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  • SAGE Publications  (123)
  • 1
    Online Resource
    Online Resource
    Clinical characterization and prognostic implications of metabolic syndrome in patients undergoing peritoneal dialysis at a Chinese center
    SAGE Publications ; 2019
    In:  Journal of International Medical Research Vol. 47, No. 11 ( 2019-11), p. 5573-5583
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 47, No. 11 ( 2019-11), p. 5573-5583
    Abstract: Metabolic syndrome (MS) is a common clinical condition associated with cardiovascular disease in patients undergoing peritoneal dialysis (PD); however, its prognostic implication among patients receiving PD remains controversial. Methods In a prospective study from January 2013 and June 2016, we enrolled 190 patients undergoing PD and followed them for 46.4 ± 30.7 months. We assessed the associations of clinical characteristics and measurements with diabetes mellitus (DM) status, MS, and prognostic outcomes among the included patients. Results We found that DM was associated with shortened duration of dialysis and poor survival. The prevalence of MS was 58.9% among all patients. We found significant differences in age, body weight, body mass index, triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, leukocytes, platelets, neutrophil percentage, and pre-albumin between patients with and without MS. We found a negative correlation trend between serum intact parathyroid hormone and MS among our patients. The arteriosclerosis index was significantly elevated in the MS group compared with the non-MS group. Serum calcium concentration and frequency of hospital admissions were significantly associated with mortality and technique failure. Conclusions MS was positively associated with cardiovascular disease. DM, and hypocalcemia. Frequent hospital admissions can predict poor prognosis in patients undergoing PD.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060519875335
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2082422-1
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  • 2
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    Moving Window Partial Least-Squares Discriminant Analysis for Identification of Different Kinds of Bezoar Samples by near Infrared Spectroscopy and Comparison of Different Pattern Recognition Methods
    SAGE Publications ; 2007
    In:  Journal of Near Infrared Spectroscopy Vol. 15, No. 5 ( 2007-10), p. 291-297
    Details
    In: Journal of Near Infrared Spectroscopy, SAGE Publications, Vol. 15, No. 5 ( 2007-10), p. 291-297
    Abstract: Moving window partial least-squares (MWPLS) regression was coupled with near infrared (NIR) spectra as an interval selection method to improve the performance of partial least squares discriminant analysis (PLSDA) models. This method was applied to the identification of artificial bezoar, natural bezoar and artificial bezoar in natural bezoar and compared with some traditional pattern recognition methods, such as principal component analysis (PCA), linear discriminant analysis (LDA) and PLSDA. The introduction of MWPLS enhanced the performance of PLSDA model. The results obtained showed that moving window partial least-squares discriminant analysis (MWPLSDA) can extract wavelength intervals with useful information and build simple yet effective classification models that can significantly improve the classification accuracy. Then MWPLSDA was used to identify natural bezoar by geographical origin; a promising result was achieved. The work showed that MWPLSDA could be a promising method for quality analysis and discrimination of chinese medical herbs according to geographical origin.
