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  • SAGE Publications  (248)
  • 1
    Online Resource
    Online Resource
    Effects of UV irradiation time on the molecular structure of typical engineering plastics and tribological properties under heavy load
    SAGE Publications ; 2022
    In:  High Performance Polymers Vol. 34, No. 3 ( 2022-04), p. 352-362
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 34, No. 3 ( 2022-04), p. 352-362
    Abstract: Exposing engineering plastics to UV irradiation can easily destroy the original molecular structure of the materials and consequently affect their tribological properties. This study investigated the effects of UV irradiation on the molecular structure of typical engineering plastics, such as polytetrafluoroethylene (PTFE) and polyether ether ketone (PEEK), and on their tribological properties under heavy loads (20 MPa). The surface morphology results showed that the appearance of PEEK changed significantly under UV irradiation. However, the change in PTFE was negligible. Under micromorphology, the processing lines of the two materials gradually became lighter with increasing UV irradiation time. The resulting infrared spectra showed that the molecular chains of both materials were broken, and new functional groups were formed under UV irradiation. Tribology testing demonstrated that with prolonged UV irradiation, the average PTFE coefficient of friction remained relatively stable, whereas that of PEEK was approximately 0.55. As the UV irradiation time increased, the wear rate of PTFE increased significantly, whereas that of PEEK showed no significant change.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/09540083211066537
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1483713-4
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  • 2
    Online Resource
    Online Resource
    The effect of zwitterionic surface content on blood circulation time of nanocapsule
    SAGE Publications ; 2020
    In:  Journal of Biomaterials Applications Vol. 35, No. 3 ( 2020-09), p. 371-384
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 35, No. 3 ( 2020-09), p. 371-384
    Abstract: Zwitterionic modification can prolong the blood circulation time of nanocarrier in vivo, but zwitterionic content will affect the functions of nanocarrier such as enzyme-responsive and intracellular or extracellular delivery. Therefore, it is necessary to explore the relationship between the zwitterionic content and circulation time of nanocarrier so as to figure out what content of zwitterion can enable the nanocarrier to obtain both the long blood circulation ability and other functions mentioned above. Herein, using nanocapsule as a research model, we investigated the nanocapsule modified with zwitterion of phosphorylcholine (PC) or carboxybetaine (CB) respectively, and through 1 H-NMR quantification we determined the zwitterionic surface content, so as to study the effect of PC or CB surface content on blood circulation performance of nanocapsule. In vivo study showed that the nanocapsule possessed an optimal surface filling ratios range for blood circulation of 43–68% for PC and of 20–68% for CB, with the longest t 1/2 =37.35 h for PC-nanocapsule and t 1/2 =45.27 h for CB-nanocapsule. Furthermore, the protein adsorption and macrophage endocytosis experiments indicated that when the surface filling ratio reached 43% for PC-nanocapsule and 20% for CB-nanocapsule, it could effectively reduce the protein adsorption and weaken macrophage endocytosis, thus explaining the phenomenon of long circulation time of nanocapsules from the point of protein adsorption and interaction with immune cells. This study proposes a new direction for designing long-circulating nanocarrier, and provides basis for constructing enzyme-responsive and intracellular or extracellular delivery platform.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328220935381
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 3
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    Human serum albumin variants in China: a molecular epidemiological investigation and literature review
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 12 ( 2021-12), p. 030006052110642-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 12 ( 2021-12), p. 030006052110642-
