GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • SAGE Publications  (28)
  • 1
    Online Resource
    Online Resource
    Evaluation of the Clinical Efficacy of Stem Cell Transplantation in the Treatment of Spinal Cord Injury: A Systematic Review and Meta-analysis
    SAGE Publications ; 2021
    In:  Cell Transplantation Vol. 30 ( 2021-01), p. 096368972110678-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 30 ( 2021-01), p. 096368972110678-
    Abstract: Stem cell transplantation has been applied to treat spinal cord injury (SCI) in clinical trials for many years. However, the clinical efficacies of stem cell transplantation in SCI have been quite diverse. The purpose of our study was to systematically investigate the efficacy of stem cell transplantation in patients with SCI. The PubMed, Web of Science, Ovid-Medline, Cochrane Library, China National Knowledge Infrastructure, VIP, Wanfang, and SinoMed databases were searched until October 27, 2020. Quantitative and qualitative data were analyzed by Review Manager 5.3 and R. Nine studies ( n = 328) were included, and the overall risk of bias was moderate. The ASIA Impairment Scale (AIS) grading improvement rate was analyzed in favor of stem cell transplantation group [odds ratio (OR) = 6.06, 95% confidence interval (CI): 3.16–11.62, P 〈 0.00001]. Urodynamic indices also showed improvement in bladder function. In subgroup analyses, the results indicated that in patients with complete (AIS A) SCI, with the application of cell numbers between n*(10 7 –10 8 ), two cell types (i.e., bone marrow–derived mesenchymal stem cells and bone marrow mononuclears), and treatment time of more than 6 months, stem cell transplantation was more beneficial for sensorimotor function ( P 〈 0.05 for all groups). The risk of fever incidence in the stem cell transplantation group was 4.22 (95% CI: 1.7–10.22, P = 0.001), and principal component analysis (PCA) suggested it was more related to transplanted cell numbers. Thus, stem cell transplantation can promote functional recovery in SCI patients. Moreover, the type and quantity of transplanted stem cells and treatment time are important factors affecting the therapeutic effect of stem cell transplantation in SCI. Further studies are needed to evaluate the effects and elucidate the mechanisms of these factors on stem cell therapy in SCI.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897211067804
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020466-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Protective effects of Panax notoginseng saponins in a rat model of severe acute pancreatitis occur through regulation of inflammatory pathway signaling by upregulation of miR-181b
    SAGE Publications ; 2018
    In:  International Journal of Immunopathology and Pharmacology Vol. 32 ( 2018-01), p. 205873841881863-
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 32 ( 2018-01), p. 205873841881863-
    Abstract: Panax notoginseng saponins are extracted from Chinese ginseng— Panax notoginseng Ledeb—and are known to have therapeutic anti-inflammatory effects. However, the precise mechanism behind their anti-inflammatory effects remains relatively unknown. To better understand how Panax notoginseng saponins exert their therapeutic benefit, we tested them in a rat model of severe acute pancreatitis (SAP). Rats received a tail vein injection of Panax notoginseng saponins and were administered 5% sodium taurocholate 2 h later. Pancreatic tissue was then harvested and levels of miR-181b, FSTL1, TREM1, TLR4, TRAF6, IRAK1, p-Akt, p-p38MAPK, NF-κBp65, and p-IκB-α were determined using Western blot and quantitative real-time polymerase chain reaction (qRT-PCR). Enzyme-linked immunosorbent assays were used to determine serum levels of tumor necrosis factor-α (TNF-α), TREM1, interleukin (IL)-6, ACAM-1, IL-8, and IL-12 and DNA-bound levels of NF-KB65 and TLR4 in pancreatic and ileum tissue. Serum levels of lipase and amylase, pancreatic myeloperoxidase (MPO) activity, and pancreatic water content were also measured. Hematoxylin and eosin staining was used for all histological analyses. Results indicated upregulation of miR-181b, but negligible levels of FSTL1, p-p38MAPK, TLR4, TRAF6, p-Akt, IRAK1, TREM1, p-NF-κBp65, and p-IκB-α, as well as negligible DNA-bound levels of NF-KB65 and TLR4. We also observed lower levels of IL-8, IL-6, ACAM-1, TNF-α, MPO, and IL-12 in the Panax notoginseng saponin–treated group when compared with controls. In addition, Panax notoginseng saponin–treated rats had significantly reduced serum levels of lipase and amylase. Histological analyses confirmed that Panax notoginseng saponin treatment significantly reduced taurocholate-induced pancreatic inflammation. Collectively, our results suggest that Panax notoginseng saponin treatment attenuated acute pancreatitis and pancreatic inflammation by increasing miR-181b signaling. These findings suggest that Panax notoginseng saponins have therapeutic potential in the treatment of taurocholate-induced SAP.
