2008035-9
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  • 6
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    Registered Replication Report: Dijksterhuis and van Knippenberg (1998)
    SAGE Publications ; 2018
    In:  Perspectives on Psychological Science Vol. 13, No. 2 ( 2018-03), p. 268-294
    Details
    In: Perspectives on Psychological Science, SAGE Publications, Vol. 13, No. 2 ( 2018-03), p. 268-294
    Abstract: Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence (“professor”) subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence (“soccer hooligans”). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%–3%) as well as a gender difference: Men showed the effect (9.3% and 7.6%), but women did not (0.3% and −0.3%). The procedure used in those replications served as the basis for this multilab Registered Replication Report. A total of 40 laboratories collected data for this project, and 23 of these laboratories met all inclusion criteria. Here we report the meta-analytic results for those 23 direct replications (total N = 4,493), which tested whether performance on a 30-item general-knowledge trivia task differed between these two priming conditions (results of supplementary analyses of the data from all 40 labs, N = 6,454, are also reported). We observed no overall difference in trivia performance between participants primed with the “professor” category and those primed with the “hooligan” category (0.14%) and no moderation by gender.
    Type of Medium: Online Resource
    ISSN: 1745-6916 , 1745-6924
    URL: Article
    DOI: 10.1177/1745691618755704
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2224911-4
    SSG: 5,2
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  • 7
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    The 2023 US 50-State National Seismic Hazard Model: Overview and implications
    SAGE Publications ; 2023
    In:  Earthquake Spectra
    Details
    In: Earthquake Spectra, SAGE Publications
    Abstract: The US National Seismic Hazard Model (NSHM) was updated in 2023 for all 50 states using new science on seismicity, fault ruptures, ground motions, and probabilistic techniques to produce a standard of practice for public policy and other engineering applications (defined for return periods greater than ∼475 or less than ∼10,000 years). Changes in 2023 time-independent seismic hazard (both increases and decreases compared to previous NSHMs) are substantial because the new model considers more data and updated earthquake rupture forecasts and ground-motion components. In developing the 2023 model, we tried to apply best available or applicable science based on advice of co-authors, more than 50 reviewers, and hundreds of hazard scientists and end-users, who attended public workshops and provided technical inputs. The hazard assessment incorporates new catalogs, declustering algorithms, gridded seismicity models, magnitude-scaling equations, fault-based structural and deformation models, multi-fault earthquake rupture forecast models, semi-empirical and simulation-based ground-motion models, and site amplification models conditioned on shear-wave velocities of the upper 30 m of soil and deeper sedimentary basin structures. Seismic hazard calculations yield hazard curves at hundreds of thousands of sites, ground-motion maps, uniform-hazard response spectra, and disaggregations developed for pseudo-spectral accelerations at 21 oscillator periods and two peak parameters, Modified Mercalli Intensity, and 8 site classes required by building codes and other public policy applications. Tests show the new model is consistent with past ShakeMap intensity observations. Sensitivity and uncertainty assessments ensure resulting ground motions are compatible with known hazard information and highlight the range and causes of variability in ground motions. We produce several impact products including building seismic design criteria, intensity maps, planning scenarios, and engineering risk assessments showing the potential physical and social impacts. These applications provide a basis for assessing, planning, and mitigating the effects of future earthquakes.