    Abstract: Bisalbuminemia is a hereditary and/or acquired abnormality characterized by a double albumin (ALB) band on serum protein electrophoresis. However, there have been no epidemiological investigations of ALB variants in Chinese populations. Methods This retrospective study examined 71,963 unrelated subjects from five provinces in southern China. ALB variants were screened by cellulose acetate electrophoresis at pH 8.6 and ALB mutations were confirmed by polymerase chain reaction-DNA sequencing. Results The average incidence of inherited bisalbuminemia in the southern Chinese population was 0.0264% (19/71,963). Thirteen cases showed slow and six showed fast genetic variants on cellulose acetate electrophoresis. Four kinds of ALB variants were identified: proalbumin Lille (p.Arg23His), ALB Castel di Sangro (p.Lys560Glu), ALB Fukuoka-1 (p.Asp587Asn), and a novel ALB Wuxi (p.Lys562Glu). The gene frequency of ALB variants in the Wuxi region (0.126%, 13/10,297) was significantly higher than in other regions in southern China, and 90.9% (10/11) of cases of proalbumin Lille were also found in the Wuxi region. Conclusions This study provides the first report of the detailed prevalence and molecular characterization of ALB variants in southern China. Compared with other areas of China, Wuxi had a different pattern of ALB variants and a high prevalence of proalbumin Lille.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211064225
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 4
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    Excessive proliferation and apoptosis of parathyroid cells contribute to primary hyperparathyroidism in rabbit model
    SAGE Publications ; 2022
    In:  Journal of Investigative Medicine Vol. 70, No. 6 ( 2022-08), p. 1392-1398
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 70, No. 6 ( 2022-08), p. 1392-1398
    Abstract: To explore the molecular pathogenesis of primary hyperparathyroidism (PHPT), we investigated the proliferation and apoptosis of parathyroid cells in a rabbit model of diet-induced PHPT. A total of 120 adult Chinese rabbits were randomly divided into normal diet (Ca:P, 1:0.7) group (control group) or a high-phosphate diet (Ca:P, 1:7) group (experimental group). The thyroid and parathyroid complexes were harvested for 1-month interval from month 1 to month 6. The expression of proliferation markers, including proliferating cell nuclear antigen (PCNA) and cyclin-D1, and B cell lymphoma-2 (Bcl-2), were evaluated by immunohistochemistry in thyroid and parathyroid tissues. Apoptosis was quantified by DNA-fragment terminal labeling. Our results demonstrated that parathyroid cells in the experimental group started proliferating from the end of the 2nd month, the expression of PCNA, Bcl-2, and cyclin-D1 were significantly higher in the PHPT group than those of the control group (p 〈 0.05). Furthermore, the apoptosis index (AI) was positively correlated with the glandular cell count and expression of PCNA in the 6th month in the PHPT group. Overall, our results suggested that excessive proliferation and apoptosis of parathyroid cells may contribute to the pathogenesis of PHPT through PCNA-related, Bcl-2-related, and cyclin-D1-related pathways.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-2021-002184
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 5
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    Online Resource
    Long non-coding RNA Down syndrome cell adhesion molecule-anti-sense 1 promotes gastric carcinoma cell proliferation and migration by regulating the miR-204/TPT1 axis
    SAGE Publications ; 2021
    In:  Human & Experimental Toxicology Vol. 40, No. 12_suppl ( 2021-12), p. S187-S195
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 40, No. 12_suppl ( 2021-12), p. S187-S195
    Abstract: Background: Several recent studies have suggested that the long non-coding RNA (lncRNA) DSCAM-AS1 (Down syndrome cell adhesion molecule - anti-sense 1) is aberrantly expressed in many malignancies. Purpose: In this study, we aimed to explore the the role of DSCAM-AS1 in gastric carcinoma. Research Design: Expression of DSCAM-AS1 mRNA, miR-204, and TPT1 (Tumor Protein, Translationally-Controlled 1) were detected using quantitative real-time polymerase chain reaction (qRT-PCR). Proliferation and apoptosis of GC cells were determined using the CCK-8 cell counting assay and flow cytometry. The rate of cell migration and invasion was determined using a transwell assay. The relationships between DSCAM-AS1, miR-204, and TPT1 were predicted and confirmed using a dual-luciferase reporter assay. Expression of TPT1 protein was quantified by Western blot. Results: In this study, we found that DSCAM-AS1 was significantly overexpressed in GC tissues and cell lines. Functional experiments indicated that GC cells with DSCAM-AS1 silencing exhibited a dynamic reduction in proliferation and migration. We identified miR-204 as a target of DSCAM-AS1 and found that it targeted TPT1 in GC cells, which further led to decreased expression of miR-204 in GC tissues and cell lines. A rescue assay revealed that knocked-down DSCAM-AS1 hindered GC progression, which was reversed upon miR-204 downregulation or TPT1 overexpression. Conclusion: We conclude that DSCAM-AS1 is expressed as a tumor oncogene in GC progression, modulated via the miR-204/TPT1 axis. These findings indicate the potential of DSCAM-AS1 as a therapeutic target for GC prevention.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/09603271211036037
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 1483723-7
