In:
Cancer Control, SAGE Publications, Vol. 23, No. 3 ( 2016-07), p. 197-207
Abstract:
Historically, oropharyngeal cancer (OPC) has been attributed to risk factors such as smoking and alcohol use. The increased incidence of OPC has been driven by human papillomavirus (HPV) infection. Methods A search of the literature involving HPV infection and OPC was performed, along with a search of ongoing clinical trials regarding HPV-positive OPC. Results This review summarizes the differences in epidemiology and prognosis of HPV-positive OPC compared with non–HPV-related OPC. It will also discuss use of de-escalating treatment to minimize toxicity while maintaining excellent outcomes. Disease management is also addressed, including prevention and follow-up recommendations for this cohort of patients. Conclusions HPV-positive OPC is a distinct disease, and efforts should be made to personalize its management. Preventive measures and vaccinations, along with de-escalation of treatment, may help optimize outcomes in this population.
Type of Medium:
Online Resource
ISSN:
1073-2748
,
1073-2748
DOI:
10.1177/107327481602300302
Language:
English
Publisher:
SAGE Publications
Publication Date:
2016
detail.hit.zdb_id:
1328503-8
Permalink
