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  • 1
    Online Resource
    Online Resource
    Considering Needle Phobia among Adult Patients During Mass COVID-19 Vaccinations
    SAGE Publications ; 2021
    In:  Journal of Primary Care & Community Health Vol. 12 ( 2021-01), p. 215013272110073-
    Details
    In: Journal of Primary Care & Community Health, SAGE Publications, Vol. 12 ( 2021-01), p. 215013272110073-
    Abstract: As mass vaccination is underway to combat the COVID-19 pandemic and achieve herd immunity, healthcare professionals need to recognize the fear and phobia of needles among their patients. Approximately 11.5 to 66 million U.S. adults may suffer from this condition. This population often avoids seeking medical care including vaccinations. The exact number of people suffering from this phobia is unknown, and the potential years of life lost in the American health care system cannot be estimated accurately. The resistance to vaccinations among this population may delay achieving herd immunity to end this current pandemic. An overview of needle phobia, vaccinations, and current treatments are explored. The use of telemedicine could prove critical for reaching this population as well as those who are hesitant about vaccinations. Providing education to healthcare providers to identify and manage these patients during the pandemic is necessary.
    Type of Medium: Online Resource
    ISSN: 2150-1327 , 2150-1327
    URL: Article
    DOI: 10.1177/21501327211007393
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2550221-9
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  • 2
    Online Resource
    Online Resource
    Comparative efficacy and discontinuation of dimethyl fumarate and fingolimod in clinical practice at 24-month follow-up
    SAGE Publications ; 2017
    In:  Multiple Sclerosis Journal - Experimental, Translational and Clinical Vol. 3, No. 3 ( 2017-09), p. 205521731771548-
    Details
    In: Multiple Sclerosis Journal - Experimental, Translational and Clinical, SAGE Publications, Vol. 3, No. 3 ( 2017-09), p. 205521731771548-
    Abstract: Dimethyl fumarate and fingolimod are oral disease-modifying therapies approved to treat relapsing multiple sclerosis. Prior observational studies and our previous 12-month investigation showed comparable clinical efficacy. Objective The purpose of this study was to assess real-world efficacy and discontinuation of dimethyl fumarate and fingolimod over 24 months in patients with multiple sclerosis. Methods Patients treated with dimethyl fumarate ( n = 395) or fingolimod ( n = 264) completed 24-month follow-up in a large academic multiple sclerosis center. Discontinuation rates and measures of disease activity were compared after propensity score weighting. The primary outcome was on-treatment annualized relapse rate ratio. Other measures included rate of drug discontinuation and brain magnetic resonance imaging activity defined as new T2 and/or gadolinium-enhancing lesions. Results Propensity score weighting showed excellent covariate balance. At 24 months, dimethyl fumarate demonstrated comparable annualized relapse rate (rate ratio = 1.45, 95% confidence interval 0.53–3.99) and brain magnetic resonance imaging activity (odds ratio = 1.38, 95% confidence interval 0.83–2.32). Dimethyl fumarate patients discontinued therapy earlier compared to fingolimod (hazard ratio = 1.40, 95% confidence interval 1.11–1.77) and were more likely to discontinue therapy due to intolerability (odds ratio = 1.98, 95% confidence interval 1.18–3.23). Conclusion Dimethyl fumarate and fingolimod had similar reductions in annualized relapse rate in clinical trials, and our real-world experience supports this observation. Dimethyl fumarate-treated patients had higher likelihood of early discontinuation, and this was mostly due to intolerability.
    Type of Medium: Online Resource
    ISSN: 2055-2173 , 2055-2173
    URL: Article
    DOI: 10.1177/2055217317715485
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2841884-0
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  • 3
    Online Resource
    Online Resource
    Contribution of Magnetic Resonance Microscopy in the 12-Week Neurotoxicity Evaluation of Carbonyl Sulfide in Fischer 344 Rats
    SAGE Publications ; 2004
    In:  Toxicologic Pathology Vol. 32, No. 5 ( 2004-08), p. 501-510
    Details
    In: Toxicologic Pathology, SAGE Publications, Vol. 32, No. 5 ( 2004-08), p. 501-510
    Abstract: In this carbonyl sulfide (COS) study, magnetic resonance microscopy (MRM) and detailed light microscopic evaluation effectively functioned in parallel to assure that the distribution and degree of pathology in the brain was accurately represented. MRM is a powerful imaging modality that allows for excellent identification of neuroanatomical structures coupled with the ability to acquire 200 or more cross-sectional images of the brain, and the ability to display them in multiple planes. F344 rats were exposed to 200—600 ppm COS for up to 12 weeks. Prior to MRM, rats were anesthetized and cardiac perfused with McDowell Trump's fixative containing a gadolinium MR contrast medium. Fixed specimens were scanned at the Duke Center for In Vivo Microscopy on a 9.4 Tesla magnetic resonance system adapted explicitly for microscopic imaging. An advantage of MRM in this study was the ability to identify lesions in rats that appeared clinically normal prior to sacrifice and the opportunity to identify lesions in areas of the brain which would not be included in conventional studies. Other advantages include the ability to examine the brain in multiple planes (transverse, dorsal, sagittal) and obtain and save the MRM images in a digital format that allows for postexperimental data processing and manipulation. MRM images were correlated with neuroanatomical and neuropathological findings. All suspected MRM images were compared to corresponding H & E slides. An important aspect of this study was that MRM was critical in defining our strategy for sectioning the brain, and for designing mechanistic studies (cytochrome oxidase evaluations) and functional assessments (electrophysiology studies) on specifically targeted anatomical sites following COS exposure.