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  • 6
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    Highway safety influencing factors in cold regions based on attribute recognition theory
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 12 ( 2018-12), p. 168781401881833-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 12 ( 2018-12), p. 168781401881833-
    Abstract: To study the problem of highway traffic safety in cold regions, a thorough statistical analysis using traffic accident historical data is used to evaluate the influencing factors on highway traffic safety. A road traffic safety indicator system for cold regions is developed to evaluate the weight of these influence factors, such as driver performance, vehicle capacity, road condition, and general impact of the traffic environment. An index system of highway traffic safety influencing factors for cold regions is developed, and an evaluation model for traffic road safety influencing factors in cold regions based on attribute recognition theory is proposed. The weight of the model is determined using an analytic hierarchy process combined with expert scoring. The evaluation model is based on single-index attribute measure values and multi-index comprehensive attribute measurement values, using the confidence criterion to identify the influence of road traffic safety factors on road traffic safety in cold regions. In addition, the fuzzy comprehensive evaluation method is used for comparative evaluation, and the evaluation results were consistent and verified the correctness and feasibility of the attribute recognition model. Results showed that the evaluation system was in good agreement with actual traffic conditions in cold regions.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814018818337
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2501620-9
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  • 7
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    A randomized controlled trial of a modified wheelchair arm-support to reduce shoulder pain in stroke patients
    SAGE Publications ; 2018
    In:  Clinical Rehabilitation Vol. 32, No. 1 ( 2018-01), p. 37-47
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 32, No. 1 ( 2018-01), p. 37-47
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215517714830
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2028323-4
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  • 8
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    Chronic B-Type Natriuretic Peptide Therapy Prevents Atrial Electrical Remodeling in a Rabbit Model of Atrial Fibrillation
    SAGE Publications ; 2019
    In:  Journal of Cardiovascular Pharmacology and Therapeutics Vol. 24, No. 6 ( 2019-11), p. 575-585
    Details
    In: Journal of Cardiovascular Pharmacology and Therapeutics, SAGE Publications, Vol. 24, No. 6 ( 2019-11), p. 575-585
    Abstract: Atrial fibrillation (AF) is an important and growing clinical problem. Current pharmacological treatments are unsatisfactory. Electrical remodeling has been identified as one of the principal pathophysiological mechanisms that promote AF, but there are no effective therapies to prevent or correct electrical remodeling in patients with AF. In AF, cardiac production and circulating levels of B-type natriuretic peptide (BNP) are increased. However, its functional significance in AF remains to be determined. We assessed the hypotheses that chronic BNP treatment may prevent the altered electrophysiology in AF, and preventing AF-induced activation of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) may play a role. Methods and Results: Forty-four rabbits were randomly divided into sham, rapid atrial pacing (RAP at 600 beats/min for 3 weeks), RAP/BNP, and sham/BNP groups. Rabbits in the RAP/BNP and sham/BNP groups received subcutaneous BNP (20 μg/kg twice daily) during the 3-week study period. HL-1 cells were subjected to rapid field stimulation for 24 hours in the presence or absence of BNP, KN-93 (a CaMKII inhibitor), or KN-92 (a nonactive analog of KN-93). We compared atrial electrical remodeling-related alterations in the ion channel/function/expression of these animals. We found that only in the RAP group, AF inducibility was significantly increased, atrial effective refractory periods and action potential duration were reduced, and the density of I Ca, L and I to decreased, while I K1 increased. The changes in the expressions of Cav1.2, Kv4.3, and Kir2.1 and currents showed a similar trend. In addition, in the RAP group, the activation of CaMKIIδ and phosphorylation of ryanodine receptor 2 and phospholamban significantly increased. Importantly, these changes were prevented in the RAP/BNP group, which were further validated by in vitro studies. Conclusions: Chronic BNP therapy prevents atrial electrical remodeling in AF. Inhibition of CaMKII activation plays an important role to its anti-AF efficacy in this model.
