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  • 1
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    Human blood metabolites and lacunar stroke: A Mendelian randomization study
    SAGE Publications ; 2023
    In:  International Journal of Stroke Vol. 18, No. 1 ( 2023-01), p. 109-116
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 18, No. 1 ( 2023-01), p. 109-116
    Abstract: Lacunar stroke accounts for a quarter of all strokes, but little is known about the underlying pathological mechanisms. Analysis of serum metabolites may allow better understanding of the underlying biological processes. Mendelian randomization (MR) can provide information on the causality of associations. Aims: To identify causal relationships between serum metabolites and lacunar stroke. Methods: We applied a two-sample MR analysis to evaluate relationships between 486 serum metabolites and lacunar stroke. The inverse-variance weighted (IVW) method was used to estimate the causal relationship of the exposure on the outcome, while sensitivity analyses were performed using MR-Egger, weighted median, and MR-PRESSO to eliminate the pleiotropy. We also performed a metabolic pathway analysis to identify potential metabolic pathways. Results: We identified 15 known (8 risk and 7 protective) and 14 unknown serum metabolites associated with lacunar stroke. Among the known risk metabolites, two were lipids (1-linoleoylglycerophosphoethanolamine and dihomo-linolenate (20:3n3 or n6)), five amino acids (kynurenine, isobutyrylcarnitine, aspartate, trans-4-hydroxyproline, and 3-methyl-2-oxovalerate), and one peptide (ADSGEGDFXAEGGGVR). The known protective metabolites included four lipids (4-androsten-3beta,17beta-diol disulfate 1, 1-palmitoleoylglycerophosphocholine, adrenate (22:4n6), and glycodeoxycholate), one amino acid (methionine), and two exogenous metabolites (homostachydrine and 2-methoxyacetaminophen sulfate). Metabolic pathway analysis identified several pathways that might be involved in the disease. Conclusion: We identified eight risk and seven protective human serum metabolites associated with lacunar stroke. Isobutyrylcarnitine was positively associated with an increased risk of lacunar stroke. In addition, 3-methyl-2-oxovalerate and aspartate may be involved in the disease pathogenesis through metabolic pathways.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930221140792
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2211666-7
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  • 2
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    Cotton-containing printing wires based on the two-dimensional braiding method for three-dimensional printing of clothing
    SAGE Publications ; 2022
    In:  Textile Research Journal Vol. 92, No. 9-10 ( 2022-05), p. 1384-1393
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 92, No. 9-10 ( 2022-05), p. 1384-1393
    Abstract: There is a large somatosensory gap between the three-dimensional (3D) printing of clothing and traditional garments due to the limitations (e.g., air permeability and skin-friendliness) of the printing materials. For this reason, the application of traditional textile materials in 3D printing has become a hot topic in the field of 3D printed clothing. Based on the above, this work prepared four kinds of cotton-containing composite solutions and then impregnated thermoplastic polyurethane core yarns in these solutions to obtain four types of 3D printed cotton-containing composite core yarns (3Dp-C-CYs). Afterward, based on the two-dimensional (2D) braiding method, four kinds of cotton-containing 3D printing wires used for fused deposition molding technology were prepared by wrapping low-melting polyester filaments around the different 3Dp-C-CYs. After comparing the printing performance of the four cotton-containing 3D printing wires, the wire containing cotton powders had the best comprehensive performance and was selected to print the cotton-containing 3D printed fabrics. The results showed that the cotton-containing 3D printed fabric has good flatness and contains a large number of cotton powders; in addition, compared with the traditional polylactic acid and acrylonitrile butadiene styrene copolymer 3D printed fabrics, the 3D printed fabric made up of cotton-containing 3D printing wire can provide a closer wearing experience to that of cotton fabric. The 3D printing wire produced by the 2D braiding method offers a new idea for applying traditional textile materials in 3D printing, showing great application potentials in the field of 3D printing of clothing.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/00405175211059208
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2209596-2
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  • 3
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    Chronic stress: a crucial promoter of cell apoptosis in atherosclerosis
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 1 ( 2020-01), p. 030006051881460-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 1 ( 2020-01), p. 030006051881460-
    Abstract: Chronic stress may lead to augmented incidence rates of coronary and cerebrovascular diseases associated with atherosclerosis. However, few studies have focused on the effect of chronic stress on atherosclerosis plaque formation. Therefore, this study was designed to directly evaluate how chronic stress affects atherosclerosis. Methods Thirty rabbits were divided into three groups: the control group, balloon-injury operation + high-fat diet model group, and chronic stress + balloon-injury operation + high-fat diet model group. Physical and social stress were induced, and proteomic methods were applied to identify specific markers. Results After protein determination, the chronic stress + balloon-injury operation + high-fat diet model group exhibited significant upregulation of the following apoptosis-related proteins: UBE2K, caspase 3, caspase 9, BAX, P53, and FAS. In particular, real-time polymerase chain reaction showed that the protein expression of caspase 9 was significantly downregulated in the stress group compared with the non-stress groups. However, the other proteins showed significantly increased expression in the stress group. Conclusion Chronic stress may promote cell apoptosis in the physiopathologic process of atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518814606
