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  • SAGE Publications  (12)
  • 1
    Online Resource
    Online Resource
    Malignant transformation and treatment of cystic mixed germ cell tumor
    SAGE Publications ; 2016
    In:  Translational Neuroscience and Clinics Vol. 2, No. 1 ( 2016), p. 25-30
    Details
    In: Translational Neuroscience and Clinics, SAGE Publications, Vol. 2, No. 1 ( 2016), p. 25-30
    Type of Medium: Online Resource
    ISSN: 2096-0441
    URL: Article
    DOI: 10.18679/CN11-6030/R.2016.001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 2
    Online Resource
    Online Resource
    Theoretical study and simulation analysis on re-entrant square cellular material’s mechanical properties
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 4 ( 2018-04), p. 168781401877239-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 4 ( 2018-04), p. 168781401877239-
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814018772391
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2501620-9
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  • 3
    Online Resource
    Online Resource
    HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity
    SAGE Publications ; 2008
    In:  Molecular Pain Vol. 4 ( 2008-01-01), p. 1744-8069-4-48-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 4 ( 2008-01-01), p. 1744-8069-4-48-
    Abstract: Safe and effective treatment for chronic inflammatory and neuropathic pain remains a key unmet medical need for many patients. The recent discovery and description of the transient receptor potential family of receptors including TRPV1 and TRPA1 has provided a number of potential new therapeutic targets for treating chronic pain. Recent reports have suggested that TRPA1 may play an important role in acute formalin and CFA induced pain. The current study was designed to further explore the therapeutic potential of pharmacological TRPA1 antagonism to treat inflammatory and neuropathic pain. Results: The in vitro potencies of HC-030031 versus cinnamaldehyde or allyl isothiocyanate (AITC or Mustard oil)-induced TRPA1 activation were 4.9 ± 0.1 and 7.5 ± 0.2 μM respectively (IC 50 ). These findings were similar to the previously reported IC 50 of 6.2 μM against AITC activation of TRPA1 [ 1 ]. In the rat, oral administration of HC-030031 reduced AITC-induced nocifensive behaviors at a dose of 100 mg/kg. Moreover, oral HC-030031 (100 mg/kg) significantly reversed mechanical hypersensitivity in the more chronic models of Complete Freunds Adjuvant (CFA)-induced inflammatory pain and the spinal nerve ligation model of neuropathic pain. Conclusion: Using oral administration of the selective TRPA1 antagonist HC-030031, our results demonstrated that TRPA1 plays an important role in the mechanisms responsible for mechanical hypersensitivity observed in inflammatory and neuropathic pain models. These findings suggested that TRPA1 antagonism may be a suitable new approach for the development of a potent and selective therapeutic agent to treat both inflammatory and neuropathic pain.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1186/1744-8069-4-48
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2174252-2
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  • 4
    Online Resource
    Online Resource
    Further Validation of the Inventory of Callous–Unemotional Traits in Chinese Children: Cross-Informants Invariance and Longitudinal Invariance
    SAGE Publications ; 2020
    In:  Assessment Vol. 27, No. 7 ( 2020-10), p. 1668-1680
    Details
    In: Assessment, SAGE Publications, Vol. 27, No. 7 ( 2020-10), p. 1668-1680
    Abstract: The present study examined the factor structure and measurement invariance of the shortened versions of the Inventory of Callous–Unemotional Traits (ICU) with data from multiple informants. Five short versions of the ICU proposed in previous studies were tested and compared through confirmatory factor analysis. The measurement invariance across different informants (i.e., self-report, parent-report, and teacher-report) and longitudinal measurement invariance for the resulting best-fitting model were tested thoroughly. Results indicated that a shortened form that consists of 11 items (ICU-11) to assess callousness and uncaring factors had excellent overall fit. Moreover, the ICU-11 was invariant across informant and occasions. However, the ICU-11 was not without limitations; the internal consistency α for the uncaring factor with self-report scores was marginal. In conclusion, our findings suggest that the ICU-11 was an excellent fit for our data and displayed measurement invariance across informants and over time. The ICU-11 may be a promising assessment tool that could be used in research to assess callous–uncaring traits in Chinese children.
