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  • SAGE Publications  (252)
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  • 1
    Online Resource
    Online Resource
    A Retrospective Evaluation of Radiotherapy for the Treatment of Local Esophageal Squamous Cell Carcinoma Recurrence after Initial Complete Surgical Resection
    SAGE Publications ; 2013
    In:  Journal of Investigative Medicine Vol. 61, No. 1 ( 2013-01), p. 34-39
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 61, No. 1 ( 2013-01), p. 34-39
    Abstract: Our purpose was to assess the efficacy of radiation therapy in the treatment of locoregional recurrence of esophageal squamous cell carcinoma recurrence after curative resection. Methods Patients with local esophageal squamous cell carcinoma recurrence who were treated at the Cancer Prevention and Treatment Center of Sun Yat-sen University from January 1990 to December 2002 and whose initial treatment was complete surgical resection (N = 152) were included. Of the 152 patients, 60 patients received treatment with radiation therapy, and the others did not receive radiation. None of the included patients received chemotherapy or radiotherapy before surgery. The Kaplan-Meier method was used to calculate the cumulative survival rate. Results The median survival time was 16.0 ± 2.7 months for those who received radiotherapy versus 6.5 ± 1.6 months for those who did not ( P 〈 0.001). The median survival time was greater (22.3 ± 4.0 months) for patients who receive a dosage greater than 50 Gy compared with those patients who received a dosage of 50 Gy or less (7.7 ± 0.3 months; P = 0.033). The overall 3- and 5-year survival rates were 16.4% and 10.4%, respectively. The 1-, 2-, and 3- year recurrence-free survival rates were 56.1 ± 4.3%, 32.9 ± 4.1%, and 22.0 ± 3.7%, respectively. Conclusion Radiotherapy may help improve the survival rate in patients with local esophageal squamous cell carcinoma recurrence after complete surgical resection who have no history of radiotherapy.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.2310/JIM.0b013e318276de92
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
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  • 2
    Online Resource
    Online Resource
    Platelet-rich plasma inhibits inflammation, apoptosis, and the NLRP3/Caspase-1 pathway and induces matrix metalloproteinases and proliferation of IL-1β-induced articular chondrocytes by downregulating T-box transcription factor 3
    SAGE Publications ; 2022
    In:  European Journal of Inflammation Vol. 20 ( 2022-01), p. 1721727X2210930-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 20 ( 2022-01), p. 1721727X2210930-
    Abstract: Osteoarthritis (OA) is a chronic joint disease characterized by osteoproliferation and the degeneration and destruction of articular cartilage. Platelet-rich plasma (PRP) is rich in various growth factors that have been reported to promote bone defect repair. This study examined the specific role and mechanism of PRP in OA. Methods OA model cells were created by treating articular chondrocytes with IL-1β. After treatment of the model cells with PRP or/and a T-box transcription factor 3 (TBX3)-overexpression plasmid, TBX3 expression was monitored via RT-qPCR, western blotting, and immunofluorescence assays. IL-1β, IL-33, and Caspase-3 levels were detected with ELISA kits. Levels of NLRP3, Caspase-1, MMP9, MMP13, and COL2A1 expression were evaluated by western blotting, and cell proliferation was assessed by the CCK-8 assay. Results Our results showed that TBX3 expression was upregulated in IL-1β-induced articular chondrocytes. IL-1β stimulation induced inflammation and the production of matrix metalloproteinases, activated Caspase-3 and the NLRP3/Caspase-1 pathway, inhibited the proliferation of articular chondrocytes; however, all those affects mediated by IL-1β could be markedly reversed by PRP. We also found that PRP alleviated IL-1β-induced inflammation, apoptosis, and extracellular matrix degradation in articular chondrocytes by inhibiting TBX3. Our findings suggest that PRP alleviates OA progression in vitro by downregulating TBX3. Conclusion PRP suppressed OA progression in vitro by inhibiting TBX3, which may be its mechanism of action in treating OA.
