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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 1979
    In:  Journal of Histochemistry & Cytochemistry Vol. 27, No. 3 ( 1979-03), p. 751-755
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 27, No. 3 ( 1979-03), p. 751-755
    Abstract: In the adult rat kidney, alanine aminotransferase (EC 2.6.1.2), aspartate aminotransferase (EC 2.6.1.1) and D-amino acid oxidase (EC 1.4.3.3) were measured in glomeruli, 4 parts of the proximal tubule, 2 parts of the distal tubule and in patches from the thin limb area and the papilla. These enzymes were measured in more limited parts of the nephron during postnatal development. Adult aspartate aminotransferase activities (percentage of the highest) ranged from 100 in the distal straight segment to 25 in the late part of the proximal straight segment to 10 in the thin limb and papillary area. Alanine aminotransferase (lower by a factor of 100 in absolute terms) was distributed as the mirror image of aspartate aminotransferase within proximal and distal tubules. D-Amino acid oxidase was 850-fold higher in proximal straight segments than in medullary structures. During development alanine aminotransferase increased 6-fold and D-amino acid oxidase, 4.5-fold in proximal straight tubules but aspartate aminotransferase increased in distal straight tubles 8-fold.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1979
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 1977
    In:  Journal of Histochemistry & Cytochemistry Vol. 25, No. 6 ( 1977-06), p. 417-431
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 25, No. 6 ( 1977-06), p. 417-431
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1977
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 1984
    In:  Journal of Histochemistry & Cytochemistry Vol. 32, No. 6 ( 1984-06), p. 655-660
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 32, No. 6 ( 1984-06), p. 655-660
    Abstract: Fibers in cross sections of human and rat muscle were typed by using histochemical ATPase stains, and the results were compared with those of quantitative enzyme assays of fragments of the same fibers dissected from serial freeze-dried sections. Two enzymes previously used to assess the metabolic type were measured in each case: lactate dehydrogenase and either adenylokinase (human fibers) or malate dehydrogenase (rat fibers). With human fibers there was essentially complete agreement between ATPase staining and the metabolic enzyme assays in distinguishing types I and II fibers. The agreement was less consistent with regard to type IIA and IIB fibers. A number of ATPase type IIC fibers were identified in one human muscle, and were found to fall between ATPase types I and IIA on the basis of metabolic enzyme assay results. Rat-fiber ATPase types I, IIA, and IIB from the plantaris muscle were rather well segregated on a two-dimensional lactate dehydrogenase-malate dehydrogenase grid. In the rat soleus muscle, ATPase types I and IIA fibers were shifted to lower lactate dehydrogenase levels, with IIC fibers interposed between them.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1984
    detail.hit.zdb_id: 1421306-0
    SSG: 12
    Location Call Number Limitation Availability
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 1994
    In:  Applied Spectroscopy Vol. 48, No. 7 ( 1994-07), p. 852-856
    In: Applied Spectroscopy, SAGE Publications, Vol. 48, No. 7 ( 1994-07), p. 852-856
    Abstract: An accessory has been designed for FT-IR spectroscopy that can be used to measure the optical properties of fiber-optic cables or serve as an interface for remote sensing probes that use fiber optics. This accessory utilizes compound parabolic concentrators (CPCs) to focus the energy from the spectrometer into the optical fiber and to also refocus the energy returning to the spectrometer onto the detector. The design was optimized for the high acceptance angle of chalcogenide mid-IR fibers. However, the use of nonimaging concentrators yields an all-reflecting system that can be used to characterize fibers with different spectral transmission ranges. This accessory has been used to investigate the spectral response, cladding effects, and impurities in various optical fibers.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 5
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 34, No. 4 ( 2020-04), p. 400-411
    Abstract: The central serotonergic system originating from the dorsal raphe nucleus (DR) plays a critical role in anxiety and trauma-related disorders such as posttraumatic stress disorder. Although many studies have investigated the role of serotonin (5-HT) within pro-fear brain regions such as the amygdala, the majority of these studies have utilized non-selective pharmacological approaches or poorly understood lesioning techniques which limit their interpretation. Aim: Here we investigated the role of amygdala-projecting 5-HT neurons in the DR in innate anxiety and conditioned fear behaviors. Methods: To achieve this goal, we utilized (1) selective lesion of 5-HT neurons projecting to the amygdala with saporin toxin conjugated to anti-serotonin transporter (SERT) injected into the amygdala, and (2) optogenetic excitation of amygdala-projecting DR cell bodies with a combination of a retrogradely transported canine adenovirus-expressing Cre-recombinase injected into the amygdala and a Cre-dependent-channelrhodopsin injected into the DR. Results: While saporin treatment lesioned both local amygdalar 5-HT fibers and neurons in the DR as well as reduced conditioned fear behavior, optical activation of amygdala-projecting DR neurons enhanced anxious behavior and conditioned fear response. Conclusion: Collectively, these studies support the hypothesis that amygdala-projecting 5-HT neurons in the DR represent an anxiety and fear-on network.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2028926-1
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 1984
    In:  Journal of Histochemistry & Cytochemistry Vol. 32, No. 11 ( 1984-11), p. 1139-1144
