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  • 1
    Online Resource
    Online Resource
    A Novel BRCA1 Gene Mutation Detected With Breast Cancer in a Vietnamese Family by Targeted Next-Generation Sequencing: A Case Report
    SAGE Publications ; 2020
    In:  Breast Cancer: Basic and Clinical Research Vol. 14 ( 2020-01), p. 117822342090155-
    Details
    In: Breast Cancer: Basic and Clinical Research, SAGE Publications, Vol. 14 ( 2020-01), p. 117822342090155-
    Abstract: Hereditary breast cancer is an inherited genetic condition, mainly caused by BRCA1 and BRCA2 gene mutations. These genetic changes can increase the risks of breast and ovarian cancers in women, while prostate and breast cancers in men. Especially, mutations in either BRCA1 or BRCA2 genes take important roles in early-onset breast cancer. The present study focused on a 47-year-old Vietnamese woman with breast cancer by applying targeted next-generation sequencing technique. A novel BRCA1 gene mutation, namely NM_007294.3 (BRCA1): c.4998insA (p. Tyr1666Terfs), was identified both in this patient and in some of the members in her family proved the fact that the mutated genes passed down through generations. This change may exponentially initiate breast cancer risks and become a valuable marker for exact clinical prognosis and treatment.
    Type of Medium: Online Resource
    ISSN: 1178-2234 , 1178-2234
    URL: Article
    DOI: 10.1177/1178223420901555
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2423804-1
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  • 2
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    Dynamic analysis of precast ultra-high performance concrete tunnel under internal explosion
    SAGE Publications ; 2023
    In:  International Journal of Protective Structures
    Details
    In: International Journal of Protective Structures, SAGE Publications
    Abstract: Underground structures hold great significance in the infrastructure of modern society. With the rapid construction of such facilities, the possibility of explosions occurring inside these structures due to unforeseen accidents or deliberate acts cannot be ignored. Past catastrophic events have demonstrated the necessity of implementing anti-blast design for underground structures, particularly in vulnerable locations. This promotes investigations into the behavior of underground structures subjected to internal explosions. For the first time, a thorough simulation model is developed using the multi-material Coupled Eulerian–Lagrangian approach to examine a full-scale precast ultra-high performance concrete (UHPC) tunnel under internal explosion. The precast tunnel structure closely resembles real construction configurations. The simulation model takes into account the simultaneous interaction between the tunnel and the surrounding soil. The accuracy of the suggested simulation model is validated against experimental results. For various explosive charge weights, tunnel lining thicknesses, materials, and tunnel shapes, extensive parametric simulations are conducted. Results obtained highlighted UHPC's superiority as a substitute for conventional concrete due to its strong blast-resistant capacity. The findings from this research also shed light on the precast UHPC tunnel's structural response to an interior explosion, that can assist designers and managers choose the best design for blast protection.
    Type of Medium: Online Resource
    ISSN: 2041-4196 , 2041-420X
    URL: Article
    DOI: 10.1177/20414196231203402
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2548257-9
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  • 3
    Online Resource
    Online Resource
    Terminal super-twisting sliding mode based on high order sliding mode observer for two DOFs lower limb system
    SAGE Publications ; 2023
    In:  Measurement and Control Vol. 56, No. 7-8 ( 2023-09), p. 1455-1470
    Details
    In: Measurement and Control, SAGE Publications, Vol. 56, No. 7-8 ( 2023-09), p. 1455-1470
    Abstract: In this paper, a novel backstepping terminal super-twisting sliding mode (TSTSM) with high order sliding mode observer (HOSMO) is proposed to control the two degrees of freedom (DOFs) Serial Elastic Actuator (SEA), inspired by a lower limb of humanoid robots. First, the dynamic model, extended from our previous study, is presented for developing the control algorithm. Secondly, the backstepping technique is utilized to separate the overall system into two subsystems. One of the challenges of SEA is to deal with the evident oscillations caused by the elastic element, which might lead to the degrading performance of load position control. In order to reduce this adverse effect, a TSTSM is proposed to control the position tracking of two subsystems. The advantages of TSTSM are the finite-time convergence despite the bounded perturbation and the dramatic reduction of the chattering phenomenon. To construct and implement the TSTSM controller, it requires the knowledge of all states, which is not available in the current lower limb system setup. Therefore, a HOSMO is utilized to estimate the unknown states. Finally, experiment results are carried out to assess the effectiveness of the proposed controller and compare it with those of different control schemes.
