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  • 1
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    Online Resource
    Serum α-Foetoprotein Level Predicts Treatment Outcome in Chronic Hepatitis C
    SAGE Publications ; 2007
    In:  Antiviral Therapy Vol. 12, No. 5 ( 2007-07), p. 797-803
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 12, No. 5 ( 2007-07), p. 797-803
    Abstract: To analyse the association between serum α-foetoprotein (AFP) levels and sustained virological response (SVR) in treated patients. Methods One-hundred patients with chronic hepatitis C were treated with pegylated interferon α-2a plus ribavirin for 48 weeks. The primary endpoint was SVR. Linear regression analysis was performed to identify clinical, biological, and histological factors affecting baseline AFP levels. The association between pretreatment serum AFP and SVR was assessed by multivariate logistic regression analysis. Results Of 100 patients, 95 were infected with genotype 4, one with genotype 1, and four with undetermined genotype. The median serum AFP level was 4.5 ng/ml and AFP values ranged from 1.2 to 49.8 ng/ml. In multivariate analysis, higher fibrosis stage and higher steatosis score were independently associated with higher serum AFP levels. SVR rate was 61.0% (61/100), and was lower for patients with AFP levels above rather than below the median value (40.8% versus 80.4%, respectively, P 〈 0.001). In multivariate analysis, including adjustment for age, gender, body mass index, steatosis score, fibrosis stage, ALT level, haemoglobin level, clotting time, HCV RNA viral load, and treatment dose received, a baseline serum AFP level above the median value was associated with a lower SVR rate (OR [95% CI]=0.10 [0.03–0.42] , P 〈 0.001). None of the seven patients with increased (above 15 ng/ml) pretreatment AFP achieved SVR. Conclusions In this study, higher baseline serum AFP levels independently predicted a lower SVR rate among patients with chronic hepatitis C. If confirmed with genotypes other than 4, these findings would suggest adding serum AFP to the list of factors predictive of treatment response.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350701200506
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
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  • 2
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    In Type 2 Diabetes Mellitus Patients, the Atherogenic Index of Plasma as a Marker of Coronary Artery Diseases
    SAGE Publications ; 2021
    In:  Indian Journal of Clinical Cardiology Vol. 2, No. 4 ( 2021-12), p. 217-221
    Details
    In: Indian Journal of Clinical Cardiology, SAGE Publications, Vol. 2, No. 4 ( 2021-12), p. 217-221
    Abstract: One-third of all deaths globally are caused by cardiovascular disease (CVD), and this percentage is predicted to climb as CVD risk factors become more widespread. Primary prevention of risk factors is the most fundamental duty in dealing with the CVD epidemic. The link between atherogenic index of plasma (AIP) and other CVD risks among university workers was investigated among study participants in order to demonstrate that AIP, not lipid profile, is a better predictor of CVDs. They discovered a link between AIP and CVD risk variables (body mass index, visceral fat, body fat, total cholesterol, low density lipoprotein cholesterol, triglyceride, glucose, and high density lipoprotein cholesterol) in people with type 2 diabetes. This comparative study was carried out in Cardiology Department, Zagazig University Hospitals. This study included 140 type 2 diabetes mellitus patients. They were classified into 2 main groups: Group 1: 70 patients with type 2 diabetes who had coronary artery disease (CAD). Group (2): 70 type 2 diabetes individuals with no indicators of CAD (admitted complaining of symptoms of angina or CA showing no significant stenotic lesions). Regarding study explained it has showed that AIP outperforms standard lipid indicators in predicting the likelihood ofdeveloping CADs in people with type 2 diabetes. In addition, the value of AIP in diabetic and prediabetic patients for predicting future CVD is being investigated. They came to the conclusion that AIP is an excellent predictor of future CVD in those with diabetes and those who are prediabetic.
