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  • SAGE Publications  (166)
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  • 1
    Online Resource
    Online Resource
    Analysis of 15 patients with systemic lupus erythematosus manifesting with negative immunofluorescence anti-nuclear antibodies after treatment
    SAGE Publications ; 2012
    In:  Lupus Vol. 21, No. 8 ( 2012-07), p. 919-924
    Details
    In: Lupus, SAGE Publications, Vol. 21, No. 8 ( 2012-07), p. 919-924
    Abstract: The purpose of this study was to investigate the clinical and laboratorial characteristics of patients with systemic lupus erythematosus (SLE) manifesting with negative immunofluorescence anti-nuclear antibodies (IFANA) after treatment for the better understanding of negative conversion of IFANA. Demographic characteristics, clinical and laboratory data of hospitalized SLE patients between March 2006 and May 2011 were retrospectively reviewed. Fifteen cases with negative IFANA were identified in 960 patients. All of the 15 patients were severe, 11 patients manifested with nephritic range proteinuria and hypoalbuminemia, 8 patients were complicated with severe infection and all of the patients had been treated with glucocorticoid and immunosuppressant. Anti-ENA antibodies were positive in 4 of 15 patients. Eight patients died after average 1-year follow-up. Collectively, negative IFANA is mainly attributed to nephritic-range proteinuria; and large-dose glucocorticoid, immunosuppressant and severe infection are also important factors for negative IFANA. Antinuclear antibody can be detected in some SLE patients with negative IFANA by changing the detection method and titer. Negative conversion of IFANA often indicates unfavorable prognosis for severe patients.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203311433139
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2008035-9
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  • 2
    Online Resource
    Online Resource
    Association study of C1qA polymorphisms with systemic lupus erythematosus in a Han population
    SAGE Publications ; 2012
    In:  Lupus Vol. 21, No. 5 ( 2012-04), p. 502-507
    Details
    In: Lupus, SAGE Publications, Vol. 21, No. 5 ( 2012-04), p. 502-507
    Abstract: Objective: The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the C1qA gene region with systemic lupus erythematosus (SLE) in a Chinese Han population. Methods: Chinese SLE patients ( n = 748) and ethnically- and geographically-matched healthy controls ( n = 750) were genotyped for the C1qA region SNPs, rs172378 and rs665691, by using the Sequenom MassArray system. Results: The Chinese Han SLE patients and controls had statistically similar frequencies of alleles, genotypes, and haplotypes of C1qA polymorphisms. Moreover, no association signal was detected on different genetic models (additive, dominant, and recessive) or in SLE subgroups stratified by various clinical manifestations. Conclusions: The C1qA SNPs, rs172378 and rs665691, confer no genetic predisposition to SLE in a Chinese Han population.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203311430702
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2008035-9
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  • 3
    Online Resource
    Online Resource
    A New Molecular Diagnostic Approach to Assess Y Chromosome Microdeletions in Infertile Men
    SAGE Publications ; 2012
    In:  Journal of International Medical Research Vol. 40, No. 1 ( 2012-02), p. 237-248
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 40, No. 1 ( 2012-02), p. 237-248
    Abstract: OBJECTIVE: A key cause of spermatogenetic failure in infertile males is microdeletions in the azoospermia factor (AZF) regions of the Y chromosome. This study screened for microdeletions in the AZF regions using suspension array technology and compared the results with those from polymerase chain reaction (PCR). METHODS: Patients with spermatogenetic failure ( n = 507) and healthy control sperm donors ( n = 100) were recruited. DNA samples were analysed using both multiplex PCR with gel electrophoresis and suspension array technology. RESULTS: The suspension array method identified 45 infertile males with Y chromosome microdeletions, while none was found in the controls. Amongst the AZF subregions, two cases had deletions in AZFa, three in AZFb, 35 in AZFc, three in AZFbc and two in AZFabc. The results from 507 patients were identical when analysed with either suspension array or multiplex PCR, however suspension array technology offered improved sensitivity, may be more accurate and could give time and cost savings. CONCLUSIONS: Suspension array technology offers a rapid and high-throughput method for Y chromosome microdeletion screening in infertile men.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323001204000124
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2082422-1
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  • 4
    Online Resource
    Online Resource
    Protective Activity of the Ethanol Extract of Cynanchum Paniculatum (Bunge) Kitagawa on Treating Herpes Simplex Encephalitis
    SAGE Publications ; 2012
    In:  International Journal of Immunopathology and Pharmacology Vol. 25, No. 1 ( 2012-01), p. 259-266
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 25, No. 1 ( 2012-01), p. 259-266
    Abstract: To date there has been no valid treatment for herpes simplex encephalitis (HSV). This study explores the protective activity of ethanol extract of Cynanchum paniculatum (bunge) kitagawa for treatment of HSV. Cell models and animal models were established and divided into 4 groups: normal group, virus group, cynanchum paniculatum group and Dexamethasone group. Flow cytometry was employed to detect apoptosis of cell model and TUNEL assay was chosen to detect apoptosis of animal tissues. The survival time of the animal models was observed. ELISA was used to measure TNF-α expression and the Greiss method to measure Nitric Oxide (NO) expression in the mouse brain. As a result, it was found that extract of Cynanchum paniculatum can improve the survival rate of HSV-infected mice. The extract could prevent apoptosis in the neuron cell model and reduce apoptosis rate in brain tissue after HSV infection. With the extract intervention, TNF-α and NO levels in brain tissue were significantly decreased in the animal model. In conclusion, the extract of Cynanchum paniculatum can prevent HSV-inducing impairment in the cell and animal model of HSE.