    Type of Medium: Online Resource
    ISSN: 1073-1911 , 1552-3489
    URL: Article
    DOI: 10.1177/1073191119845052
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2083220-5
    SSG: 5,2
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  • 5
    Online Resource
    Online Resource
    Preparation and Odour Properties of ( S )-3-Mercapto-1-Heptyl Acetate
    SAGE Publications ; 2014
    In:  Journal of Chemical Research Vol. 38, No. 6 ( 2014-06), p. 343-346
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 38, No. 6 ( 2014-06), p. 343-346
    Abstract: Synthesis of ( S)-3-mercapto-1-heptyl acetate was achieved in four steps. Sharpless asymmetric epoxidation of ( E)-2-heptenol yielded (2 R,3 R)-2,3-epoxy-1-heptanol, which was treated with thiourea in the presence of Ti(OPr i ) 4 to give (2 S,3 S)-2,3-epithio-1-heptanol, reduction of which followed by acetylation afforded ( S)-3-mercapto-1-heptyl acetate in 91% ee. The optically active product possessed a tropical fruit aroma reminiscent of mango and passion fruit, with berry, ester-like, sweet, and pepper-like aspects.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751914X13989627250405
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 3010810-X
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  • 6
    Online Resource
    Online Resource
    Multi-objective optimization of crash box filled with three-dimensional cellular structure under multi-angle impact loading
    SAGE Publications ; 2021
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 235, No. 9 ( 2021-08), p. 2397-2412
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 235, No. 9 ( 2021-08), p. 2397-2412
    Abstract: Oblique impact loading conditions are common in automobile collision accidents, which strongly influence the energy absorption performance of thin-walled structures. In this paper, a novel three-dimensional (3-D) hexagonal structure-filled crash box with better comprehensive crashworthiness under multiple working conditions is proposed. First, the finite element models of four 3-D typical cellular structures (hexagon structure, re-entrant hexagon structure, star-shape structure, double arrow structure) are established. The dynamic responses of four structures under different impact angles (from 0° to 30°) and impact velocities (from 5 to 15 m/s) are discussed. The results reveal that the 3-D hexagonal structure has great advantages in terms of the energy absorption at varying inclination angles. Second, the 3-D hexagonal structure is filled in the crash box in the form of gradient distribution. The multi-island genetic algorithm (MIGA) based on the response surface model (RSM) is utilized to explore the optimal design of crash box. Compared with the traditional crash box, the optimal 3-D hexagonal structure-filled crash box increases 18.9% in specific energy absorption and decreases 21.7% in maximum peak force, which demonstrates great potential for applications in impact engineering.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/0954407021998174
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2032754-7
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  • 7
    Online Resource
    Online Resource
    Psychometric evaluation of the Chinese version of the media Health Literacy Questionnaire: A validation study
    SAGE Publications ; 2023
    In:  DIGITAL HEALTH Vol. 9 ( 2023-01)
    Details
    In: DIGITAL HEALTH, SAGE Publications, Vol. 9 ( 2023-01)
    Abstract: The media play an important role in health promotion and disease prevention, while at the same time, a variety of mixed health messages in the media are beginning to pose new challenges to them. However, there is a lack of media health literacy (MHL) assessment tools in China. Therefore, the purpose of this study was to translate the Media Health Literacy (MeHLit) questionnaire into Chinese and to assess its psychometric properties. Methods This cross-sectional study was conducted from October to December 2022, and a methodological study of the translation and validation of the MeHLit questionnaire was conducted. Results As a result of an extensive translation and cultural adaptation process, the final MeHLit questionnaire was developed, which includes five dimensions and 21 items. Cronbach's α value of the questionnaire was 0.859, and Cronbach's α value of the dimensions ranged from 0.776 to 0.911, which is fairly good. As a result, the test–retest reliability coefficient and the split-half reliability coefficient of the questionnaire are both equal to 0.907. Its content validity index was 0.946, suggesting a reasonable level of content validity. Through exploratory factor analysis, a five-factor structure was identified based on the eigenvalues, total variance explained, and scree plot. As a result of the validation factor analysis, all recommended fit indicators were appropriate. Conclusion The Chinese version of the MeHLit questionnaire has been successfully introduced in China. It has shown good psychometric properties among the Chinese public and can be used as a tool to evaluate MHL in health screening.
