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  • SAGE Publications  (94)
  • 1
    Online Resource
    Online Resource
    A fast robust guidance scheme for a hypersonic vehicle in the diving phase
    SAGE Publications ; 2018
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 232, No. 6 ( 2018-05), p. 1087-1102
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 232, No. 6 ( 2018-05), p. 1087-1102
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410017705898
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2032759-6
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  • 2
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    Protective effects of pterostilbene on ulcerative colitis in rats via suppressing NF-κB pathway and activating PPAR-γ
    SAGE Publications ; 2019
    In:  European Journal of Inflammation Vol. 17 ( 2019-01), p. 205873921984015-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 17 ( 2019-01), p. 205873921984015-
    Abstract: Our study aimed to investigate the protective effects and potential mechanisms of pterostilbene on rats with ulcerative colitis (UC). We established 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced colitis rat model. Rats were randomly divided into three groups, including control group, model group, and pterostilbene group (30 mg/kg). Disease activity index (DAI) including body weight, stool consistency, and gross bleeding was measured. The concentration of superoxide dismutases (SODs), glutathione superoxide (GSH-px), malondialdehyde (MDA), and methylpropanediol (MPO) in serum were detected by enzyme-linked immunosorbent assay (ELISA). The levels of interleukin-1 beta (IL-1β), IL-17, IL-6, and tumor necrosis factor–alpha (TNF-α) in serum were also analyzed by ELISA kits. Histological evaluations of colons were conducted. The levels of peroxisome-proliferator-activated receptor–γ (PPAR-γ), nuclear factor-κB (NF-κB), ZO-1, and Occludin were analyzed by immunohistochemistry. Compared with model group, pterostilbene notably suppressed the production of TNF-α, IL-17, IL-1β, IL-6, MDA and MPO in serum, and markedly increased the SOD and GSH-Px activity in serum. Pterostilbene significantly attenuated macroscopic damage and histological injury, when compared with model rats. Furthermore, pterostilbene also markedly activated the expression of PPAR-γ, ZO-1, and Occludin, and suppressed the expression of NF-κB. The protective effects of pterostilbene might be associated with suppression of NF-κB and activation of PPAR-γ. Pterostilbene might be a promising therapeutic agent for colitis treatment.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/2058739219840152
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2584683-8
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  • 3
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    Association of Angiotensin-Converting Enzyme Gene 2350G〉A Polymorphism With Myocardial Infarction in a Chinese Population
    SAGE Publications ; 2009
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 15, No. 4 ( 2009-08), p. 435-442
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 15, No. 4 ( 2009-08), p. 435-442
    Abstract: Angiotensin-converting enzyme ( ACE) gene 2350G 〉 A polymorphism has the most significant effect on plasma ACE concentrations. But the association between this polymorphism and myocardial infarction (MI) is presently unknown. We carried out a case-control study in the Chinese Han population. ACE2350G 〉 A genotypes of 231 patients with MI and 288 healthy controls were detected by PCR-RFLP. Differences in frequencies of ACE genotypes and alleles and their associations with clinical features were assessed. The distribution of the ACE2350G 〉 A genotypes (GG, GA, and AA) was 20.78%, 51.08%, and 28.14% in the MI group and 31.60%, 46.53%, and 21.87% in controls, respectively ( P = .0167).The frequency of the A allele in the MI group was significantly higher than that in controls (53.68% vs 45.14%, P = .0062). The A allele carriers (GA + AA genotypes) had approximately 2-fold increased risk of MI when compared with the GG genotype (odds ratio = 1.76; 95% confidence interval = 1.24-3.52). There were no significant differences among the 3 genotypes in plasma levels of lipids, apolipoproteins, high-sensitivity C-reactive protein, and soluble CD40 ligand in either the MI group or the control group ( P 〉 .05). No statistical difference was observed between ACE2350G 〉 A polymorphism and severity of the coronary lesions ( P 〉 .05). These results suggest that ACE2350G 〉 A polymorphism is associated with acute MI, and A allele carrier is an independent risk factor for acute MI in the Chinese Han population.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029608316013
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2230591-9
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  • 4