    Type of Medium: Online Resource
    ISSN: 0967-0335 , 1751-6552
    URL: Article
    DOI: 10.1255/jnirs.743
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2021280-X
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  • 3
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    Fibrin Sheath Formation and Intimal Thickening after Catheter Placement in Dog Model: Role of Hemodynamic Wall Shear Stress
    SAGE Publications ; 2015
    In:  The Journal of Vascular Access Vol. 16, No. 4 ( 2015-07), p. 275-284
    Details
    In: The Journal of Vascular Access, SAGE Publications, Vol. 16, No. 4 ( 2015-07), p. 275-284
    Abstract: To investigate the role of wall shear stress in aspects of the formation of fibrin sheath and intimal thickening in a dog model. Methods Tunneled silicone 14.5-F catheters were inserted into the left internal jugular vein in eight dogs. The dogs were separated into two groups according to catheter indwelling time of 14 and 28 days. All dogs underwent extracorporeal circulation three times a week. Multidetector computed tomography venography (MDCTV) examination was used to examine the catheter tip thrombus. After the animals were sacrificed, histological and immunohistochemistry evaluations were performed to confirm specific cell populations. We used computer modeling to generate wall shear stress profiles for the blood flow through the catheter. Results Catheter-related sheaths were identified in all catheter specimens, but there was no fibrin sheath around the catheter tip. There were also differences in wall shear stress between the different venous wall sites. Differences in vein wall thickening at different sites have been found at both 14 days (intima to media (I/M) ratio S1 vs S2: p = 0.01, S3 vs S4: p 〈 0.01) and 28 days (I/M ratio S1 vs S2: p 〈 0.01, S3 vs S4: p 〈 0.05). Conclusions After catheter placement, fibrin sheath formation partially covered the catheter. Meanwhile, focal areas of intimal thickening were also seen in the venous wall adjacent to the sites of high wall shear stress. These findings indicate an important role of wall shear stress profiles in fibrin sheath formation and intimal thickening.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    URL: Article
    DOI: 10.5301/jva.5000358
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2079292-X
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  • 4
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    FT–IR Studies on Langmuir–Blodgett Films of Novel Phosphorus Amphiphiles: Spontaneous Polycondensation at the Air/Water Interface
    SAGE Publications ; 2005
    In:  Journal of Chemical Research Vol. 2005, No. 6 ( 2005-06), p. 385-387
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2005, No. 6 ( 2005-06), p. 385-387
    Abstract: A series of amphiphilic N-(O,O-dihexadecyl)phosphorylamino acids were designed and synthesised, and the transmission FT–IR spectroscopic investigation of their Langmuir–Blodgett films (LB films) on CaF 2 substrates indicates the spontaneous polycondensation at the air/water interface before the deposition.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/0308234054506866
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 3010810-X
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  • 5
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    Investigation of Spontaneous Polycondensation of N-(O, O-Ditetradecyl) Phosphorylalanine in Highly Ordered Films by Ftir Spectroscopy
    SAGE Publications ; 2004
    In:  Journal of Chemical Research Vol. 2004, No. 2 ( 2004-02), p. 143-144
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2004, No. 2 ( 2004-02), p. 143-144
    Abstract: Spontaneous polycondensation to polypeptides on both cast films and Langmuir-Blodgett films (LB films) of N-(O, O-ditetradecyl)phosphorylalanine (DNTP-L-Ala) was studied by FTIR transmission spectroscopy.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/030823404323000521
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 3010810-X
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  • 6
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    Circulating tumor cells dynamics during chemotherapy predict survival and response in advanced non-small-cell lung cancer patients
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Medical Oncology Vol. 15 ( 2023-01), p. 175883592311678-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 15 ( 2023-01), p. 175883592311678-
