GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    History of Laser in BPH therapy
    SAGE Publications ; 2014
    In:  Urologia Journal Vol. 81, No. 23_suppl ( 2014-01), p. S38-S42
    Details
    In: Urologia Journal, SAGE Publications, Vol. 81, No. 23_suppl ( 2014-01), p. S38-S42
    Abstract: Laser technology has been used in the treatment of BPH for more than 15–20 years in order to challenge transurethral resection of the prostate. The aim of this review article is to analyze the evolution of laser in BPH therapy, from early coagulative techniques - progressively abandoned for their elevated postoperative morbidity and unfavorable outcomes - to the newer techniques of vaporization, resection and enucleation of the prostate. A better comprehension of tissue-laser interactions, the improvement of laser technology and a growing clinical experience have lead to the development of different laser systems (Holmium, KTP, Thulium laser) that challenge TURP. Today, HoLEP and, secondarily, PVP are the laser techniques supported by more clinical evidences and represent valid alternatives to TURP.
    Type of Medium: Online Resource
    ISSN: 0391-5603 , 1724-6075
    URL: Article
    DOI: 10.5301/RU.2014.11985
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2557852-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Ejaculatory System Cysts: A Case Report
    SAGE Publications ; 2014
    In:  Urologia Journal Vol. 81, No. 23_suppl ( 2014-01), p. S32-S37
    Details
    In: Urologia Journal, SAGE Publications, Vol. 81, No. 23_suppl ( 2014-01), p. S32-S37
    Abstract: Male pelvic floor cysts are a rare clinical entity that include: Wolffian duct remnants, Müllerian duct remnants, cysts of the seminal vesicles, prostate and ejaculatory duct/vas deferens cysts. Case Report We report the clinical case of a 21-year-old male patient with a history of previous surgery in childhood and more precisely: partial colectomy for congenital megacolon, removal of dysplastic right kidney and subsequent surgical adhesiolysis for bowel obstruction. At 17, the patient was submitted to MRI for groin pain with an incidental finding of a cystic mass at the level of the right seminal vesicle. Consequently, a TUR-ED was performed at another urology unit, for a suspected seminal vesicle ectasia, without resolution of pain symptoms. The patient was referred to us for persistent genitourinary infections, ejaculation disorder and episodes of gross hematuria. An additional MRI confirmed the presence of a cystic mass of 5,5 cm with a suspected opening into prostatic urethra. Urethrocystoscopy and urethrocystography retrograde confirmed this anatomical communication. For the persistence of the symptoms we performed retropubic surgical exeresis of the mass, with a histopathological finding of benign cyst of the vas deferens. Two major postoperative complications were reported: a pelvic hematoma that required surgical exploration and a urinary extravasation at the level of prostatic urethra, which resolved with prolonged urethral catheterization. Conclusions Male pelvic floor cysts are a rare disease with a complex clinical and therapeutic management. A correct diagnosis is based on clinical signs and symptoms together with imaging studies of the pelvic region. The high risk of erectile dysfunction and ejaculatory disorders correlated to a surgical approach, recommend a treatment of these lesions only for symptomatic cases.
