In:
Antiviral Therapy, SAGE Publications, Vol. 5, No. 4 ( 2000-05), p. 267-272
Abstract:
The virological and immunological efficacy of the triple regimen containing nevirapine (once or twice daily), didanosine (once daily) and stavudine, in antiretroviral-naive patients infected with HIV-1, was evaluated in an open-label, prospective, non-randomized, multi-centre, 52-week study. The first 60 patients (VIRGO I) received nevirapine as the standard dose, 200 mg twice daily; the subsequent 40 patients (VIRGO II) received nevirapine at a dose of 400 mg once daily. All patients received 400 mg of didanosine once daily and 40 mg of stavudine twice daily, adjusted for body weight. At baseline, the median CD4 cell count and plasma viral load (pVL) were 414 cells/mm 3 and 4.59 log 10 copies/ml in VIRGO I, and 412 cells/mm 3 and 4.87 log 10 copies/ml in VIRGO II. Using an intent-to-treat, ‘non-completer equals failure’, analysis, 78% (95% CI, 68–88%) of patients in VIRGO I and 68% (95% CI, 53–83%) of those in VIRGO II had a pVL 〈 500 copies/ml at 24 weeks; the proportions achieving a pVL of 〈 50 copies/ml were 62% (95% CI, 50–74%) and 50% (95% CI, 35–65%), respectively. The week 24 median CD4 cell count increase was 168 cells/mm 3 (VIRGO I) and 139 cells/mm 3 (VIRGO II). At week 52, 39/45 (87%) of VIRGO I patients had pVL 〈 500 copies/ml and 30/45 (67%) 〈 50 copies/ml. Of the 100 patients, 44 experienced grade 2 to 4 adverse events; 20 permanently discontinued study medication because of an adverse event. Combination therapy with the three reverse transcriptase (RT) inhibitors stavudine, once-daily didanosine and either once- or twice-daily nevirapine could be considered as an alternative option for first-line antiretroviral therapy.
Type of Medium:
Online Resource
ISSN:
1359-6535
,
2040-2058
DOI:
10.1177/135965350000500405
Language:
English
Publisher:
SAGE Publications
Publication Date:
2000
detail.hit.zdb_id:
2118396-X
SSG:
15,3
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