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    Bone repair scaffold coated with bone morphogenetic protein-2 for bone regeneration in murine calvarial defect model: Systematic review and quality evaluation
    SAGE Publications ; 2019
    In:  The International Journal of Artificial Organs Vol. 42, No. 7 ( 2019-07), p. 325-337
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 42, No. 7 ( 2019-07), p. 325-337
    Abstract: To systematically assess the effects of hydroxyapatite bone repair scaffold coated with bone morphogenetic protein-2 on murine calvarial defect models and to determine the quality of studies according to the Animal Research Reporting in In Vivo Experiments guidelines. Internet search was performed in duplicate using PubMed, MEDLINE, Ovid and Embase databases (without restrictions on publication date). The Animal Research Reporting in In Vivo Experiments guidelines were used to evaluate the quality of selected studies. Following screening, 12 studies were eligible for the review. Studies with average quality coefficients predominated (66.67%), followed by poor (25%) and excellent (8.33%) quality coefficients. Minimum quality scores were assigned to the Animal Research Reporting in In Vivo Experiments guideline items: housing and husbandry (9), allocation (11), outcomes (12), interpretation (18) and generalizability (19). Sprague–Dawley rats were the most frequently used (50%) species, and most studies had a sample size of more than 30 (58.33%). A defect dimension of 5 mm was the most common (33.33%). The biological hydroxyapatite composite scaffold was common (50%), and the bioactive factors were bone morphogenetic protein-2 (50%) and recombinant human bone morphogenetic protein-2 (50%). Histomorphometric results showed that bone morphogenetic protein-2 enhanced the capacity to regenerate bone considerably. In addition, scaffolds with bone morphogenetic protein-2 resulted in a significant increase in the blood vessel in the new bone. The findings suggested that data on animal experiments of hydroxyapatite scaffold coated with bone morphogenetic protein-2 in murine calvarial defect models lack homogeneity. Animal experiment should follow the Animal Research Reporting in In Vivo Experiments guidelines to promote the high quality, integrity and reproducibility. This systematic review suggested that bone morphogenetic protein-2 enhanced the capacity to regenerate bone and the angiogenesis in the new bone.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/0391398819834944
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 1474999-3
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  • 5
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    Association of Pneumonia With Short- and Long-Term Mortality After Cardiac Surgery
    SAGE Publications ; 2016
    In:  Journal of Intensive Care Medicine Vol. 31, No. 6 ( 2016-07), p. 420-421
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications, Vol. 31, No. 6 ( 2016-07), p. 420-421
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/0885066616644899
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2001472-7
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  • 6
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    Study on acoustic performance of new spiral sound absorbing and insulating metamaterial
    SAGE Publications ; 2024
    In:  Journal of Low Frequency Noise, Vibration and Active Control Vol. 43, No. 2 ( 2024-06), p. 939-955
    Details
    In: Journal of Low Frequency Noise, Vibration and Active Control, SAGE Publications, Vol. 43, No. 2 ( 2024-06), p. 939-955
    Abstract: Middle and low frequency band sound waves have strong penetration and diffraction abilities during the propagation process, making it difficult to attenuate. The control of middle and low frequency broadband sound waves has become a challenging topic. Therefore, it is necessary to develop new materials or structures with middle and low frequency sound absorption, insulation, and noise reduction functions. The special properties of acoustic metamaterial provide new ideas for the development of sound absorption and insulation. In order to effectively control the noise in the lower frequency band, a new spatial spiral acoustic metamaterial was designed. First, the mechanism of band gap characteristics of a new spatial spiral acoustic metamaterial is analyzed. Then, a new spatial spiral acoustic metamaterial is completed through the finite element software COMSOL Multiphysics and the calculation and analysis of sound absorption and insulation performance in the 100–2500 Hz frequency band are completed. With the help of 3D printing, the preparation of metamaterial is completed, and the comparative experimental study of sound absorption and insulation performance of spiral acoustic metamaterial is carried out to verify the accuracy of the calculation method.