    Type of Medium: Online Resource
    ISSN: 2632-4636 , 2632-4644
    URL: Article
    DOI: 10.1177/26324636211031362
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 3010340-X
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  • 3
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    Incidence and predictors of mismatch after mechanical mitral valve replacement
    SAGE Publications ; 2019
    In:  Asian Cardiovascular and Thoracic Annals Vol. 27, No. 7 ( 2019-09), p. 535-541
    Details
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 27, No. 7 ( 2019-09), p. 535-541
    Abstract: Patient-prosthesis mismatch after mitral valve replacement has an unfavorable postoperative hemodynamic outcome, which underlines the importance of identifying and preventing prosthesis- and patient-related risk factors. This study was conducted to determine the incidence and identify possible predictors of patient-prosthesis mismatch. Methods A prospective study was conducted on 715 patients with a mean age of 42 ± 11 years who underwent mechanical mitral valve replacement between 2013 and 2017. The effective orifice area of the prostheses was estimated by the continuity equation, and a mismatch was defined as an effective orifice area index ≤1.2 cm 2 ·m −2 . The mean clinical and echocardiographic follow-up was 26.74 ± 11.58 months. Multivariate regression analysis was performed to identify predictors of patient-prosthesis mismatch. Results Patient-prosthesis mismatch was detected in 382 (53.4%) patients. A small mechanical prosthesis ( 〈 27 mm) was inserted in 54.3%. Mortality during follow-up was 9% (65 patients). Patient-prosthesis mismatch was identified in patients with preoperative rheumatic mitral valve pathology, associated tricuspid regurgitation, higher New York Heart Association class, preoperative atrial fibrillation, mitral stenosis, and small preoperative left ventricular dimensions. Multivariate analysis identified mitral stenosis, preoperative atrial fibrillation, and small postoperative left ventricular end-diastolic dimension as risk factors for patient-prosthesis mismatch. Conclusion Patient-prosthesis mismatch is a common sequela after mechanical mitral valve replacement. Identification of predictors of patient-prosthesis mismatch can help so that a preoperative strategy can be implemented to avoid its occurrence.
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    URL: Article
    DOI: 10.1177/0218492319869560
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2044527-1
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  • 4
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    L-Shaped Arthroscopic Posterior Capsular Release in Frozen Shoulder
    SAGE Publications ; 2021
    In:  Video Journal of Sports Medicine Vol. 1, No. 2 ( 2021-03), p. 263502542110000-
    Details
    In: Video Journal of Sports Medicine, SAGE Publications, Vol. 1, No. 2 ( 2021-03), p. 263502542110000-
    Abstract: The inadequate arthroscopic release of the tight posterior capsule in frozen shoulder may result in limited postoperative shoulder internal rotation. Indication: The purpose of this article is to describe an L-shaped arthroscopic posterior capsular release to overcome the limited internal rotation that may be encountered following the standard longitudinal technique. Operative intervention is indicated in patients with refractory shoulder stiffness with limitation of internal rotation of grade 0, +2, +4 (according to the Constant-Murley Score), after failure of conservative measures for 3 to 6 months. The technique is contraindicated if less than 3 months of physical therapy, shoulder stiffness due to osseous deformity, infection, or cuff tear arthropathy. Technique: After performing a standard anterior capsular release, the scope is shifted to the anterior portal to perform posterior capsular release by introducing the radiofrequency ablation device through the posterior portal. Posterior release begins from the glenoid level down to the 6 o’clock position until the back fibers of the infraspinatus muscle appear. Then the hook-tip part of the radiofrequency ablation device is used to perform a transverse release in the posterior capsule, starting from the beginning of the longitudinal limb. The transverse limb is performed in a stepwise manner going step-by-step laterally but ending before reaching the rotator cuff to avoid any damage of the cuff. After that, the shoulder was manipulated according to Codman technique. Results: A comparative study was performed on 43 patients with primary frozen shoulder to compare the standard longitudinal (22 patients) and L-shaped (21 patients) posterior capsular release. At the final follow-up, there was a statistically significant improvement in the internal rotation range of motion in the L-shaped group ( P 〈 .001). There was no loss of function over time. Moreover, there were no infections, instability, or axillary nerve injury in either group. Discussion/Conclusion: Restriction of internal rotation in frozen shoulder has been attributed to posterior capsular tightness. The L-shaped arthroscopic posterior capsular release in patients with primary frozen shoulder significantly improves the postoperative internal rotation range of motion.
