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  • 1
    Online Resource
    Online Resource
    Genotoxicity of Chemical Compounds Identification and Assessment by Yeast Cells Transformed With GFP Reporter Constructs Regulated by the PLM2 or DIN7 Promoter
    SAGE Publications ; 2015
    In:  International Journal of Toxicology Vol. 34, No. 1 ( 2015-01), p. 31-43
    Details
    In: International Journal of Toxicology, SAGE Publications, Vol. 34, No. 1 ( 2015-01), p. 31-43
    Abstract: Yeast cells transformed with high-copy number plasmids comprising a green fluorescent protein (GFP)-encoding gene optimized for yeast under the control of the new DIN7 or PLM2 and the established RNR2 and RAD54 promoters were used to assess the genotoxic potential of chemical compounds. The activity of potential DNA-damaging agents was investigated by genotoxicity assays and by OxoPlate assay in the presence of various test compounds. The fluorescence signal generated by GFP in response to DNA damage was related to the different concentrations of analytes and the analyte-dependent GFP synthesis. The use of distinct DNA damage-inducible promoters presents alternative genotoxicity testing strategies by selective induction of promoters in response to DNA damage. The new DIN7 and PLM2 systems show higher sensitivity than the RNR2 and RAD54 systems in detecting 4-nitroquinoline- N-oxide and actinomycin D. Both DIN7 and PLM2 systems are able to detect camptothecin while RNR2 and RAD54 systems are not. Automated laboratory systems with assay performance on 384-well microplates provide for cost-effective high-throughput screening of DNA-damaging agents, reducing compound consumption to about 53% as compared with existing eukaryotic genotoxicity bioassays.
    Type of Medium: Online Resource
    ISSN: 1091-5818 , 1092-874X
    URL: Article
    DOI: 10.1177/1091581814566870
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 1500682-7
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  • 2
    Online Resource
    Online Resource
    Professional Preparedness Implications of Workplace Violence against Medical Students in Hospitals: A Cross-Sectional Study
    SAGE Publications ; 2023
    In:  INQUIRY: The Journal of Health Care Organization, Provision, and Financing Vol. 60 ( 2023-01)
    Details
    In: INQUIRY: The Journal of Health Care Organization, Provision, and Financing, SAGE Publications, Vol. 60 ( 2023-01)
    Abstract: Workplace violence is an increasing public health concern around the world. In Vietnam, attacks on healthcare workers have become a huge issue in recent years. Our study aims to shed more light on the issue and look at what variables affect acts of violence toward healthcare workers. We conducted this cross-sectional study by surveying 550 medical students from 3 universities in Vietnam. Following this survey on SurveyMonkey’s platform (surveymonkey.com), the participants were suggested to invite their associates who met the selection criteria to join in this online survey. The structured questionnaire included demographics and details on the violence. There were 90.5% of respondents were medical students, the mean age was 23.3, and verbal abuse had a prevalence rate of 29.3%. Women respondents are less likely to suffer from violent experiences than men (OR = 0.48, 95% CI = 0.28-0.84), and those specializing in nurse and technician also faced a lower rate of acts of aggression (physical violence: OR = 0.35; 95% CI = 0.19-0.63, sexual harassment: OR = 0.36; 95% CI = 0.15-0.87, and any type of violence: OR = 0.55, 95% CI = 0.37-0.82). Medical students working in Ho Chi Minh City (OR = 0.55; 95% CI = 0.34-0.89), and other regions (OR = 0.40; 95% CI = 0.19-0.85) were significantly less likely to face verbal abuse than those working in Hanoi. The workplace culture needs to be changed to make sure that people feel comfortable reporting, especially those who are younger. Protecting medical students also ensures patient safety since victims of assault in the workplace can have severe aftereffects affecting their ability to provide good patient care. Hence, policies need to be implemented at both the government and hospital administration levels to keep health workers safe.
    Type of Medium: Online Resource
    ISSN: 0046-9580 , 1945-7243
    URL: Article
    DOI: 10.1177/00469580231179894
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2147137-X
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  • 3
    Online Resource
    Online Resource
    A Case of Renal Inflammatory Pseudotumor Leading to Nephrectomy
    SAGE Publications ; 2021
    In:  Journal of Investigative Medicine High Impact Case Reports Vol. 9 ( 2021-01), p. 232470962110032-
    Details
    In: Journal of Investigative Medicine High Impact Case Reports, SAGE Publications, Vol. 9 ( 2021-01), p. 232470962110032-
    Abstract: Inflammatory pseudotumor (IPT) of the kidney is a rare benign disorder with unknown etiology. In IPT patients, some nonspecific symptoms might present, such as fever, hematuria, and back pain. As it can appear on computed tomography and magnetic resonance imaging as a hypovascular mass with surrounding fat stranding, IPT can be misdiagnosed as a primary tumor. Since the clinical symptoms, radiographic features, and preoperative findings can be inconsistent, it is imperative to confirm IPT based on histopathological assessment. In the present study, we describe a case of renal IPT in a 13-year-old girl. The patient was treated with nephrectomy of the right kidney since the preoperative diagnosis was renal carcinoma. Pathological examination revealed an IPT. This article emphasizes the importance of preoperative definitive diagnosis in avoiding unnecessary nephrectomy.
