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  • 1
    Online Resource
    Online Resource
    Detection of Salmonella spp. in veterinary samples by combining selective enrichment and real-time PCR
    SAGE Publications ; 2017
    In:  Journal of Veterinary Diagnostic Investigation Vol. 29, No. 6 ( 2017-11), p. 844-851
    Details
    In: Journal of Veterinary Diagnostic Investigation, SAGE Publications, Vol. 29, No. 6 ( 2017-11), p. 844-851
    Abstract: Rapid screening for enteric bacterial pathogens in clinical environments is essential for biosecurity. Salmonella found in veterinary hospitals, particularly Salmonella enterica serovar Dublin, can pose unique challenges for culture and testing because of its poor growth. Multiple Salmonella serovars including Dublin are emerging threats to public health given increasing prevalence and antimicrobial resistance. We adapted an automated food testing method to veterinary samples and evaluated the performance of the method in a variety of matrices including environmental samples ( n = 81), tissues ( n = 52), feces ( n = 148), and feed ( n = 29). A commercial kit was chosen as the basis for this approach in view of extensive performance characterizations published by multiple independent organizations. A workflow was established for efficiently and accurately testing veterinary matrices and environmental samples by use of real-time PCR after selective enrichment in Rappaport–Vassiliadis soya (RVS) medium. Using this method, the detection limit for S. Dublin improved by 100-fold over subculture on selective agars (eosin–methylene blue, brilliant green, and xylose–lysine–deoxycholate). Overall, the procedure was effective in detecting Salmonella spp. and provided next-day results.
    Type of Medium: Online Resource
    ISSN: 1040-6387 , 1943-4936
    URL: Article
    DOI: 10.1177/1040638717728315
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2265211-5
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  • 2
    Online Resource
    Online Resource
    Ductal Plate Malformation in the Liver of Boxer Dogs : Clinical and Histological Features
    SAGE Publications ; 2016
    In:  Veterinary Pathology Vol. 53, No. 3 ( 2016-05), p. 602-613
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 53, No. 3 ( 2016-05), p. 602-613
    Abstract: Ductal plate malformations (DPMs) represent developmental biliary disorders with a wide phenotypic spectrum. This study characterizes DPM in 30 Boxer dogs. Median age was 1.5 (range, 0.3–10.0) years, with 12 dogs 〈 1 year. Clinical features included increased serum levels of liver enzymes (28), gastrointestinal signs (16), poor body condition (14), abdominal effusion (9), and hepatic encephalopathy (2). Additional malformations included gallbladder atresia (8), atrophied left liver (2), absent quadrate lobe with left-displaced gallbladder (1), portal vasculature atresia (left liver, 1), intrahepatic portosystemic shunt (1), and complex intrahepatic arteriovenous malformation (1). All dogs had portal tracts dimensionally expanded by a moderate-to-severe multiple small bile duct phenotype embedded in abundant extracellular matrix; 80% displayed variable portal-to-portal bridging. Quantitative analysis confirmed significantly increased fibrillar collagen and a 3-fold increased portal tract area relative to 6 Boxer and 10 non-Boxer controls. Biliary phenotype was dominated by tightly formed CK19-positive ductules, typically 10 to 15 μm in diameter, with 3 to 〉 30 profiles per portal tract, reduced luminal apertures, and negative Ki-67 immunoreactivity. CK19-positive biliary epithelium intersected directly with zone 1 hepatocytes as a signature feature when considered with other DPM characteristics. Phenotypic variation included a multiple small bile duct phenotype (all dogs), predominantly thin-walled sacculated ducts (4), well-formed saccular ducts (4), and sacculated segmental, interlobular, and intralobular ducts (Caroli malformation, 2 dogs, one with bridging portal fibrosis). Histologic evidence of portal venous hypoperfusion accompanied increased biliary profiles in every case. We propose that this spectrum of disorders be referred to as DPM with appropriate modifiers to characterize the unique phenotypes.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/0300985815610567
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2106608-5
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  • 3
    Online Resource
    Online Resource
    Assessing Theoretical Conclusions With Blinded Inference to Investigate a Potential Inference Crisis
    SAGE Publications ; 2019
    In:  Advances in Methods and Practices in Psychological Science Vol. 2, No. 4 ( 2019-12), p. 335-349
    Details
    In: Advances in Methods and Practices in Psychological Science, SAGE Publications, Vol. 2, No. 4 ( 2019-12), p. 335-349
    Abstract: Scientific advances across a range of disciplines hinge on the ability to make inferences about unobservable theoretical entities on the basis of empirical data patterns. Accurate inferences rely on both discovering valid, replicable data patterns and accurately interpreting those patterns in terms of their implications for theoretical constructs. The replication crisis in science has led to widespread efforts to improve the reliability of research findings, but comparatively little attention has been devoted to the validity of inferences based on those findings. Using an example from cognitive psychology, we demonstrate a blinded-inference paradigm for assessing the quality of theoretical inferences from data. Our results reveal substantial variability in experts’ judgments on the very same data, hinting at a possible inference crisis.
