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  • 1
    In: Foot & Ankle International, SAGE Publications, Vol. 44, No. 7 ( 2023-07), p. 606-616
    Abstract: The conventional operative method to treat an osteochondral lesion of the talus (OLT) is through bone marrow stimulation (BMS). Autologous osteochondral transplantation (AOT) is being used as an alternative option in cases with a large OLT, accompanying subchondral cyst, and/or failed BMS. We aimed to compare the intermediate-term clinical and radiologic results between medial and lateral OLTs after an AOT procedure. Methods: Among the patients who underwent AOT, 45 cases with at least 3 years’ follow-up were included in this retrospective study. We had 15 cases of lateral lesions and selected 30 cases of medial lesions matched for age and gender. Lateral lesions were resurfaced without an osteotomy; medial lesion resurfacing was combined with a medial malleolar osteotomy. Clinical assessment was performed using the Foot and Ankle Outcome Score (FAOS) and Foot and Ankle Ability Measure (FAAM). Radiographic assessment included the irregularity of articular surface (subchondral plate), the progression of degenerative arthritis, and the change of the talar tilt. Results: The mean FAOS and FAAM scores significantly improved after surgery in both groups. Up to 1 year postoperatively, there was significant difference in FAAM scores between the both groups (mean 75.3 points in medial group and 87.2 points in lateral group, P  〈  .001). Delayed union or malunion of the malleolar osteotomy was found in 4 cases (13%) in the medial group. In addition, the progression of joint degeneration was observed in 3 cases (10%) in the medial group. There were no significant differences in the irregularity of articular surface and the change of talar tilt between both groups. Conclusion: A comparison between medial and lateral OLTs treated with AOT demonstrated comparable intermediate-term clinical outcomes. However, patients with medial OLT required a longer period to restore ability for daily and sport activities. In addition, we found more complications and higher rate of progression in the radiologic arthritis grade after medial malleolar osteotomy. Level of Evidence: Level IV, retrospective comparative study.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2129503-7
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Therapeutic Advances in Medical Oncology Vol. 10 ( 2018-01), p. 175883591879462-
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 10 ( 2018-01), p. 175883591879462-
    Abstract: Oral cancer metastasis is a devastating process that contributes to poor prognosis and high mortality, yet its detailed underlying mechanisms remain unclear. Here, we aimed to evaluate metastasis-specific markers in oral cancer and to provide comprehensive recognition concerning functional roles of the specific target in oral cancer metastasis. Methods: Lectin, galactoside-binding, soluble, 1 (LGALS1) was identified by secretomic analysis. LGALS1 expression of patient samples with oral cancer on the tissue microarray were examined by immunochemical (IHC) staining. Small interfering RNA (siRNA)-mediated knockdown of LGALS1 revealed the role of LGALS1 in oral cancer metastasis in vitro and in vivo. Results: LGALS1 was observed to be upregulated in highly invasive oral cancer cells, and elevated LGALS1 expression was correlated with cancer progression and lymph node metastasis in oral cancer tissue specimens. Functionally, silencing LGALS1 resulted in suppressed cell growth, wound healing, cell migration, and cell invasion in oral cancer cells in vitro. Knockdown of LGALS1 in highly invasive oral cancer cells dramatically inhibited lung metastasis in an in vivo mouse model. Mechanistic studies suggested p38 mitogen-activated protein kinase (MAPK) phosphorylation, upregulated MMP-9, and mesenchymal phenotypes of epithelial-mesenchymal transition (EMT) in highly invasive oral cancer cells, whereas siRNA against LGALS1 resulted in the inactivation of p38 MAPK pathway, downregulated MMP-9, and EMT inhibition. Conclusions: These findings demonstrate that elevated LGALS1 is strongly correlated with oral cancer progression and metastasis, and that it could potentially serve as a prognostic biomarker and an innovative target for oral cancer therapy.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2503443-1
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  • 3
    In: Lupus, SAGE Publications, Vol. 29, No. 6 ( 2020-05), p. 547-553
    Abstract: Urine levels of immunoglobulin binding protein 1 (IGBP1) are increased in patients with lupus nephritis (LN) compared with systemic lupus erythematosus (SLE) patients without nephritis. However, the clinical significance of IGBP1 level in plasma is unclear. We aimed to evaluate whether the plasma level of IGBP1 can predict future development of LN in SLE patients without nephritis. Methods Forty-three SLE patients without nephritis were followed for 5 years. Plasma IGBP1 levels were measured using ELISA, and clinical and laboratory data were obtained at study entry. Development of LN was confirmed by renal biopsy. Cox regression analysis was performed to identify factors associated with development of LN, and receiver operating characteristic curve analysis was used to determine the predictive value of each factor. Results Of the total 43 patients, eight (18.6%) developed LN during the follow-up period. Compared with patients who did not develop LN, those who developed LN had higher levels of plasma IGBP1 (6.3 ng/ml (range 4.3–9.6 ng/mL) vs. 13.3 ng/ml (range 7.2–31.3 ng/ml); p =  0.023). In the Cox regression analysis, higher CRP (hazard ratio (HR) = 1.325, 95% confidence interval (CI) 1.073–1.637, p =  0.009), anti-dsDNA antibody (Ab; HR = 1.066, 95% CI 1.012–1.124, p =  0.017) and plasma IGBP1 (HR = 1.091, 95% CI 1.034–1.152, p =  0.002) were associated with future development of LN. Among these factors, anti-dsDNA Ab (area under the curve (AUC)=0.893) had the highest predictive value followed by plasma IGBP1 (AUC = 0.761) and CRP (AUC = 0.634). A combination of anti-dsDNA Ab and plasma IGBP1 as a composite predictor was highly specific (97%) for predicting the development of LN. Conclusions Plasma IGBP1 can be used complementarily with anti-dsDNA Ab for detecting SLE patients at a higher risk of developing LN.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2008035-9
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  The American Journal of Sports Medicine Vol. 45, No. 8 ( 2017-07), p. 1881-1887