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/039463201202500128
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2505963-4
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  • 5
    Online Resource
    Online Resource
    Investigation of Normal and Malignant Tissue Samples from the Human Stomach Using Fourier Transform Raman Spectroscopy
    SAGE Publications ; 2002
    In:  Applied Spectroscopy Vol. 56, No. 5 ( 2002-05), p. 570-573
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 56, No. 5 ( 2002-05), p. 570-573
    Abstract: Fourier transform (FT) Raman studies of 40 tissue samples from the human stomach, including 22 normal and 18 malignant tissue samples, were performed. These stomach tissue samples had been classified as normal or malignant on the basis of pathological studies and biopsy detection. The results indicate that a series of major bands in the FT-Raman spectrum can be used to distinguish the malignant tissue from the normal tissue. Subtraction spectra support the result of the spectroscopic identification. Statistical analysis is also in agreement with the FT-Raman measurements.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1366/0003702021955330
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 6
    Online Resource
    Online Resource
    The Effects of Chronic Vitamin A Excess on Bone Remodeling in Aged Rats
    SAGE Publications ; 1989
    In:  Experimental Biology and Medicine Vol. 191, No. 2 ( 1989-06-01), p. 103-107
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 191, No. 2 ( 1989-06-01), p. 103-107
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/00379727-191-42894
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1989
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Experimental study on electrode displacement fluctuation characteristics during resistance spot welding
    SAGE Publications ; 2011
    In:  Science and Technology of Welding and Joining Vol. 16, No. 2 ( 2011-02), p. 140-145
    Details
    In: Science and Technology of Welding and Joining, SAGE Publications, Vol. 16, No. 2 ( 2011-02), p. 140-145
    Abstract: Electrode displacement has been used to monitor resistance spot weld quality for long, but the fluctuation of the electrode displacement has not been well studied. This paper analysed the mechanism of the displacement fluctuation by collecting the welding current and electrode displacement during welding process and extracted the incremental pulse expansion of the electrode displacement, which was named as the displacement fluctuation peak. Through metallurgical experiments, the relationship of the displacement fluctuation peak with the weld nugget growth during resistance spot welding process was analysed. The whole process can be divided into four successive stages, and five characteristic points of the displacement fluctuation peak curve were selected to online predict the weld quality. The variation in the displacement fluctuation peak curve under different welding currents was studied, and the results showed that the displacement fluctuation characteristics can be used to effectively evaluate the weld quality.