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/2058738418818630
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2505963-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Activation of Extracellular Signal-Regulated Protein Kinase 5 is Essential for Cystitis- and Nerve Growth Factor-Induced Calcitonin Gene-Related Peptide Expression in Sensory Neurons
    SAGE Publications ; 2012
    In:  Molecular Pain Vol. 8 ( 2012-01-01), p. 1744-8069-8-48-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 8 ( 2012-01-01), p. 1744-8069-8-48-
    Abstract: Cystitis causes considerable neuronal plasticity in the primary afferent pathways. The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensitization has not been investigated. Results: In a rat cystitis model induced by cyclophosphamide (CYP) for 48 h, the mRNA and protein levels of the excitatory neurotransmitter calcitonin gene-related peptide (CGRP) are increased in the L6 dorsal root ganglia (DRG) in response to bladder inflammation. Cystitis-induced CGRP expression in L6 DRG is triggered by endogenous nerve growth factor (NGF) because neutralization of NGF with a specific NGF antibody reverses CGRP up-regulation during cystitis. CGRP expression in the L6 DRG neurons is also enhanced by retrograde NGF signaling when NGF is applied to the nerve terminals of the ganglion-nerve two-compartmented preparation. Characterization of the signaling pathways in cystitis- or NGF-induced CGRP expression reveals that the activation (phosphorylation) of extracellular signal-regulated protein kinase (ERK)5 but not Akt is involved. In L6 DRG during cystitis, CGRP is co-localized with phospho-ERK5 but not phospho-Akt. NGF-evoked CGRP up-regulation is also blocked by inhibition of the MEK/ERK pathway with specific MEK inhibitors U0126 and PD98059, but not by inhibition of the PI3K/Akt pathway with inhibitor LY294002. Further examination shows that cystitis-induced cAMP-responsive element binding protein (CREB) activity is expressed in CGRP bladder afferent neurons and is co-localized with phospho-ERK5 but not phospho-Akt. Blockade of NGF action in vivo reduces the number of DRG neurons co-expressing CGRP and phospho-CREB, and reverses cystitis-induced increases in micturition frequency. Conclusions: A specific pathway involving NGF-ERK5-CREB axis plays an essential role in cystitis-induced sensory activation.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1186/1744-8069-8-48
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2174252-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Research on customer-oriented optimal configuration of product scheme based on Pareto genetic algorithm
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture Vol. 229, No. 1 ( 2015-01), p. 148-156
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications, Vol. 229, No. 1 ( 2015-01), p. 148-156
    Abstract: Product configuration is the key to mass customization, which is based on configuration modeling and solutions. A customer-oriented optimal configuration model is built to achieve an optimal configuration for a product scheme. Based on a product platform and customer requirements, a dual-objective “performance-cost” optimization model for customized products is proposed. This model is based on the Pareto genetic algorithm for configuration optimization through which optimal solutions for customer requirements can be obtained, including multiple choices for selection as well as reference to schemes that can enable customers to participate in the product design. In this study, a case is studied to prove the feasibility and effectiveness of the proposed model.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/0954405414524742
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2032745-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Self–Esteem among Chinese Cohorts: Its Temporal Trend and Its Relationships with Socioecological Factors, 1993–2016
    SAGE Publications ; 2020
    In:  European Journal of Personality Vol. 34, No. 2 ( 2020-03), p. 203-214
    Details
    In: European Journal of Personality, SAGE Publications, Vol. 34, No. 2 ( 2020-03), p. 203-214
    Abstract: Self–esteem affects individuals in a variety of psychological processes substantially and extensively. While an increase in self–esteem over time was observed in the USA, different patterns of temporal change in self–esteem were observed in other societies. We analysed the responses ( n = 305 229) collected between 1993 and 2016 from 609 articles to examine the patterns of temporal change in self–esteem in China and its relations with socioecological conditions. Additionally, we explored the patterns in different groups, including secondary school students (158 samples; n = 97 751), college students (427 samples; n = 153 474), and community participants (232 samples; n = 54 004). Some major findings were noted: (i) overall, the level of self–esteem increased over time. However, we also found a significant curvilinear trend in self–esteem with a decline followed by a recent increase; (ii) some evidence for the relationship between socioecological factors and self–esteem was obtained; and (iii) the patterns varied in different cohort groups. Specifically, secondary school students showed a different pattern, in which their self–esteem level did not show a significant linear trend and was not correlated with the examined socioecological factors. The implications on the theories for the relationship between personality characteristics and socioecological conditions were discussed.