    Type of Medium: Online Resource
    ISSN: 2055-2076 , 2055-2076
    URL: Article
    DOI: 10.1177/20552076231203801
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2819396-9
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  • 8
    Online Resource
    Online Resource
    Malignant Transformation and Treatment of Cystic Mixed Germ Cell Tumor
    SAGE Publications ; 2016
    In:  Translational Neuroscience and Clinics Vol. 2, No. 1 ( 2016-03), p. 25-30
    Details
    In: Translational Neuroscience and Clinics, SAGE Publications, Vol. 2, No. 1 ( 2016-03), p. 25-30
    Abstract: The authors report an extremely unusual presentation and management of a children pineal mixed germ cell tumor mainly composed of immature teratoma, aiming to summarize main theraptic points by literature review. Methods A cystic lesion located in the rear of third ventricle in a child was detected 3 years ago with no other therapy performed except for a ventriculo-peritoneal shunt. During the following 3 years, intermitted regular brain MRI demonstrated no evidence of lesion aggrandizement. However from 20 days before admission to our institute the patient began to present acutely with exacerbating clinical symptoms meanwhile brain MRI showed signs of abrupt revulsions of initial lesion without any incentive cause. Neurological examination revealed a significant rising of serum tumor marker level. Then surgical resection was performed immediately after admission which was followed by correlative two-course chemotherapy. Results Postoperative brain MRI demonstrated totally removing of the lesion in rear of third ventricle. Serum tumor marker level decreased remarkably after surgery and declined to normal level after two-course chemotherapy. No obvious neurological deficit occurred except for short-term memory difficulty which gradually recovered within two weeks. Soon after the second course chemotherapy the patient was currently asymptomatic and returned to school. Conclusions (1) To ensure definitive diagnosis and proper therapecutic protocols benefit from grasping clinical features of mixed germ cell tumor. (2) Overall preoperative investigation including serum tumor marker level is as critical as neurological imaging examination. (3) Surgical excision is confirmed to be the key modality of treatment. With the regarding of mixed germ cell tumor, never highlight total resection too much. (4) Postoperative adjuvant chemotherapy is recommended as further intensive treatment to improve the prognosis of mix germ cell tumor.
    Type of Medium: Online Resource
    ISSN: 2096-0441
    URL: Article
    DOI: 10.18679/CN11-6030_R.2016.001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 9
    Online Resource
    Online Resource
    Leukocyte and Platelet Related Inflammatory Indicators and Risk of Carotid and Femoral Plaques: A Population-Based Cross-Sectional Study in Southeast China
    SAGE Publications ; 2022
    In:  Angiology
    Details
    In: Angiology, SAGE Publications
    Abstract: The associations between several blood inflammatory indicators and risk of vascular plaques remain inconclusive. A total of 4596 native rural residents in Southeast China were enrolled from the Fuqing cohort study. Blood cell counts and their composite indexes including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and 2 novel indicators (systemic immune inflammation index (SII) and systemic immune inflammation response index (SIRI)) were considered as inflammatory indicators. Common carotid and femoral intima-media thickness (IMT) and plaques were assessed using B-mode ultrasound. Unconditional or multinomial logistic regression was used to evaluate potential associations. The prevalence of multiple femoral plaques (defined as IMT ≥1.5 mm) was significantly higher among participants with the highest tertile of total leukocyte count (odds ratio, 1.78), neutrophil count (1.88), monocyte count (2.51), platelet count (1.68), NLR (1.93), PLR (1.57), SII (2.10), and SIRI (2.94). Higher levels of neutrophil count, platelet count, NLR, and SII were also found to have significant linear dose-response relationships with the prevalence of stenosis, especially in femoral arteries. In conclusion, several blood inflammatory biomarkers may contribute to, or are associated with, the presence of IMT ≥1.5 mm or stenosis especially in femoral arteries.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/00033197221129723
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2065911-8
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  • 10
    Online Resource
    Online Resource
    Stress corrosion cracking behavior of micro-arc oxidized AZ31 alloy
    SAGE Publications ; 2020
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 234, No. 8 ( 2020-04), p. 1640-1652
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 234, No. 8 ( 2020-04), p. 1640-1652
    Abstract: The stress corrosion cracking behaviors of micro-arc oxidized AZ31 magnesium alloy were studied by using the slow tensile test in air and 3.5 wt.% NaCl solution. Results showed that compared with the substrate, the stress corrosion cracking susceptibility of the micro-arc oxidized specimens was obvious improved apparently in 3.5 wt.% NaCl solution, due to the good corrosion resistance of the specimens after micro-arc oxidized coating treatment. In addition, regardless of the micro-arc oxidized treatment, it was the mixed fracture in air and the cleavage fracture in 3.5 wt.% NaCl solution. The micro-arc oxidized coating had no direct effect on the fracture mechanism of the alloy. It was closely related to the nature of the material and the environment of the material servicing.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406219894029
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2024890-8
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