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  • 1
    Online Resource
    Online Resource
    Entry Site Is Associated With Aortic Enlargement After Pre-emptive Endovascular Repair for Uncomplicated Type B Aortic Dissection
    SAGE Publications ; 2023
    In:  Journal of Endovascular Therapy
    Details
    In: Journal of Endovascular Therapy, SAGE Publications
    Abstract: We aimed to examine the mid-term results corresponding to the entry site in patients who underwent pre-emptive thoracic endovascular aortic aneurysm repair (TEVAR) for uncomplicated type B aortic dissection (TBAD). Methods: We included 27 patients who underwent pre-emptive TEVAR for uncomplicated TBAD between September 2014 and December 2019. We divided the patients into 2 groups depending on the proximal landing zone (zone 2 group, zone ≥3 group) and retrospectively analyzed the risk of all-cause and aorta-related mortality, aortic events (rupture, open conversion, and secondary intervention), and aortic enlargement (≥5 mm). Results: The median age of the patients was 53 (47–65) years. The median duration from the onset of uncomplicated TBAD to TEVAR was 43 (30–99) days, and the median follow-up duration was 48 (36–57) months. The maximum preoperative diameter of the dissected aorta was 40 mm in the zone 2 group and 35 mm in the zone ≥3 group (p=0.134). There was no case of hospital death or spinal cord ischemia; however, there was 1 (3.7%) case of perioperative stroke in the zone 2 group. Multivariate analysis of the risk factors for aortic enlargement following pre-emptive TEVAR for uncomplicated TBAD revealed that only zone 2 landing was an independent risk factor. The estimated Kaplan-Meier curve showed a higher rate of aortic enlargement in the zone 2 group at 4 years after pre-emptive TEVAR (46.4% vs 0%, log-rank test; p=0.011). Conclusions: In this study on TBAD, we found that zone 2 landing was associated with aortic enlargement after pre-emptive TEVAR. In cases where the distance from the left subclavian artery to a major entry point was short, there were more cases of aortic dilatation. Clinical Impact The effectiveness of entry closure for type B aortic dissection was demonstrated in the INSTEAD XL trial. The cause of aortic enlargement after pre-emptive endovascular treatment for type B aortic dissection remains controversial. In the present study, zone 2 landing was a risk factor for aortic enlargement after pre-emptive thoracic endovascular aortic aneurysm repair (TEVAR) for uncomplicated type B dissection. Patients with zone 2 landing should be closely followed up after pre-emptive TEVAR.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    URL: Article
    DOI: 10.1177/15266028231161224
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2049858-5
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  • 2
    Online Resource
    Online Resource
    Immunoreactive Glucagon in the Smooth Muscle Cells of the Rat Cerebral Artery: An Immunohistochemical Analysis
    SAGE Publications ; 1984
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 4, No. 2 ( 1984-06), p. 305-307
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 4, No. 2 ( 1984-06), p. 305-307
    Abstract: The presence of immunoreactive glucagon (IRG) in smooth muscle of the cerebral arteries of rats was demonstrated immunohistochemically using two antisera against pancreatic glucagon, OAL-123 and Unger's 30K. Based on the results and on our previous radioimmunoassay and gel filtration study, the smooth muscle cells of the blood vessels may be one of the extrapancreatic sources of IRG in the plasma.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/jcbfm.1984.43
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1984
    detail.hit.zdb_id: 2039456-1
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  • 3
    Online Resource
    Online Resource
    Why are Infant Gerbils More Resistant Than Adults to Cerebral Infarction after Carotid Ligation?
