GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • SAGE Publications  (17)
  • 1
    In: Antiviral Therapy, SAGE Publications, Vol. 24, No. 7 ( 2019-10), p. 473-483
    Abstract: This 5-year follow-up of the CCgenos cross-sectional study aimed to observe real-life outcomes in a cohort of 997 Han Chinese patients with chronic HCV infection and to explore the impacts of HCV genotype, patient characteristics and treatment status. Methods Clinical information and centralized HCV RNA measures were collected every 6/3 months for untreated/treated patients. Overall disease progression was defined as ≥1 of: de novo development of cirrhosis, Child-Turcotte-Pugh score increased by ≥2 points (if cirrhosis at baseline), progression to decompensated cirrhosis, hepatocellular carcinoma (HCC), liver transplant or death. Cox regression assessed risk factors for the time from estimated infection to cirrhosis or HCC. Logistic regression assessed risk factors for incidence rates of cirrhosis and overall disease progression. Results 281 of 514 patients enrolled across China completed 5 years of follow-up. Overall disease progression occurred in 36/364 (9.9%) treated patients and 35/148 (23.6%) untreated patients (odds ratio = 0.35; 95% CI 0.21, 0.59; P 〈 0.0001). Overall disease progression occurred in 6/231 (2.6%) patients achieving sustained virological response at 24 weeks (SVR24) versus 11/82 (13.4%) who did not ( P=0.0002). Cirrhosis development was significantly associated with abnormal aspartate aminotransferase (AST), age ≥40 years, body mass index ≥28 kg/m 2 , HCV GT1, platelet count 〈 100x10 9 /l, and AST to platelet ratio index (APRI) ≥2 (multivariate Cox regression, P 〈 0.05). HCC was significantly associated with HCV GT1 and platelet count 〈 100x10 9 /l (multivariate Cox regression, P 〈 0.05). Conclusions Achieving SVR24 significantly reduced the probability of overall disease progression but no significant difference was seen for both cirrhosis and HCC during 5 years of follow-up.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 41, No. 5 ( 2021-05), p. 1013-1025
    Abstract: In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min −1 ) compared to their wild-type counterpart (0.56 ± 0.1 min −1 , p  〈  0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2039456-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 9 ( 2018-09), p. 168781401879333-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 9 ( 2018-09), p. 168781401879333-
    Abstract: Conventional decoupling approaches usually employ first-order reliability method to deal with probabilistic constraints in a reliability-based design optimization problem. In first-order reliability method, constraint functions are transformed into a standard normal space. Extra non-linearity introduced by the non-normal-to-normal transformation may increase the error in reliability analysis and then result in the reliability-based design optimization analysis with insufficient accuracy. In this article, a decoupling approach is proposed to provide an alternative tool for the reliability-based design optimization problems. To improve accuracy, the reliability analysis is performed by first-order asymptotic integration method without any extra non-linearity transformation. To achieve high efficiency, an approximate technique of reliability analysis is given to avoid calculating time-consuming performance function. Two numerical examples and an application of practical laptop structural design are presented to validate the effectiveness of the proposed approach.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2501620-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Journal of Vibration and Control Vol. 24, No. 18 ( 2018-09), p. 4353-4366
    In: Journal of Vibration and Control, SAGE Publications, Vol. 24, No. 18 ( 2018-09), p. 4353-4366
    Abstract: With the development of subway lines in urban areas, building structures are sometimes subjected to train-induced vibrations, and there is a need to develop prediction models to evaluate the vibration serviceability. In this paper, a new type of subway-depot system is investigated, where subway trains run through the top story of a 3-story metro depot, while the first two stories were developed for offices and shops to avoid the waste of large city areas. Considering the increasing use of such a structural system and the possible serviceability problems, the floor vibrations of a metro depot under moving subway trains were numerically simulated, where the train-track system was treated as the vibration source and studied separately, and the influence of train speed and fastener configuration on the vibration response was discussed. The metro depot was modeled taking the stiffness of the partition walls into account, and vibration responses of the building at different locations were compared and validated through field tests. Besides, vibration level of the second floor was evaluated using an acceleration index that considers frequency weighting. Finally, parameter analysis was carried out so as to provide some references to the vibration control.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2070247-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Journal of Vibration and Control Vol. 25, No. 4 ( 2019-02), p. 763-776
    In: Journal of Vibration and Control, SAGE Publications, Vol. 25, No. 4 ( 2019-02), p. 763-776
