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  • SAGE Publications  (8)
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  • SAGE Publications  (8)
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  • 1
    Online Resource
    Online Resource
    Perfusion-sensitive parameters of intravoxel incoherent motion MRI in rectal cancer: evaluation of reproducibility and correlation with dynamic contrast-enhanced MRI
    SAGE Publications ; 2019
    In:  Acta Radiologica Vol. 60, No. 5 ( 2019-05), p. 569-577
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 60, No. 5 ( 2019-05), p. 569-577
    Abstract: Intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) acquires tumor perfusion information without injection of contrast medium, which is promising in tumor assessment. However, its consistency with dynamic contrast-enhanced MRI (DCE-MRI), a more widely used method for tumor perfusion evaluation, is not revealed in rectal cancer. Purpose In this study, we aimed to investigate the correlation of perfusion-sensitive parameters derived from IVIM-MRI with DCE-MRI and measurement reproducibility of IVIM-MRI parameters in rectal cancer. Material and Methods Forty-seven rectal cancer patients underwent IVIM-MRI with 16 b-values and DCE-MRI. The perfusion fraction ( f), pseudo-diffusion coefficient ( D*), and f· D* were measured by two radiologists independently and correlated with the transfer constant ( K trans ), reflux constant ( k ep ), and extravascular extracellular fractional volume ( v e ) obtained from DCE-MRI. Results Pearson’s correlation analyses of IVIM-MRI and DCE-MRI parameters showed fair to moderate correlation between f and K trans ( r = 0.461, P = 0.001), followed by f and k ep ( r = 0.430, P = 0.003), f·D*, and K trans ( r = 0.425, P = 0.003), f·D*, and k ep ( r = 0.384, P = 0.008). There was no significant correlation between v e and f, v e and D*, v e and f· D*, D* and K trans , and D* and k ep . The reproducibility of IVIM-MRI measurements was moderate. For parameter f, intraclass correlation coefficient (ICC) = 0.71 (0.53–0.82), coefficient of variation (CV) = 13.05 ± 0.02%, limit of agreement (LoA) = −0.05–0.04; for parameter D*, ICC = 0.55 (0.32–0.72), CV = 20.28 ± 3.23%, LoA = −9.6–8.4. Conclusion Perfusion-sensitive parameters derived from IVIM-MRI correlated fairly to moderately with DCE-MRI in rectal cancer patients and showed moderate measurement reproducibility. IVIM-MRI supplements routine high-resolution MRI without contrast enhancement to provide information of tumor microcirculation.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185118791201
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024579-8
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Social Network Analysis of Nonprofits in Disaster Response: The Case of Twitter During the COVID-19 Pandemic in the United States
    SAGE Publications ; 2022
    In:  Social Science Computer Review
    Details
    In: Social Science Computer Review, SAGE Publications
    Abstract: The COVID-19 pandemic has created complex problems that require organizations to collaborate within and across the sector line. Social media data can provide insights into how nonprofits interact for the pandemic response from both social network and geographical perspectives. This study innovatively investigated the connection and interaction patterns among 74 National Voluntary Organizations Active in Disaster (NVOAD) nonprofits and three government agencies based on structural analyses and content analyses of their Twitter communications during the long-term global COVID-19 pandemic. The daily tweeting quantities of all nonprofits were generally consistent with the pandemic severity in the United States before July 2020 and remained stable afterward. Nonprofits’ tweets can reflect their purposes of sharing information, building communities, and taking actions for disaster response. Government agencies played leadership roles in providing COVID-19 guidelines and information. Human services, International and Foreign Affairs, and Public and Societal Benefit nonprofits, especially American Red Cross played central roles in the nonprofit communication network. Possible explanations include the following: (1) Geographically, connections and interactions among nonprofits are more likely to happen within the same city or in neighboring states. (2) Both mission homophily and heterophily contribute to connections and interactions among nonprofits, depending on their subsectors. The findings not only help the public better understand how nonprofits are collaboratively fighting the pandemic, but also provide guidance for nonprofits to plan for better interactions and communications in future disaster response.