    Type of Medium: Online Resource
    ISSN: 2324-7096 , 2324-7096
    URL: Article
    DOI: 10.1177/23247096211003224
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2710326-2
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  • 4
    Online Resource
    Online Resource
    Validity of the International Physical Activity Questionnaire–Short Form for Application in Asian Countries: A Study in Vietnam
    SAGE Publications ; 2020
    In:  Evaluation & the Health Professions Vol. 43, No. 2 ( 2020-06), p. 105-109
    Details
    In: Evaluation & the Health Professions, SAGE Publications, Vol. 43, No. 2 ( 2020-06), p. 105-109
    Abstract: This is the first study in the Asia-Pacific region to examine the criterion validity of the self-reported International Physical Activity Questionnaire–Short form (IPAQ-SF) using accelerometers, in terms of achieving the World Health Organization’s (WHO) recommended physical activity guidelines for health benefits. Vietnamese adults aged 40–65 years ( n = 240) wore an ActiGraph GT3X + accelerometer for at least 5 days and completed the Vietnamese version of the IPAQ-SF. Correlations between IPAQ-SF and accelerometer-measured physical activity intensities varied from .087 to .232. Mean difference in moderate–vigorous physical activity was 0.699 min/day (95% limits: [−107, 109]). Agreement on the classification of achieving the WHO’s physical activity guidelines was 69.16%. The IPAQ-SF identified 71.86% of adults who met the guidelines, whereas 56.09% of those not meeting the guidelines were classified correctly. The IPAQ-SF was found to have acceptable criterion validity and is a useful instrument to classify Vietnamese adults as achieving or not achieving the WHO’s physical activity guidelines for health benefits.
    Type of Medium: Online Resource
    ISSN: 0163-2787 , 1552-3918
    URL: Article
    DOI: 10.1177/0163278718819708
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2067657-8
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  • 5
    Online Resource
    Online Resource
    Prevalence of and Risk Factors for Type 2 Diabetes Mellitus in Vietnam : A Systematic Review
    SAGE Publications ; 2015
    In:  Asia Pacific Journal of Public Health Vol. 27, No. 6 ( 2015-09), p. 588-600
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 27, No. 6 ( 2015-09), p. 588-600
    Abstract: This systematic review examined trends in the prevalence of type 2 diabetes mellitus (T2DM) and identified its risk factors among adults in Vietnam. PubMed, Web of Science, Wiley Online Library, and Scopus databases were searched to identify relevant literature. The search yielded 10 studies, including 2 national surveys and 8 regional investigations. National prevalence estimates of T2DM were 2.7% in 2002 and 5.4% in 2012. The estimates for the northern region were 1.4% in 1994 and 3.7% in 2012 and those for the southern region were 3.8% in 2004, 7.0% in 2008, and 12.4% in 2010. The major determinants of T2DM included older age, urban residence, high levels of body and abdominal fat, physical inactivity, sedentary lifestyle, genetic factors, and hypertension. The prevalence rate by gender was variable in both national and regional studies. There was insufficient information available on some potentially important risk factors such as smoking, dietary intake, income, and educational level. Our review signifies a rapidly growing prevalence of T2DM in Vietnam and suggests that extra effort is required to prevent and control this disease.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539515595860
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2394975-2
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  • 6
    Online Resource
    Online Resource
    Gestational Diabetes and Breastfeeding Outcomes: A Systematic Review
    SAGE Publications ; 2019
    In:  Asia Pacific Journal of Public Health Vol. 31, No. 3 ( 2019-04), p. 183-198
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 31, No. 3 ( 2019-04), p. 183-198
    Abstract: Studies of gestational diabetes mellitus in relation to breastfeeding are limited, while their findings are inconsistent. This systematic review was conducted to assess the associations between gestational diabetes and breastfeeding outcomes. An initial search of PubMed, Web of Science, and ProQuest identified 518 studies, and after applying the inclusion criteria, 16 studies were finally included in the review. Four studies reported that “exclusive/predominant/full breastfeeding” rates at discharge were lower in mothers with gestational diabetes than in those without gestational diabetes, and 2 studies showed a shorter duration of “exclusive/predominant breastfeeding” in the former than in the latter. However, most studies found no apparent difference in the rate of “breastfeeding initiation”, “any breastfeeding” duration, or “any breastfeeding” in hospital and at discharge between mothers with and without gestational diabetes. In summary, mothers with gestational diabetes were less likely to exclusively breastfeed their infants and may have a shorter breastfeeding duration than other mothers.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539519833497
