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  • 1
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    SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study
    SAGE Publications ; 2022
    In:  Multiple Sclerosis Journal Vol. 28, No. 7 ( 2022-06), p. 1034-1040
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 28, No. 7 ( 2022-06), p. 1034-1040
    Kurzfassung: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination.
    Materialart: Online-Ressource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/13524585211035318
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2008225-3
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  • 2
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    Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study
    SAGE Publications ; 2013
    In:  Multiple Sclerosis Journal Vol. 19, No. 11 ( 2013-10), p. 1508-1517
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 19, No. 11 ( 2013-10), p. 1508-1517
    Kurzfassung: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS). Objectives: The CoSMo study evaluated the association between CCSVI and MS. Methods: The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded. Results: The study involved 35 MS centers across Italy and included 1874 subjects aged 18–55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72–3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53–4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47–2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers. Conclusions: CCSVI is not associated with MS.
    Materialart: Online-Ressource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458513501231
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2008225-3
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  • 3
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    Influence of Circulating Endothelin-1 and Asymmetric Dimethylarginine on Whole Brain Circulation Time in Multiple Sclerosis
    SAGE Publications ; 2017
    In:  Biomarker Insights Vol. 12 ( 2017-01-01), p. 117727191771251-
    Details
    In: Biomarker Insights, SAGE Publications, Vol. 12 ( 2017-01-01), p. 117727191771251-
    Kurzfassung: Blood-brain barrier (BBB) breakdown, inflammatory and immune cell activation, and chronic cerebral hypoperfusion are features of multiple sclerosis (MS). The aim is to determine the influence of endothelin-1 (ET1) and asymmetric dimethylarginine (ADMA) on cerebral circulation time (CCT) in patients with MS. In all, 64 patients with MS (39 relapsing-remitting [RR]-MS; 25 secondary progressive [SP] -MS subtype) and 37 controls (C) were studied. Cerebral circulation time was obtained by angiography. Plasmatic ET1 and ADMA were measured by enzyme-linked immunosorbent assay. Lesion load (LL) and brain volume (BV) were obtained by magnetic resonance imaging. Cerebral circulation time was correlated to ET1, ADMA, LL, BV, disease duration (DD), and Expanded Disability Status Scale (EDSS). In MS, both ET1 and ADMA were significantly higher than C ( P  〈  .0001); CCT was approximately 2 times lower than C ( P  〈  .0001) and significantly slower in SP than in RR-MS ( P = .0215). Cerebral circulation time significantly correlated with ET1 in SP-MS ( r = 0.38), whereas in RR-MS CCT significantly correlated with DD ( r = 0.75). The LL, BV, and EDSS did not correlate with CCT. Endothelin-1 significantly influences CCT delay in SP-MS. Diversely, CCT in RR-MS is independent of ET1 and correlates significantly with DD. We conclude that in RR-MS, DD responds to neurovascular damage accumulation. It is supposed that high ET1 and ADMA levels stem from a protective response to early insults, aimed at opposing nitric oxide overproduction, whereas persistent pathological ET1 and ADMA levels translate into detrimental long-term effects, due to increased brain micro-vessel resistance.
    Materialart: Online-Ressource
    ISSN: 1177-2719 , 1177-2719
    URL: Article
    DOI: 10.1177/1177271917712514
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2256754-9
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  • 4
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    Impaired Cerebral Perfusion in Multiple Sclerosis: Relevance of Endothelial Factors
    SAGE Publications ; 2018
    In:  Biomarker Insights Vol. 13 ( 2018-01-01), p. 117727191877480-
    Details
    In: Biomarker Insights, SAGE Publications, Vol. 13 ( 2018-01-01), p. 117727191877480-
    Kurzfassung: Magnetic resonance imaging techniques measuring in vivo brain perfusion and integrity of the blood-brain barrier have developed rapidly in the past decade, resulting in a wide range of available methods. This review first discusses their principles, possible pitfalls, and potential for quantification and outlines clinical application in neurological disorders. Then, we focus on the endothelial cells of the blood-brain barrier, pointing out their contribution in regulating vascular tone by production of vasoactive substances. Finally, the role of these substances in brain hypoperfusion in multiple sclerosis is discussed.
    Materialart: Online-Ressource
    ISSN: 1177-2719 , 1177-2719
    URL: Article
    DOI: 10.1177/1177271918774800
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2018
    ZDB Id: 2256754-9
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  • 5
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    Frequently Misdiagnosed Extrapelvic Endometriosis Lesions: Case Reports and Review of the Literature
    SAGE Publications ; 2014
    In:  Journal of Endometriosis and Pelvic Pain Disorders Vol. 6, No. 2 ( 2014-04), p. 67-78
    Details
    In: Journal of Endometriosis and Pelvic Pain Disorders, SAGE Publications, Vol. 6, No. 2 ( 2014-04), p. 67-78
    Kurzfassung: Extrapelvic endometriosis is a rare condition defined as the presence of endometriotic stroma and glands outside the pelvis and elsewhere in the body. The cervix, vagina, vulva, intestinal tract, urinary tract, diaphragm, abdominal wall, inguinal canal, thoracic cage and lungs, extremities and even the central and peripheral nervous system can be involved. Because extrapelvic endometriosis is located in unusual sites, it is often confused with other pathologic conditions. This can lead to a difficult and challenging diagnosis and management. In the presence of recurrent, cyclical and catamenial symptoms, extragenital endometriotic lesions should be suspected. The aim of our paper is to report 9 cases of rare locations of extrapelvic endometriosis and to provide a literature review.
