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  • SAGE Publications  (2)
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  • SAGE Publications  (2)
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  • 1
    In: Therapeutic Advances in Respiratory Disease, SAGE Publications, Vol. 14 ( 2020-01), p. 175346662093577-
    Abstract: EML4-ALK rearranged malignant pleural mesothelioma (MPM) is rare and its responses to anaplastic lymphoma kinase (ALK) inhibitors, including alectinib and lorlatinib, remain unexplored. In this case report, we describe a patient with EML4-ALK-rearranged stage IIIB MPM who was administered with alectinib and lorlatinib as first-line and fourth-line therapy, respectively. He had remarkable response evaluated as partial response on both regimens lasting approximately 3.5 months on each regimen. His plasma samples were collected during the treatment course and submitted for targeted sequencing to understand the molecular mechanisms of his therapeutic resistance. Sequencing analysis revealed the emergence of ALK I1171N and L1196M at alectinib progression. Meanwhile, ALK I1171N, L1196M, and G1202R mutations were identified at lorlatinib progression, wherein L1196M is confirmed to be in cis to G1202R. We speculate that these multiple mutations synergistically mediated his resistance to both alectinib and lorlatinib. Our report describes the detection of EML4-ALK rearrangement in a patient with MPM who had remarkable therapeutic response with ALK inhibitors. Moreover, our case also revealed acquired mechanisms of lorlatinib resistance mediated by multiple mutations ALK I1171N, L1196M, and G1202R, contributing an incremental step to our understanding of the complexity of acquired resistance mechanisms in sequential ALK inhibitor therapy. The reviews of this paper are available via the supplemental material section.
    Type of Medium: Online Resource
    ISSN: 1753-4666 , 1753-4666
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2387506-9
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  HERD: Health Environments Research & Design Journal Vol. 16, No. 1 ( 2023-01), p. 142-160
    In: HERD: Health Environments Research & Design Journal, SAGE Publications, Vol. 16, No. 1 ( 2023-01), p. 142-160
    Abstract: The objective of this study is to explore healthcare resource accessibility in Harbin, a typical city in a cold region in China. Background: Recently, investments in the construction of medical resources have been increasing annually in China, and consequently, the allocation of these resources has improved. Snow and ice on surfaces in China’s cold regions have certain effects on the traffic capacity of urban roads, leading to a great difference in the accessibility of medical resources in winter and summer. Methods: The basic spatial data, including spatial road data, medical facility data, and population distribution data, are analyzed using geographic information system. Then, a spatial barrier model is used to measure healthcare accessibility based on geographic and population weighting; we explore the accessibility of hospitals under the influence of weather by defining a novel distance attenuation function. Finally, the accessibility of medical institutions in the study area is explored by analyzing data about the related separation factors. Results: It was found that the spatial distribution of medical resources was not equal, and the dominant resources were concentrated in the city center. Some regions are always in an advantageous position regardless of traffic conditions. In contrast, in areas far from the city center, the accessibility of medical resources significantly decreases in winter. Conclusions: These results will help optimize the layout of medical institutions and improve medical equality and propose strategies for the optimization of the accessibility of urban medical institutions in cold regions of China.
    Type of Medium: Online Resource
    ISSN: 1937-5867 , 2167-5112
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2525547-2
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