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  • 1
    Online Resource
    Online Resource
    Correlation between serum free triiodothyronine levels and risk stratification in Chinese patients with acute coronary syndrome receiving percutaneous coronary intervention
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 9 ( 2020-09), p. 030006052095718-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 9 ( 2020-09), p. 030006052095718-
    Abstract: Low serum free triiodothyronine (FT3) levels are associated with the occurrence of coronary heart disease and with the prognosis of cardiovascular diseases. This study aimed to investigate the relationship between FT3 levels and risk stratification in Chinese Han patients with acute coronary syndrome (ACS) receiving percutaneous coronary intervention (PCI) treatment. Methods Plasma FT3 levels and other parameters were measured in 191 patients with ACS who received PCI. The risk of adverse cardiovascular events was assessed using the Age, Creatinine, and Ejection Fraction (ACEF) score. Results FT3 levels were significantly lower in the high-risk group than in the medium- and low-risk groups. Serum FT3 levels were negatively linearly correlated with the ACEF score (r = −0.590). Stepwise regression analysis showed a negative correlation between FT3 levels and the risk of adverse cardiovascular events as measured by the ACEF score (standardized β = −0.261). Conclusion Serum FT3 levels are negatively related to risk stratification in patients with ACS. Serum FT3 levels may be used as a potential predictor for adverse outcomes of patients with ACS undergoing PCI.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520957180
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Effect of berberine on LPS-induced expression of NF- κ B/MAPK signalling pathway and related inflammatory cytokines in porcine intestinal epithelial cells
    SAGE Publications ; 2020
    In:  Innate Immunity Vol. 26, No. 7 ( 2020-10), p. 627-634
    Details
    In: Innate Immunity, SAGE Publications, Vol. 26, No. 7 ( 2020-10), p. 627-634
    Abstract: Berberine is an alkaloid extracted from medicinal plants such as Coptis chinensis and Phellodendron chinense. It possesses anti-inflammatory, anti-tumour and anti-oxidation properties, and regulates Glc and lipid metabolism. This study explored the mechanisms of the protective effects of berberine on barrier function and inflammatory damage in porcine intestinal epithelial cells (IPEC-J2) induced by LPS. We first evaluated the effects of berberine and LPS on cell viability. IPEC-J2 cells were treated with 5 μg/ml LPS for 1 h to establish an inflammatory model, and 75, 150 and 250 μg/ml berberine were used in further experiments. The expression of IL-1β, IL-6 and TNF-α was measured by RT-PCR. The key proteins of the NF-κB/MAPK signalling pathway (IκBα, p-IκBα, p65, p-p65, c-Jun N-terminal kinase (JNK), p-JNK, p38, p-p38, ERK1/2 and p-ERK1/2) were detected by Western blot. Upon exposure to LPS, IL-1β, IL-6 and TNF-α mRNA levels and p-IκBα p-p65 protein levels were significantly enhanced. Pre-treatment with berberine reduced the expression of inflammatory factors and was positively correlated with its concentration, and dose dependently inhibited the expression of IκBα, p-IκBα, p-p65, p-p38 and JNK. These results demonstrated that pre-treating intestinal epithelial cells with berberine was useful in preventing and treating diarrhoea induced by Escherichia coli in weaned pigs.