    Type of Medium: Online Resource
    ISSN: 1362-1718 , 1743-2936
    URL: Article
    DOI: 10.1179/1362171810Y.0000000006
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2053754-2
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  • 8
    Online Resource
    Online Resource
    Transient response of the hygro-thermo-elastic field in hollow cylinders under heat-moisture shock via hyperbolic non-Fourier heat conduction and non-Fick diffusion
    SAGE Publications ; 2021
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 235, No. 15 ( 2021-08), p. 2795-2809
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 235, No. 15 ( 2021-08), p. 2795-2809
    Abstract: The classical Fourier heat conduction theory as well as the widely used Fick’s diffusion law predicts an infinite wave velocity. This is physically unrealistic. By generalizing the classical Fourier’s and Fick’s laws, this paper presents a hyperbolic diffusion law to apply heat and moisture coupling. The transient response of the hygro-thermo-elastic field in infinitely long hollow cylinders subjected to sudden heat and moisture shock on the inner and outer surfaces is studied. With the aid of the Laplace transform and the decoupling technique, the closed-form solutions of temperature, moisture, elastic displacement and stresses are determined respectively. The analytical results show that the thermal and moisture relaxation time effect between temperature and moisture is significant for composites. Compared with the classic counterpart, the finite hygrothermal wave speed of the pipe is achieved and decreases with the relaxation time rising. The temperature, moisture, elastic displacement and stresses are calculated. Numerical results are displayed graphically to show the influence of the phase lag of heat/moisture flux on the response of the hygro-thermo-elastic fields. Non-Fourier and non-Fick effects are remarkable between the classic model and hyperbolic hygrothermal coupling model. Some drawbacks induced by the classical Fourier’s and Fick’s laws are averted.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406220954473
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2024890-8
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  • 9
    Online Resource
    Online Resource
    Detection of the Treponema pallidum gene and variation of treponemal DNA load before and after therapy
    SAGE Publications ; 2012
    In:  International Journal of STD & AIDS Vol. 23, No. 3 ( 2012-03), p. e6-e8
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 23, No. 3 ( 2012-03), p. e6-e8
    Abstract: We explored a genetic detection method for Treponema pallidum (TP) in the peripheral blood of infected patients to compare the loads of treponemal DNA before and after therapy and to see if this new technique enabled assessment of therapeutic effect and detection of serum resistance. Polymerase chain reaction was used for a qualitative detection of TP DNA in peripheral blood and then a semiquantitative method was adopted to estimate the load of TP DNA in blood, both before and after treatment of syphilis. Among 30 untreated patients, three cases were TP DNA-positive. Among 42 treated patients with demonstrated serum resistance, three cases were TP DNA-positive. Five cases in which the rapid plasma reagin had become negative had no detectable TP DNA in their peripheral blood. The TP DNA load in blood after treatment was significantly lower than that before therapy. We conclude that the detection of TP DNA in peripheral blood of TP-infected patients is not yet sufficiently sensitive, but we observed that TP DNA load declines significantly after treatment.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1258/ijsa.2009.009054
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2009782-7
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  • 10
    Online Resource
    Online Resource
    Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron
    SAGE Publications ; 2020
    In:  Human & Experimental Toxicology Vol. 39, No. 8 ( 2020-08), p. 1118-1129
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 39, No. 8 ( 2020-08), p. 1118-1129
    Abstract: Methamphetamine (MA) abuse induces neurotoxicity and causes neuronal cell apoptosis. Gastrodin is a traditional Chinese herbal medicine used for the treatment of nerve injuries, spinal cord injuries, and some central nervous system diseases as well. The present study investigated the neuroprotective effects of gastrodin against MA-induced neurotoxicity in neuronal cells and its potential protective mechanism. Methods: The primary cortex neuronal culture was divided into four groups (control group, MA group, MA + gastrodin group, and MA + gastrodin + small interfering RNA group). The neurotoxicity of MA was assessed by detecting apoptotic cells by terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay and cell viability by cell counting kit 8 (CCK-8) method, the Tuj1-positive cells and the average axonal length were detected by immunofluorescence, and the expressions of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), cAMP-response element-binding (CREB), and brain-derived neurotrophic factor (BDNF) proteins were detected by Western blot. Results: The results of CCK-8 assay showed that 0.5 mM MA was an optimal concentration that induced neurotoxicity ( p 〈 0.01). Pretreatment with 25 mg/L gastrodin exerted maximum protective effects on neuronal cells. The expression levels of cAMP, PKA, phosphorylated PKA, CREB, phosphorylated CREB, and BDNF proteins were decreased in the MA group, and pretreatment with gastrodin upregulated the expression levels of these proteins ( p 〈 0.01). The expressions of PKA and CREB proteins showed no significant changes in the control group, MA group, and gastrodin group. Compared the MA + gastrodin + small interfering RNA group with MA + gastrodin group, the Tuj1-positive cells and the average axonal length were decreased significantly, while the number of apoptotic cells was increased ( p 〈 0.05). Conclusion: Gastrodin has neuroprotective effects against MA-induced neurotoxicity, which exerts neuroprotective effects via regulation of cAMP/PKA/CREB signaling pathway and upregulates the expression of BDNF.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/0960327120911438
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 1483723-7
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