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  • SAGE Publications  (327)
  • 1
    Online Resource
    Online Resource
    B-Cell–Derived TGF-β1 Inhibits Osteogenesis and Contributes to Bone Loss in Periodontitis
    SAGE Publications ; 2023
    In:  Journal of Dental Research Vol. 102, No. 7 ( 2023-07), p. 767-776
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 102, No. 7 ( 2023-07), p. 767-776
    Abstract: B cells play a vital role in the elimination of periodontal pathogens, the regulation of the immune response, and the induction of tissue destruction. However, the role of B cells in the dysfunction of mesenchymal stem cell (MSC) differentiation to osteoblasts in periodontitis (PD) has been poorly studied. Here we show that the frequency of CD45 − CD105 + CD73 + MSCs in inflamed periodontal tissues is significantly decreased in patients with PD compared with that of healthy controls. CD19 + B cells dominate the infiltrated immune cells in periodontal tissues of patients with PD. Besides, B-cell depletion therapy reduces the alveolar bone loss in a ligature-induced murine PD model. B cells from PD mice express a high level of TGF-β1 and inhibit osteoblast differentiation by upregulating p-Smad2/3 expression and downregulating Runx2 expression. The inhibitory effect of PD B cells on osteoblast differentiation is reduced by TGF-β1 neutralization or Smad2/3 inhibitor. Importantly, B-cell–specific knockout of TGF-β1 in PD mice significantly increases the number of CD45 − CD105 + Sca1 + MSCs, ALP-positive osteoblast activity, and alveolar bone volume but decreases TRAP-positive osteoclast activity compared with that from control littermates. Lastly, CD19 + CD27 + CD38 − memory B cells dominate the B-cell infiltrates in periodontal tissues from both patients with PD and patients with PD after initial periodontal therapy. Memory B cells in periodontal tissues of patients with PD express a high level of TGF-β1 and inhibit MSC differentiation to osteoblasts. Thus, TGF-β1 produced by B cells may contribute to alveolar bone loss in periodontitis, in part, by suppressing osteoblast activity.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/00220345231161005
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2057074-0
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  • 2
    Online Resource
    Online Resource
    The Growth Hormone Receptor Gene is Associated with Mandibular Height in a Chinese Population
    SAGE Publications ; 2005
    In:  Journal of Dental Research Vol. 84, No. 11 ( 2005-11), p. 1052-1056
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 84, No. 11 ( 2005-11), p. 1052-1056
    Abstract: Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor ( GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial morphology and single-nucleotide polymorphisms (SNPs) in GHR in an unselected healthy Chinese population. We systematically screened the 10 exons and nearby introns of GHR and identified 6 SNPs. Using 4 SNPs as markers, we studied the relationships between genotypes and craniofacial linear measurements. Individuals with the genotype CC of polymorphism I526L had a significantly greater mandibular ramus length (condylion-gonion/ articulare-gonion) than those with genotype AC or AA. Haplotype analysis showed that there were also significant differences between the long and short mandibular height groups in an extreme population. Our results indicate that the GHR gene polymorphism I526L is associated with mandibular height in the Chinese population.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/154405910508401116
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2057074-0
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  • 3
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    Online Resource
    The Synergistic Therapeutic Effect of Temozolomide and Hyperbaric Oxygen on Glioma U251 Cell Lines is Accompanied by Alterations in Vascular Endothelial Growth Factor and Multidrug Resistance-Associated Protein-1 Levels
    SAGE Publications ; 2012
    In:  Journal of International Medical Research Vol. 40, No. 3 ( 2012-06), p. 995-1004
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 40, No. 3 ( 2012-06), p. 995-1004
    Abstract: OBJECTIVE: Temozolomide (TMZ) is an oral alkylating agent widely used in the treatment of refractory glioma. Its efficacy is limited, however, by poor cancer cell penetration and drug resistance. The present study, therefore, aimed to investigate whether hyperbaric oxygen (HBO) may facilitate drug delivery and enhance the anticancer effect of TMZ. METHODS: Cultured glioma U251 cells were treated with HBO, TMZ, or TMZ + HBO, or were untreated (controls). Rates of growth inhibition, cell death and apoptosis were investigated using the 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl-2 H-tetrazolium bromide (MTT) assay, propidium iodide staining and flow cytometry, respectively. Protein levels of vascular endothelial growth factor (VEGF) and multidrug resistance-associated protein-1 (MRP-1) were evaluated by enzyme-linked immunosorbent assay. RESULTS: Compared with TMZ or HBO alone, combined treatment with both therapies synergistically inhibited growth and induced apoptosis and death of cultured glioma U251 cells, which was accompanied by a significant decrease in levels of VEGF and MRP-1. CONCLUSIONS: TMZ and HBO synergistically induced the apoptosis of glioma cells, possibly through reduced vascularization and inhibition of drug resistance. The combination of TMZ and HBO may be a powerful treatment for malignant glioma.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323001204000318