    Type of Medium: Online Resource
    ISSN: 2635-0254 , 2635-0254
    URL: Article
    DOI: 10.1177/26350254211000065
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 3077909-1
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  • 5
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    Role of microRNA-21 and microRNA-155 as biomarkers for bronchial asthma
    SAGE Publications ; 2021
    In:  Innate Immunity Vol. 27, No. 1 ( 2021-01), p. 61-69
    Details
    In: Innate Immunity, SAGE Publications, Vol. 27, No. 1 ( 2021-01), p. 61-69
    Abstract: MicroRNA (miRNA)-21 and miRNA-155 are important regulators of gene expression of different immunological molecules. This study aimed to investigate the role of miRNA-21 and miRNA-155 as biomarkers in asthma by comparing their serum expression levels in asthmatic patients to those in healthy controls and correlating their levels with serum IL-4. The expression levels of miRNA-21 and miRNA-155 were evaluated by quantitative RT-PCR. Serum levels of IL-4 were determined using ELISA. Asthmatic patients showed significantly higher serum miRNA-21 and miRNA-155 expression levels compared to controls. A statistically significant positive correlation between the expression levels of miRNA-21 and IL-4 serum levels in asthmatic patients was detected. Nonetheless, no correlation was detected between miRNA-155 expression and each of IL-4 and miRNA-21. A receiver operating characteristic curve analysis showed that at a cut-off value of 1.37, the sensitivity of miRNA-21 as an asthma biomarker was 100% and the specificity was 95%. At a cut-off value of 1.96, the sensitivity of miRNA-155 as an asthma biomarker was 100% and the specificity was 100%. It can be concluded that miRNA-21 and miRNA-155 are potential non-invasive biomarkers in the diagnosis of eosinophilic asthma and its response to therapy.
    Type of Medium: Online Resource
    ISSN: 1753-4259 , 1753-4267
    URL: Article
    DOI: 10.1177/1753425920901563
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2381250-3
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  • 6
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    Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity
    SAGE Publications ; 2022
    In:  Journal of Cardiovascular Pharmacology and Therapeutics Vol. 27 ( 2022-01-01), p. 107424842211326-
    Details
    In: Journal of Cardiovascular Pharmacology and Therapeutics, SAGE Publications, Vol. 27 ( 2022-01-01), p. 107424842211326-
    Abstract: Pulmonary hypertension (PHT) is common in β-thalassemia patients due to hemolysis, iron overload and diminished nitric oxide (NO) levels. Biochemical markers can help to understand the pathophysiology and to introduce new therapies for this condition. Aim: This study aimed to evaluate the effectiveness of L-arginine and sildenafil in thalassemia children with PHT at both clinical and biochemical levels. Methods and Results: In a randomized controlled study, 60 β-thalassemia major children with PHT were divided into 3 equal groups; Control group (Conventional thalassemia and PHT management), L-arginine group (Conventional + Oral L-arginine 0.1 mg.kg −1 daily), and sildenafil group (Conventional + Oral sildenafil 0.25 mg.kg −1 two times a day) for 60 days. Tricuspid Regurgitant Jet Velocity (TRJV) with Doppler echocardiography along with serum levels of NO, asymmetric dimethylarginine (ADMA), interleukin 1-beta (IL-1β), E-selectin, and visfatin were followed-up at baseline, 30, and 60 days after treatment. Both drugs reduced the TRJV significantly. NO was significantly higher in both L-arginine and sildenafil groups after 60 days compared to baseline, while visfatin levels were lower. Only L-arginine reduced ADMA levels compared to baseline, while sildenafil did not. E-selectin and IL-1β levels did not change remarkably by both drugs. NO and TRJV showed significant negative correlations in both treatment groups. Conclusion: L-arginine and sildenafil could clinically ameliorate chronic PHT whereas, L-arginine showed superiority to sildenafil on some biochemical markers.
