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  • SAGE Publications  (11)
  • 1
    Online Resource
    Online Resource
    Neutrophil to Lymphocyte Ratio as a Predictor of Restenosis After Angioplasty and Stenting for Asymptomatic Carotid Stenosis
    SAGE Publications ; 2019
    In:  Angiology Vol. 70, No. 2 ( 2019-02), p. 160-165
    Details
    In: Angiology, SAGE Publications, Vol. 70, No. 2 ( 2019-02), p. 160-165
    Abstract: The inflammatory response plays a vital role in the development of in-stent restenosis (ISR) after carotid angioplasty and stenting (CAS). The neutrophil to lymphocyte ratio (NLR) has been suggested as a sensitive inflammatory marker. We explored the association between NLR and ISR in CAS patients. A total of 427 patients who underwent CAS were enrolled. Neutrophil to lymphocyte ratio was measured before the procedure. Clinical examination and radiographic evaluation were performed at 6 months and annually after the procedure. In-stent restenosis was defined as ≥50% stenosis in the treated lesion. Cox regression was used to identify predictors of ISR after CAS. Of the 459 arteries (in 427 patients) with CAS, 72 (15.7%) were identified with ISR during a mean follow-up of 14.6 (19.1) months (range, 0.7-120.7 months). Increased NLR (≥2.13) was significantly related to ISR in patients with asymptomatic stenosis ( P = .001). However, significance was not observed in symptomatic stenosis. On multivariate analysis, baseline NLR ≥ 2.13 (hazard ratio [HR], 2.74; 95% confidence interval [CI] , 1.46-5.14), smoking (HR, 1.99; 95% CI, 1.11-3.58), residual stenosis (HR, 1.12; 95% CI, 1.09-1.15), and baseline glucose level (HR, 1.01; 95% CI, 1.01-1.02) were associated with ISR. Elevated NLR may be a predictor of ISR after CAS for asymptomatic stenosis.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319718784805
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2065911-8
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  • 2
    Online Resource
    Online Resource
    Association Between Anemia Status and the Risk of Different Types of Heart Failure: A RCSCD-TCM Study in China
    SAGE Publications ; 2023
    In:  Angiology
    Details
    In: Angiology, SAGE Publications
    Abstract: We investigated the association between anemia status and the risk of heart failure (HF) in patients with coronary heart disease (CHD) based on a multi-center, large-sample and retrospective cross-sectional study including 89,207 patients. Heart failure was categorized as HF with reduced ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF), and HF with mid-range ejection fraction (HFmrEF). In multi-adjusted models, compared with patients without anemia, mild anemia (odds ratio [OR] 1.71; 95% confidence interval [CI] 1.53–1.91; P 〈 .001), moderate anemia (OR 3.68; 95% CI, 3.25–4.17; P 〈 .001), and severe anemia (OR 8.02; 95% CI, 6.50–9.88; P 〈 .001) were associated with the risk of HF among CHD patients. Men aged 〈 65 years were more likely to develop HF. In subgroup analyses, the multi-adjusted ORs and 95% CI of HFpEF, HFrEF, and HFmrEF related to anemia were 3.24 (95% CI 1.43–7.33), 2.22 (95% CI 1.28–3.84), and 2.55 (95% CI 2.24–2.89), respectively. These findings suggest that anemia might be associated with increased risk of different types of HF, especially HFpEF.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/00033197231161908
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2065911-8
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  • 3
    Online Resource
    Online Resource
    Life span and motility effects of ethanolic extracts from Sophora moorcroftiana seeds on Caenorhabditis elegans
    SAGE Publications ; 2016
    In:  Pharmacognosy Magazine Vol. 0, No. 0 ( 2016), p. 0-
    Details
    In: Pharmacognosy Magazine, SAGE Publications, Vol. 0, No. 0 ( 2016), p. 0-
    Type of Medium: Online Resource
    ISSN: 0973-1296
    URL: Article
    DOI: 10.4103/0973-1296.179652
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2274976-7
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  • 4
    Online Resource
    Online Resource
    Study on the mechanism of the formation of polygon-shaped wheels on subway vehicles
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit Vol. 230, No. 1 ( 2016-01), p. 129-137
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit, SAGE Publications, Vol. 230, No. 1 ( 2016-01), p. 129-137
    Abstract: This paper discusses the mechanism responsible for the formation of polygon-shaped wheels; the aim is to solve the problem of their occurrence on subway vehicles. This phenomenon occurs mainly as a result of wheel/rail vertical forces created by the vibration of the wheelset over several complete revolutions of the wheel. In addition, a relationship linking the phase angle between two adjacent vertices, the main vibration frequency and running speed of the polygonal wheel is derived. Then, considering a subway vehicle that is powered by a linear induction motor and applying the multi-body system dynamics model, the main frequency of the wheel/rail vertical force under various running speeds is investigated. Analysis of the speed and main frequency value of a subway vehicle covered in this study revealed that a polygonal wheel with nine vertices can be generated in the speed range 72 to 80 km/h.