    Type of Medium: Online Resource
    ISSN: 8755-2930 , 1944-8201
    URL: Article
    DOI: 10.1177/87552930231215428
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2183411-8
    SSG: 16,13
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  • 8
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    No clinically meaningful difference in 1-year patient-reported outcomes among major approaches for primary total hip arthroplasty
    SAGE Publications ; 2022
    In:  HIP International Vol. 32, No. 5 ( 2022-09), p. 568-575
    Details
    In: HIP International, SAGE Publications, Vol. 32, No. 5 ( 2022-09), p. 568-575
    Abstract: Debate continues around the most effective surgical approach for primary total hip arthroplasty (THA). This study’s purpose was to compare 1-year patient-reported outcome measures (PROMs) of patients who underwent direct anterior (DA), transgluteal anterolateral (AL)/direct lateral (DL), and posterolateral (PL) approaches. Methods: A prospective consecutive series of primary THA for osteoarthritis ( n = 2390) were performed at 5 sites within a single institution with standardised care pathways (20 surgeons). Patients were categorised by approach: DA ( n = 913; 38%), AL/DL ( n = 505; 21%), or PL ( n = 972; 41%). Primary outcomes were pain, function, and activity assessed by 1-year postoperative PROMs. Multivariable regression modeling was used to control for differences among the groups. Wald tests were performed to test the significance of select patient factors and simultaneous 95% confidence intervals were constructed. Results: At 1-year postoperative, PROMs were successfully collected from 1842 (77.1%) patients. Approach was a statistically significant factor for 1-year HOOS pain ( p = 0.002). Approach was not a significant factor for 1-year HOOS-PS ( p = 0.16) or 1-year UCLA activity ( p = 0.382). Pairwise comparisons showed no significant difference in 1-year HOOS pain scores between DA and PL approach ( p  〉  0.05). AL/DL approach had lower (worse) pain scores than DA or PL approaches with differences in adjusted median score of 3.47 and 2.43, respectively ( p  〈  0.05). Conclusions: Patients receiving the AL/DL approach had a small statistical difference in pain scores at 1 year, but no clinically meaningful differences in pain, activity, or function exist at 1-year postoperative.
    Type of Medium: Online Resource
    ISSN: 1120-7000 , 1724-6067
    URL: Article
    DOI: 10.1177/1120700021992013
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1475775-8
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  • 9
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    EpidemIBD: rationale and design of a large-scale epidemiological study of inflammatory bowel disease in Spain
    SAGE Publications ; 2019
    In:  Therapeutic Advances in Gastroenterology Vol. 12 ( 2019-01), p. 175628481984703-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481984703-
    Abstract: Inflammatory bowel disease (IBD) is associated with a considerable burden to the patient and society. However, current data on IBD incidence and burden are limited because of the paucity of nationwide epidemiological studies, heterogeneous designs, and a low number of participating centers and sample size. The EpidemIBD study is a large-scale investigation to provide an accurate assessment of the incidence of IBD in Spain, as well as treatment patterns and outcomes. Methods: This multicenter, population-based incidence cohort study included patients aged 〉 18 years with IBD (Crohn’s disease, ulcerative colitis, or unclassified IBD) diagnosed during 2017 in 108 hospitals in Spain, covering 50% of the Spanish population. Each participating patient will attend 10 clinic visits during 5 years of follow up. Demographic data, IBD characteristics and family history, complications, treatments, surgeries, and hospital admissions will be recorded. Results: The EpidemIBD study is the first large-scale nationwide study to investigate the incidence of IBD in Spain. Enrollment is now completed and 3627 patients are currently being followed up. Conclusions: The study has been designed to overcome many of the limitations of previous European studies into IBD incidence by prospectively recruiting a large number of patients from all regions of Spain. In addition to epidemiological information about the burden of IBD, the 5-year follow-up period will also provide information on treatment patterns, and the natural history and financial burden of IBD.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/1756284819847034
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 10
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    Heterogeneity of thymic epithelial cell (TEC) keratins--immunohistochemical and biochemical evidence for a subset of highly differentiated TEC in the mouse.
    SAGE Publications ; 1985
    In:  Journal of Histochemistry & Cytochemistry Vol. 33, No. 7 ( 1985-07), p. 687-694
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 33, No. 7 ( 1985-07), p. 687-694
    Abstract: The mouse thymic epithelial network was studied using three different anti-keratin antibodies. One of these antibodies, KL1, exclusively recognized a small subset of medullary epithelial cells characterized by its content of a high molecular weight keratin (63 kD). Since epithelial differentiation is known to be associated with the acquisition of high molecular weight keratins, KL1-positive cells, which express the Ia antigen and secrete thymulin, may represent a subset of highly differentiated cells among mouse thymic epithelial cells (TEC). These data reflect the heterogeneity of the thymic epithelium and support the concept that distinct TEC subsets might provide the thymus with different microenvironments.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1177/33.7.2409128
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1985
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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