    Type of Medium: Online Resource
    ISSN: 0890-2070 , 1099-0984
    URL: Article
    DOI: 10.1002/per.2238
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 1501719-9
    detail.hit.zdb_id: 624551-1
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Association Between CRISPLD2 Polymorphisms and the Risk of Nonsyndromic Clefts of the Lip and/or Palate : A Meta-analysis
    SAGE Publications ; 2018
    In:  The Cleft Palate-Craniofacial Journal Vol. 55, No. 3 ( 2018-03), p. 328-334
    Details
    In: The Cleft Palate-Craniofacial Journal, SAGE Publications, Vol. 55, No. 3 ( 2018-03), p. 328-334
    Abstract: Nonsyndromic clefts of the lip and/or palate (NSCL/P) are one of the most common polygenic diseases. Recently, many studies focused on the association between CRISPLD2 polymorphisms and NSCL/P risk. However, some studies have shown opposite results. In this study, meta-analysis was used to confirm whether CRISPLD2 polymorphism was associated with NSCL/P, and the possible mechanism between CRISPLD2 and NSCL/P was explored. Methods: Relevant studies were conducted on PubMed, Ovid, EBSCO, CINAHL, FMRS, Web of Science, CNKI, and Wanfang databases from their inception up to June 31, 2016. Review Manager 5.0.24 was used to analyze whether CRISPLD2 polymorphism was involved in NSCL/P by pooling odds ratios (ORs) and 95% confidence intervals (CIs). Potential publication bias was evaluated by visual inspection of the funnel plot. Results: CRISPLD2 rs4783099 was associated with cleft lip and/or palate (CL/P) statistically (OR = 3.18, P 〈 .01). Compared to genotype TT, genotypes CC and CT were correlated significantly (OR = 2.04, P = .04) with CL/P. No evidence showed an association between genetic variation at the CRISPLD2 locus and cleft palate only (CP). Conclusion: The polymorphism of CRISPLD2 rs4783099 is correlated with an increased risk of CL/P.
    Type of Medium: Online Resource
    ISSN: 1055-6656 , 1545-1569
    URL: Article
    DOI: 10.1177/1055665617738995
    RVK:
    XA 36625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2030056-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Formaldehyde induces ferritinophagy to damage hippocampal neuronal cells
    SAGE Publications ; 2021
    In:  Toxicology and Industrial Health Vol. 37, No. 11 ( 2021-11), p. 685-694
    Details
    In: Toxicology and Industrial Health, SAGE Publications, Vol. 37, No. 11 ( 2021-11), p. 685-694
    Abstract: Formaldehyde (FA) causes neurotoxicity and contributes to the occurrence of neurodegenerative diseases. However, the mechanism of FA-induced neurotoxicity has not been fully elucidated. Ferritinophagy, an autophagy process of ferritin mediated by the nuclear receptor coactivator 4 (NCOA4), is a potential mechanism of neurotoxicity. In this study, we explored whether ferritinophagy is associated with the neurotoxicity of FA. Our results showed that FA (50, 100, 200 μM; 24 h) exposure upregulated ferritinophagy in the mouse hippocampal neuronal HT22 cells, which was evidenced by the upregulated autophagic flux, the increased colocalizations of NCOA4 with ferritin heavy chain (FTH1) and NCOA4 with microtubule-associated protein 1 light chain-3B (LC3B), the augmented expression of NCOA4, and the reduced content of FTH1. We also found that FA (0.1, 1, and 10 μmol, i.c.v., 7d) administration boosted ferritinophagy in the hippocampus of Sprague-Dawley (SD) rats, which was demonstrated by the accumulated autophagosomes, the increased expressions of LC3II/I and NCOA4, and the decreased contents of p62 and FTH1 in the hippocampus. Further, we confirmed that inhibition of ferritinophagy by silencing the expression of NCOA4 decreased FA-induced toxic damage in HT22 cells. These results indicated that FA induces neurotoxicity by promoting ferritinophagy. Our findings suggest a potential mechanism insight into the FA-induced neurotoxicity, which in turn provides a new thought for the treatment of FA-related neurodegenerative diseases.