    Type of Medium: Online Resource
    ISSN: 0894-4393 , 1552-8286
    URL: Article
    DOI: 10.1177/08944393221130674
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2021894-1
    SSG: 3,4
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Baseline Resistance-Associated Substitutions may Impact DAA Response among Treatment Failure Chronic Hepatitis C Patients with Pegylated Interferon and Ribavirin in Real Life
    SAGE Publications ; 2020
    In:  Antiviral Therapy Vol. 25, No. 5 ( 2020-07), p. 245-255
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 25, No. 5 ( 2020-07), p. 245-255
    Abstract: To evaluate the impact of baseline resistance-associated substitutions (RASs) on direct-acting antiviral (DAA) treatment response among pegylated interferon in combination with ribavirin (PR) failing patients in a real-life setting. Methods Blood samples and clinical data from 171 patients who failed PR treatment were collected. All of them received rescue DAA regimens. RAS identified in the NS3, NS5A and NS5B regions by Sanger sequencing method were compared by DAA regimen and HCV subtypes. We assessed sustained virological response at 12 weeks (SVR12) and evaluated the impact of baseline RASs on the effectiveness of DAA regimens in clinical practice. Results The overall SVR12 rates were: 89.47% (153/171), 92.1% (117/127) in patients without cirrhosis versus 81.8% (36/44) in those with cirrhosis, without significant difference (χ 2 =3.69, P=0.08); 87.9% in genotype (GT)1b patients ( n=116) versus 93.8% in GT2a ( n=32) versus 90.5% in GT3 ( n=21) versus 100% in GT6 ( n=2), without significant difference (χ 2 =1.02, P=0.84); 66.7% in asunaprevir (ASV) + daclatasvir (DCV) regimen ( n=24) versus 94.0% in sofosbuvir (SOF)-based regimen ( n=133), with significant difference (χ 2 =19.7, P=0.001). Our results showed that the prevalence of NS3, NS5A, NS5B RASs was 45.02%, 39.76% and 71.34%, respectively, and higher incidence of RASs in cirrhosis than without cirrhosis (81.8% versus 63.8%), with a statistically significant difference (χ 2 =4.92, P=0.03). In the ASV/DCV cohort ( n=24), 4 of 11 patients (36.4%) with baseline NS3/NS5A RASs achieved SVR12, whereas 12 of 13 patients (92.3%) without RASs achieved SVR12, with significant difference (χ 2 =8.39, P=0.008). However, this relationship was not seen in the SOF-based subgroup (94.6% versus 92.7%; χ 2 =0.18, P=0.7). Treatment failure with DAAs occurred in 10.53% ( n=18) of our study population, baseline NS5A substitution including L31M or Y93H ( n=13) was the most frequently detected RAS, rescue regimen with velpatasvir (VEL)/SOF + ribavirin (RBV) for 12 weeks or 24 weeks was highly effective in patients who failed previous use of NS5A inhibitors, regardless of GT or cirrhosis. Conclusions Natural RASs are common in Chinese patients failing with PR treatment. High prevalence of clinically relevant RASs (such as L31M, Y93H) supports the appropriateness of HCV resistance tests to properly guide DAA-based therapy. These findings might be used to select salvage therapies.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP3369
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Molecular dynamics simulation and experimental study on the lubrication of graphene additive films
    SAGE Publications ; 2020
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 234, No. 12 ( 2020-12), p. 1957-1972
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 234, No. 12 ( 2020-12), p. 1957-1972
    Abstract: Friction between silicon nitride (Si 3 N 4 ) and bearing steel (GCr15) affects the hybrid bearing performance. The effects of graphene as an additive in n-hexadecane (C 16 H 34 ) lubricating oil on the lubricating properties of a Si 3 N 4 -GCr15 friction pair were studied. The effects of pressure and shear velocity on the coefficient of friction and friction force were probed experimentally, while the changes in the van der Waals energy, shear stress, and thickness of the solid film in the lubrication area were simulated by molecular dynamics methods. Graphene additives increased the van der Waals energy and thickness of the solid film in the lubrication region, while reducing the shear stress of the Si 3 N 4 -GCr15 friction pair, coefficient of friction, and friction force. Furthermore, the lower the overall shearing velocity, the lower was the van der Waals energy and shear stress, and the thicker was the solid film. Finally, as the pressure and shear velocity increased, graphene exerted a greater influence on the lubricating properties of the Si 3 N 4 -GCr15 friction pair.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/1350650119899213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2032767-5
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  • 5
    Online Resource
    Online Resource
    Development of a Safety Assessment Tool for Long-Span Bridges : Case Study of Sutong Bridge in China
    SAGE Publications ; 2014
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2451, No. 1 ( 2014-01), p. 97-102
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2451, No. 1 ( 2014-01), p. 97-102