    Type of Medium: Online Resource
    ISSN: 0954-4097 , 2041-3017
    URL: Article
    DOI: 10.1177/0954409714529269
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2024901-9
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  • 5
    Online Resource
    Online Resource
    Effect of nutritional risk on cognitive function in patients with chronic obstructive pulmonary disease
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 2 ( 2021-02), p. 030006052199012-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 2 ( 2021-02), p. 030006052199012-
    Abstract: We aimed to clarify the cognitive function of patients with chronic obstructive pulmonary disease (COPD) and different nutritional status. Methods Among 95 patients with COPD in this retrospective study, we administered the Nutritional Risk Screening 2002 (NRS 2002) and Mini-Mental State Examination (MMSE). We recorded patients’ clinical characteristics, comorbidities, and laboratory measurements. According to NRS 2002 scores, patients were divided into two groups: no nutritional risk with NRS 2002  〈  3 ( n = 54) and nutritional risk, with NRS 2002 ≥ 3 ( n = 41). Results We found a negative correlation between NRS 2002 and MMSE scores in participants with COPD ( r = −0.313). Patients with nutritional risk were more likely to be cognitively impaired than those with no nutritional risk. Multivariate logistic regression analysis indicated that malnutrition was an independent risk factor for cognitive impairment, after adjusting for confounders (odds ratio [OR] = 4.120, 95% confidence interval [CI] : 1.072–15.837). We found a similar association between NRS 2002 and MMSE scores at 90-day follow-up using a Pearson’s correlation test ( r = −0.493) and logistic regression analysis (OR = 7.333, 95% CI: 1.114–48.264). Conclusions Patients with COPD at nutritional risk are more likely to have cognitive impairment.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060521990127
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 6
    Online Resource
    Online Resource
    Reply to Letter by Dr Demirtas et al “Cerebrovascular Events in Stenting for Carotid Artery Stenosis”
    SAGE Publications ; 2019
    In:  Angiology Vol. 70, No. 2 ( 2019-02), p. 188-188
    Details
    In: Angiology, SAGE Publications, Vol. 70, No. 2 ( 2019-02), p. 188-188
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319718808920
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2065911-8
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  • 7
    Online Resource
    Online Resource
    Life span and motility effects of ethanolic extracts from Sophora moorcroftiana seeds on Caenorhabditis elegans
    SAGE Publications ; 2016
    In:  Pharmacognosy Magazine Vol. 12, No. 46 ( 2016), p. 228-
    Details
    In: Pharmacognosy Magazine, SAGE Publications, Vol. 12, No. 46 ( 2016), p. 228-
    Type of Medium: Online Resource
    ISSN: 0973-1296
    URL: Article
    DOI: 10.4103/0973-1296.182152
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2274976-7
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  • 8
    Online Resource
    Online Resource
    Association of periprocedural perfusion non-improvement with recurrent stroke after endovascular treatment for Intracranial Atherosclerotic Stenosis
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Neurological Disorders Vol. 15 ( 2022-01), p. 175628642211431-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 15 ( 2022-01), p. 175628642211431-
    Abstract: Predictors of recurrent stroke after endovascular treatment for symptomatic intracranial atherosclerotic stenosis (ICAS) remain uncertain. Objectives: Among baseline characteristics, lesion features, and cerebral perfusion changes, we try to explore which factors are associated with the risk of recurrent stroke in symptomatic ICAS after endovascular treatment. Design: Consecutive patients with symptomatic ICAS of 70–99% receiving endovascular treatment were enrolled. All patients underwent whole-brain computer tomography perfusion (CTP) within 3 days before and 3 days after the endovascular treatment. Baseline characteristics, lesion features, and cerebral perfusion changes were collected. Methods: Cerebral perfusion changes were evaluated with RAPID software and calculated as preprocedural cerebral blood flow (CBF)  〈  30%, time to maximum of the residue function (Tmax)  〉  6 s, and Tmax  〉  4 s volumes minus postprocedural. Cerebral perfusion changes were divided into periprocedural perfusion improvement ( 〉 0 ml) and non-improvement (⩽ 0 ml). Recurrent stroke within 180 days was collected. The Cox proportional hazards analysis analyses were performed to evaluate factors associated with recurrent stroke. Results: From March 2021 to December 2021, 107 patients with symptomatic ICAS were enrolled. Of the 107 enrolled patients, 30 (28.0%) patients underwent balloon angioplasty alone and 77 patients (72.0%) underwent stenting. The perioperative complications occurred in three patients. Among CBF  〈  30%, Tmax  〉  6 s, and Tmax  〉  4 s volumes, Tmax  〉  4 s volume was available to evaluate cerebral perfusion changes. Periprocedural perfusion improvement was found in 77 patients (72.0%) and non-improvement in 30 patients (28.0%). Nine patients (8.4%) suffered from recurrent stroke in 180-day follow-up. In Cox proportional hazards analysis adjusted for age and sex, perfusion non-improvement was associated with recurrent stroke [hazards ratio (HR): 4.472; 95% CI: 1.069–18.718; p = 0.040]. Conclusion: In patients with symptomatic ICAS treated with endovascular treatment, recurrent stroke may be related to periprocedural cerebral perfusion non-improvement. Registration: http://www.chictr.org.cn . Unique identifier: ChiCTR2100052925.