    Type of Medium: Online Resource
    ISSN: 1074-2484 , 1940-4034
    URL: Article
    DOI: 10.1177/10742484221132671
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 7
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    Hierarchical Structure of the Wechsler Adult Intelligence Scale–Fourth Edition with an Egyptian Sample
    SAGE Publications ; 2019
    In:  Journal of Psychoeducational Assessment Vol. 37, No. 3 ( 2019-06), p. 395-404
    Details
    In: Journal of Psychoeducational Assessment, SAGE Publications, Vol. 37, No. 3 ( 2019-06), p. 395-404
    Abstract: The Wechsler Adult Intelligence Scale–Fourth Edition (WAIS-IV) is one of the most well-known tests in the field of adult intelligence assessment. This study explores the validity of the Egyptian adaptation for the subscales of the WAIS-IV. Confirmatory factor analysis (CFA) indicated that the first-order, second-order, and bifactor models of both the five-factor Cattel–Horn–Carroll (CHC) and the four-factor structures fitted with the WAIS-IV. When the Arithmetic subscale was pathed to Perceptual Reasoning and Working Memory, the modified four first-order factor showed a better fit than any other model. Estimates of internal consistency revealed that Cronbach’s alpha was very high (.91) for the WAIS-IV scale and for four-factor structures (ranging from .81 to .95), while [Formula: see text] was low (0.61) for the WAIS-IV scale and for four-factor structures, ranging from 0.20 to 0.68. Overall, these findings provided adding evidence about the dimensionality of WAIS-IV with a new sample.
    Type of Medium: Online Resource
    ISSN: 0734-2829 , 1557-5144
    URL: Article
    DOI: 10.1177/0734282917732857
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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  • 8
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    Dietary folate protects against azoxymethane-induced aberrant crypt foci development and oxidative stress in rat colon
    SAGE Publications ; 2011
    In:  Experimental Biology and Medicine Vol. 236, No. 9 ( 2011-09), p. 1005-1011
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 236, No. 9 ( 2011-09), p. 1005-1011
    Abstract: Azoxymethane (AOM) induces cancer and oxidative stress in rat colon. This study tested the hypothesis that dietary folate supplementation protects against AOM-induced oxidative stress and reduces aberrant crypt foci (ACF) development in rat colon. Fifty-four weanling male albino rats, with an average body weight of 50 ± 5 g, were randomly divided into three groups – A, B and C (18 rats per group) – and fed 2, 8 or 40 mg of folic acid per kg of supplemented diets, respectively, throughout the eight weeks' experimental period. The animals were supplied with diet and water ad libitum for four weeks and they reached an average body weight of 100 g. Thereafter each group was then further randomly subdivided into three subgroups (six rats per subgroup): control, vehicle and AOM-injected groups. The control group did not receive any treatment (neither AOM injection nor saline), the rats in the vehicle group were given 1 mL intraperitoneal injection of saline once a week for two weeks and the rats in the AOM-injected group were given two intraperitoneal injections of AOM dissolved in saline once a week for two weeks totaling 30 mg/kg body weight. After the last AOM injection, animals were continuously fed ad libitum their specified diet for two weeks of last AOM injection, all rats were sacrificed, and colon tissues were collected and used for ACF enumeration and measurements of glutathione (GSH) and total antioxidant capacity (TAC). The results revealed that AOM-injected rats showed lower levels of GSH and TAC as compared with control and vehicle groups. Folic acid-supplemented diets suppressed the AOM-induced ACF and GSH depletion in a dose-dependent manner and augmented the TAC. It was concluded that folic acid supplementation protects against the AOM-induced ACF formation by suppressing the AOM-induced GSH depletion in rat colon cells.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2011.011010
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020856-X
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  • 9
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    Effective Chromium Adsorption From Aqueous Solutions and Tannery Wastewater Using Bimetallic Fe/Cu Nanoparticles: Response Surface Methodology and Artificial Neural Network