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2394975-2
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  • 7
    Online Resource
    Online Resource
    Damarane- type Saponins from Gynostemma Longipes and their Cytotoxic Activity
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 8 ( 2015-08), p. 1934578X1501000-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 8 ( 2015-08), p. 1934578X1501000-
    Abstract: Two new damarane- type saponins, named gylongiposides II-III (1 and 2), along with one known compound, (23 S)-3β,20ζ,21ζ-trihydroxy-19-oxo-21,23-epoxydammar-24-ene 3- O-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside, were isolated from the leaves of Gynostemma longipes C.Y.Wu. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS spectra. Compounds 1–3 exhibited moderate activity against four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7, with IC 50 values ranging from 9.8 ± 2.1 to 49.6 ± 2.6 μM.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501000808
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 8
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    Online Resource
    A New Coumarin and Cytotoxic Activities of Constituents from Cinnamomum cassia
    SAGE Publications ; 2014
    In:  Natural Product Communications Vol. 9, No. 4 ( 2014-04), p. 1934578X1400900-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 9, No. 4 ( 2014-04), p. 1934578X1400900-
    Abstract: A new coumarin derivative, coumacasia (1) and eight known compounds, coumarin (2), cinnamaldehyde (3), 2-methoxycinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), coniferaldehyde (6), cinnamic acid (7), 2-hydroxycinnamic acid (8), and cinnamic alcohol (9), were isolated from the methanol extract of Cinnamomum cassia. Their structures were elucidated by spectral data and by comparison with the reported literature. The cytotoxic activities of compounds 1-9 were evaluated with two human cancer cell lines, HL-60 and A-549. Compound 1 showed growth inhibitory effects in the HL-60 and A-549 cell lines with IC 50 values of 8.2 ± 0.5 and 11.3 ±1.1 μM, respectively. Compounds 3-6, and 8 exhibited moderate cytotoxicity with IC 50 values ranging from 20.5 to 65.6 μM.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1400900414
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    A Rare Case of Fungal Burn Wound Infection Caused by Fusarium solani in Vietnam
    SAGE Publications ; 2020
    In:  Journal of Investigative Medicine High Impact Case Reports Vol. 8 ( 2020-01), p. 232470962091212-
    Details
    In: Journal of Investigative Medicine High Impact Case Reports, SAGE Publications, Vol. 8 ( 2020-01), p. 232470962091212-
    Abstract: A patient with extensive burn injuries was admitted to the National Hospital of Burns in Hanoi, Vietnam, and diagnosed with fungal wound infection by histological examination of skin biopsy samples. Fusarium solani was isolated and identified by analysis of its morphological features and the sequence of the internal transcribed spacer region. The isolation showed in vitro resistant to fluconazole, voriconazole, itraconazole, amphotericin B, and caspofungin. Invasive fusariosis is difficult to treat due to its angioinvasive property and its lacking amenability to treatment with antifungal drugs. This infection is rare and has not been reported so far in Vietnam.
    Type of Medium: Online Resource
    ISSN: 2324-7096 , 2324-7096
    URL: Article
    DOI: 10.1177/2324709620912122
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2710326-2
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  • 10
    Online Resource
    Online Resource
    Tobacco and Alcohol Use Among Ethnic Minorities in Vietnam
    SAGE Publications ; 2020
    In:  Asia Pacific Journal of Public Health Vol. 32, No. 8 ( 2020-11), p. 387-397
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 32, No. 8 ( 2020-11), p. 387-397
    Abstract: This study investigates the prevalence of tobacco and alcohol uses and associated factors among 12 ethnic minorities in Vietnam in 2019. A cross-sectional survey was conducted among 5172 people aged ≥15 years. The prevalence of smoking and drinking was 19.7% and 29.9%, respectively, and significantly higher among men than women. These numbers were heterogeneous across ethnic minorities. Smoking prevalence was high among Ba Na (25.9%), Cham An Giang (22.3%), Khmer (23.5%), La Hu (26.3%), Ta Oi (30.7%), and Bru Van Kieu (29.6%) ethnicities whereas that of Gie Trieng and Mnong ethnicities was low (3.7% and 9.5%, respectively). Drinking prevalence ranged from 1.4% in Cham An Giang ethnicity to 68.6% in Ba Na ethnicity. A wide ethnic disparity on tobacco and alcohol use could be explained by the ethnic variation of lifestyles, social norms, and cultural features. Our findings suggest the need to develop ethnic-specific interventions to mitigate the smoking and drinking prevalence.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539520956444
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2394975-2
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