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 32, No. 11 ( 1984-11), p. 1139-1144
    Abstract: Rabbit antisera were raised against a synthetic growth hormone releasing factor, which was originally isolated from a human pancreatic endocrine tumor (hpGRF-44). The antisera obtained showed no significant cross-reactivity with a variety of neurohormonal peptides. In addition to its occurrence in the human, but not in the rat, hypothalamus, hpGRF-44-like immunoreactivity was identified in human gastric antrum and human as well as rat pancreatic islets, using an indirect immunoperoxidase technique. Staining of serial sections and double staining revealed that in the gastric antrum the immunoreactivity was largely confined to gastrin (G) cells, whereas in pancreatic islets polypeptide (pp) cells were reactive. The physiological significance of these findings remains to be established.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1984
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine Vol. 230, No. 5 ( 2016-05), p. 421-428
    In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, SAGE Publications, Vol. 230, No. 5 ( 2016-05), p. 421-428
    Abstract: Mechanical evaluation of total knees is frequently required for aspects such as wear, strength, kinematics, contact areas, and force transmission. In order to carry out such tests, we developed a crouching simulator, based on the Oxford-type machine, with novel features including a synthetic knee including ligaments. The instrumentation and data processing methods enabled the determination of contact area locations and interface forces and moments, for a full flexion–extension cycle. To demonstrate the use of the simulator, we carried out a comparison of two different total knee designs, cruciate retaining and substituting. The first part of the study describes the simulator design and the methodology for testing the knees without requiring cadaveric knee specimens. The degrees of freedom of the anatomic hip and ankle joints were reproduced. Flexion–extension was obtained by changing quadriceps length, while variable hamstring forces were applied using springs. The knee joint was represented by three-dimensional printed blocks on to which the total knee components were fixed. Pretensioned elastomeric bands of realistic stiffnesses passed through holes in the block at anatomical locations to represent ligaments. Motion capture of the knees during flexion, together with laser scanning and computer modeling, was used to reconstruct contact areas on the bearing surfaces. A method was also developed for measuring tibial component interface forces and moments as a comparative assessment of fixation. The method involved interposing Tekscan pads at locations on the interface. Overall, the crouching machine and the methodology could be used for many different mechanical measurements of total knee designs, adapted especially for comparative or parametric studies.
    Type of Medium: Online Resource
    ISSN: 0954-4119 , 2041-3033
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2032763-8
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care Vol. 4, No. 1 ( 2015-06), p. 42-49
    In: Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care, SAGE Publications, Vol. 4, No. 1 ( 2015-06), p. 42-49
    Abstract: Issues with workflow integration have contributed to slow rates of EHR adoption in specialty care settings. Based on the insights generated during collegial discussions with physician Subject Matter Experts (SMEs), we identified unique end-user needs to improve EHR workflow in two specialty outpatient care settings. These include supporting coordination between physicians and specialized technicians, data integration with specialized software and devices, following specialty-specific norms for medical terminology, and adding unique data fields. Targeted recommendations for EHR developers are made to meet these needs.
    Type of Medium: Online Resource
    ISSN: 2327-8595 , 2327-8595
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2821352-X
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 1980
    In:  Applied Spectroscopy Vol. 34, No. 2 ( 1980-03), p. 167-171
    In: Applied Spectroscopy, SAGE Publications, Vol. 34, No. 2 ( 1980-03), p. 167-171
    Abstract: Room temperature Fourier transform infrared measurements on some contaminated silicon wafers are presented. Use of subtractive techniques readily allows both carbon and oxygen concentrations of about 0.1 ppm atomic to be obtained in relatively short measurement times (about 1 min), providing an adequate “pure” wafer is used as the reference standard.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1980
    detail.hit.zdb_id: 1474251-2
    SSG: 11
    Location Call Number Limitation Availability
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 1975
    In:  Applied Spectroscopy Vol. 29, No. 3 ( 1975-05), p. 226-230
    In: Applied Spectroscopy, SAGE Publications, Vol. 29, No. 3 ( 1975-05), p. 226-230
    Abstract: Some form of information compression is essential if one is to be able to utilize effectively the increasingly large data compilations. One approach is to eliminate the intensity information, leaving spectra packed in a peak/no peak format. This paper reports the comparison of two simple discriminant functions for classifying binary infrared data. For the multicategory problem of 13 classes used in this investigation, random guessing would achieve about 8% correct classification. A dot product calculation produces 49.1% correct classification, while a distance measurement produces 58.7%. The results from this investigation are also qualitatively compared to previous work using infrared data which retained some intensity information. It is found that the binary packing of spectral data shows great promise in the area of infrared analysis.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1975
    detail.hit.zdb_id: 1474251-2
    SSG: 11
    Location Call Number Limitation Availability
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