    Type of Medium: Online Resource
    ISSN: 0020-2940
    URL: Article
    DOI: 10.1177/00202940231156195
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2712343-1
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  • 4
    Online Resource
    Online Resource
    Backstepping-based model reference adaptive controller for a multi-axial system in the presence of external disturbance and saturated input
    SAGE Publications ; 2018
    In:  Transactions of the Institute of Measurement and Control Vol. 40, No. 3 ( 2018-02), p. 776-784
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 40, No. 3 ( 2018-02), p. 776-784
    Abstract: This paper presents a backstepping-based model reference adaptive controller for a multi-axial system in the presence of external disturbance and saturated input. The proposed controller synthesizes the backstepping technique and the model reference adaptive control method to construct control inputs for recursive structure and uncertain modelling of the multi-axial system. To cope with the limit of saturated input, an auxiliary system is adopted. A dead-zone modification is introduced to avoid the drift phenomenon of adjusted adaptive parameters. The stability of the proposed controller is proven by Lyapunov’s theory while considering the effect of the auxiliary system and the dead-zone modification in the design stage. The effectiveness and performance of the proposed controller are evaluated by experiment on a transformer winding system.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331216673696
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2025882-3
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  • 5
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    Online Resource
    A bio-mimetic cellular structure for mitigating the effects of impulsive loadings – A numerical study
    SAGE Publications ; 2021
    In:  Journal of Sandwich Structures & Materials Vol. 23, No. 6 ( 2021-09), p. 1929-1955
    Details
    In: Journal of Sandwich Structures & Materials, SAGE Publications, Vol. 23, No. 6 ( 2021-09), p. 1929-1955
    Abstract: Re-entrant and honeycomb cellular structures have shown potential for mitigating the effects of extreme loadings such as those imposed by impacts and near-range air blast. However, these cellular geometries can buckle locally and collapse in the immediate vicinity of the loading, which can limit their effectiveness as a protective element. These deficiencies can be addressed by mimicking alternate, naturally occurring, cellular structures, including that of the porcupine quill, which is studied here. The quill possesses several distinct features that effectively counteract buckling and bending, and minimise weight. This study mimics several structural features of the quill to develop a novel cellular design for counteracting air blast loads such as those associated with detonations of high explosives. The performance of the bio-mimetic structure is benchmarked against traditional hexagonal and re-entrant designs, which have been documented in the archival literature. The quill-inspired structure offers more design freedom than the traditional cellular geometries. By iteratively mimicking several of the structural features of the porcupine quill, an optimal balance between local buckling and collapse can be realised, which minimises the reaction on the target below and maximises energy dissipation.
    Type of Medium: Online Resource
    ISSN: 1099-6362 , 1530-7972
    URL: Article
    DOI: 10.1177/1099636220908581
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2098561-7
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  • 6
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    Online Resource
    Cross-coupling synchronous velocity control using model reference adaptive control scheme in an unsymmetrical biaxial winding system
    SAGE Publications ; 2018
    In:  Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering Vol. 232, No. 9 ( 2018-10), p. 1245-1259
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering, SAGE Publications, Vol. 232, No. 9 ( 2018-10), p. 1245-1259
    Abstract: Motion control with high accuracy for each axial system is the fundamental requirement to reduce a synchronous motion error of a multi-axis system. Especially, designing a model-based controller for an uncertainty system with unknown parameters is not easy without using system identification. To overcome the mentioned issue, this article proposes a cross-coupling synchronous velocity controller using a backstepping-based model reference adaptive control scheme in an unsymmetrical biaxial winding system called a transformer winding system. The proposed controller deals not only with the uncertainty but also with the recursive structure of the system. The backstepping technique for the recursive structural system and the model reference adaptive control method for the uncertainty of the system are designed to stabilize two axial systems with unknown parameters. An auxiliary system is added to build the proposed controller for coping with input constraints of physical actuators. To improve the proposed controller’s ability to cope with external disturbances, a dead-zone modification is utilized to modify the adaptation laws to avoid the drift phenomenon. Moreover, a cross-coupling mechanism is integrated into the proposed controller to reduce the synchronous velocity error between the velocities of the biaxial winding system. The proposed controller is also transformed into discrete time to be run on a digital signal processor alone chip. The experimental results are shown to verify the high performance and efficiency of the proposed controller for practical applications.