    Type of Medium: Online Resource
    ISSN: 1721-727X , 2058-7392
    URL: Article
    DOI: 10.1177/1721727X221093056
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2584683-8
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  • 3
    Online Resource
    Online Resource
    Predictive Value of Adenoid-Nasopharyngeal Ratio in the Diagnosis of Secretory Otitis Media
    SAGE Publications ; 2022
    In:  Ear, Nose & Throat Journal
    Details
    In: Ear, Nose & Throat Journal, SAGE Publications
    Abstract: To explore the associated factors of otitis media with effusion (OME) and analyze the diagnostic value of the adenoid-nasopharyngeal (A/N) ratio to OME. Methods Patients with adenoid hypertrophy (AH) recently in 2 years were collected, including sex, age, duration, with/without rhinosinusitis, and examination results, including Cone Beam Computerized Tomography (CBCT) sinus imaging, tympanometry, pure tone audiometry (PTA), blood test, and allergen detection. According to Liden/Jerger’s classification, the patients were divided into two groups: Type B and type C, which were defined as the tympanometry abnormal group (TAG), and the rest were classified as the tympanometry normal group (TNG). Results A total of 316 children were included in this study. Age and duration were significantly younger and shorter in TAG (6.0(4.0-9.0) vs.5.0(4.0-7.0)); 12.0(4.0-24.0) vs.6.0(2.0-12.0)). Compared to TNG, the allergen test results of fx5 (protein, milk, cod, wheat, peanut, and soybean) in TAG were higher (0.09(0.04-0.25) vs.0.14(0.05-0.45)), but eosinophilia in blood was lower (count: 0.21(0.13-0.35) vs. 0.18(0.12-0.27); ratio: 3.10 (1.90-4.70) vs. 2.50 (1.65-3.80)). A/N ratio and Visual obstruction ratio had a statistical difference (Z = −3.770, P 〈 .01) but the two ratios didn’t have too much disparity (0.82(0.74-0.88) VS 0.80(0.75-0.80)), and they had a positive correlation (r = 0.345, P 〈 .01). A/N ratio of TAG was higher than TNG (0.78(0.70-0.85) vs. 0.86(0.82-0.90)) and had a positive correlation with increasing negative middle ear pressure (r = −3.777, P 〈 .01). A/N ratio was an associated factor of OME (OR:1355.611, P = .006), the cut-off value of A/N ratio was 0.815(sensitivity: 75.3%, specificity: 64.3%, area under the curve (AUC): 0.747) Conclusions A/N ratio indirectly reflected the abnormality of tympanometry in this study. When A/N ratio reaches 0.815, patients are at a higher risk of having OME so it could be a predictor of OME in patients with adenoid hypertrophy.
    Type of Medium: Online Resource
    ISSN: 0145-5613 , 1942-7522
    URL: Article
    DOI: 10.1177/01455613221144496
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2067528-8
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  • 4
    Online Resource
    Online Resource
    Comparative analysis of three common imaging modalities for nasolabial cysts
    SAGE Publications ; 2023
    In:  Journal of International Medical Research Vol. 51, No. 1 ( 2023-01), p. 030006052211472-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 51, No. 1 ( 2023-01), p. 030006052211472-
    Abstract: To compare the clinical diagnostic value of ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI) for nasolabial cysts. Methods The clinical and imaging data of 20 patients with 21 nasolabial cysts confirmed surgically and histopathologically were retrospectively analyzed. Results The largest cyst was 3.4 × 2.7 × 2.3 cm, and the smallest cyst was 1.1 × 0.7 × 0.5 cm. All cysts were located in the soft tissue between the nasolabial fold and maxillary bone. USG showed sensitivity of 95%, accuracy of 95%, and a missed diagnosis rate of 5%; CT showed sensitivity of 80%, accuracy of 80%, and a missed diagnosis rate of 20%; and MRI showed sensitivity of 85%, accuracy of 85%, and a missed diagnosis rate of 15%. Conclusions USG showed higher sensitivity and accuracy and a lower missed diagnosis rate than CT and MRI. Therefore, USG is worth popularizing on a large scale for the diagnosis of nasolabial cysts.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605221147201
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2082422-1
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  • 5
    Online Resource
    Online Resource
    Schwannoma in the Olfactory Groove: Two Case Reports
    SAGE Publications ; 2022
    In:  Ear, Nose & Throat Journal
    Details
    In: Ear, Nose & Throat Journal, SAGE Publications
    Abstract: The occurrence of an isolated schwannoma in the olfactory groove is extremely rare. We herein present 2 cases of schwannomas in the olfactory groove that were treated with endoscopic excision. In these 2 cases, the tumor originated in the cribriform plate and cerebrospinal fluid rhinorrhea occurred after tumor resection, which was repaired using tissue grafts.