    SAGE Publications ; 1983
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 3, No. 3 ( 1983-09), p. 381-385
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 3, No. 3 ( 1983-09), p. 381-385
    Abstract: Younger gerbils have been found to be more resistant than adults to cerebral infarction after carotid ligation. In this study, the perfused cerebral area after bilateral common carotid occlusion was evaluated in infant, young, and adult Mongolian gerbils by the carbon black perfusion method to assess the existence and significance of collateral blood vessels between the vertebrobasilar and carotid circulations. Nineteen gerbils were divided into three groups (i.e., infant, young and adult gerbils aged 3–4, 5–7, and 10–17 weeks, respectively). After bilateral common carotid artery occlusion, carbon black was injected directly into the left ventricle by cardiac puncture through the closed thorax. In five of eight infant gerbils, the whole brain was perfused by carbon black, while in the remaining three, only the cerebellum and brainstem were stained well, and marked bilateral cerebral pallor was observed. On the other hand, carbon black did not perfuse the brain region supplied by the carotid arteries, both in young and adult gerbils (11 animals in total). These results suggest that infant gerbils might have a more highly developed network of collateral blood vessels between the vertebrobasilar and carotid circulations, and the existence of such a significant network might be the basis for the fact that infant gerbils are resistant to cerebral infarction following carotid ligation. We propose that gerbils should be used as a stroke model only when they are 5 weeks old or older.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/jcbfm.1983.55
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1983
    detail.hit.zdb_id: 2039456-1
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  • 4
    Online Resource
    Online Resource
    Total Steroid Intake is Associated With Hospital Mortality in Patients With Pan-Peritonitis due to Colorectal Perforation
    SAGE Publications ; 2022
    In:  The American Surgeon
    Details
    In: The American Surgeon, SAGE Publications
    Abstract: Patients with pan-peritonitis (PP) due to colorectal perforation have high mortality rate because colorectal perforation causes septic shock. The association between total steroid intake (TSI) and hospital mortality of such patients is not clear. Methods One hundred forty-two patients who underwent surgery for PP due to colorectal perforation were reviewed. Patients were divided into two groups by 8000 mg of TSI. The cut-off value of TSI was determined using a receiver operating characteristic curve for hospital mortality. Results The cut-off value of TSI for hospital mortality was 8000 mg. Patients with TSI 〉 8000 mg had high rate of hemodialysis, hospital mortality, and elevated neutrophil ratio ( 〉 95%) compared with those with TSI≤8000 mg. Multivariate analyses revealed that TSI ( 〉 8000/≤8000, mg) (OR, 9.669; 95% CI, 1.011-92.49; P = .049) was significantly associated with hospital mortality as well as bleeding volume ( 〉 1000/≤1000, mL) (OR, 26.08; 95% CI, 3.566-190.4; P = .001), lymphocyte ratio (≤4/ 〉 4, %) (OR, 7.988; 95% CI, 1.498-42.58; P = .015) and C-reactive protein (≤7.5/ 〉 7.5, mg/dL) (OR, 41.66; 95% CI, 4.784-33.33; P = .001). Discussion There was a significant association between TSI and hospital mortality in patients with PP due to colorectal perforation as well as intraoperative bleeding and systemic inflammatory markers.
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/00031348221136576
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    CD3 and CD20 co-expression in a case of canine peripheral T-cell lymphoma with prominent cardiac and peripheral nerve involvement
    SAGE Publications ; 2018
    In:  Journal of Veterinary Diagnostic Investigation Vol. 30, No. 5 ( 2018-09), p. 779-783
    Details
    In: Journal of Veterinary Diagnostic Investigation, SAGE Publications, Vol. 30, No. 5 ( 2018-09), p. 779-783
    Abstract: An 8-y 9-mo-old male Pug dog was presented because of anorexia, hindlimb ataxia, vomiting, and progressive weight loss. Clinical examinations revealed atrophic hindlimb muscles with decreased postural reaction, enlargement of the cardiac silhouette and megaesophagus on radiograph, and reduced cardiac contractility on ultrasonography. The dog died 10 d after the initial examination, and an autopsy was performed. Grossly, the heart was enlarged, with multifocal-to-coalescing extensive plaque-like areas of discoloration on the epicardial surface. On cross-section, the ventricles were moderately dilated, and discoloration extended into the myocardium. Peripheral lymph nodes were of normal size. Histologically, atypical lymphoid cells replaced the myocardium and also extensively infiltrated peripheral nerve bundles in various organs. With immunohistochemistry, the neoplastic cells exhibited strong immunoreactivity for CD3 and CD20, and were negative for CD8, granzyme B, CD79α, and Pax5. Double-label immunofluorescence confirmed co-expression of CD3 and CD20 by the neoplastic cells. Molecular clonality analysis presented a clonal T-cell receptor gamma gene rearrangement. The case was diagnosed as a CD3+/CD20+ peripheral T-cell lymphoma with prominent cardiac and peripheral nerve involvement, indicating neurolymphomatosis.
    Type of Medium: Online Resource
    ISSN: 1040-6387 , 1943-4936
    URL: Article
    DOI: 10.1177/1040638718794765
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2265211-5
    SSG: 22
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  • 6
    Online Resource
    Online Resource
    Reversal of Neurological Deficits by Levallorphan in Patients with Acute Ischemic Stroke
    SAGE Publications ; 1985
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 5, No. 3 ( 1985-09), p. 469-472
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 5, No. 3 ( 1985-09), p. 469-472
    Abstract: This study was conducted to examine the effect of the intramuscular injection of levallorphan tartrate (1.0 mg), a mixed agonist-antagonist opiate, on the neurological signs, symptoms, and vital signs in 19 patients with acute ischemic stroke. A temporary improvement of hemiplegia or hemiparesis was observed within several minutes after levallorphan injection in 13 of the patients. There were no significant alterations in blood pressure or pulse rate after injection. The findings indicate that levallorphan may have a temporary improving effect on neurological deficits in acute ischemic stroke. In addition, observation of the response to levallorphan may serve to predict the prognosis of the final neurological outcome in this type of patient.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/jcbfm.1985.64
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1985
    detail.hit.zdb_id: 2039456-1
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