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2082422-1
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  • 4
    Online Resource
    Online Resource
    Dynamic behaviours of the rotor non-linear system with fixed—tilting-pad journal bearings support
    SAGE Publications ; 2010
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 224, No. 10 ( 2010-10-01), p. 1037-1047
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 224, No. 10 ( 2010-10-01), p. 1037-1047
    Abstract: The variational constraint approach is used to calculate the non-linear oil force of fixed—tilting-pad journal bearings. The non-linear oil force of a single pad is calculated by the proposed method in its coordinate system and its Jacobi matrix is calculated simultaneously for compatibility. The oil force, damping, and stiffness coefficients of the bearing are obtained by the assembly method. The unbalanced responses of the symmetrical rigid rotor dynamic system supported by fixed—tilting-pad journal bearings are analysed by the Runge—Kutta method and a Poincaré map. The effects of the pivot ratio and the preload on the stability of the rotor are analysed. The numerical results reveal complex non-linear behaviours of the system, such as periodic, period-doubling, period-13, and quasi-periodic motion.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1243/13506501JET788
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2032767-5
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  • 5
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    Online Resource
    Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E
    SAGE Publications ; 2010
    In:  Genes & Cancer Vol. 1, No. 1 ( 2010-01-01), p. 26-39
    Details
    In: Genes & Cancer, SAGE Publications, Vol. 1, No. 1 ( 2010-01-01), p. 26-39
    Type of Medium: Online Resource
    ISSN: 1947-6019 , 1947-6027
    URL: Article
    DOI: 10.1177/1947601909358184
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2538519-7
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  • 6
    Online Resource
    Online Resource
    Transgenic Rescue of Enamel Phenotype in Ambn Null Mice
    SAGE Publications ; 2010
    In:  Journal of Dental Research Vol. 89, No. 12 ( 2010-12), p. 1414-1420
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 89, No. 12 ( 2010-12), p. 1414-1420
    Abstract: Ameloblastin null mice fail to make an enamel layer, but the defects could be due to an absence of functional ameloblastin or to the secretion of a potentially toxic mutant ameloblastin. We hypothesized that the enamel phenotype could be rescued by the transgenic expression of normal ameloblastin in Ambn mutant mice. We established and analyzed 5 transgenic lines that expressed ameloblastin from the amelogenin ( AmelX) promoter and identified transgenic lines that express virtually no transgene, slightly less than normal (Tg+), somewhat higher than normal (Tg++), and much higher than normal (Tg+++) levels of ameloblastin. All lines expressing detectable levels of ameloblastin at least partially recovered the enamel phenotype. When ameloblastin expression was only somewhat higher than normal, the enamel covering the molars and incisors was of normal thickness, had clearly defined rod and interrod enamel, and held up well in function. We conclude that ameloblastin is essential for dental enamel formation.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/0022034510379223
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2057074-0
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  • 7
    Online Resource
    Online Resource
    The Association of Dysglycaemia and Cardiovascular Disease in Patients with Metabolic Syndrome
    SAGE Publications ; 2009
    In:  Journal of International Medical Research Vol. 37, No. 5 ( 2009-10), p. 1486-1492
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 37, No. 5 ( 2009-10), p. 1486-1492