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 45, No. 8 ( 2017-07), p. 1881-1887
    Abstract: Although numerous studies have examined the anatomic characteristics of the anterior cruciate ligament (ACL), its actual shape remains unclear. Purpose: To determine the average shape of the ACL by analyzing its cross section through the use of high-resolution magnetic resonance imaging (MRI) data. Study Design: Descriptive laboratory study. Methods: The study included 96 MRIs, conducted using a 3.0-T magnet, to analyze the shape of the ACL. Three-dimensional, curved multiplanar reconstruction was used to obtain cross sections at 7 points (femoral insertion; midsubstance 1, 2, 3, 4, and 5 from the femoral side to the tibial side; and tibial insertion). The width and thickness of cross sections were measured by 2 independent observers, and the ratio of width to thickness was calculated to determine the proportions of each cross section. The 7 cross sections were accumulated and standardized to generate an average model through the use of image analysis software developed by the authors. Results: The mean ± SD width (femoral insertion, 17.02 ± 2.17 mm; tibial insertion, 17.33 ± 2.03 mm) and thickness (femoral insertion, 11.03 ± 1.75 mm; tibial insertion, 10.09 ± 1.70 mm) of both insertions were significantly larger than those of midsubstance 4 (width, 9.99 ± 1.87 mm; thickness, 6.53 ± 1.25 mm) ( P 〈 .001). The mean ratios of width to thickness of the 7 cross sections from femoral insertion to tibial insertion were 1.57 ± 0.23, 3.36 ± 0.57, 3.07 ± 0.81, 2.18 ± 0.54, 1.56 ± 0.32, 2.16 ± 0.48, and 1.75 ± 0.28, respectively. The shape of the cross section at midsubstance 4 was an oval isthmus, which was the most narrow and well-balanced shape. It was transformed into a wide band at midsubstance 1 and 5. The shape of the femoral insertion was semicircular, with its anterior side slightly straight and its posterior side convex. The tibial insertion was kidney bean–shaped. Conclusion: On 3.0-T MRI, the ACL has a “bow tie” shape, including an oval isthmus, with a semicircular femoral insertion and kidney bean–shaped tibial insertion. Clinical Relevance: The measurement method will allow surgeons to quantitatively diagnose partial injuries of the ACL using a noninvasive system in actual patients.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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    SSG: 31
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2013
    In:  Transactions of the Institute of Measurement and Control Vol. 35, No. 5 ( 2013-07), p. 583-592
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 35, No. 5 ( 2013-07), p. 583-592
    Abstract: To reduce energy consumption for sustainable and energy-efficient manufacturing, continuous energy monitoring and process tracking of industrial machines are essential. In this paper, we introduce a novel approach to reduce the number of required sensors in process tracking by identifying the operational states based on real-time energy data. Finite-state machines are used to model the engineering processes, and a two-stage framework for online classification of real-time energy measurement data in terms of machine operational states is proposed for energy audit and machine scheduling. The first stage uses advanced signal processing techniques to reduce noise while preserving important features, and the second stage uses intelligent pattern recognition algorithms to cluster energy consumption patterns. Our proposed two-stage framework is evaluated on an industrial injection moulding system using a Savizky–Golay filter and a neural network, and our experimental results show a 95.85% accuracy in identification of machine operational states.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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  • 6
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 26, No. 2 ( 2012-03), p. e81-e84
    Abstract: Despite the importance of olfactory function, no effective medications have been identified to treat olfactory disorders. This study was performed to evaluate the functional recovery of olfaction damaged by 3-methylindole (3MI) in a mouse model with hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins). Methods In a randomized placebo-controlled trial, 24 healthy female BALB/c mice (aged 9–10 weeks and weighing 18–20 g each) were randomly allocated to statin-treated or control groups. Olfactory loss was induced by i.p. injections of 3MI. Atorvastatin (10 mg/kg) or normal saline was then administered per os with a gastric tube for 3 weeks. The effects of treatment were evaluated by food-finding tests and Western blot analysis. Results Both groups showed complete losses of olfactory function 1 week after 3MI injection. Three weeks after 3MI injection, 9 of the 12 mice in the statin-treated group (75%) passed a food-finding test, in which they were able to find the food within 3 minutes, at least two times out of three trials. However, only two mice in the control group (16.6%) passed the food-finding test, and this difference was statistically significant (p = 0.004; chi-square test). The expression level of the olfactory marker protein was also elevated in the statin-treated group (p = 0.030; Wilcoxon rank sum test). Conclusion Statins are associated with recovery of olfaction after 3MI injection in a mouse model.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2554548-6
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  Journal of Educational Computing Research Vol. 52, No. 4 ( 2015-07), p. 455-474
    In: Journal of Educational Computing Research, SAGE Publications, Vol. 52, No. 4 ( 2015-07), p. 455-474
    Abstract: This paper describes a learning system, named My-Bookstore, where students buy (make records of) books (paper books) which they have read, and then sell (recommend) the books they like to others. This system is designed to encourage elementary students' classroom reading and book recommendation. The long-term influence of the My-Bookstore system on students' reading in terms of word usage and perception among 204 first-grade students who had used the system for three semesters was investigated. The results indicated that (a) the students borrowed a large number of books and were willing to recommend their favorite books in My-Bookstore; (b) most of the students felt that the overall use experience of the My-Bookstore was attractive, and the goal of the game was relevant to their reading. They also had confidence in recommending books and felt satisfaction when other students accepted their recommendations.