    Abstract: Buildings may experience excessive floor vibrations due to inner excitations such as walking people and running machines, or ground motion caused by the road traffic. Therefore, it is often necessary to evaluate the vibration level at the design stage. In this paper, a frequency domain-based model for predicting vertical vibrations of a building floor is provided, where the floor is simplified as a rectangular plate stiffened by beams in two orthogonal directions, while vertical motion and rotation of the slab–column joints are viewed as the unknown degrees of freedom. The dynamic stiffness matrix of the whole structure is obtained from those of the floor and column elements. To validate the proposed solution, a five-story building was analyzed, and frequency spectra were compared with those from the finite element method. Besides, a prototype building was analyzed and validated based on field measured data. It is found that the proposed solution could predict vibration responses with satisfactory accuracy, and is more computationally efficient than finite element analysis.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2070247-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Applied Psychological Measurement Vol. 41, No. 8 ( 2017-11), p. 579-599
    In: Applied Psychological Measurement, SAGE Publications, Vol. 41, No. 8 ( 2017-11), p. 579-599
    Abstract: Large-scale assessments are supported by a large item pool. An important task in test development is to assign items into scales that measure different characteristics of individuals, and a popular approach is cluster analysis of items. Classical methods in cluster analysis, such as the hierarchical clustering, K-means method, and latent-class analysis, often induce a high computational overhead and have difficulty handling missing data, especially in the presence of high-dimensional responses. In this article, the authors propose a spectral clustering algorithm for exploratory item cluster analysis. The method is computationally efficient, effective for data with missing or incomplete responses, easy to implement, and often outperforms traditional clustering algorithms in the context of high dimensionality. The spectral clustering algorithm is based on graph theory, a branch of mathematics that studies the properties of graphs. The algorithm first constructs a graph of items, characterizing the similarity structure among items. It then extracts item clusters based on the graphical structure, grouping similar items together. The proposed method is evaluated through simulations and an application to the revised Eysenck Personality Questionnaire.
    Type of Medium: Online Resource
    ISSN: 0146-6216 , 1552-3497
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 224215-1
    detail.hit.zdb_id: 2002941-X
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2006
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 1954, No. 1 ( 2006-01), p. 45-51
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 1954, No. 1 ( 2006-01), p. 45-51
    Abstract: Based on a large sample survey conducted in 2004, this paper presents a market analysis of the bicycle delivery service systems in Beijing. The discussion includes distribution companies, distribution services, employment, employees, and customers. In addition to the sample survey, on-the-spot visits and additional analyses were carried out. Future trends in bicycle delivery service systems in Beijing are also presented. Based on a strengths, weaknesses, opportunities, and threats (SWOT) model analysis, the paper also forecasts and suggests methods for repositioning bicycle delivery service systems in Chinese cities. The suggestions are China-specific and are meant to assist the regulatory authorities in the supervision of the transport logistics system and the standardization of delivery service by means of bicycle.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2403378-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  International Journal of Damage Mechanics Vol. 31, No. 10 ( 2022-11), p. 1592-1612
    In: International Journal of Damage Mechanics, SAGE Publications, Vol. 31, No. 10 ( 2022-11), p. 1592-1612
    Abstract: A series of triaxial compression tests were conducted on deep-buried marble to reveal its deformation and failure characteristics along with the formation mechanism under high in-situ stress. The effects of confining pressure on the strength, deformation of marble samples were firstly analyzed. Then, the internal failure characteristics and energy evolution of the samples were comprehensively investigated based on the micro-CT scanning technology and energy balance theory. Results show that the strength and deformation at damage stress and peak stress points of marble samples increase with the increase of confining pressure. Micro-CT reconstructions reveal that the microcracks in the uniaxial compression sample are mainly tensile cracks and the failure exhibits obvious brittleness and splitting characteristics. The failure mode of triaxial compression samples gradually changes to shear failure with the increase of confining pressure. The number of cracks decreases first and then increases, and the damage is intensified around the main shear failure plane of samples under high confining pressure, resulting in a large number of conjugate secondary cracks. Further, with the increase of confining pressure, the strength increases linearly at energy hardening point, but increases nonlinearly at energy softening point. At the peak stress point, both total energy U tp and dissipated energy U dp increase in a concave function, while the elastic strain energy U ep and the circumferential strain energy U 3p (negative direction) increase linearly. Besides, the damage evolution driven by energy can be roughly divided into hardening phase, energy storage phase, damage softening phase, and residual phase. These results can provide a useful reference for further understanding the failure mechanism of rock under high in-situ stress for disaster prevention.