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 4
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    Computer-assisted prediction of atherosclerotic intimal thickness based on weight of adrenal gland, interleukin-6 concentration, and neural networks
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 1 ( 2020-01), p. 030006051983962-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 1 ( 2020-01), p. 030006051983962-
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060519839625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 5
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    Factors associated with failure of high-flow nasal cannula oxygen therapy in patients with severe COVID-19: a retrospective case series
    SAGE Publications ; 2022
    In:  Journal of International Medical Research Vol. 50, No. 5 ( 2022-05), p. 030006052211035-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 50, No. 5 ( 2022-05), p. 030006052211035-
    Abstract: To identify factors associated with high-flow nasal cannula (HFNC) therapy failure in patients with severe COVID-19. Methods We retrospectively examined clinical and laboratory data upon admission, treatments, and outcomes of patients with severe COVID-19. Sequential Organ Failure Assessment (SOFA) scores were also calculated. Results Of 54 patients with severe COVID-19, HFNC therapy was successful in 28 (51.9%) and unsuccessful in 26 (48.1%). HFNC therapy failure was more common in patients aged ≥60 years and in men. Compared with patients with successful HFNC therapy, patients with HFNC therapy failure had higher percentages of fatigue, anorexia, and cardiovascular disease; a longer time from symptom onset to diagnosis; higher SOFA scores; a higher body temperature, respiratory rate, and heart rate; more complications, including acute respiratory distress syndrome, septic shock, myocardial damage, and acute kidney injury; a higher C-reactive protein concentration, neutrophil count, and prothrombin time; and a lower arterial partial pressure of oxygen/fraction of inspired oxygen (PaO 2 /FiO 2 ). However, male sex, a low PaO 2 /FiO 2 , and a high SOFA score were the only independent factors significantly associated with HFNC therapy failure. Conclusions Male sex, a low PaO 2 /FiO 2 , and a high SOFA score were independently associated with HFNC therapy failure in patients with severe COVID-19.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605221103525
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2082422-1
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  • 6
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    Linking Holocene East Asian monsoon variability to solar forcing and ENSO activity: Multi-proxy evidence from a peatland in Northeastern China
    SAGE Publications ; 2021
    In:  The Holocene Vol. 31, No. 6 ( 2021-06), p. 966-982
    Details
    In: The Holocene, SAGE Publications, Vol. 31, No. 6 ( 2021-06), p. 966-982
    Abstract: High-resolution proxy-based paleoenvironmental records derived from peatlands provide important insights into climate changes over centennial to millennial timescales. In this study, we present a composite climatic index (CCI) for the Hani peatland from northeastern China, based on an innovative combination of pollen-spore, phytolith, and grain size data. We use the CCI to reconstruct variations of the East Asian summer monsoon (EASM) intensity during the Holocene. This is accomplished with complete ensemble empirical mode decomposition (CEEMD), REDFIT, and cross-wavelet coherency analysis to reveal the periodicities (frequencies) of the multi-proxy derived CCI sequences and to assess potential external forcing of the EASM. The results showed that periodicities of ca. 300–350, 475, 600, 1075, and 1875 years were present in the Hani CCI sequence. Those periodicities are consistent with previously published periodicities in East Asia, indicating they are a product of external climate controls over an extensive region, rather than random variations caused by peatland-specific factors. Cross-wavelet coherency analysis between the decomposed CCI components and past solar activity reconstructions suggests that variations of solar irradiation are most likely responsible for the cyclic characteristics at 500-year frequency. We propose a conceptual model to interpret how the sun regulates the monsoon climate via coupling with oceanic and atmospheric circulations. It seems that slight solar irradiation changes can be amplified by coupling with ENSO events, which result in a significant impact on the regional climate in the East Asian monsoon area.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683621994662
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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  • 7
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    Carotid–Femoral Pulse Wave Velocity in the Prediction of Cardiovascular Events and Mortality: An Updated Systematic Review and Meta-Analysis
    SAGE Publications ; 2018
    In:  Angiology Vol. 69, No. 7 ( 2018-08), p. 617-629
    Details
    In: Angiology, SAGE Publications, Vol. 69, No. 7 ( 2018-08), p. 617-629
    Abstract: Arterial stiffness (AS) is a predictor of coronary artery outcomes in patients with cardiovascular disease (CVD). Carotid–femoral pulse wave velocity (cf-PWV) is a commonly used method for assessing AS. This study aimed to assess the relationship between cf-PWV and clinical CVD events. Of the 786 studies identified, 19 studies were included in the final meta-analysis. Meta-analysis revealed that participants with high cf-PWV by 1 standard deviation (SD), 1 m/s, and cutoff points have a high pooled relative risk for CVD events (1 SD: 1.25, 95% confidence interval [CI]: 1.19-1.31; 1 m/s: 1.12, 95% CI: 1.07-1.18; and cutoff points: 1.80, 95% CI: 1.45-2.14) and CVD mortality (1 SD: 1.23, 95% CI: 1.15-1.31; 1 m/s: 1.09, 95% CI: 1.04-1.14; and cutoff points: 1.85, 95% CI: 1.46-2.24). In addition, we found that the predictive value of increased AS was higher in patients with higher disease risk for total CVD events and CVD mortality than in other patients. Carotid–femoral pulse wave velocity is a useful biomarker to improve the prediction of CV risk for patients and identify high-risk populations who may benefit from aggressive CV risk factor management.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319717742544