    Type of Medium: Online Resource
    ISSN: 0391-5603 , 1724-6075
    URL: Article
    DOI: 10.5301/RU.2014.11999
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2557852-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Multiple Marker Studies on a Malignant Fibrous Histiocytoma with Primary Cutaneous Localization
    SAGE Publications ; 1988
    In:  Tumori Journal Vol. 74, No. 5 ( 1988-09), p. 609-615
    Details
    In: Tumori Journal, SAGE Publications, Vol. 74, No. 5 ( 1988-09), p. 609-615
    Abstract: Continuing controversy exists concerning a possible relation between neoplastic cells of malignant fibrous histiocytoma (MFH) and the mononuclear phagocyte system. The aim of this study was to investigate the membrane and cytoenzymatic phenotype of a primary cutaneous MFH, storiform pleomorphic type, and to compare these data with ultrastructural observations. Cytoplasmic proteins (acid phosphatase, non specific esterase, alpha-1 antitrypsin, and lysozyme) suggestive of a mononuclear phagocyte origin were demonstrated in varying amounts in neoplastic cells infiltrating the dermis. Consistent with these data, two (LeuM3 and OKM5) out of four (OKM1 and LeuM1) monoclonal antibodies directed against mononuclear phagocyte antigens stained most of the neoplastic cells. Class II MCH antigens (DR and DQ) were variably expressed on distinct groups of neoplastic cells, suggesting different activation/differentiation states. The results favor the view that the present case of primary cutaneous MFH was of mononuclear phagocyte origin. However, the observed phenotypic profile was expressed on neoplastic cells irrespective of their ultrastructural morphology (histiocytic or fibroblastic). Together with previous data in the literature, the latter finding corroborates the view that distinction between these two cell types in MFH is likely to reflect divergent growth and differentiation patterns rather than histogenesis.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089168807400520
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1988
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Medication holidays in osteoporosis: evidence-based recommendations from the Italian guidelines on ‘Diagnosis, risk stratification, and continuity of care of fragility fractures’ based on a systematic literature review
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Musculoskeletal Disease Vol. 15 ( 2023-01)
    Details
    In: Therapeutic Advances in Musculoskeletal Disease, SAGE Publications, Vol. 15 ( 2023-01)
    Abstract: Noncommunicable, chronic diseases need pharmacological interventions for long periods or even throughout life. The temporary or permanent cessation of medication for a specific period, known as a ‘medication holiday,’ should be planned by healthcare professionals. Objectives: We evaluated the association between continuity (adherence or persistence) of treatment and several outcomes in patients with fragility fractures in the context of the development of the Italian Guidelines. Design: Systematic review. Data Sources and Methods: We systematically searched PubMed, Embase, and the Cochrane Library up to November 2020 for randomized clinical trials (RCTs) and observational studies that analyzed medication holidays in patients with fragility fracture. Three authors independently extracted data and appraised the risk of bias of the included studies. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation methodology. Effect sizes were pooled in a meta-analysis using random effects models. Primary outcomes were refracture and quality of life; secondary outcomes were mortality and treatment-related adverse events. Results: Six RCTs and nine observational studies met our inclusion criteria, ranging from very low to moderate quality. The adherence to antiosteoporotic drugs was associated with a lower risk of nonvertebral fracture [relative risk (RR) 0.42, 95% confidence interval (CI) 0.20–0.87; three studies] than nonadherence, whereas no difference was detected in the health-related quality of life. A reduction in refracture risk was observed when continuous treatment was compared to discontinuous therapy (RR 0.49, 95% CI 0.25–0.98; three studies). A lower mortality rate was detected for the adherence and persistence measures, while no significant differences were noted in gastrointestinal side effects in i ndividuals undergoing continuous versus discontinuous treatment. Conclusion: Our findings suggest that clinicians should promote adherence and persistence to antiosteoporotic treatment in patients with fragility fractures unless serious adverse effects occur.
    Type of Medium: Online Resource
    ISSN: 1759-720X , 1759-7218
    URL: Article
    DOI: 10.1177/1759720X231177110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2516075-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Anti-sclerostin antibodies: a new frontier in fragility fractures treatment
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Musculoskeletal Disease Vol. 15 ( 2023-01)
    Details
    In: Therapeutic Advances in Musculoskeletal Disease, SAGE Publications, Vol. 15 ( 2023-01)
    Abstract: Bone fragility is the determinant of the increased risk of minimal trauma fracture and must be treated with a multimodal approach that includes pharmacological therapy, physical exercise, and adequate nutrition. Pharmacological therapy, to date based on the administration of antiresorptive drugs, such as bisphosphonates and denosumab, or osteoanabolic drugs, such as teriparatide and abaloparatide, has shown to be effective in reducing the risk of fracture in osteoporotic patients. In the context of the cellular and molecular mechanisms that regulate bone metabolism, the discovery of the Wnt signaling pathway and its role in bone tissue homeostasis has allowed the identification of sclerostin as an inhibitor of osteoblastic activity and simultaneously as a stimulator of osteoclastic activity. Therefore, the use of a monoclonal antibody, romosozumab, against this protein has been tested as a potential drug with a dual action, stimulating bone neo-apposition and inhibiting bone resorption. The efficacy of romosozumab has been demonstrated in numerous clinical trials against both placebo and other drugs commonly used in the treatment of patients affected by osteoporosis. The advantages of this drug lie above all in its rapid action which makes it particularly suitable in clinical situations where it is necessary to improve bone strength very quickly due to the imminent risk of fragility fracture. Clinical studies and guidelines suggest romosozumab as an initial drug in an ideal sequential approach from osteoanabolic to antiresorptive drugs. Some aspects of cardiovascular safety remain to be fully investigated, therefore its use in osteoporotic patients at high cardiovascular risk should be avoided until further data become available.