    Abstract: Circulating tumor cells (CTCs) are prognostic biomarker in non-small-cell lung cancer (NSCLC). CTCs could also be used as predictor of efficacy of systemic treatments in advanced NSCLC. Objectives: We described the dynamic changes of CTCs during first-line platinum-based chemotherapy in advanced NSCLC and clarified the correlation between CTC counts and efficacy of chemotherapy. Design: Chemotherapy is administered and blood specimens are collected at four time points from baseline to disease progression for CTC detection. Methods: This multicenter prospective study enrolled patients with previously untreated stage III or IV NSCLC fit for standard platinum-based chemotherapy. Bloods were sampled as per standard operating procedures at baseline, cycle 1 and cycle 4 of chemotherapy, and at disease progression for CTC analysis using the CellSearch system. Results: Among 150 patients enrolled, median overall survival (OS) was 13.8, 8.4, and 7.9 months in patients with CTC − , KIT − CTC, and KIT + CTC at baseline ( p = 0.002). Patients with persistent negative CTC (46.0%) had longer progression-free survival [5.7 months, 95% confidence interval (CI): 5.0–6.5 versus 3.0 months, 0.6–5.4; hazard ratio (HR): 0.34, 95% CI: 0.18–0.67) and OS (13.1 months, 10.9–15.3 versus 5.6 months, 4.1–7.1; HR: 0.17, 0.08–0.36) compared with patients with persistent positive CTC (10.7%), which was not impacted by chemotherapy. Chemotherapy decreased CTC from 36.0% (54/150) to 13.7% (13/95). Conclusions: CTC persistent presence during treatment represents poor prognosis and resistance to chemotherapy in advanced NSCLC. Chemotherapy could effectively eliminate CTCs. Molecular characterization and the functionalization of CTC will be warranted for further intensive investigation. Trial registration: NCT01740804.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359231167818
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2503443-1
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  • 7
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    Heterometallic coordination polymers: Treatment activity on diabetic foot by reducing the excess inflammatory response in the plantar tissue
    SAGE Publications ; 2021
    In:  Journal of Chemical Research Vol. 45, No. 1-2 ( 2021-01), p. 49-55
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 45, No. 1-2 ( 2021-01), p. 49-55
    Abstract: Two new heterometallic coordination polymers formulated as {[LaCo(2.5-pydc) 2 (H 2 O) 4 ]Cl·4H 2 O} n (1, 2,5-H 2 pydc = pyridine-2,5-dicarboxylic acid) and {[LaCo 2 Cl 3 (4,4′-bpdc) 2 (H 2 O) 3 ]·H 2 O} n (2, 4,4′-H 2 bpdc = 2,2′-bipyridyl-4,4′-dicarboxylic acid) have been solvothermally synthesized using the coordination between rare earth/transition metal ions and pyridinedicarboxylic acids. To develop new candidates for enhancing the therapeutic effect of improved negative pressure suction for diabetic foot, the activities of compounds 1 and 2 were studied. First, the ELISA (enzyme linked immunosorbent assay) detection kit was used and the inflammatory cytokines in the plantar tissue were measured. Besides, the TLR-4-NF-κB signaling pathway was measured with real-time reverse transcription-polymerase chain reaction.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.1177/1747519820923277
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 8
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    Qualitative Analysis Using UPLC-Q-TOF/MS and a Systematic Network Pharmacology-Based Strategy to Investigate the Active Constituents and Potential Mechanisms Against Breast Cancer in the Fruit Body of Sanghuangporus vaninii
    SAGE Publications ; 2024
    In:  Natural Product Communications Vol. 19, No. 5 ( 2024-05)
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 19, No. 5 ( 2024-05)
    Abstract: Objective: To predict the pharmacodynamic material basis and mechanism of Chinese medicinal mushroom Sanghuangporus vaninii (Ljub.) L.W. Zhou & Y.C. Dai ( SV) against breast cancer based on ultraperformance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and network pharmacology. Methods: We explored the compositional basis of SV using UPLC-Q-TOF/MS, then the potential targets and key pathways involved in the anti-breast cancer effect were predicted using a network pharmacology approach. Molecular docking was performed with the key compounds and the hub targets to confirm the results of the network pharmacology screening. Results: A total of 53 chemical components were identified, including 4 organic acids, 6 catechins, 13 pyranones, 13 flavonoids, and 17 fatty acids. 33 polyphenols and 144 corresponding targets were found to be significantly associated with its anti-breast cancer activity. Molecular docking results showed that the core compound could significantly bind to the core target. Conclusion: The anti-proliferative effect of SV against breast cancer could be attributed to a combination of multi-component, multi-target, and multi-channel mechanisms. The key active compound of SV in the treatment of breast cancer may be phellibaumin B, naringenin, hesperetin, sterubin, phelligrin A and phelligrin C, and the molecular mechanism may be related to the key targets MMP9, EGF, and EGFR, and that signaling pathways such as MAPK and PI3K-Akt may be responsible for SV-induced growth inhibition in breast cancer cells.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X241255275