    Type of Medium: Online Resource
    ISSN: 0192-6233 , 1533-1601
    URL: Article
    DOI: 10.1080/01926230490493918
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2056753-4
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  • 4
    Online Resource
    Online Resource
    Triplet State Processes in Aqueous Colloidal Dispersions of Polycyclic Aromatic Hydrocarbons at Room Temperature
    SAGE Publications ; 1985
    In:  Applied Spectroscopy Vol. 39, No. 3 ( 1985-05), p. 516-519
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 39, No. 3 ( 1985-05), p. 516-519
    Abstract: A unique and facile means of producing room-temperature phosphorescence (RTP) from colloidal or microcrystalline suspensions of aromatic molecules in aqueous media is reported. Unlike previously reported RTP techniques, colloidal RTP is insensitive to quenching by dissolved oxygen. Delayed fluorescence was observed from several non-phosphorescent species. Potential uses of the technique are for the determination of the solubility of highly insoluble compounds and the ability to distinguish between suspended and dissolved matter.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1366/0003702854248629
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1985
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 5
    Online Resource
    Online Resource
    A proposed protocol for acceptance and constancy control of computed tomography systems: A Nordic Association for Clinical Physics (NACP) work group report
    SAGE Publications ; 2013
    In:  Acta Radiologica Vol. 54, No. 2 ( 2013-03), p. 188-198
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 54, No. 2 ( 2013-03), p. 188-198
    Abstract: Quality assurance (QA) of computed tomography (CT) systems is one of the routine tasks for medical physicists in the Nordic countries. However, standardized QA protocols do not yet exist and the QA methods, as well as the applied tolerance levels, vary in scope and extent at different hospitals. Purpose To propose a standardized protocol for acceptance and constancy testing of CT scanners in the Nordic Region. Material and Methods Following a Nordic Association for Clinical Physics (NACP) initiative, a group of medical physicists, with representatives from four Nordic countries, was formed. Based on international literature and practical experience within the group, a comprehensive standardized test protocol was developed. Results The proposed protocol includes tests related to the mechanical functionality, X-ray tube, detector, and image quality for CT scanners. For each test, recommendations regarding the purpose, equipment needed, an outline of the test method, the measured parameter, tolerance levels, and the testing frequency are stated. In addition, a number of optional tests are briefly discussed that may provide further information about the CT system. Conclusion Based on international references and medical physicists’ practical experiences, a comprehensive QA protocol for CT systems is proposed, including both acceptance and constancy tests. The protocol may serve as a reference for medical physicists in the Nordic countries.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1258/ar.2012.120254
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2024579-8
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  • 6
    Online Resource
    Online Resource
    Screening and management of gestational diabetes mellitus in Scottish obstetric units: a national survey
    SAGE Publications ; 2015
    In:  Scottish Medical Journal Vol. 60, No. 1 ( 2015-02), p. 37-43
    Details
    In: Scottish Medical Journal, SAGE Publications, Vol. 60, No. 1 ( 2015-02), p. 37-43
    Abstract: The last study of screening practices for gestational diabetes (GDM) in the UK concluded that a lack of consensus about screening was due to a lack of clinical guidelines. We aimed to determine current practices in Scotland since new guidelines recommended that diagnosis should be made at a lower level of hyperglycaemia. Method and results An online questionnaire designed to investigate the screening and management of GDM was distributed to all maternity units in Scotland managing women with GDM ( n = 15) for completion by relevant clinical team members. The response rate was 100%. Considerable variation in clinical practice existed between units. Thirteen units (86.7%) had adopted the lower glucose tolerance values for diagnosis of GDM (fasting ≥5.1 mmol/L; 2-h ≥8.5 mmol/L) recommended by the Scottish Intercollegiate Guidelines Network in 2010. Available data from units using this guideline ( n = 3) revealed a significant increase in the percentage of women diagnosed with GDM between 2010 and 2012 (2010: 1.28%, 2012: 2.54%; p  〈  0.0001). Conclusion Despite provision of clinical guidelines, there are still inconsistencies in screening and management of GDM in Scotland. If a similar increase in the prevalence of GDM is experienced across Scotland, there will be major implications for health care provision and resource allocation.
