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  • 1
    Online Resource
    Online Resource
    Compressive Strength of Composite/Concrete Cylinders after Low Energy Impact
    SAGE Publications ; 2001
    In:  Journal of Reinforced Plastics and Composites Vol. 20, No. 10 ( 2001-07), p. 849-870
    Details
    In: Journal of Reinforced Plastics and Composites, SAGE Publications, Vol. 20, No. 10 ( 2001-07), p. 849-870
    Abstract: This paper deals with the repair of the concrete cylinder by fiber reinforced composites fabricated through the filament winding method. Composites fabricated by the method can reinforce concrete cylinders efficiently because they provide comprehensive and multi-axial reinforcing effects. In this work, three winding angles were adopted to wind six layers of glass/epoxy composite jacket onto the concrete cylinder. These three winding angles combined with different lay-up sequence form seven types of composite/concrete cylinders. The compression after impact (CAI) test was conducted on the seven composite/concrete cylinders. These experiments were designed to investigate the influence of winding angles and lay-up sequence of the composite on the CAI strength. It is found that the highest CAI strength among the composite wound concrete cylinder is 4.81 times higher than that of the concrete cylinder without the reinforced composite. In addition, the former has higher failure strain than the latter. The impact resistance can be evaluated by a compression after impact/compression before impact (CAI/CBI) strength ratio. It is also detected that although impact damage has been introduced, the fracture of composite/concrete cylinder under compression may not be initiated from the impact site. Moreover, the failure strengths are influenced by damage mechanisms of the cylinders, and the damage modes for the concrete cylinder and wound composites are related. In this paper, the damage mechanisms of different wound concrete cylinders under CAI test were discussed.
    Type of Medium: Online Resource
    ISSN: 0731-6844 , 1530-7964
    URL: Article
    DOI: 10.1177/073168401772678968
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2051886-9
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  • 2
    Online Resource
    Online Resource
    Compressive Strength of Composite/Concrete Cylinders after Low Energy Impact
    SAGE Publications ; 2001
    In:  Journal of Reinforced Plastics and Composites Vol. 20, No. 10 ( 2001-07-01), p. 849-870
    Details
    In: Journal of Reinforced Plastics and Composites, SAGE Publications, Vol. 20, No. 10 ( 2001-07-01), p. 849-870
    Abstract: This paper deals with the repair of the concrete cylinder by fiber reinforced composites fabricated through the filament winding method. Composites fabricated by the method can reinforce concrete cylinders efficiently because they provide comprehensive and multi-axial reinforcing effects. In this work, three winding angles were adopted to wind six layers of glass/epoxy composite jacket onto the concrete cylinder. These three winding angles combined with different lay-up sequence form seven types of composite/concrete cylinders. The compression after impact (CAI) test was conducted on the seven composite/concrete cylinders. These experiments were designed to investigate the influence of winding angles and lay-up sequence of the composite on the CAI strength. It is found that the highest CAI strength among the composite wound concrete cylinder is 4.81 times higher than that of the concrete cylinder without the reinforced composite. In addition, the former has higher failure strain than the latter. The impact resistance can be evaluated by a compression after impact/compression before impact (CAI/CBI) strength ratio. It is also detected that although impact damage has been introduced, the fracture of composite/concrete cylinder under compression may not be initiated from the impact site. Moreover, the failure strengths are influenced by damage mechanisms of the cylinders, and the damage modes for the concrete cylinder and wound composites are related. In this paper, the damage mechanisms of different wound concrete cylinders under CAI test were discussed.
    Type of Medium: Online Resource
    ISSN: 0731-6844 , 1530-7964
    URL: Article
    DOI: 10.1177/15307964-01020010-02
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2051886-9
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  • 3
    Online Resource
    Online Resource
    Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders
    SAGE Publications ; 2015
    In:  Cell Transplantation Vol. 24, No. 10 ( 2015-10), p. 1915-1930
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 24, No. 10 ( 2015-10), p. 1915-1930
    Abstract: The ocular surface is the outermost part of the visual system that faces many extrinsic or intrinsic threats, such as chemical burn, infectious pathogens, thermal injury, Stevens–Johnson syndrome, ocular pemphegoid, and other autoimmune diseases. The cornea plays an important role in conducting light into the eyes and protecting intraocular structures. Several ocular surface diseases will lead to the neovascularization or conjunctivalization of corneal epithelium, leaving opacified optical media. It is believed that some corneal limbal cells may present stem cell-like properties and are capable of regenerating corneal epithelium. Therefore, cultivation of limbal cells and reconstruction of the ocular surface with these limbal cell grafts have attracted tremendous interest in the past few years. Currently, stem cells are found to potentiate regenerative medicine by their capability of differentiation into multiple lineage cells. Among these, the most common cell sources for clinical use are embryonic, adult, and induced stem cells. Different stem cells have varied specific advantages and limitations for in vivo and in vitro expansion. Other than ocular surface diseases, culture and transplantation of corneal endothelial cells is another major issue for corneal decompensation and awaits further studies to find out comprehensive solutions dealing with nonregenerative corneal endothelium. Recently, studies of in vitro endothelium culture and ρ-associated kinase (ROCK) inhibitor have gained encouraging results. Some clinical trials have already been finished and achieved remarkable vision recovery. Finally, nanotechnology has shown great improvement in ocular drug delivery systems during the past two decades. Strategies to reconstruct the ocular surface could combine with nanoparticles to facilitate wound healing, drug delivery, and even neovascularization inhibition. In this review article, we summarized the major advances of corneal limbal stem cells, limbal stem cell deficiency, corneal endothelial cell culture/transplantation, and application of nanotechnology on ocular surface reconstruction. We also illustrated potential applications of current knowledge for the future treatment of ocular surface diseases.