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2065911-8
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  • 8
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    A Multi-Stage Approach for Empty Container Repositioning Under Coordination Among Liner Carriers
    SAGE Publications ; 2021
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2675, No. 7 ( 2021-07), p. 424-437
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2675, No. 7 ( 2021-07), p. 424-437
    Abstract: This paper studies the empty container repositioning (ECR) problem considering the exchange of slots and empty containers among liner shipping companies. It is common for an individual shipping company to seek an optimal solution for ECR and cargo routing to maximize its own benefits. To achieve cooperation among shipping companies, a multi-stage solution strategy is proposed. With the inverse optimization technique, the guide leasing prices of slots and empty containers among shipping companies are derived considering the schedule of vessels and cargo routing. Based on the guide leasing price, a cooperative model is formulated to minimize the total cost, which includes the transportation cost for laden containers, the inventory holding cost, the container leasing cost, and the repositioning cost. All the involved shipping companies are expected to follow the best solution of ECR and cargo routing to achieve a cooperative and stable optimum. A real-world shipping network operated by three liner shipping companies is used as a case study with promising numerical results.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/03611981211021550
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2403378-9
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  • 9
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    Bioinformatics analysis of key biomarkers for retinoblastoma
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 6 ( 2021-06), p. 030006052110222-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 6 ( 2021-06), p. 030006052110222-
    Abstract: To identify key genes involved in occurrence and development of retinoblastoma. Methods The microarray dataset, GSE5222, was downloaded from the gene expression omnibus (GEO) database. Differentially expressed genes (DEGs) between unilateral and bilateral retinoblastoma were identified and functional enrichment analysis performed. The protein–protein interaction (PPI) network was constructed and analysed by STRING and Cytoscape. Results DEGs were mainly associated with activation of cysteine-type endopeptidase activity involved in apoptotic process and small molecule catabolic process. Seven genes (WAS, GNB3, PTGER1, TACR1, GPR143, NPFF and CDKN2A) were identified as HUB genes. Conclusion Our research provides more understanding of the mechanisms of the disease at a molecular level and may help in the identification of novel biomarkers for retinoblastoma.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211022210
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 10
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    Prognostic Values of Platelet-Associated Indicators in Resectable Lung Cancers
    SAGE Publications ; 2019
    In:  Technology in Cancer Research & Treatment Vol. 18 ( 2019-01-01), p. 153303381983726-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 18 ( 2019-01-01), p. 153303381983726-
    Abstract: Lung cancer is the leading cause of cancer death. Platelet-related indictors, including platelet count, plateletcrit, mean platelet volume, and platelet distribution width, not only associate with morphology and functions of platelet but also correlate with tumor development and metastasis. In the present study, we investigated the values of platelet-related indictors in the prognosis evaluation of resectable lung cancers. Methods: In total, 101 patients with resectable lung cancer were recruited in this study. Patients were divided into 2 groups according to the median pretreatment values. To evaluate the individual value changes after treatment, we introduced the concept of post-/pretreatment ratio (≤1 indicated value was not increased after treatment, while 〉 1 suggested increased value). Results: The high pretreatment platelet count level was correlated with larger tumor size. High pretreatment plateletcrit level was associated with more lymph nodes metastasis. Patients with high pretreatment plateletcrit level had worse overall survival, whereas pretreatment platelet count, mean platelet volume, and platelet distribution width levels were not correlated with outcomes. Surgery had no impact on the values of platelet count, plateletcrit, mean platelet volume, or platelet distribution width. Adjuvant chemotherapy significantly decreased the values of platelet count and plateletcrit, whereas it had no effect on the values of mean platelet volume or platelet distribution width. Whole course of treatment (surgery combined with adjuvant chemotherapy) significantly decreased the values of platelet count and platelet distribution width, whereas it had no effect on the values of plateletcrit or mean platelet volume. Post-/pretreatment platelet count, plateletcrit, mean platelet volume, and platelet distribution width ratios were not correlated with outcomes. Univariate analyses demonstrated that American Joint Committee on Cancer stage and pretreatment plateletcrit level were significant risk factors for prognosis. Cox regression analysis revealed that no factor independently associated with worse survival. Conclusion: Pretreatment plateletcrit level could be a potential prognostic factor in resectable lung cancers.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033819837261
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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