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 9
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    Ketoacid Supplementation Partially Improves Metabolic Parameters in Patients on Peritoneal Dialysis
    SAGE Publications ; 2015
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 35, No. 7 ( 2015-12), p. 736-742
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 35, No. 7 ( 2015-12), p. 736-742
    Abstract: A low protein diet supplemented with ketoacids has been shown to improve the metabolic profile, including insulin resistance, in patients with chronic kidney disease (CKD), but whether ketoacids alone exert similar effects is unknown. In this prospective randomized controlled trial, we aimed to evaluate the effects of ketoacid supplementation on insulin resistance, systemic inflammation, oxidative stress and endothelial dysfunction among 100 CKD patients undergoing peritoneal dialysis (PD). Methods Patients from one Chinese PD center were randomly assigned to take ketoacids (12 tablets per day) ( n = 50) versus a control group ( n = 50) for 6 months in an open-label parallel-arm design. Daily protein intake of 0.8 – 1.2 g/kg/d and daily energy intake of 25 – 35 kcal/kg/d was prescribed to both groups. Insulin resistance was evaluated using homeostatic model assessment (HOMA-IR) index as the primary outcome. We assessed systemic inflammation using high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6), oxidative stress using plasma oxidized low density lipoprotein (oxLDL), adipokines using leptin and adiponectin and endothelial dysfunction using serum soluble intercellular adhesion molecule-1 (sICAM) and soluble vascular adhesion molecule-1 (sVCAM) as secondary outcomes. Results There were no significant differences in baseline characteristics between the 2 groups except a slightly higher age in patients assigned to the intervention. A total of 89% of participants completed the 6-month intervention. There was no significant difference in the change of HOMA-IR values from baseline between groups after adjusting for baseline age, gender, body mass index and HOMA-IR. For secondary outcomes, hs-CRP varied significantly between groups ( p = 0.02), increasing over time for the control group while remaining stable for the ketoacid group. Similarly, the leptin/adiponectin ratio (LAR) differed between groups ( p 〈 0.001), remaining stable in the ketoacid group but increasing in the control group. Conclusion Ketoacid therapy administered for 6 months had no effect on HOMA-IR but resulted in improvements in hs-CRP and LAR, suggesting metabolic benefit. Future studies are needed to confirm these results and any potential benefit in vascular health of PD patients.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.3747/pdi.2014.00151
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2075957-5
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  • 10
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    The relationship between elevated serum uric acid and arterial stiffness in a healthy population
    SAGE Publications ; 2020
    In:  Vascular Vol. 28, No. 4 ( 2020-08), p. 494-501
    Details
    In: Vascular, SAGE Publications, Vol. 28, No. 4 ( 2020-08), p. 494-501
    Abstract: This study aims to investigate the relationship between serum uric acid and arterial stiffness in a healthy population. Methods Among the 979 participants, baPWV was non-invasively measured, the circulating levels of uric acid were tested, and the uric acid polymorphisms (rs2231142 and rs11722228) were genotyped. Then, the Mendelian randomization method was employed to test the relationship between serum uric acid and arterial stiffness in a healthy population. Results After adjusting for age, gender, antihypertensive medication, body mass index, waist-to-hip ratio, urea nitrogen, creatinine and diabetic mellitus, there was a significant allelic difference in uric acid levels for each genotype ( P  〈  0.0001 for rs2231142; P =  0.007 for rs11722228). However, there were no differences on the potential confounders between the genotypes of rs2231142 and rs11722228 ( P  〉  0.05). The baPWV was significantly associated with circulating levels of uric acid after adjusting for cardiovascular risk factors and other potential confounders ( P =  0.002). However, neither the single polymorphism, nor the accumulation of culprit alleles was associated with baPWV ( P =  0.92 for rs2231142; P =  0.60 for rs11722228; P for trend = 0.77 for the combined analysis of culprit alleles). Conclusion These results do not support the causal role of circulating levels of uric acid in the development of arterial stiffness.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538120913721
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2143006-8
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