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  • 1
    Online Resource
    Online Resource
    Follow-up Management of Patients After Transsphenoidal Approach for Resection of Pituitary Adenomas
    SAGE Publications ; 2020
    In:  American Journal of Rhinology & Allergy Vol. 34, No. 2 ( 2020-03), p. 150-155
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 34, No. 2 ( 2020-03), p. 150-155
    Abstract: Endoscopic transsphenoidal adenomectomy (eTSA) is widely utilized for resection of pituitary adenoma. eTSA patients undergo healing for weeks to months and are potentially at risk for complications. Multidisciplinary follow-up monitoring is necessary. We hypothesized that patients with deviations from the routine postoperative course, broadly termed complications of interest (COI) in this study, following eTSA would increase the duration of follow-up in the rhinology clinic. Methods Retrospective review was performed on patients undergoing eTSA for pituitary adenoma from August 2007 to May 2016 at a single tertiary care center. COIs were reviewed for their influence on follow-up time. Results A total of 985 patient records were reviewed (mean age 51.0 ± 15.7 years, 55.2% female), of which, 21.1% of patients had a deviation from the expected postoperative course (7.0% rhinologic, 10.8% surgical, 0.6% perioperative medical, and 2.7% endocrinologic COIs). The most common COI was cerebrospinal fluid leak 5.6% (n = 55) followed by sinusitis 5.0% (n = 49). Moreover, 935 patients (94.9%) attended rhinology follow-up (172 patients with COI). For patients seen postoperatively by the rhinology service, COIs significantly increased the number of rhinologic follow-up visits (median 2 [interquartile range, IQR: 2–3] vs 3 visits [IQR: 2–4], P  〈  .001), duration of rhinologic follow-up (median 54.0 days [IQR: 43.0–104.0] vs 88.0 days [IQR: 54.5–242.0] , P  〈  .001), and duration of overall multidisciplinary follow-up (median 354.0 days [IQR: 104.0–789.0] vs 537.0 days [IQR: 171.5–1313.5] , P  〈  .001), compared to those without COIs. Conclusions Patients who develop postoperative complications after eTSA have significantly extended follow-up with the multidisciplinary team.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.1177/1945892419879806
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2554548-6
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  • 2
    Online Resource
    Online Resource
    Cognitive-Behavioural Group Therapy for Hong Kong Chinese Adults with Mental Health Problems
    SAGE Publications ; 1991
    In:  Australian & New Zealand Journal of Psychiatry Vol. 25, No. 4 ( 1991-12), p. 524-534
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 25, No. 4 ( 1991-12), p. 524-534
    Abstract: Ninety-one Chinese in the community, aged between 18 and 45, with mental health problems ranging from mild to moderate degree, were treated by cognitive behavioural group therapy (CBGT) for a period of 3 months. All subjects were assessed on multiple measures at 4 time points: screening, pre-treatment (after 3 months), post-treatment and at 3-month follow-up. Attendance was good. A standard practice manual was developed to ensure consistent treatment by 2 group workers. After controlling for the placebo effect in the waiting period, treatment effect was demonstrated which was sustained after a three month period. The all-round improvement included a decrease in psychiatric symptoms, improvement in self-assessment, better and more social activities and being more able to cope with problems. In terms of psychiatric diagnosis, depressed subjects gained the most benefit and personality disorder subjects the least. Parents seemed to benefit more than non-parents.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.3109/00048679109064446
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1991
    detail.hit.zdb_id: 2003849-5
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  • 3
    Online Resource
    Online Resource
    A Community Study of Preschool Behaviour Disorder in New Zealand
    SAGE Publications ; 1995
    In:  Australian & New Zealand Journal of Psychiatry Vol. 29, No. 3 ( 1995-09), p. 454-462
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 29, No. 3 ( 1995-09), p. 454-462
    Abstract: A two stage epidemiological study of 320 children aged between 2.5 and 5 years of age, from eight randomly selected preschool centres, was performed in order (1) to test the psychometrics of the Behaviour Check List (BCL), a parent report instrument for preschool children, (2) to estimate the prevalence, and (3) to describe the correlates of preschool behaviour disorder. After the initial screening using the BCL, the Hyperactivity Scale (HAS) and the Internalising Disorder Scale (IDS), parents were interviewed using the Behaviour Screening Questionnaire (BSQ); the children were examined using the Rutter and Graham's interview. Data was also collected on family functioning, maternal mental health, social adversity, development, physical health and perinatal history. The BCL was found to be a reliable and valid screening measure. A cut off point of 8+ was established for New Zealand preschoolers; this is lower than that in the UK sample, illustrating the importance of retesting the instruments in a different culture. The prevalence rate of behaviour problems based on clinical diagnosis was 22.5%. Results of logistic regression analysis showed that poor family functioning, poor maternal mental health and parental separation were associated significantly with behaviour disorder. This study emphasises the need to identify preschool behaviour disorder and associated risk factors to enable an early intervention.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.3109/00048679509064954
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1995
    detail.hit.zdb_id: 2003849-5