    Type of Medium: Online Resource
    ISSN: 1056-7895 , 1530-7921
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2052623-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Applied Spectroscopy Vol. 76, No. 5 ( 2022-05), p. 599-608
    In: Applied Spectroscopy, SAGE Publications, Vol. 76, No. 5 ( 2022-05), p. 599-608
    Abstract: Optofluidic devices are of high interest for online monitoring and analyzing biochemical targets in water by integrating the complex on-chip pretreatment of target analytes and spectral analysis. Compared with the traditional bulk equipment, versatile optical detection and biochemical analysis are more easily integrated on an optofluidic chip, which promotes the development of on-chip real-time rapid detection and monitoring. Here, we report an optofluidic platform for online monitoring total phosphorous in water by absorption spectrometry, which naturally combines the merits of both the photo-Fenton effect and microfluidics to realize the rapid on-chip digestion of phosphate at room temperature and normal pressure. The functional cells for chromogenic reaction and optical absorption detection are, respectively, fabricated on the platform to analyze the content of total phosphorus in surface water. In the experiment, the on-chip digestion time of phosphate is dramatically declined to 8.6 sec, and thus, the detection time is greatly shortened to a few minutes. The detection range of total phosphorus is demonstrated as 0.005–1.00 mg L −1 , which satisfies the detection requirements of most environmental water samples. Its availability for measuring the total phosphorous in real water samples is also verified. Predictably, this platform is adapted to on-chip analysis of many other biochemical targets in water.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1474251-2
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2021
    In:  European Journal of Ophthalmology Vol. 31, No. 4 ( 2021-07), p. 2013-2019
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 31, No. 4 ( 2021-07), p. 2013-2019
    Abstract: To assess the safety of pars plana vitrectomy (PPV) in patients undergoing systemic treatment with aspirin. Methods: This prospective study enrolled consecutive patients undergoing PPV under percutaneous retrobulbar anesthesia between February 2016 and July 2018. Sixty-seven eyes from 67 patients on regular aspirin therapy were randomized into two groups: the continuation group (33 eyes), with aspirin continued during the perioperative period; and the discontinuation group (34 eyes), with aspirin discontinued for 3 to 7 days before surgery. Forty-three eyes from 43 patients who had no antiplatelet/anticoagulant therapy were used as a control group. Results: There was no significant difference in the incidence of hemorrhagic complications or the need for additional operations due to hemorrhagic complications among the three groups ( p = 0.740 and p = 0.324, respectively). None of the patients in these three groups suffered from thromboembolic events during the follow-up period. Except for one case (3.0%) of lid ecchymosis in the continuation group, no eye experienced bleeding complications associated with the retrobulbar local anesthesia. In the continuation group, three eyes (9.1%) demonstrated postoperative hyphema that resolved spontaneously. In the discontinuation group, two eyes (5.9%) suffered from postoperative vitreous hemorrhage, of which one eye required secondary surgery and the other cleared spontaneously. One eye (2.9%) in the discontinuation group demonstrated postoperative hyphema that absorbed spontaneously. Three eyes (7.0%) in the control group experienced hyphema that absorbed spontaneously. Conclusion: The outcomes of our study indicate that PPV under retrobulbar anesthesia can be safely performed without discontinuing systemic aspirin therapy.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 1475018-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...