    Materialart: Online-Ressource
    ISSN: 2284-0265 , 2284-0273
    URL: Article
    DOI: 10.5301/je.5000188
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2014
    ZDB Id: 2808441-X
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  • 6
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    Quantification of Casein Fractions and of Some of Their Genetic Variants in Phosphate Buffer by near Infrared Spectroscopy
    SAGE Publications ; 2013
    In:  Journal of Near Infrared Spectroscopy Vol. 21, No. 5 ( 2013-10), p. 385-394
    Details
    In: Journal of Near Infrared Spectroscopy, SAGE Publications, Vol. 21, No. 5 ( 2013-10), p. 385-394
    Kurzfassung: Milk casein and casein fraction contents have a great influence on milk rennet properties and cheese yield so that the selection of dairy cattle with genetic characteristics suitable for milk transformation is of great interest to dairy farms and firms. The possibility of a rapid and accurate determination of these parameters would be very useful to predict milk aptitude to cheese making. This work aimed to determine casein fractions and their genetic variants content using near infrared (NIR) spectroscopy in reconstituted casein samples by comparing the performance of different NIR equipment (a monochromator instrument and a Fourier transform instrument) and different modes of measurement (reflectance and transflectance) in order to evaluate the best operative conditions for this application. Fifty-eight raw milk samples, collected from different farms in the Asturias region, Spain, were analysed for protein (TP%) and non caseinic nitrogen (NCN%) content using the Kjeldahl method. Casein content was calculated as the difference between TP and NCN content. Casein fractions (α s0 -, α s1 -, α s2 -, κ-casein) and genetic variants of β-casein (βB- βA1-, βA2-casein) were determined by a capillary electrophoresis system. Samples were ultra-centrifuged to obtain native casein and then reconstituted in phosphate buffer (pH = 6.8) at the same original milk concentration, previously determined by the Kjeldahl method. Spectra were collected at 37°C with a FT-NIR instrument in transflectance mode and a monochrometer in both transflectance and reflectance mode. Partial least square (PLS) analyses performed on transflectance spectra showed good prediction ability for all variables—(min R 2 = 0.80 for κ-casein; max R 2 = 0.94 for βA2–casein), with the exception of α s2 -casein. NIR spectroscopy has the ability to determine and quantify casein genetic variants and could be used to select milk for its final purpose and to predict the aptitude of milk to cheese-making.
    Materialart: Online-Ressource
    ISSN: 0967-0335 , 1751-6552
    URL: Article
    DOI: 10.1255/jnirs.1072
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2021280-X
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  • 7
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    MRI Helps Depict Clinically Undetectable Risk Factors in Advanced Stage Retinoblastomas
    SAGE Publications ; 2015
    In:  The Neuroradiology Journal Vol. 28, No. 1 ( 2015-02), p. 52-61
    Details
    In: The Neuroradiology Journal, SAGE Publications, Vol. 28, No. 1 ( 2015-02), p. 52-61
    Kurzfassung: This study compared high-resolution MRI with histology in advanced stage retinoblastomas in which ophthalmoscopy and ultrasonography did not give an exhaustive depiction of the tumour and/or its extension. MRI of orbits and head in 28 retinoblastoma patients (28 eyes) treated with primary enucleation were evaluated. Iris neoangiogenesis, infiltrations of optic nerve, choroid, anterior segment and sclera suspected at MR and histology were compared. Abnormal anterior segment enhancement (AASE) was also correlated with histologically proven infiltrations. Brain images were also evaluated. Significant values were obtained for: prelaminar optic nerve (ON) sensitivity (0.88), positive predictive value (PPV) (0.75) and negative predictive value (NPV) (0.71); post-laminar ON sensitivity (0.50), specificity (0.83), PPV (0.50) and NPV (0.83); overall choroid sensitivity (0.82), and massive choroid NPV (0.69); scleral specificity (1), and NPV (1). AASE correlated with iris neoangiogenesis in 14 out of 19 eyes, and showed significant values for: overall ON PPV (0.65), prelaminar ON sensitivity (0.65), and PPV (0.61), post-laminar ON NPV (0.64); overall choroid sensitivity (0.77), PPV (0.59) and NPV (0.73); scleral NPV (0.83); anterior segment sensitivity (1), and NPV (1). Odds ratios (OR) and accuracy were significant in scleral and prelaminar optic nerve infiltration. Brain examination was unremarkable in all cases. High-resolution MRI may add important findings to clinical evaluation of advanced stage retinoblastomas.