    Type of Medium: Online Resource
    ISSN: 1759-720X , 1759-7218
    URL: Article
    DOI: 10.1177/1759720X231197094
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2516075-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Effect of climatic and palaeoenvironmental changes on the occurrence of Holocene bats in the Swiss Alps
    SAGE Publications ; 2010
    In:  The Holocene Vol. 20, No. 5 ( 2010-08), p. 711-721
    Details
    In: The Holocene, SAGE Publications, Vol. 20, No. 5 ( 2010-08), p. 711-721
    Abstract: A large-scale palaeozoological study compared 45 14 C-dated bat remains from the southern and northern Swiss Alps with palaeovegetational and palaeoclimatic data. Four thermophilous (warm-demanding) and four psychrophilous (cold-tolerant) bat species, mainly forest dwellers, were selected for the study. Myotis blythii is the oldest bat species recorded in the Alps, i.e. on the southern side, going back to the early Holocene at 10 500 cal. BP. Our study showed that thermophilous species (e.g. Myotis bechsteinii and Rhinolophus hipposideros) were most abundant during the Holocene climatic optimum in Central Europe (10 000—4000 cal. BP), when warm-demanding mixed forests were dominant. Psychrophilous species such as Myotis brandtii also occurred during the climatic optimum, but most of the samples fall into the onset of the late Holocene (Sub-Atlantic period), when summer temperatures were already declining. These species declined in the southern Alps after 4000 cal. BP, when fire was intensively used by humans to convert portions of the forest into open land. This fire practice modified forest species composition and structure, with effects on forest-dwelling bat communities. We conclude that during the early and mid Holocene bat community compositions mainly depended on climate and related vegetation and forest structure dynamics. With increasing land use during the mid and late Holocene, anthropogenic changes of forest composition and creation of open habitats increasingly co-determined bat-population dynamics in the Alps. These Swiss findings are in agreement with previous results from eastern Central Europe.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683609358912
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    The routes for embolization of dural carotid cavernous fistulas when the endovascular approach is indicated as a first-line strategy
    SAGE Publications ; 2019
    In:  Interventional Neuroradiology Vol. 25, No. 1 ( 2019-02), p. 66-70
    Details
    In: Interventional Neuroradiology, SAGE Publications, Vol. 25, No. 1 ( 2019-02), p. 66-70
    Abstract: Multiple ways to access the dural carotid cavernous fistula have been described. The aim of the present study was to assess the results of embolization of a dural carotid cavernous fistula via different routes using endovascular accesses as a first-line strategy. Methods A retrospective data analysis of a consecutive series of 63 patients presenting with dural carotid cavernous fistula was performed. Results The dural carotid cavernous fistula was accessed by an endovascular approach in 58 patients (92.1%) and by direct puncture in five patients (7.9%). The inferior petrosal sinus was the main route accessed (65%). A recanalization of an occluded inferior petrosal sinus was obtained in 20.6% of cases. The access via either facial ophthalmic veins or the superior petrosal sinus was obtained in 20.6% and 3.1% of cases, respectively. Complete angiographic occlusion of a dural carotid cavernous fistula immediately after treatment was achieved in 53 patients (84.1%), whereas 10 patients (15.9%) displayed a partial occlusion. Treatment-related complications were observed in two patients (3.2%). Conclusions In this study, the endovascular approach allowed dural carotid cavernous fistula embolization in most patients. The inferior petrosal sinus, even when thrombosed, was the main route used to access the dural carotid cavernous fistula, followed by the facial vein, direct cavernous sinus puncture, and the superior petrosal sinus.
