In:
Natural Product Communications, SAGE Publications, Vol. 18, No. 10 ( 2023-10)
Abstract:
Objective: Alpinia is a big genus of flowering plants in the family Zingiberaceae. The plants of this genus are generally aromatic due to their essential oils. The current study aims to identify chemical compositions in the rhizome and leaf oils of Alpinia vietnamica H.Đ. Trần, Luu & Škorničk. Methods: Essential oils of A vietnamica rhizomes and leaves obtained by hydrodistillation were investigated by the gas chromatography–flame ionization detection/mass spectrometry (GC–FID/MS) analysis. A vietnamica essential oils have been subjected to cytotoxic and α-glucosidase inhibitory assays. The protein interactions of the major compounds were viewed by molecular docking study. Results: In general, monoterpene hydrocarbons (60.4%-62.5%) and their oxygenated derivatives (18.1%-29.0%) were the main chemical classes of the rhizome and leaf oils. In the meantime, 1,8-cineole (25.7%-29.0%), β-pinene (12.8%-21.3%), geraniol (9.0%-15.2%), and α-pinene (6.1%-7.5%) can be seen as the main compounds. A vietnamica essential oils showed cytotoxicity toward four cancer cell lines KB, Hep-G2, Lu-1, and MCF-7 with IC 50 values of 82.39 to 254.1 µg/mL. Significantly, the leaf oil (IC 50 115.18 µg/mL) was better than the standard compound acarbose (IC 50 156.68 µg/mL) in the α-glucosidase inhibitory assay. The results of molecular docking simulation suggested that 1,8-cineole, geraniol, α-pinene, and β-pinene could generate a similar inhibition (binding affinities) with acarbose, and the hydrogen and hydrophobic interactions played contributory roles in the binding to α-glucosidase enzyme. Conclusion: Further phytochemical investigations on this species, especially chromatographic separations to isolate bioactive metabolites, are needed. As well, pharmacological experiments are welcome since the current study is the first result.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X231206280
Language:
English
Publisher:
SAGE Publications
Publication Date:
2023
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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