    Type of Medium: Online Resource
    ISSN: 1753-4259 , 1753-4267
    URL: Article
    DOI: 10.1177/1753425920930074
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2381250-3
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  • 3
    Online Resource
    Online Resource
    Numerical modeling and constitutive model verification for high-strength automotive steel
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 237, No. 3 ( 2023-02), p. 630-642
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 237, No. 3 ( 2023-02), p. 630-642
    Abstract: In this paper, the quasi-static and dynamic tensile tests with a gauge length of 20 mm for dual-phase (DP) 780 steel were conducted under strain rates ranging from 10 −3 to 10 3 /s. The neglected details and differences between the quasi-static and dynamic tensile test conditions were investigated to develop an accurate numerical modeling method. A high-precision combination method for the empirical constitutive model was proposed and utilized in the developed numerical model to verify the ability of the constitutive model to reproduce the experimental data at different strain rates. The excellent results indicate that the adjusted determination coefficient of the constitutive model, the adjustable range of the extrapolation curves, and the proportion factor P in the combined constitutive model are the key parameters for accurately describing the quasi-static and dynamic mechanical behavior before and after the necking.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/09544062221124840
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024890-8
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  • 4
    Online Resource
    Online Resource
    The effect of internal pressure change on the temperature rise and the amount of filling hydrogen of high pressure storage tank
    SAGE Publications ; 2022
    In:  Advances in Mechanical Engineering Vol. 14, No. 8 ( 2022-08), p. 168781322211210-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 14, No. 8 ( 2022-08), p. 168781322211210-
    Abstract: Hydrogen has been considered as a feasible energy carry for fuel cell vehicles, which offers a clean and efficient alternative for transportation. In the currently developed hydrogen compression cycle system, hydrogen is compressed through a compressor and stored in the tank as high pressure. The hydrogen is filled from high pressure station into hydrogen storage system in fuel cell vehicles. In the study, theoretical and simulation are performed by presenting a mathematical model for the temperature rise during filling process in the hydrogen storage tank at the pressure of 50 MPa compressed hydrogen system. For a high-pressure tank (HPT) that can store hydrogen at a hydrogen filling station, the temperature rise of hydrogen with the pressure change during the filling process, the amount of hydrogen filling in the tank, and the convective heat transfer coefficient in the tank were calculated. The calculated temperature was compared with numerical and theoretical methods. Appropriate theoretical formulas were presented through mathematical modeling for changes that occur when high-pressure storage tanks were filled, and hydrogen properties were analyzed using the REFPROP program. 3D modeling was performed for the high-pressure storage tank, and the analysis was conducted under adiabatic conditions. When the pressure was increased to 50 MPa in the initial vacuum state, and when the residual pressure was 18 MPa, it was 25, 50, 75,and 100 MPa, and hydrogen inside the storage tank of the temperature rise and the amount of hydrogen filling were investigated. The results of this study will be useful for the design and construction of compressed hydrogen tank for hydrogen charging system.
    Type of Medium: Online Resource
    ISSN: 1687-8132 , 1687-8140
    URL: Article
    DOI: 10.1177/16878132221121030
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2501620-9
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  • 5
    Online Resource
    Online Resource
    Virtual simulation technology based research on subsoiling process
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 233, No. 5 ( 2019-03), p. 1493-1503
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 233, No. 5 ( 2019-03), p. 1493-1503
    Abstract: A novel simulation method to research subsoiling process is proposed in this paper. The influence of changing depth of tines cutting soil caused by subsoiler’s structure, road roughness and excitation of tyre and road on subsoiling is investigated. Soil model is divided into three layers, the different characteristics of soil in different depths are also considered. Firstly, a 3D geometry model of tractor–subsoiler system is established. Secondly, road roughness test is designed to measure elevation data of a farmland, then its surface is reconstructed based on harmonic superposition theory. Thirdly, a virtual prototyping model of tractor–subsoiler system is developed, and the depth curves of tines cutting soil with time are obtained based on the reconstructed farmland. Finally, with the method of finite element method (FEM) and smoothed particle hydrodynamics (SPH) coupling, MAT147 (MAT_FHWA_SOIL) soil material model which is layered, and depth curves of tines cutting soil, the finite element dynamic analysis of tines cutting soil is simulated. With subsoiling resistance as verification index, the simulation data are compared with the field experimental data. Under subsoiler oscillatory operation, the error rate of simulation is 3.78%. Under subsoiler non-oscillatory operation, the error rate of simulation is 5.02%. The simulation results agree well with the experimental results, which proves that the proposed simulation method can be a good substitute for the subsoiling physical test.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406218774358
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024890-8
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  • 6
    Online Resource
    Online Resource