    Abstract: The objective of this study was to investigate the relationship between increased prevalence of cardiovascular disease and glucose regulation status in Chinese patients with metabolic syndrome (MetS). All patients underwent an oral glucose tolerance test (2-h post-load plasma glucose) to determine their glucose regulation status and had their brachial–ankle pulse wave velocity (baPWV) measured. Of the 590 patients included in the study, 115 (19.5%) had normal glucose tolerance, 114 (19.3%) had impaired fasting glucose (IFG) alone, 38 (6.4%) had impaired glucose tolerance (IGT) alone, 197 (33.4%) had diabetes mellitus and 126 (21.4%) had combined glucose intolerance (CGI; IFG plus IGT). Patients with diabetes mellitus had a significantly higher baPWV compared with all other groups and patients with CGI had a significantly higher baPWW compared with patients with IFG. Dysglycaemia was common in patients with MetS. An increased prevalence of cardiovascular disease in patients with MetS was related to their glucose regulation status.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323000903700525
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2082422-1
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  • 8
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    Online Resource
    Functional Effects of SNPs in MYH9 and Risks of Nonsyndromic Orofacial Clefts
    SAGE Publications ; 2018
    In:  Journal of Dental Research Vol. 97, No. 4 ( 2018-04), p. 388-394
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 97, No. 4 ( 2018-04), p. 388-394
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/0022034517743930
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 9
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    Online Resource
    Minimum effective plasma concentration of efavirenz in treatment-naïve Chinese HIV-infected patients
    SAGE Publications ; 2010
    In:  International Journal of STD & AIDS Vol. 21, No. 12 ( 2010-12), p. 810-813
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 21, No. 12 ( 2010-12), p. 810-813
    Abstract: To assess the relationship between mean efavirenz (EFV) plasma concentration and clinical effect during the first 48 weeks of combination antiretroviral therapy (cART), the baseline CD4 cell count was recorded and plasma EFV concentration and CD4 cell count were measured every 12 weeks. HIV-RNA viral load was determined in the 48th week of cART. In total, 42 subjects were recruited and grouped according to their mean concentration of EFV during the study period: groups A, B and C with EFV concentrations (mean) 〈 2 mg/L (1.8 mg/L), 2–4 mg/L (2.9 mg/L) and 〉 4 mg/L (5.5 mg/L), respectively. The CD4 cell counts in group C increased more quickly than in groups B and A, although this was not statistically significant (211 ± 176/μL versus 151 ± 145/μL and 172 ± 105/μL, respectively; P = 0.799). Groups B and C had higher rates of HIV viral load suppression than group A ( P = 0.017). For treatment-naïve Chinese HIV-infected patients, EFV plasma concentrations above 2 mg/L appear to suppress HIV replication more effectively than concentrations below 2 mg/L.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1258/ijsa.2010.010114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2009782-7
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  • 10
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    Online Resource
    Remote ischemic preconditioning improves spatial learning and memory ability after focal cerebral ischemia-reperfusion in rats
    SAGE Publications ; 2013
    In:  Perfusion Vol. 28, No. 6 ( 2013-11), p. 546-551
    Details
    In: Perfusion, SAGE Publications, Vol. 28, No. 6 ( 2013-11), p. 546-551
    Abstract: Using a rodent model of middle cerebral artery occlusion (MCAO), we investigated the effect of remote ischemic preconditioning (RIPC) on spatial learning and memory ability after focal cerebral ischemia-reperfusion (I/R). Method: Thirty-six male Sprague-Dawley rats were randomly allocated into 3 groups (n=12, each): sham group, rats were subjected to sham operations without MCAO and RIPC; I/R group, rats were subjected to 1h of MCAO followed by 3 days of reperfusion; I/R+RIPC group, rats were subjected to RIPC and 1h MCAO followed by 3 days of reperfusion. The spatial learning and memory ability of the rats was measured by the Morris water maze task.The activity of cholineacetyltransferase (ChAT) in the hippocampus CA 1 region was observed by an immunohistochemistry method. Results: In the Morris water maze task, MCAO elicited a significant decrease of the ability of spatial learning and memory in contrast to the sham group. Meanwhile, RIPC induced a significantly shorter prolongation of the escape latency (p 〈 0.05); greater number passing through the platform (p 〈 0.05) and less time for exploring the target quadrant (p 〈 0.05) as compared with values for the I/R group. Furthermore, the number of ChAT positive cells in the CA1 region in the I/R+RIPC group was strikingly more than those of the I/R group (p 〈 0.05). Conclusions: RIPC could improve the ability of spatial learning and memory after focal cerebral ischemia-reperfusion probably due to its protection of the cholinergic neurons in the hippocampal CA1 region.
    Type of Medium: Online Resource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/0267659113487766
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2029611-3
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