    Type of Medium: Online Resource
    ISSN: 0036-9330 , 2045-6441
    URL: Article
    DOI: 10.1177/0036933014563458
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2141765-9
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  • 7
    Online Resource
    Online Resource
    Effect of annual influenza immunization on antibody response in lung transplant patients
    SAGE Publications ; 2009
    In:  Progress in Transplantation Vol. 19, No. 2 ( 2009-06), p. 153-159
    Details
    In: Progress in Transplantation, SAGE Publications, Vol. 19, No. 2 ( 2009-06), p. 153-159
    Type of Medium: Online Resource
    ISSN: 1526-9248 , 2164-6708
    URL: Article
    DOI: 10.7182/prtr.19.2.13w14567571r1u12
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2864264-8
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  • 8
    Online Resource
    Online Resource
    Healing Response of Rat pulp Treated with an Injectable Keratin Hydrogel
    SAGE Publications ; 2017
    In:  Journal of Applied Biomaterials & Functional Materials Vol. 15, No. 3 ( 2017-01), p. 244-250
    Details
    In: Journal of Applied Biomaterials & Functional Materials, SAGE Publications, Vol. 15, No. 3 ( 2017-01), p. 244-250
    Abstract: Keratin has shown promising outcomes as a biomaterial due to its inherent bioactivity, biocompatibility and regenerative effects. The effect of keratin on repair and regeneration of dental tissues has never been studied before. Current therapies to treat pulp tissues involve its replacement with inert, synthetic materials that do not have a proper biological function, leading to failure and tooth loss. This study aimed to develop a biocompatible keratin hydrogel (KH) suitable for pulp therapies. Methods Keratins extracted from sheep wool were isolated, quantified and reconstituted to form KH. Different concentrations of keratin gel suitable for dental application were characterized by rheological analysis. The optimized gel based on flow characteristics was studied further for microstructure including porosity, percentage swelling ratio and contact angle measurements, using analytical tools such as scanning electron microscopy (SEM), micro-computed tomography and goniometer. To assess both biocompatibility and pulpal response, KH was implanted into rat upper molar teeth following partial pulpotomy. After 28 days, the tissue sections were analyzed by histological and immunohistochemical methods to identify dentin matrix protein 1 (DMP-1) formation and compared with control (Ca(OH) 2 -treated) teeth. Results The results of the study demonstrated a viscous and injectable, porous, dimensionally stable, hydrophilic and biocompatible gel that allowed pulp healing to occur by a reparative response, with widespread DMP-1 expression. Conclusions The findings of this study indicate that keratins can be developed as a biomaterial source for alternate biological treatment options for pulp therapies.
    Type of Medium: Online Resource
    ISSN: 2280-8000 , 2280-8000
    URL: Article
    DOI: 10.5301/jabfm.5000346
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2673624-X
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  • 9
    Online Resource
    Online Resource
    The impact of cigarette smoking on cognitive processing speed and brain atrophy in multiple sclerosis
    SAGE Publications ; 2023
    In:  Multiple Sclerosis Journal Vol. 29, No. 7 ( 2023-06), p. 846-855
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 29, No. 7 ( 2023-06), p. 846-855
    Abstract: Smoking is associated with an increased risk of multiple sclerosis (MS) and disability worsening. The relationship between smoking, cognitive processing speed, and brain atrophy remains uncertain. Objective: To quantify the impact of smoking on processing speed and brain volume in MS and to explore the longitudinal relationship between smoking and changes in processing speed. Methods: A retrospective study of MS patients who completed the processing speed test (PST) between September 2015 and March 2020. Demographics, disease characteristics, smoking history, and quantitative magnetic resonance imaging (MRI) were collected. Cross-sectional associations between smoking, PST performance, whole-brain fraction (WBF), gray matter fraction (GMF), and thalamic fraction (TF) were assessed using multivariable linear regression. The longitudinal relationship between smoking and PST performance was assessed by linear mixed modeling. Results: The analysis included 5536 subjects of whom 1314 had quantitative MRI within 90 days of PST assessment. Current smokers had lower PST scores than never smokers at baseline, and this difference persisted over time. Smoking was associated with reduced GMF but not with WBF or TF. Conclusion: Smoking has an adverse relationship with cognition and GMF. Although causality is not demonstrated, these observations support the importance of smoking cessation counseling in MS management.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/13524585231172490
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2008225-3
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  • 10
    Online Resource
    Online Resource
    The Chiefs of Naval Operations
    SAGE Publications ; 1983
    In:  International Journal Vol. 38, No. 3 ( 1983), p. 512-
    Details
    In: International Journal, SAGE Publications, Vol. 38, No. 3 ( 1983), p. 512-
    Type of Medium: Online Resource
    ISSN: 0020-7020
    URL: Article
    DOI: 10.2307/40202166
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1983
    detail.hit.zdb_id: 2530042-8
    detail.hit.zdb_id: 2254714-9
    SSG: 8
    SSG: 3,6
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