    Materialart: Online-Ressource
    ISSN: 1971-4009 , 2385-1996
    URL: Article
    DOI: 10.15274/nrj-2014-10103
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2015
    ZDB Id: 2622347-8
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  • 8
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    Contrast-Enhanced Magnetic Resonance Imaging of Fibrovascular Tissue Ingrowth within Synthetic Hydroxyapatite Orbital Implants in Children
    SAGE Publications ; 2011
    In:  European Journal of Ophthalmology Vol. 21, No. 5 ( 2011-09), p. 521-528
    Details
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 21, No. 5 ( 2011-09), p. 521-528
    Materialart: Online-Ressource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.5301/EJO.2011.6298
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2011
    ZDB Id: 1475018-1
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  • 9
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    Development of a near Infrared Method for the Quantification of the Main Classes of Fatty Acids Obtained from Raw Milk by Solvent-Free Extraction
    SAGE Publications ; 2013
    In:  Journal of Near Infrared Spectroscopy Vol. 21, No. 5 ( 2013-10), p. 395-408
    Details
    In: Journal of Near Infrared Spectroscopy, SAGE Publications, Vol. 21, No. 5 ( 2013-10), p. 395-408
    Kurzfassung: The determination of the fatty acid (FA) profile of milk fat, which is the most complex dietary fat, is more and more for both the definition of nutritional labelling and the study of the genetic variability in bovine milk fat quality. For these reasons, the development of infrared techniques for the rapid evaluation of FA profiles is gaining much wider interest. In this research, a method for the rapid determination of saturated, unsaturated, monounsaturated, polyunsaturated and trans FAs, expressed on 100g of total milk FAs, is reported. The FA profile was estimated from the transmission spectrum (optical pathlength of 6 mm) obtained from the fat extracted by hot centrifugation, without solvents. Authentic triglyceride standards were used in order to perform the spectral band assignments. The whole data set included 135 raw milk samples collected from cows fed either a total mixed ration or grazed on mountain pastures. Ninety five samples were selected for model development (calibration set); the prediction models were then validated by an independent validation set composed by 40 samples. The prediction model for the saturated FA content showed a correlation coefficient of determination ( r 2 ) = 0.96, standard error of prediction ( SEP) = 0.97 (g 100 g −1 of total FAs), ratio of errors ( RER) = 22.8 and ratio of performance to deviation ( RPD) = 4.6. Monounsaturated, polyunsaturated and trans FAs provided r 2 = 0.95, 0.90 and 0.97, RER = 20.4, 12.5 and 32.1 and RPD = 4.2, 2.8 and 5.2, respectively. The ability to predict the concentration of some saturated single FAs, also grouped according to their chain length, was also investigated. Satisfactory screening performances were found for C14, C16 and C18 FAs, as well as for the amount of the groups including medium (12–17 carbon atoms) and long (18–22 carbon atoms) FAs.
    Materialart: Online-Ressource
    ISSN: 0967-0335 , 1751-6552
    URL: Article
    DOI: 10.1255/jnirs.1074
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2021280-X
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  • 10
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    [1H] Magnetic Resonance Spectroscopy of Urine: Diagnosis of a Guanidinoacetate Methyl Transferase Deficiency Case
    SAGE Publications ; 2010
    In:  Journal of Child Neurology Vol. 25, No. 1 ( 2010-01), p. 98-101
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 25, No. 1 ( 2010-01), p. 98-101
    Kurzfassung: For the first time, the use of urine [ 1 H] magnetic resonance spectroscopy has allowed the detection of 1 case of guanidinoacetate methyl transferase in a database sample of 1500 pediatric patients with a diagnosis of central nervous system impairment of unknown origin. The urine [ 1 H] magnetic resonance spectroscopy of a 9-year-old child, having severe epilepsy and nonprogressive mental and motor retardation with no apparent cause, revealed a possible guanidinoacetic acid increase. The definitive assignment of guanidinoacetic acid was checked by addition of pure substance to the urine sample and by measuring [ 1 H]-[ 1 H] correlation spectroscopy. Diagnosis of guanidinoacetate methyl transferase deficiency was further confirmed by liquid chromatography—mass spectrometry, brain [ 1 H] magnetic resonance spectroscopy, and mutational analysis of the guanidinoacetate methyl transferase gene. The replacement therapy was promptly started and, after 1 year, the child was seizure free. We conclude that for this case, urine [ 1 H] magnetic resonance spectroscopy screening was able to diagnose guanidinoacetate methyl transferase deficiency.
    Materialart: Online-Ressource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073809336120
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2010
    ZDB Id: 2068710-2
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