    Type of Medium: Online Resource
    ISSN: 0748-2337 , 1477-0393
    URL: Article
    DOI: 10.1177/07482337211048582
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2010891-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Co-infusion of high-dose haploidentical donor cells and CD19-targeted CART cells achieves complete remission, successful donor engraftment and significant CART amplification in advanced ALL
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592092760-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592092760-
    Abstract: Autologous CD19-targeted chimeric antigen receptor-modified T cells (CD19-CART) remarkably improved the outcome of patients with advanced B-cell acute lymphoblastic leukemia (B-ALL). However, the application and outcomes of allogeneic CART cells is still uncertain. Two patients with advanced B-ALL were enrolled to receive a co-infusion of high-dose human leukocyte antigen-haploidentical donor granulocyte colony-stimulating factor mobilized peripheral blood mononuclear cells (GPBMCs; 21.01–25.34 × 10 8 /kg) and the same donor-derived CD19-targeted CART cells (8.44–22.19 × 10 6 /kg) without additional in vitro gene-editing following a reinduction chemotherapy as precondition. They achieved complete remission and full donor chimerism (FDC) with ongoing 20- and 4-month leukemia-free survival. A significant amplification of donor CART cells was detected in peripheral blood and/or cerebrospinal fluid and was associated with the formation of FDC. The highest amount of copies of the donor CART cells reached 4962 per µg of genomic DNA (gDNA) and 2449 per µg of gDNA, and the longest persistence was 20 months associated with B cell aplasia. Two patients experienced Grade II or III cytokine release syndromes and developed controllable Grade II intestinal acute graft-versus-host disease (GVHD) or limited chronic oral GVHD. High-dose donor GPBMC infusion may enhance amplification and persistence of haploidentical CD19-targeted CART cells, suggesting an alternative therapy for advanced B-ALL patients.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920927605
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Successful embolization and long-term follow-up of a rare neonatal diaphragmatic hemangioma
    SAGE Publications ; 2015
    In:  SAGE Open Medical Case Reports Vol. 3 ( 2015-01-01), p. 2050313X1561547-
    Details
    In: SAGE Open Medical Case Reports, SAGE Publications, Vol. 3 ( 2015-01-01), p. 2050313X1561547-
    Abstract: Congenital hemangioma of the diaphragm is an extremely rare disease in childhood. Methods: We report a newborn presenting with progressive respiratory distress and massive right hydrothorax due to congenital diaphragmatic hemangioma, requiring sustained ventilation support and chest drainage. The angiography revealed that the giant diaphragmatic hemangioma was supplied by the right internal thoracic, inferior diaphragmatic, and intercostal arteries. The selective embolization of the main feeding vessels was successfully achieved using the Embosphere particulates. Results: The clinical long-term follow-up demonstrated the resolution of the symptoms, pleural effusion, and nearly complete regression of the hemangioma at 18 months of age. Conclusion: Transcatheter embolization can provide an efficient therapy for symptomatic diaphramatic hemangioma.
    Type of Medium: Online Resource
    ISSN: 2050-313X , 2050-313X
    URL: Article
    DOI: 10.1177/2050313X15615471
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2736953-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Buckling capacity of steel circular hollow section considering the restraint of welded hollow spherical joints
    SAGE Publications ; 2023
    In:  International Journal of Space Structures Vol. 38, No. 3 ( 2023-09), p. 193-203
    Details
    In: International Journal of Space Structures, SAGE Publications, Vol. 38, No. 3 ( 2023-09), p. 193-203
    Abstract: An integral finite element model of steel circular hollow section and welded hollow spherical joints is established to consider the restraint of welded hollow spherical joints on steel circular hollow section in this paper. The buckling modes are used as the initial geometrical imperfection forms of the steel circular hollow section. Based on the statistics method, a method for calculating the buckling capacity design value of the steel circular hollow section with uniform reliability considering the restraint of welded hollow spherical joints is established, and the formula for calculating error of this value at certain confidence is deduced. The relationships between the buckling capacity design value of steel circular hollow section and the structural parameters of the member and joint are determined quantitatively by linear regression method. A practical formula for the buckling capacity design value of steel circular hollow section considering the restraint of welded hollow spherical joints is derived. Compared to the results calculated by the design code indicates that if the difference of restraint effect which is caused by different welded hollow spherical joint is ignored, the buckling capacity value of steel circular hollow section calculated based on the unified effective length coefficient may be bigger or smaller than that of the actual case. Therefore, refined consideration should be placed on the different restraint of welded hollow spherical joints of different sizes on steel circular hollow section, and the restraint of the end joints should be accurately considered when determining the buckling capacity of steel circular hollow sections.
    Type of Medium: Online Resource
    ISSN: 0956-0599 , 2059-8033
    URL: Article
    DOI: 10.1177/09560599231167012
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2030949-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...