    Type of Medium: Online Resource
    ISSN: 0959-6518 , 2041-3041
    URL: Article
    DOI: 10.1177/0959651818779509
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2024903-2
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  • 7
    Online Resource
    Online Resource
    Risk factors of Pancreatic Cancer in Vietnam: A Matched Case–Control Hospital-Based Study
    SAGE Publications ; 2021
    In:  Cancer Control Vol. 28 ( 2021-01-01), p. 107327482198932-
    Details
    In: Cancer Control, SAGE Publications, Vol. 28 ( 2021-01-01), p. 107327482198932-
    Abstract: Data about the risk factors and pancreatic cancer in developing countries remain limited. We investigated for the first time the role of a number of risk factors (family cancer history, smoking, alcohol consumption, diabetes, inflammation disease, HBV infection) associated with pancreatic cancer among Vietnamese patients. Methods: We included all patients hospitalized at 4 Northern Vietnamese hospitals (Vietnam National Cancer Hospital, Bach Mai, Viet Duc, Thai Nguyen) and diagnosed with pancreatic cancer during the period from 2017 to 2019. Risk factors of eligible patients were collected and assessed the associations using a matched control study and logistic regression model analysis. Results: We identified 196 patients with diagnosis of pancreatic cancer of which 114 males and 82 females. The average age of the patient at the time of diagnosis was 58.28 years (standard deviation of 12.94, ranging from 25 to 87). Most of patients were diagnosed at advanced stage (85%). Smoking, diabetes, inflammation disease significantly increased the cancer risks (OR and 95% CI were 2.42 (1.38-4.37), 3.09 (1.54-6.68), 2.21 (1.42-3.45), respectively). HBV infection demonstrated a significant link with pancreatic cancer in univariate model (OR = 2.94 (1.08-9.36)), but not in multivariate model. However, cancer family history and alcohol drinkers did not show any significantly increased risk related to pancreatic cancer. Conclusions: Our finding showed smoking, diabetes, inflammation disease significantly increased the risk of pancreatic cancer in Vietnam.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    URL: Article
    DOI: 10.1177/1073274821989320
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2004182-2
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  • 8
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    Social work field education in Vietnam: Challenges and recommendations for a better model
    SAGE Publications ; 2022
    In:  International Social Work Vol. 65, No. 6 ( 2022-11), p. 1216-1231
    Details
    In: International Social Work, SAGE Publications, Vol. 65, No. 6 ( 2022-11), p. 1216-1231
    Abstract: Given the rapid expansion in social work education, universities in Vietnam are facing tremendous challenges in organizing effective field practicum. This article explores the current field practicum models in Vietnam, its strengths, challenges and recommendations for enhancement. The study utilized a case-study approach in which focus groups and in-depth interviews were conducted. The key strengths included diverse and comprehensive content, and enthusiasm and support from field supervisors and instructors. The key challenges were lack of qualified field supervisors, loose collaboration between universities and field agencies, and inadequate student assessment methods. Specific recommendations are presented that fit the contexts of Vietnam.
    Type of Medium: Online Resource
    ISSN: 0020-8728 , 1461-7234
    URL: Article
    DOI: 10.1177/0020872820930264
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2050567-X
    SSG: 3,4
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  • 9
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    Typhoid fever, complicated by syncope due to relative bradycardia: A case report
    SAGE Publications ; 2023
    In:  SAGE Open Medical Case Reports Vol. 11 ( 2023-01), p. 2050313X2311771-
    Details
    In: SAGE Open Medical Case Reports, SAGE Publications, Vol. 11 ( 2023-01), p. 2050313X2311771-
    Abstract: In a United Nations (UN) staff member headquarters in South Sudan, we present a rare typhoid fever complicated by syncope due to relative bradycardia. A 25-year-old male presented to our hospital with a high fever, diarrhea, and no vomiting. He had no substantial medical background. He was diagnosed with an unspecified digestive disorder and received initial treatment. Two syncope episodes were recorded in the Level 1 hospital. He was referred to our hospital at the 30th hour and the third fainting occurred. Electrocardiogram showed bradycardia with a heart rate of 40 beats/min. The atropine test was negative; the initial diagnosis was sinus sickness syndrome. Microbiology tests later suggested typhoid infection. Then, the diagnosis changed to relative bradycardia caused by Salmonella typhi; and he was orally treated with the third-generation Quinolone antibiotic. He significantly improved and got discharged on the seventh day. In conclusion, typhoid remains a real and present threat to UN staff and civilians in South Sudan.
    Type of Medium: Online Resource
    ISSN: 2050-313X , 2050-313X
    URL: Article
    DOI: 10.1177/2050313X231177108
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2736953-5
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  • 10
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    A New Cycloartane Glucoside from Rhizophora stylosa
    SAGE Publications ; 2014
    In:  Natural Product Communications Vol. 9, No. 9 ( 2014-09), p. 1934578X1400900-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 9, No. 9 ( 2014-09), p. 1934578X1400900-
    Abstract: Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic ( 1 H and 13 C NMR, HSQC, HMBC, 1 H- 1 H COSY, NOESY) and HR-ESI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1400900909
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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