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368914X685744
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2020466-8
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  • 4
    Online Resource
    Online Resource
    Nanomedicine-based Curcumin Approach Improved ROS Damage in Best Dystrophy-specific Induced Pluripotent Stem Cells
    SAGE Publications ; 2019
    In:  Cell Transplantation Vol. 28, No. 11 ( 2019-11), p. 1345-1357
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 28, No. 11 ( 2019-11), p. 1345-1357
    Abstract: Best dystrophy (BD), also termed best vitelliform macular dystrophy (BVMD), is a juvenile-onset form of macular degeneration and can cause central visual loss. Unfortunately, there is no clear definite therapy for BD or improving the visual function on this progressive disease. The human induced pluripotent stem cell (iPSC) system has been recently applied as an effective tool for genetic consultation and chemical drug screening. In this study, we developed patient-specific induced pluripotent stem cells (BD-iPSCs) from BD patient-derived dental pulp stromal cells and then differentiated BD-iPSCs into retinal pigment epithelial cells (BD-RPEs). BD-RPEs were used as an expandable platform for in vitro candidate drug screening. Compared with unaffected sibling-derived iPSC-derived RPE cells (Ctrl-RPEs), BD-RPEs exhibited typical RPE-specific markers with a lower expression of the tight junction protein ZO-1 and Bestrophin-1 (BEST1), as well as reduced phagocytic capabilities. Notably, among all candidate drugs, curcumin was the most effective for upregulating both the BEST1 and ZO-1 genes in BD-RPEs. Using the iPSC-based drug-screening platform, we further found that curcumin can significantly improve the mRNA expression levels of Best gene in BD-iPSC-derived RPEs. Importantly, we demonstrated that curcumin-loaded PLGA nanoparticles (Cur-NPs) were efficiently internalized by BD-RPEs. The Cur-NPs-based controlled release formulation further increased the expression of ZO-1 and Bestrophin-1, and promoted the function of phagocytosis and voltage-dependent calcium channels in BD-iPSC-derived RPEs. We further demonstrated that Cur-NPs enhanced the expression of antioxidant enzymes with a decrease in intracellular ROS production and hydrogen peroxide-induced oxidative stress. Collectively, these data supported that Cur-NPs provide a potential cytoprotective effect by regulating the anti-oxidative abilities of degenerated RPEs. In addition, the application of patient-specific iPSCs provides an effective platform for drug screening and personalized medicine in incurable diseases.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689719860130
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2020466-8
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  • 5
    Online Resource
    Online Resource
    Novel multi-drugs incorporating hybrid-structured nanofibers enhance alkylating agent activity in malignant gliomas
    SAGE Publications ; 2019
    In:  Therapeutic Advances in Medical Oncology Vol. 11 ( 2019-01), p. 175883591987555-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 11 ( 2019-01), p. 175883591987555-
    Abstract: Malignant gliomas (MGs) are highly chemotherapy-resistant. Temozolomide (TMZ) and carmustine (BiCNU) are alkylating agents clinically used for treating MGs. However, their effectiveness is restrained by overexpression of the DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) in tumors. O 6 -benzylguanine (O 6 -BG) is a nonreversible inhibitor of MGMT, it promotes the cytotoxicity of alkylating chemotherapy. The authors have developed a hybrid-structured nanofibrous membrane (HSNM) that sequentially delivers high concentrations of O 6 -BG, BiCNU, and TMZ in an attempt to provide an alternative to the current therapeutic options for MGs. Methods: The HSNMs were implanted onto the cerebral surface of pathogen-free rats following surgical craniectomy, while the in vivo release behaviors of O 6 -BG, TMZ, and BiCNU from the HSNMs were explored. Subsequently, the HSNMs were surgically implanted onto the brain surface of two types of tumor-bearing rats. The survival rate, tumor volume, malignancy of tumor, and apoptotic cell death were evaluated and compared with other treatment regimens. Results: The biodegradable HSNMs sequentially and sustainably delivered high concentrations of O 6 -BG, BiCNU, and TMZ for more than 14 weeks. The tumor-bearing rats treated with HSNMs demonstrated therapeutic advantages in terms of retarded and restricted tumor growth, prolonged survival time, and attenuated malignancy. Conclusion: The results demonstrated that O 6 -BG potentiates the effects of interstitially transported BiCNU and TMZ. Therefore, O 6 -BG may be required for alkylating agents to offer maximum therapeutic benefits for the treatment of MGMT-expressing tumors. In addition, the HSNM-supported chemoprotective gene therapy enhanced chemotherapy tolerance and efficacy. It can, therefore, potentially provide an improved therapeutic alternative for MGs.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835919875555
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2503443-1
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