In:
Journal of International Medical Research, SAGE Publications, Vol. 46, No. 3 ( 2018-03), p. 1063-1072
Abstract:
To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients. Methods This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T 0 ), skin incision (T 1 ), cutting the gallbladder (T 2 ), suturing the peritoneum (T 3 ), skin closure (T 4 ), sputum suction (T 5 ), extubation (T 6 ) and 1 min (T 7 ), 5 min (T 8 ), 10 min (T 9 ), and 15 min (T 10 ) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T 7 , T 8 , T 9 and T 10 were recorded. Results A total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T 5 , T 6 , T 7 and T 8 ; and the Steward recovery scores at T 7 and T 8 were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C. Conclusion Creatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients.
Type of Medium:
Online Resource
ISSN:
0300-0605
,
1473-2300
DOI:
10.1177/0300060517744957
Language:
English
Publisher:
SAGE Publications
Publication Date:
2018
detail.hit.zdb_id:
2082422-1
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