    Abstract: This paper provides a safety assessment tool (SAT) for long-span bridges in China. The authors selected the Sutong Yangtze River Bridge, one of the largest long-span bridges in China, for a case study. Currently, safety assessment of long-span bridges in China is primarily based on human judgment. No effective method exists for estimating the traffic crash risk of long-span bridges under various conditions; this situation creates difficulty in providing effective safety control strategy and developing counter-measures. In this study, the Traffic Software Integrated System was used to simulate the traffic on the Sutong Bridge. A safety assessment model (SAM) was developed from four contributing factors: traffic volume, free-flow speed, percentage of heavy vehicles, and weather conditions. SAM was used as the basis for developing an SAT that could aid policy makers and traffic professionals in better understanding of traffic safety of the Sutong Bridge: (a) a risk map was created to indicate different safety levels of the bridge under various conditions and (b) a user interface was designed to allow users to identify the safety level of the bridge quickly and easily.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2451-11
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2403378-9
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  • 6
    Online Resource
    Online Resource
    Alterations of MicroRNA Expression in the Liver, Heart, and Testis of Mice Upon Exposure to Repeated Low-Dose Radiation
    SAGE Publications ; 2018
    In:  Dose-Response Vol. 16, No. 3 ( 2018-07-01), p. 155932581879956-
    Details
    In: Dose-Response, SAGE Publications, Vol. 16, No. 3 ( 2018-07-01), p. 155932581879956-
    Abstract: MicroRNAs (miRs), which regulate target gene expression at the post-transcriptional level, play a crucial role in inducing biological effects upon high-dose ionizing radiation. Yet, the miR expression profiles in response to repeated low-dose radiation (LDR) in vivo have not been elucidated. This study investigated the response profiles of 11 miRs with functions involved in metabolism, DNA damage and repair, inflammation, and fibrosis in mouse liver, heart, and testis upon repeated LDR exposure for 4 months. The expression profiles were evaluated using stem-loop quantitative reverse transcription polymerase chain reaction immediately and at 2 months after LDR exposure. The expression profiles varied significantly at both time points. At the organ level, the heart was the most affected, followed by the liver and testis, in which significant miR upregulation related to DNA damage response was found. Metabolism-related miRs decreased in the liver and increased in the testis. The current results showed immediate and long-lasting alterations in the miR expression profiles in response to repeated LDR in different organs.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325818799561
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2440820-7
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  • 7
    Online Resource
    Online Resource
    Low-Dose Radiation Induces Cell Proliferation in Human Embryonic Lung Fibroblasts but not in Lung Cancer Cells : Importance of ERK1/2 and AKT Signaling Pathways
    SAGE Publications ; 2016
    In:  Dose-Response Vol. 14, No. 1 ( 2016-03-01), p. 155932581562217-
    Details
    In: Dose-Response, SAGE Publications, Vol. 14, No. 1 ( 2016-03-01), p. 155932581562217-
    Abstract: Hormesis and adaptive responses are 2 important biological effects of low-dose ionizing radiation (LDR). In normal tissue, LDR induces hormesis as evinced by increased cell proliferation; however, whether LDR also increases tumor cell proliferation needs to be investigated. In this study, cell proliferation was assayed by total cell numbers and the Cell Counting Kit 8 assay. Mitogen-activated protein kinases (MAPK)/extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3′ -kinase(PI3K)-Akt (PI3K/AKT) phosphorylation were determined by Western blot analysis. Human embryonic lung fibroblast 2BS and lung cancer NCI-H446 cell lines were irradiated with LDR at different doses (20-100 mGy). In response to 20 to 75 mGy X-rays, cell proliferation was significantly increased in 2BS but not in NCI-H446 cells. In 2BS cells, LDR at 20 to 75 mGy also stimulated phosphorylation of MAPK/ERK pathway proteins including ERK, MEK, and Raf and of the PI3K/AKT pathway protein AKT. To test whether ERK1/2 and AKT pathway activation was involved in the stimulation of cell proliferation in 2BS cells, the MAPK/ERK and PI3K/AKT pathways were inhibited using their specific inhibitors, U0126 and LY294002. U0126 decreased the phosphorylation of ERK1/2, and LY294002 decreased the phosphorylation of AKT; each could significantly inhibit LDR-induced 2BS cell proliferation. However, LDR did not stimulate these kinases, and kinase inhibitors also did not affect cell proliferation in the NCI-H446 cells. These results suggest that LDR stimulates cell proliferation via the activation of both MAPK/ERK and PI3K/AKT signaling pathways in 2BS but not in NCI-H446 cells. This finding implies the potential for applying LDR to protect normal tissues from radiotherapy without diminishing the efficacy of tumor therapy.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325815622174
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2440820-7
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  • 8
    Online Resource
    Online Resource
    Creation of a National Agenda for STEM Education for Students With Visual Impairments
    SAGE Publications ; 2022
    In:  Journal of Visual Impairment & Blindness Vol. 116, No. 5 ( 2022-09), p. 749-751
    Details
    In: Journal of Visual Impairment & Blindness, SAGE Publications, Vol. 116, No. 5 ( 2022-09), p. 749-751
    Type of Medium: Online Resource
    ISSN: 0145-482X , 1559-1476
    URL: Article
    DOI: 10.1177/0145482X221134372
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2060706-4
    SSG: 5,3
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