    Type of Medium: Online Resource
    ISSN: 2515-2459 , 2515-2467
    URL: Article
    DOI: 10.1177/2515245919869583
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2904847-3
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  • 4
    Online Resource
    Online Resource
    Long-Term Neuroprotection by Benzodiazepine: Full Versus Partial Agonists after Transient Cerebral Ischemia in the Gerbil
    SAGE Publications ; 1998
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 18, No. 5 ( 1998-05), p. 548-558
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 18, No. 5 ( 1998-05), p. 548-558
    Abstract: The ability of diazepam, a benzodiazepine full agonist, and imidazenil, a benzodiazepine partial agonist, to protect hippocampal area CA1 neurons from death for at least 35 days after cerebral ischemia was investigated. Diazepam (10 mg/kg) administered to gerbils 30 and 90 minutes after forebrain ischemia produced significant protection of hippocampal area CA1 pyramidal neurons 7 days later. In gerbils surviving for 35 days, diazepam produced the same degree of neuroprotection (70% ± 30%) in the hippocampus compared with 7 days after ischemia. The therapeutic window for diazepam was short; there was no significant neuroprotection when the administration of diazepam was delayed to 4 hours after ischemia. The neuroprotective dose of diazepam also produced hypothermia (~32°C) for several hours after injection. To assess the role of hypothermia in neuroprotection by diazepam, hypothermia depth and duration was simulated using a cold-water spray in separate gerbils. Seven days after ischemia, neuroprotection by hypothermia was similar to that produced by diazepam. However, 35 days after ischemia, there was no significant protection by hypothermia, suggesting that hypothermia does not play a significant role in long-term diazepam neuroprotection. Imidazenil (3 mg/kg), which produced only minimal hypothermia, protected area CA1 of hippocampus to the same degree as that by diazepam 7 days after ischemia. At 35 days after ischemia, significant protection remained, but it was considerably reduced compared with 7 days. Like diazepam, the therapeutic window for imidazenil was short. Imidazenil neuroprotection was lost when the drug was administered as early as 2 hours after ischemia. The ability of ischemia to produce deficits in working memory and of benzodiazepines to prevent the deficits also was investigated. Gerbils trained on an eight-arm radial maze before ischemia demonstrated a significant increase in the number of working errors 1 month after ischemia. The ischemia-induced deficits in working memory were completely prevented by diazepam but not by imidazenil. There was a significant, but weak, negative correlation between the degree of CA1 pyramidal cell survival and the number of working errors in both the diazepam and imidazenil groups. Thus, if given early enough during reperfusion, both benzodiazepine full and partial agonists are neuroprotective for at least 35 days, but the lack of sedating side effects of imidazenil must be weighed against its reduced efficacy.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1097/00004647-199805000-00010
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 2039456-1
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  • 5
    Online Resource
    Online Resource
    Circumstances, Descriptive Characteristics, and Pathologic Findings in Dogs Suspected of Starving
    SAGE Publications ; 2016
    In:  Veterinary Pathology Vol. 53, No. 5 ( 2016-09), p. 1087-1094
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 53, No. 5 ( 2016-09), p. 1087-1094
    Abstract: The authors reviewed the case circumstances, population characteristics, gross, and histopathologic findings in 40 cases of emaciated dogs with a suspected diagnosis of starvation. The dogs’ estimated age ranged from 3 months to geriatric. Nineteen breeds were represented, including small-breed ( n = 11), large-breed ( n = 13), and pit bull–type ( n = 16) dogs. The median body condition score was 1 out of 9 (Purina scale). Various diseases were identified as the cause of death in 7 dogs, while the cause of death in the other 33 dogs was starvation due to exogenous causes (SEC). Circumstances associated exclusively with SEC included being found in a vacated residence and death during temperature extremes or severe weather. Dogs with SEC did not differ significantly from diseased dogs in body condition score, sex, neuter status, or breed category (small, large, or pit bull type). Gross findings associated exclusively with SEC included severe hair matting and traumatic injuries. Diseased dogs had an empty stomach significantly more often than SEC dogs, which frequently had food and/or foreign material in the stomach. In 5 of the 7 cases where disease was the cause of death, disease involved the gastrointestinal tract. Gross and histopathologic changes commonly found in SEC and diseased dogs included the following: gross loss of muscle mass and absence of subcuticular fat; serous atrophy of omental, perirenal, epicardial, and bone marrow fat; atrophy of the liver, skin, thyroid gland, and testicle; gastric mucosal petechiae and ecchymoses; melena; and splenic hemosiderophages.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/0300985815575049
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 6
    Online Resource
    Online Resource
    Hispanic Overweight and Obese Children : Thirty Cases Managed With Standard WIC Counseling or Motivational Interviewing
    SAGE Publications ; 2014
    In:  ICAN: Infant, Child, & Adolescent Nutrition Vol. 6, No. 1 ( 2014-02), p. 35-43
    Details
    In: ICAN: Infant, Child, & Adolescent Nutrition, SAGE Publications, Vol. 6, No. 1 ( 2014-02), p. 35-43
    Abstract: Through Value Enhanced Nutrition Assessment and other techniques, the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) engages clients to set their own nutrition goals. A case series of 30 Hispanic children (2-4.5 years) at ≥85th body mass index (BMI) percentile and their caregivers were followed through an urban WIC clinic. The dyads received either standard counseling ( n = 15) or motivational interviewing (MI; n = 15) by one bilingual WIC nutritionist during 4 regularly scheduled visits over 6 months. Repeated measurements of anthropometric data, dietary patterns, and physical activity were obtained at each visit. Longitudinal bivariate analyses of caregiver concerns and goal selection were conducted along with mean comparisons of anthropometric and food frequency measures. Participation in counseling sessions as rated by the nutritionist was assessed by comparing Wilcoxon rank-sum scores. After counseling, children lost an adjusted mean weight of 0.878 kg (95% confidence interval = 0.280-1.717). A decline in median BMI of more than 3 percentiles ( P = .042) was observed with both counseling approaches. Caregiver-reported vegetable intake of children increased an average of one additional serving in the MI-counseled group by visit 3 ( P = .013) despite MI recipient caregivers being scored as significantly more distracted than standard WIC participants in the first visit ( P = .036). MI is a viable option for WIC counseling to improve diet and health outcomes in participants, particularly in addressing child BMI status and vegetable intake. Public health professionals should examine scalability of the MI approach among larger samples of WIC participants and other innovative techniques to improve client focus during counseling.