    SAGE Publications ; 2021
    In:  Air, Soil and Water Research Vol. 14 ( 2021-01), p. 117862212110281-
    Details
    In: Air, Soil and Water Research, SAGE Publications, Vol. 14 ( 2021-01), p. 117862212110281-
    Abstract: Tannery industrial effluent is one of the most difficult wastewater types since it contains a huge concentration of organic, oil, and chrome (Cr). This study successfully prepared and applied bimetallic Fe/Cu nanoparticles (Fe/Cu NPs) for chrome removal. In the beginning, the Fe/Cu NPs was equilibrated by pure aqueous chrome solution at different operating conditions (lab scale), then the nanomaterial was applied in semi full scale. The operating conditions indicated that Fe/Cu NPs was able to adsorb 68% and 33% of Cr for initial concentrations of 1 and 9 mg/L, respectively. The removal occurred at pH 3 using 0.6 g/L Fe/Cu dose, stirring rate 200 r/min, contact time 20 min, and constant temperature 20 ± 2ºC. Adsorption isotherm proved that the Khan model is the most appropriate model for Cr removal using Fe/Cu NPs with the minimum error sum of 0.199. According to khan, the maximum uptakes was 20.5 mg/g Cr. Kinetic results proved that Pseudo Second Order mechanism with the least possible error of 0.098 indicated that the adsorption mechanism is chemisorption. Response surface methodology (RSM) equation was developed with a significant p-value = 0 to label the relations between Cr removal and different experimental parameters. Artificial neural networks (ANNs) were performed with a structure of 5-4-1 and the achieved results indicated that the effect of the dose is the most dominated variable for Cr removal. Application of Fe/Cu NPs in real tannery wastewater showed its ability to degrade and disinfect organic and biological contaminants in addition to chrome adsorption. The reduction in chemical oxygen demand (COD), biological oxygen demand (BOD), total suspended solids (TSS), total phosphorus (TP), total nitrogen (TN), Cr, hydrogen sulfide (H 2 S), and oil reached 61.5%, 49.5%, 44.8%, 100%, 38.9%, 96.3%, 88.7%, and 29.4%, respectively.
    Type of Medium: Online Resource
    ISSN: 1178-6221 , 1178-6221
    URL: Article
    DOI: 10.1177/11786221211028162
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 10
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    Susceptibility Assessment of Multidrug Resistant Bacteria to Natural Products
    SAGE Publications ; 2020
    In:  Dose-Response Vol. 18, No. 3 ( 2020-07-01), p. 155932582093618-
    Details
    In: Dose-Response, SAGE Publications, Vol. 18, No. 3 ( 2020-07-01), p. 155932582093618-
    Abstract: The aim of this study was to examine the effect of some natural compounds against multidrug-resistant bacteria. Methods: Forty-three bacterial strains were collected. Disc diffusion and minimum inhibitory concentration (MIC) tests were carried out for natural compounds including quercetin, Acacia nilotica, Syzygium aromaticum, and Holothuria atra. Scanning electron microscope analysis and bacterial DNA apoptosis assays were performed. Results: Staphylococcus aureus strains were resistant to imipenim, ampicillin, and penicillin. Most Escherichia coli strains were resistant to amoxicillin, clavulanat, and ampicillin. Finally, tigecycline was effective with Klebsiella pneumoniae and was resistant to all antibiotics. Only S aromaticum had an antibacterial effect on K pneumoniae. Most S aureus strains were sensitive to S aromaticum, A nilotica, and quercetin. All examined natural extracts had no effect on E coli. Holothuria atra had no effect on any of the strains tested. Minimum inhibitory concentration and minimum bactericidal concentration values for examined plants against S aureus were 6.25 to 12, 1.6 to 3.2, and 9.12 to 18.24 mg/mL, respectively. Syzygium aromaticum was active against K pneumoniae with an MIC of 12.5 mg/mL. Scanning electron microscope analysis performed after 24 and 48 hours of incubation showed bacterial strains with distorted shapes and severe cell wall damage. Syzygium aromaticum, quercetin, and A nilotica showed clear fragmentations of S aureus DNA. Conclusions: Current findings confirmed the beneficial effect of using natural products such as clove (S aromaticum), quercetin, and A nilotica as a promising therapy to overcome multidrug resistant bacteria.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325820936189
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2440820-7
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