    Type of Medium: Online Resource
    ISSN: 0145-5613 , 1942-7522
    URL: Article
    DOI: 10.1177/01455613221139405
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2067528-8
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  • 6
    Online Resource
    Online Resource
    Synthesis and Anticoccidial Activity of ethyl 6-substitutedbenzyloxy-7-alkoxy-4-hydroxyquinoline-3-carboxylates
    SAGE Publications ; 2009
    In:  Journal of Chemical Research Vol. 2009, No. 4 ( 2009-04), p. 252-254
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2009, No. 4 ( 2009-04), p. 252-254
    Abstract: A series of novel ethyl 6-substitutedbenzyloxy-7-alkoxy-4-hydroxyquinoline-3-carboxylates have been designed and synthesised from 4-nitro-2-alkoxyphenol. Their structures have been characterised by 1 H NMR, HRMS and IR spectra. Anticoccidial activities of these compounds were evaluated according to the ACI (the anticoccidial index) method. The results indicated that three of the tested compounds exhibited anticoccidial activities against Eimeria tenella in chicken feed with a dose of 27 mg/kg.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/030823409X439726
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 3010810-X
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  • 7
    Online Resource
    Online Resource
    Internal unsteady flow characteristics of centrifugal pump based on entropy generation rate and vibration energy
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering Vol. 233, No. 3 ( 2019-06), p. 456-473
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, Vol. 233, No. 3 ( 2019-06), p. 456-473
    Abstract: The transient fluid exciting force induced by unsteady flow in the centrifugal pump is the only exciting force that cannot be effectively eliminated. In order to explore the vibration problem caused by unsteady flow in the centrifugal pump, the steady and unsteady numerical calculations of the internal flow in a centrifugal pump with low specific speed were carried out under different flow rate conditions. With volute circumferential pressure pulsation test, the accuracy of numerical calculations was verified. At the same time, the vibration acceleration sensors were arranged in different positions of the pump body to complete the vibration characteristics experiment under different working conditions. Based on the numerical results, the amount and location of the internal flow loss of the centrifugal pump were predicted by the entropy generation rate method. According to the results of the vibration test, the vibration energy distribution of the centrifugal pump under different working conditions was obtained. In combination with the entropy generation rate and vibration energy distribution, the change rules of flow loss and the vibration energy with the flow condition of the pump were analyzed. By using the frequency-domain analysis method, the pressure pulsation, the unsteady radial fluid exciting force fluctuation and the vibration acceleration were compared and analyzed to study the change rules of the pressure pulsation, the unsteady fluid exciting force and the vibration characteristics with the flow rate. The results show that the internal flow loss is mainly concentrated in the impeller runner near the volute tongue under low flow condition and the internal flow loss under large flow rate condition is mainly concentrated in the volute channel near the pump outlet. The vibration induced by the unsteady flow in the centrifugal pump is mainly low-frequency vibration, which is very sensitive to the change of the flow rate. The vibration energy in the middle- and high-frequency ranges is almost not affected by the working condition. The internal flow loss and the low-frequency vibration energy change with the flow condition, showing similar change rules.