    Type of Medium: Online Resource
    ISSN: 1591-0199 , 2385-2011
    URL: Article
    DOI: 10.1177/1591019918796493
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2571161-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    TRAIN: Training through Research Application Italian Initiative
    SAGE Publications ; 2011
    In:  The International Journal of Biological Markers Vol. 26, No. 2 ( 2011-04), p. 136-138
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 26, No. 2 ( 2011-04), p. 136-138
    Abstract: Training through Research Application Italian iNitiative (TRAIN) is a mobility program financed under the EU action called “Cofinancing of regional, national and international programs” (COFUND) of the European Commission Seventh Framework Program (FP7) – People, and has been designed to encourage the promotion and development of international programs of research through mobility at various stages of research careers. The aim of TRAIN is to improve translational skills in the field of cancer by promoting a three-year international mobility program assigning a total of 51 fellowships subdivided into incoming, outgoing and reintegration fellowships. The TRAIN proposal has been submitted in February 2009 to the European Commission in reply to the 2008 FP7-PEOPLECOFUND call and has been successfully evaluated. TRAIN is addressed to postdoctoral scientists or scientists who have at least four years' full-time equivalent research experience and who wish to improve their careers spending one year abroad. The mobility program is open also to non-Italian experienced scientists wishing to spend one year in an Italian research center or private company. Part of the scheme is targeted to experienced Italian scientists who have completed at least three years of research in a foreign country and are interested in returning to Italy. TRAIN is part of an overall Italian strategy outlined by the International Program of the Italian Cancer Network “Alleanza Contro il Cancro” to promote Italian participation in the building of the European Area for translational cancer research and to enhance the interaction between academy and industry.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.5301/JBM.2011.8377
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 1475778-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Bone fragility: conceptual framework, therapeutic implications, and COVID-19-related issues
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Musculoskeletal Disease Vol. 14 ( 2022-01), p. 1759720X2211334-
    Details
    In: Therapeutic Advances in Musculoskeletal Disease, SAGE Publications, Vol. 14 ( 2022-01), p. 1759720X2211334-
    Abstract: Bone fragility is the susceptibility to fracture even for common loads because of structural, architectural, or material alterations of bone tissue that result in poor bone strength. In osteoporosis, quantitative and qualitative changes in density, geometry, and micro-architecture modify the internal stress state predisposing to fragility fractures. Bone fragility substantially depends on the structural behavior related to the size and shape of the bone characterized by different responses in the load–deformation curve and on the material behavior that reflects the intrinsic material properties of the bone itself, such as yield and fatigue. From a clinical perspective, the measurement of bone density by DXA remains the gold standard for defining the risk of fragility fracture in all population groups. However, non-quantitative parameters, such as macro-architecture, geometry, tissue material properties, and microcracks accumulation can modify the bone’s mechanical strength. This review provides an overview of the role of different contributors to bone fragility and how these factors might be influenced by the use of anti-osteoporotic drugs and by the COVID-19 pandemic.
    Type of Medium: Online Resource
    ISSN: 1759-720X , 1759-7218
    URL: Article
    DOI: 10.1177/1759720X221133429
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2516075-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Diagnostic approach to monkeypox outbreak, a case-control study
    SAGE Publications ; 2023
    In:  International Journal of STD & AIDS Vol. 34, No. 5 ( 2023-04), p. 338-345
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 34, No. 5 ( 2023-04), p. 338-345
    Abstract: An international outbreak of the monkeypox (MPX) virus is ongoing with a different clinical presentation than previously reported. Objective A monocentric retrospective study was designed to investigate clinical predictors of confirmed MPX cases among a group of patients referred for MPX screening. Furthermore, the additional value of performing a real-time polymerase chain reaction (RT-PCR) on multiple anatomical sites was analyzed. Methods Between 28/05/2022 and 22/07/2022, the medical records of patients referred for MPX screening were investigated. Patients with positive RT-PCR were defined as cases, while the ones with negative RT-PCR as controls. Multivariable regression analysis was performed to estimate predictors of MPX diagnosis. Results Among the 141 included patients, 85 (60%) had at least one positive RT-PCR for MPX. Carrying out RT-PCR only on the swab obtained by skin lesion sampling, 7 patients (7/85: 8%) would have been misdiagnosed. Multivariable regression analysis showed significant differences in the independent variables: “being men who have sex with men (MSM)”, “living with HIV”, “having multiple sexual partners in the last 3 weeks”, and “having skin lesions in the anogenital area” for prediction of MPX diagnosis. These four discriminants were used to create a score to improve diagnosis in patients screened for MPX. Conclusion MPX diagnosis was associated with being MSM, living with HIV, having multiple sexual partners, and presenting with anogenital skin lesions. In this study, the derived score had good sensitivity and specificity to predict MPX diagnosis. Finally, performing multi-site swabs for MPX RT-PCR might lower false negative rates.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1177/09564624231152789
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2009782-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...