    Type of Medium: Online Resource
    ISSN: 0735-6331 , 1541-4140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 55234-3
    detail.hit.zdb_id: 2071875-5
    SSG: 5,3
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 1998
    In:  American Journal of Rhinology Vol. 12, No. 5 ( 1998-09), p. 363-366
    In: American Journal of Rhinology, SAGE Publications, Vol. 12, No. 5 ( 1998-09), p. 363-366
    Abstract: Paraffin-embedded tissues of 42 sinonasal inverted papillomas were subjected to polymerase chain reaction using type-specific primers pairs of HPV 6, 11, 16, 18, and 33. Two cases of HPV 11 and one of HPV 6 were amplified in 36 samples of benign inverted papilloma, and two cases of HPV 16 were amplified in five samples of inverted papilloma with co-existing squamous cell carcinoma. Inverted papillomas recurred in 1 (16%) of 6 cases exhibiting dysplasia, and in 3 (10%) of 30 cases not exhibiting dysplasia. Inverted papillomas also recurred in 2 (66%) of 3 cases positive for HPV, and in 2 (6%) of 33 cases negative for HPV. These results suggest that HPV may be involved in the pathogenesis of inverted papillomas, may cause malignant transformation of inverted papillomas, and that there may be an apparent relationship between HPV infection and the recurrence of sinonasal inverted papillomas.
    Type of Medium: Online Resource
    ISSN: 1050-6586 , 1539-6290
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 2083922-4
    detail.hit.zdb_id: 2554548-6
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  • 9
    In: Perceptual and Motor Skills, SAGE Publications, Vol. 117, No. 2 ( 2013-10), p. 411-426
    Abstract: This study investigated the effects of distraction tasks—such as sending a text message with a cellphone and searching navigation with car navigation system—on the driving performance of 29 highly experienced taxi drivers in their 50 s. All participants were instructed to drive using a driving simulator for 2 min. while maintaining a constant distance from the vehicle in front and a constant speed. Participants drove without any distractions for the first minute. For an additional minute, they performed Driving Only or performed a task while driving (Driving + Sending Text Message or Driving + Searching Navigation). An unexpected situation, in which the participant had to stop abruptly due to a sudden stop of the preceding vehicle, occurred during this period. Driving performance during the unexpected situation was evaluated by car control variables, medial-lateral coefficient of variation and brake time, and by motion variables such as the jerk-cost function. Compared to Driving Only, jerk-cost function, medial-lateral coefficient of variation, and brake time increased during Driving + Sending Text Message or Driving + Searching Navigation.
    Type of Medium: Online Resource
    ISSN: 0031-5125 , 1558-688X
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2066876-4
    SSG: 5,2
    SSG: 7,11
    SSG: 31
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  • 10
    In: Cell Transplantation, SAGE Publications, Vol. 23, No. 4-5 ( 2014-05), p. 399-406
    Abstract: Human mesenchymal stem cells (hMSCs) are currently available for a range of applications and benefits and have become a good material for regenerative medicine, tissue engineering, and disease therapy. Before ex vivo expansion, isolation and characterization of primary hMSCs from peripheral tissues are key steps for obtaining adequate materials for clinical application. The proportion of peripheral stem cells is very low in surrounding tissues and organs; thus the recovery ratio will be a limiting factor. In this review, we summarized current common methods used to isolate peripheral stem cells, as well as the new insights revealed to improve the quantity of stem cells and their stemness. These strategies offer alternative ways to acquire hMSCs in a convenient and/or effective manner, which is important for clinical treatments. Improved isolation and mass amplification of the hMSCs while ensuring their stemness and quantity will be an important step for clinical use. Enlarged suitable hMSCs are more clinically applicable for therapeutic transplants and may help people live longer and better.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2020466-8
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