    Type of Medium: Online Resource
    ISSN: 0954-4089 , 2041-3009
    URL: Article
    DOI: 10.1177/0954408918765289
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024897-0
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  • 8
    Online Resource
    Online Resource
    A Rare Case of Metastatic Clear Cell Renal Cell Carcinoma to the Petroclival Region Presenting as Posterior Cranial Neuropathies
    SAGE Publications ; 2023
    In:  Ear, Nose & Throat Journal
    Details
    In: Ear, Nose & Throat Journal, SAGE Publications
    Abstract: We present a case of metastatic renal cell carcinoma (RCC) to the petroclival region with clinical symptoms manifested as posterior cranial neuropathies. A 65-year-old male presented with headache symptom for over 1 year, during which time he was diagnosed with RCC and underwent right nephrectomy. However, the headache symptom and cranial neuropathies had been attributed to cranial neuritis all the time until the surgical removal of metastatic tumor in the petroclival region led to the diagnosis of metastatic RCC. RCC has a tendency for metastasis early. The incidence of spread of RCC to brain is a rarity in clinical practice. When a patient presents with cranial nerve neuropathies, the possibility of metastatic RCC should be sought. Brain metastases display nonspecific presentations, and it is useful to examine with magnetic resonance imaging and computed tomography scans radiologically.
    Type of Medium: Online Resource
    ISSN: 0145-5613 , 1942-7522
    URL: Article
    DOI: 10.1177/01455613231182670
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2067528-8
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  • 9
    Online Resource
    Online Resource
    Clinical Effectiveness of Gene Therapy on Critical Limb Ischemia : A Meta-analysis of 5 Randomized Controlled Clinical Trials
    SAGE Publications ; 2014
    In:  Vascular and Endovascular Surgery Vol. 48, No. 5-6 ( 2014-07), p. 372-377
    Details
    In: Vascular and Endovascular Surgery, SAGE Publications, Vol. 48, No. 5-6 ( 2014-07), p. 372-377
    Abstract: Therapeutic angiogenesis using gene therapy is a novel strategy for the treatment of critical limb ischemia (CLI). We conducted a meta-analysis to evaluate the efficacy and safety of gene therapy for the treatment of CLI with no option of revascularization. Randomized placebo controlled trials of gene therapy on CLI were identified by searching PubMed (from 1990 to October 2013) and EMBASE (from 1990 to October 2013). Five eligible studies were selected for the meta-analysis. Among these studies, a total of 425 patients received gene therapy of either fibroblast growth factor 1 or hepatocyte growth factor, and 365 patients were given placebo. No statistical differences were observed between the 2 groups in major amputation or death at 1 year (risk ratio [RR], 0.83; 95% confidence interval [CI] , 0.51-1.39; P = .48) and wound healing at 6 months (RR, 1.55; 95% CI, 0.73-3.28; P = .25). Gene therapy had similar occurrence of serious adverse events as control (RR, 1.05; 95% CI, 0.97-1.14; P = .23).
    Type of Medium: Online Resource
    ISSN: 1538-5744 , 1938-9116
    URL: Article
    DOI: 10.1177/1538574414539397
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2095223-5
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  • 10
    Online Resource
    Online Resource
    Research on the influence of micropits structure on the tribological performance of friction pairs
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 233, No. 2 ( 2019-02), p. 317-325
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 233, No. 2 ( 2019-02), p. 317-325
    Abstract: According to the traditional lubrication theory, the smoother the friction pairs the better the friction performance. But in recent years, a large number of theoretical and experimental results have shown that the friction surface with microstructure can effectively improve the tribological performance of friction pairs. For smooth surface and micro-dimple surface with different shapes of friction pairs, the two-dimensional finite element model is established based on the Navier–Stokes calculation equation of the fluid, and the effect of hydrodynamic effects arising from micro-dimple structure with different shapes on friction performance of friction pairs is analyzed. Through friction and wear testing, the friction properties of smooth surface and micro-dimple surface friction pairs are compared and analyzed. Theoretical simulation and experimental verification show that the surface of friction pairs with micropits can obviously improve the lubrication conditions of friction pairs and effectively improve the tribological properties of friction pairs.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/1350650118770336
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032767-5
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