    Type of Medium: Online Resource
    ISSN: 1941-4064 , 1941-4072
    URL: Article
    DOI: 10.1177/1941406413510175
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2476961-7
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  • 7
    Online Resource
    Online Resource
    Gender and the Socioeconomic Gradient in Mortality
    SAGE Publications ; 1999
    In:  Journal of Health and Social Behavior Vol. 40, No. 1 ( 1999-03), p. 17-
    Details
    In: Journal of Health and Social Behavior, SAGE Publications, Vol. 40, No. 1 ( 1999-03), p. 17-
    Type of Medium: Online Resource
    ISSN: 0022-1465
    URL: Article
    DOI: 10.2307/2676376
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 1999
    detail.hit.zdb_id: 2010257-4
    SSG: 5,2
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  • 8
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    Online Resource
    Community Pharmacist–Provided Extended Diabetes Care
    SAGE Publications ; 2009
    In:  Annals of Pharmacotherapy Vol. 43, No. 5 ( 2009-05), p. 882-889
    Details
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 43, No. 5 ( 2009-05), p. 882-889
    Abstract: Pharmacists in various settings have been effective in initiating diabetes treatment. Patients with diabetes require ongoing disease management, and community pharmacists are in a strategic position to provide such extended care. Little is known, however, about the effects of community pharmacist–provided interventions beyond the initial treatment period. Objective To evaluate the effect of community pharmacist–provided extended diabetes care service on primary clinical outcomes, including hemoglobin A 1c (A1C), low-density lipoprotein cholesterol (LDL-C), and blood pressure, and on patients' reported self-care activities. Methods A randomized controlled trial was conducted in patients with diabetes. Participants had already completed at least 2 diabetes education sessions at a local diabetes education center. Nine specially trained pharmacists administered interventions during up to 4 quarterly visits per patient. Interventions included discussing medications, clinical goals, and self-care activities with patients and recommending medication changes to physicians when appropriate. The main outcome measures were 12-month changes in A1C, LDL-C, blood pressure, and self-report of self-care activities. Results Seventy-eight patients participated in the study (36 intervention, 42 control); 66 were included in the final analysis (31 intervention, 35 control). Compared with changes in the control group, patients who received interventions significantly increased the number of days per week that they engaged in a set of diet and diabetes self-care activities (1.25 and 0.73 more days/wk, respectively). The mean 12-month changes for A1C, LDL-C, and blood pressure were not significantly different between the 2 study groups. Conclusions Although pharmacist-provided interventions did not demonstrate statistically significant improvements in clinical outcomes over the study period, study results did show that pharmacists were effective at increasing the number of days that patients spent engaging in healthy diet and diabetes self-care activities. Addressing lifestyle and self-care behaviors can be a beneficial component of a pharmacist-provided extended diabetes care service.
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    URL: Article
    DOI: 10.1345/aph.1L605
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2053518-1
    SSG: 15,3
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  • 9
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    An Unusual Cause of Failure to Ventilate
    SAGE Publications ; 2018
    In:  Journal of Investigative Medicine High Impact Case Reports Vol. 6 ( 2018-01), p. 232470961878117-
    Details
    In: Journal of Investigative Medicine High Impact Case Reports, SAGE Publications, Vol. 6 ( 2018-01), p. 232470961878117-
    Type of Medium: Online Resource
    ISSN: 2324-7096 , 2324-7096
    URL: Article
    DOI: 10.1177/2324709618781174
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2710326-2
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  • 10
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    Online Resource
    Dissociation of Noncovalently Held Polymers of Human and Rabbit IgM
    SAGE Publications ; 1970
    In:  Experimental Biology and Medicine Vol. 134, No. 3 ( 1970-07-01), p. 667-671
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 134, No. 3 ( 1970-07-01), p. 667-671
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/00379727-134-34857
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1970
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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