    Type of Medium: Online Resource
    ISSN: 1461-3484 , 2048-4046
    URL: Article
    DOI: 10.1177/14613484231219150
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2025887-2
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  • 7
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    Experimental study of the fretting wear behavior of Inconel 690 alloy under alternating load conditions
    SAGE Publications ; 2018
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 232, No. 11 ( 2018-11), p. 1343-1351
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 232, No. 11 ( 2018-11), p. 1343-1351
    Abstract: This study investigated the fretting wear behavior of the nuclear power material Inconel 690 alloy. An improved PLINT high-temperature fretting tester was used on an Inconel 690 tube against a 1Cr13 cylinder at different temperatures (25 ℃ and 300 ℃) under alternating load conditions. The fretting-wear mechanism and the kinetic characteristic of Inconel 690 alloy were analyzed. Results showed that the fretting running behavior was closely related to the normal excitation frequency. In parallelogram shaped F t – D curves, the friction fluctuates periodically, and accordingly the fretting was running in the slip regime. The steady-state friction force at room temperature in air was higher than that at 300 ℃. Moreover, the damage behavior of the fretting for Inconel 690 alloy strongly depended on the normal load, displacement amplitude, temperature, and excitation frequency in atmospheric environment. A superposition effect of fretting wear behavior was discovered because of the combined effect of alternating normal and tangential forces; thus, delamination became more significant. Abrasive wear and delamination were the major mechanisms in Inconel 690 alloy at room temperature in ambient air. The dominant mechanisms at 300 ℃ were the abrasive wear, oxidation wear, and delamination.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/1350650117750790
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2032767-5
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  • 8
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    Forming mechanism of radial V-shaped microgrooves on plate using step punching method
    SAGE Publications ; 2015
    In:  Advances in Mechanical Engineering Vol. 7, No. 2 ( 2015-01-01), p. 168781401456849-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 7, No. 2 ( 2015-01-01), p. 168781401456849-
    Abstract: The finned surface can increase the specific surface area, which could enhance the boiling efficiency of the working medium to realize the enhancement of heat transfer performance. This research adopted a step punching method to form a radial microgroove structure on the surface of a copper plate. The scanning electron microscopy analysis indicates that when the pressed metal is in the deformation range, it will flow under extrusion and is subject to the reaction force from the metal outside the deformation range, so a micro-finned structure nearby the punching tool is formed. And the deformation area of the formed microgroove is higher than the workpiece’s primitive surface. The relationships of the punching interference length L i with θ c , a c , and α pt are analyzed; and the influence of forming parameters on the groove surface morphology as well as the relationships among these parameters are discussed. When the punching depth a c is 0.3 mm and the punching feeding angle θ c is 2°–4°, the finned surface of the radial V-shaped microgrooves can be obtained.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814014568492
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2501620-9
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  • 9
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    Radiofrequency Ablation Combined With Transarterial Chemoembolization for Specially Located Small Hepatocellular Carcinoma
    SAGE Publications ; 2018
    In:  Technology in Cancer Research & Treatment Vol. 17 ( 2018-01), p. 153303381878852-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 17 ( 2018-01), p. 153303381878852-
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033818788529
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 10
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    Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases
    SAGE Publications ; 2007
    In:  Perspectives in Medicinal Chemistry Vol. 1 ( 2007-01), p. PMC.S212-
    Details
    In: Perspectives in Medicinal Chemistry, SAGE Publications, Vol. 1 ( 2007-01), p. PMC.S212-
    Abstract: Protein misfolding and aggregation cause a large number of neurodegenerative diseases in humans due to (i) gain of function as observed in Alzheimer's disease, Huntington's disease, Parkinson's disease, and Prion's disease or (ii) loss of function as observed in cystic fibrosis and α1-antitrypsin deficiency. These misfolded proteins could either lead to the formation of harmful amyloids that become toxic for the cells or to be recognized and prematurely degraded by the protein quality control system. An increasing number of studies has indicated that some low-molecular-weight compounds named as chemical chaperones can reverse the mislocalization and/or aggregation of proteins associated with human conformational diseases. These small molecules are thought to non-selectively stabilize proteins and facilitate their folding. In this review, we summarize the probable mechanisms of protein conformational diseases in humans and the use of chemical chaperones and inhibitors as potential therapeutic agents against these diseases. Furthermore, recent advanced experimental and theoretical approaches underlying the detailed mechanisms of protein conformational changes and current structure-based drug designs towards protein conformational diseases are also discussed. It is believed that a better understanding of the mechanisms of conformational changes as well as the biological functions of these proteins will lead to the development and design of potential interfering compounds against amyloid formation associated with protein conformational diseases.
    Type of Medium: Online Resource
    ISSN: 1177-391X , 1177-391X
    URL: Article
    DOI: 10.4137/PMC.S212
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2517178-1
    SSG: 15,3
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