    Type of Medium: Online Resource
    ISSN: 1074-2484 , 1940-4034
    URL: Article
    DOI: 10.1177/1074248419854749
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2230155-0
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  • 9
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    Chinese expert consensus recommendations for the administration of immune checkpoint inhibitors to special cancer patient populations
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Medical Oncology Vol. 15 ( 2023-01)
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 15 ( 2023-01)
    Abstract: Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1, programmed cell death ligand 1, and cytotoxic T lymphocyte-associated antigen-4 have shown significantly durable clinical benefits and tolerable toxicities and have improved the survival of patients with various types of cancer. Since 2018, the National Medical Products Administration of China has approved 17 ICIs as the standard treatment for certain advanced or metastatic solid tumors. As ICIs represent a broad-spectrum antitumor strategy, the populations eligible for cancer immunotherapy are rapidly expanding. However, the clinical applications of ICIs in cancer patient populations with special issues, a term that refers to complex subgroups of patients with comorbidities, special clinical conditions, or concomitant medications who are routinely excluded from prospective clinical trials of ICIs or are underrepresented in these trials, represent a great real-world challenge. Although the Chinese Society of Clinical Oncology (CSCO) has provided recommendations for screening before the use of ICIs in special populations, the recommendations for full-course management remain insufficient. The CSCO Expert Committee on Immunotherapy organized leading medical oncology and multidisciplinary experts to develop a consensus that will serve as an important reference for clinicians to guide the proper application of ICIs in special patient populations. This article is a translation of a study first published in Chinese in The Chinese Clinical Oncology (ISSN 1009-0460, CN 32-1577/R) in May 2022 (27(5):442–454). The publisher of the original paper has provided written confirmation of permission to publish this translation in Therapeutic Advances in Medical Oncology.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359231187205
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2503443-1
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  • 10
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    Vericiguat reduces electrical and structural remodeling in a rabbit model of atrial fibrillation
    SAGE Publications ; 2023
    In:  Journal of Cardiovascular Pharmacology and Therapeutics Vol. 28 ( 2023-01)
    Details
    In: Journal of Cardiovascular Pharmacology and Therapeutics, SAGE Publications, Vol. 28 ( 2023-01)
    Abstract: Purpose: The molecular etiology of atrial fibrillation (AF) and its treatment are poorly understood. AF involves both electrical and structural features. Vericiguat can ameliorate cardiac remodeling in heart failure. The effects of vericiguat on AF, however, are unclear. Here, the actions of vericiguat on atrial structural and electrical remodeling in AF and its possible mechanisms were investigated. Methods and Results: Thirty-six rabbits were randomly allocated to four groups, namely, sham, RAP (pacing with 600 beats/min over three weeks), vericiguat-treated (three weeks’ pacing plus daily oral dose of 1.5 mg/kg of vericiguat), and vericiguat-treated only. HL-1 cells received rapid pacing with or without vericiguat. Parameters including electrophysiology, echocardiography, histology, Ca 2+ levels, and I CaL density, as well as levels of TRPC6, CaN, NFAT4, p-NFAT4, Cav1.2, collagen I, collagen III, and ST2 were measured. Significant changes of above proteins expression level, circulating biochemical indices, Ca 2+ concentrations, and I CaL density in both animals and cell models, these effects were significantly restored by vericiguat. Vericiguat also reversed the enlarged atrium and significantly reduced myocardial fibrosis, together with preventing reduced atrial effective refractory periods (AERPs) and AF induction rate. Conclusion: Vericiguat thus ameliorated AF-associated structural and electrical remodeling. These findings suggest the potential of vericiguat for treating AF.
    Type of Medium: Online Resource
    ISSN: 1074-2484 , 1940-4034
    URL: Article
    DOI: 10.1177/10742484231185252
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2230155-0
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