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  • 4
    Online Resource
    Online Resource
    Evaluation of In-Office Cryoablation of Posterior Nasal Nerves for the Treatment of Rhinitis
    SAGE Publications ; 2021
    In:  Allergy & Rhinology Vol. 12 ( 2021-01), p. 215265672098856-
    Details
    In: Allergy & Rhinology, SAGE Publications, Vol. 12 ( 2021-01), p. 215265672098856-
    Abstract: Chronic rhinitis is a common condition generally treated with medical therapies. However, 10–22% of patients are refractory to medical therapies. A cryotherapy handheld device targeting the postganglionic nerve fibers of the posterior nasal nerve (PNN) now serves as an additional option for therapy. This study evaluates the efficacy of the cryosurgical ablation device of the PNN in the clinic setting. Methods This was a prospective single-arm trial of 24 adult patients at seven locations within a large health maintenance organization. Patients with chronic rhinitis that failed medical therapy were offered an in-office cryoablation of PNN. Patients completed the Total Nasal Symptom Score (TNSS) questionnaire consisting of 5 items reported based on the previous 12 hours and 2 weeks at the following time points: pre-treatment, 30 days, 90 days and 1 year post-treatment. Results Following cryoablation of the PNN, the TNSS 12-hour symptom score improved from 6.92 (±2.9) to 3.17 (±2.4, P  〈  0.001) at 30 days, 2.92 (±1.4, P  〈  0.001) at 90 days and 3.08 (±2.6, P  〈  0.001) at 1 year post treatment. Similar results were noted for the 2 weeks scores improving from 7.75 (±3.1) to 3.79 (±2.1, P  〈  0.001) at 30 days, 3.88 (±1.9, P  〈  0.001) at 90 days and 3.76 (±2.1, P  〈  0.001) at 1 year post-treatment. 64.7% of respondents stated the procedure decreased or eliminated nasal sprays. Conclusions Our independent evaluation of cryoablation of the PNN shows improvement in nasal symptoms over a 1 year period and is consistent with other published data.
    Type of Medium: Online Resource
    ISSN: 2152-6567 , 2152-6567
    URL: Article
    DOI: 10.1177/2152656720988565
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 3162459-5
    detail.hit.zdb_id: 2675684-5
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  • 5
    Online Resource
    Online Resource
    Silver Nanoparticles Inhibit Hepatitis B virus Replication
    SAGE Publications ; 2008
    In:  Antiviral Therapy Vol. 13, No. 2 ( 2008-02), p. 253-262
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 13, No. 2 ( 2008-02), p. 253-262
    Abstract: Silver nanoparticles have been shown to exhibit promising cytoprotective activities towards HIV-infected T-cells; however, the effects of these nanoparticles towards other kinds of viruses remain largely unexplored. The aim of the present study was to investigate the effects of silver nanoparticles on hepatitis B virus (HBV). Methods Monodisperse silver nanoparticles with mean particle diameters of ∼10 nm (Ag10Ns) and ∼50 nm (Ag50Ns) were prepared from AgNO 3 in HEPES buffer. The in vitro anti-HBV activities of these particles were determined using the HepAD38 cell line as infection model. Results Ag10Ns and Ag50Ns were able to reduce the extracellular HBV DNA formation of HepAD38 cells by 〉 50% compared with the vehicle control (that is, HepAD38 cells in the absence of silver nanoparticles). Silver nanoparticles had little effect on the amount of HBV covalently closed circular DNA (cccDNA), but could inhibit the formation of intracellular HBV RNA. Gel mobility shift assays indicated that Ag10Ns bound HBV double-stranded DNA at a DNA:silver molar ratio of 1:50; an absorption titration assay showed that the nanoparticles have good binding affinity for HBV DNA with a binding constant ( K b ) of (8.8 ±1.0)x10 5 dm 3 mol -1 . As both the viral and Ag10Ns systems are in the nanometer size range, we found that Ag10Ns could directly interact with the HBV viral particles as revealed by transmission electronic microscopy. Conclusions Silver nanoparticles could inhibit the in vitro production of HBV RNA and extracellular virions. We hypothesize that the direct interaction between these nanoparticles and HBV double-stranded DNA or viral particles is responsible for their antiviral mechanism.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350801300210
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Evaluation of Outcome in Child and Adolescent Mental Health Services: Children with Persistent Conduct Problems
    SAGE Publications ; 2001
    In:  Clinical Child Psychology and Psychiatry Vol. 6, No. 1 ( 2001-01), p. 109-124
    Details
    In: Clinical Child Psychology and Psychiatry, SAGE Publications, Vol. 6, No. 1 ( 2001-01), p. 109-124
    Abstract: This article focuses on the evaluation of outcome in child and adolescent mental health services. We examined the outcomes of 46 children with persistent conduct problems by gathering at baseline and six months information from multiple informants on multiple domains including the functioning of the child, risk factors, and parents’ and children’s perceptions of the treatment process. A statistically significant reduction in oppositional/conduct symptoms was reported six months after the initial clinical contact. However, the majority of the group still scored within the clinical range. The various outcome measures are correlated to only a mild to moderate degree. Teachers did not notice the same degree of change at school, despite the changes noticed by parents. Symptom improvement and satisfaction with a service are two separate issues. Parents’ satisfaction was related to their perception of the therapist and the therapy offered. Their satisfaction was high if they perceived that the therapist was able to communicate well, show care and concern, and if the therapy was perceived as organized. Much can be learned from a comprehensive outcome measurement system within a mental health service.