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/17562864221143178
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2442245-9
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  • 9
    Online Resource
    Online Resource
    Association between basilar artery stenosis features, vertebral artery stenosis and perforator stroke after stenting
    SAGE Publications ; 2023
    In:  Interventional Neuroradiology
    Details
    In: Interventional Neuroradiology, SAGE Publications
    Abstract: We investigated the relationship between basilar artery (BA) atherosclerotic stenosis features and vertebral artery (VA) stenosis and explored whether BA stenosis features are associated with perforator stroke after stenting. Methods Patients with BA stenosis who underwent HRMRI and DSA were recruited. Patients were divided into proximal BA stenosis and middle-or-distal BA stenosis groups, and then subgroup analyses were performed based on whether they had VA stenosis. BA plaque features were evaluated by HRMRI. Artery stenosis was measured by DSA. The incidence of perforator stroke after BA stenting was recorded, and the potential association between BA stenosis features and perforator stroke was analyzed. Results One hundred and seventy-four patients were consecutively enrolled. Patients with proximal BA stenosis had a higher proportion of severe stenosis than those with middle-or-distal BA stenosis ( P = 0.027). In the subgroup analysis, this difference mainly existed in patients complicated with VA stenosis ( P = 0.023). Patients with proximal BA stenosis had a higher proportion of strong plaque enhancement than those with middle-or-distal BA stenosis ( P  〈  0.001), especially in those with vertebrobasilar junction (VBJ) stenosis ( P  〈  0.001). Perforator stroke after BA stenting occurred in five patients, of whom four had lateral wall BA plaques, four had plaque enhancement and four had proximal BA stenosis. Conclusion Patients with proximal BA stenosis had a higher proportion of severe stenosis and strong plaque enhancement, particularly in patients complicated with VA stenosis and VBJ stenosis. Perforator stroke after BA stenting may be related to distribution, burden and characteristics of BA lesions.
    Type of Medium: Online Resource
    ISSN: 1591-0199 , 2385-2011
    URL: Article
    DOI: 10.1177/15910199231164840
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2571161-1
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  • 10
    Online Resource
    Online Resource
    Fraction From Lycium barbarum Polysaccharides Reduces Immunotoxicity and Enhances Antitumor Activity of Doxorubicin in Mice
    SAGE Publications ; 2018
    In:  Integrative Cancer Therapies Vol. 17, No. 3 ( 2018-09), p. 860-866
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 17, No. 3 ( 2018-09), p. 860-866
    Abstract: The aim of the present study was to investigate whether fraction from Lycium barbarum polysaccharide (LBP) could reduce immunotoxicity and enhance antitumor activity of doxorubicin (Dox) in mice. A water-soluble LBP fraction, designated LBP3, was isolated from edible Chinese herbal Lycium barbarum and used in this study. To investigate the effect of LBP3 on Dox-induced immunotoxicity, tumor-free mice were used and treated with either normal saline, Dox, or Dox plus LBP3. To investigate the effect of LBP3 on antitumor activity of Dox, H22 tumor-bearing mice were used and treated with either normal saline, Dox, LBP3, or Dox plus LBP3. The results showed that LBP3 did not protect against the body weight loss caused by Dox, but it promoted the recovery of body weight starting at day 5 after Dox treatment in tumor-free mice. LBP3 also improved peripheral blood lymphocyte counts, promoted cell cycle recovery in bone marrow cells, and restored the cytotoxicity of natural killer cells. Furthermore, in H22 tumor-bearing mice, LBP3 enhanced antitumor activity of Dox and improved peripheral blood lymphocyte counts and the cytotoxicity of splenocytes. In brief, our results demonstrated that LBP3 could reduce the immunotoxicity and enhance antitumor activity of Dox.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735417753544
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2101248-9
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