    Type of Medium: Online Resource
    ISSN: 1359-1045 , 1461-7021
    URL: Article
    DOI: 10.1177/1359104501006001009
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2004602-9
    SSG: 5,2
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  • 7
    Online Resource
    Online Resource
    Children who are Cruel to Animals: A Revisit
    SAGE Publications ; 1999
    In:  Australian & New Zealand Journal of Psychiatry Vol. 33, No. 1 ( 1999-02), p. 29-36
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 33, No. 1 ( 1999-02), p. 29-36
    Abstract: Objective: There is a paucity of research regarding children who are cruel to animals (CTA). Previous studies have suggested that being CTAis linked with recurrent aggression in adulthood. In this report, children with persistent conduct problems who are CTA are examined. Method: Aclinic-referred sample of 141 children and a community sample of 36 children between the ages of 5–12 were assessed using a test battery of questionnaires for parents, teachers and the child on mental health symptoms, self-perception, demographics and psychosocial factors. Forty of the clinic-referred children and one of the community group were rated by their parents as sometimes or definitely cruel to animals. The CTA, non-CTAand community samples were compared. Results: The CTA group had more conduct symptoms compared with the non-CTA group. However, the older CTA group unexpectedly reported a higher self-esteem compared with the non-CTA group. There was no significant difference between the two clinic-referred groups in gender, attention deficit hyperactivity disorder and internalising symptoms, and psychosocial factors. Conclusion: Being CTA is possibly a marker of a subgroup of conduct disorder which has a poor prognosis.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.1046/j.1440-1614.1999.00528.x
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1999
    detail.hit.zdb_id: 2003849-5
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  • 8
    Online Resource
    Online Resource
    Stroma-Rich Castleman's Disease with Superimposed Kikuchi's Lymphadenitis-Like Changes
    SAGE Publications ; 1997
    In:  International Journal of Surgical Pathology Vol. 4, No. 4 ( 1997-04), p. 197-201
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 4, No. 4 ( 1997-04), p. 197-201
    Abstract: The authors report a retroperitoneal lesion showing the hitherto undescribed coexistence of hyaline-vascular Castleman's disease and Kikuchi's lymphadenitis-like changes, the only feature in common for these two disease processes being the consistent presence of plasmacytoid monocytes (plasmacytoid T-cells). The Castleman's disease was classifiable as the stroma-rich variant, with broad interfollicular zones occupying 90% of the cross-sectional areas. The interfollicular regions were rich in atypical plump spindly cells with indistinct cell borders, oval nuclei, vesicular chromatin, and distinct nucleoli; they were disposed in fascicles and whorls around and between the hyaline-vascular follicles. The exact nature of these atypical stromal cells could not be ascertained because they were immunohistochemically inert except for vimentin expression. Scattered throughout the interfollicular areas were multiple discrete foci comprising plasmacytoid monocytes, karyorrhectic debris, activated lymphoid cells, histiocytes with twisted nuclei and crescentic histiocytes, as characteristic of Kikuchi's lymphadenitis. Although the coexistence of Castleman's disease and Kikuchi's lymphadenitis-like changes can be coincidental, it is also possible that the latter might represent an unusual aberrant local immune reaction to the stromal overgrowth in the Castleman's lesion.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/106689699700400401
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
    detail.hit.zdb_id: 2070102-0
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  • 9
    Online Resource
    Online Resource
    Comparison of Treatments of Persistent Conduct Problems in Primary School Children: A Preliminary Evaluation of a Modified Cognitive-Behavioural Approach
    SAGE Publications ; 1998
    In:  Australian & New Zealand Journal of Psychiatry Vol. 32, No. 3 ( 1998-06), p. 379-386
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 32, No. 3 ( 1998-06), p. 379-386
    Abstract: Objective: Treatment for persistent conduct problems in primary school children was developed using a modification of cognitive-behavioural therapy (MCBT). Its effectiveness was evaluated by comparing it with conjoint family therapy (FT) and eclectic therapy (ET). Method: Children with persistent conduct problems were randomly assigned to one of three treatment groups. They were assessed prior to treatment and then 6 months after. Measures included symptoms of the child; parents' mental health; stress of parenting; family functioning; and parental relationship. In addition, parents' and children's perception of the therapy were assessed and a treatment record was developed to track the treatment process. Results: Thirty-two children were recruited for the study. No statistically significant differences were found in terms of effectiveness between the three groups. In terms of parents' perception of the therapy, there was no difference on the perception of the qualities of the therapists, but on the perception of therapy MCBT was considered to be higher in cognitive-behavioural orientation. Conclusion: Further research using a larger sample is required to evaluate MCBT. The study supports the idea that controlled treatment studies can be carried out within busy mental health services.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.3109/00048679809065530
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 2003849-5
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