    Preconditioning with hydrogen sulfide prevents bone cancer pain in rats through a proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway
    SAGE Publications ; 2018
    In:  Experimental Biology and Medicine Vol. 243, No. 1 ( 2018-01), p. 57-65
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 243, No. 1 ( 2018-01), p. 57-65
    Abstract: Bone cancer pain (BCP) is a severe type of hyperpathic pain occurring with primary bone tumors or advanced cancers which metastasize to bones. BCP can detrimentally reduce quality of life and presents a challenge to modern medicine. Studies have shown that exogenous H 2 S may act as a neuroprotectant to protect against some diseases in central nervous system. The preset study aimed to investigate the antinociceptive effect of H 2 S in BCP. We first measured the changes of serum H 2 S in patients with BCP and analyzed the relationship between them, then investigated the effect of H 2 S preconditioning on BCP, and explored the mechanism in rat model. Our results revealed that serum H 2 S level was negatively correlated with pain scores. In the rat model of BCP, preconditioning with H 2 S significantly reduced BCP, demonstrated by the decrease of thermal hyperalgesia and mechanical allodynia. The mechanism of H 2 S preconditioning may involve microglia deactivation and inflammation inhibition in the spinal cord, in which the proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway is activated. Impact statement Bone cancer pain (BCP) significantly decreases the life quality of patients or their life expectancy and causes a severe health burden to the society. However, as the exact mechanism of BCP is still poorly understood, no effective treatment has been developed yet. There are some pain medicines now, but they have some inevitable side effects. Additional therapeutic strategies are urgently needed. First, we revealed that preconditioning with H 2 S significantly reduced BCP, demonstrated by the decrease of thermal hyperalgesia and mechanical allodynia. Second, the mechanism of H 2 S preconditioning was elucidated. It may involve microglia deactivation and inflammation inhibition in the spinal cord, in which the proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway is activated. This novel finding may significantly help us to understand the difference between the roles of endogenous H 2 S and exogenous H 2 S in the development of BCP and present us a new strategy of pain management.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370217740859
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2020856-X
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  • 7
    Online Resource
    Online Resource
    Multiple functions of policosanol in elderly patients with dyslipidemia
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 7 ( 2020-07), p. 030006052093608-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 7 ( 2020-07), p. 030006052093608-
    Abstract: To determine the multiple functions of policosanol in elderly dyslipidemia patients. Methodology: There were 294 elderly dyslipidemia patients enrolled into this clinical study. They were randomly divided into four groups, as follows: 20 mg policosanol (group A, n = 64); 10 mg policosanol (group B, n = 72); 20 mg atorvastatin (group C, n = 91); and 10 mg policosanol + 20 mg atorvastatin (group D, n = 62). Plasma platelet count, platelet aggregation rate, circulating endothelial cell (CEC) count, high sensitivity C-reactive protein (hs-CRP), and carotid intima–media thickness (IMT) were measured before the study (week 0) and at weeks 12, 24, and 52. Results In group A, the platelet aggregation rate caused by adenosine diphosphate (ADP) after treatment was significantly decreased compared with before treatment (48.79% ± 20.29% vs. 40.37% ± 23.56%), but the arachidonic acid (AA)-induced platelet aggregation rates were similar. The platelet aggregation rates induced by AA and ADP in groups B, C, and D did not change significantly. CEC counts and hs-CRP and homocysteine levels in all groups after treatment were significantly lower compared with before treatment, but carotid IMTs were similar. Conclusion Policosanol regulates blood lipid levels and improves endothelial cell function, and it could delay the progress of atherosclerosis. Trial registration number: ChiCTR-RRC-17013396 (retrospectively registered).
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520936082
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 8
    Online Resource
    Online Resource
    Experimental and Theoretical Studies on Plastic Torsional Buckling of Steel Buckling-Restrained Braces
    SAGE Publications ; 2014
    In:  Advances in Structural Engineering Vol. 17, No. 6 ( 2014-06), p. 871-880
    Details
    In: Advances in Structural Engineering, SAGE Publications, Vol. 17, No. 6 ( 2014-06), p. 871-880
    Abstract: A type of partly-welded BRB was proposed in this paper to mitigate the unfavourable effect of the welds on the low-cycle fatigue property of BRBs. Three partly-welded BRB specimens under different strain amplitudes were tested and the plastic torsional buckling of the end portion was observed in two specimens. According to the experimental results, the strain amplitude is an important factor for the torsional buckling of the end portion. The critical stress declines with the increase of the strain amplitude, while the maximum compressive stress increases with the growth of the strain amplitude. Even though the hysteretic behaviour of specimens under large strain amplitudes met the requirement by seismic provisions (AISC 2010), torsional buckling is an undesired failure mode for BRBs, which leads to great torsional deformation of BRBs. Based on the principle of minimum potential energy, a theoretical formula of the critical stress was provided in this paper, which gave a good prediction to the failure mode. Moreover, a recommendation value of the calculated length based on the theoretical equation was given for the design to avoid torsional buckling in the unrestrained part of the BRB's yielding segment.
    Type of Medium: Online Resource
    ISSN: 1369-4332 , 2048-4011
    URL: Article
    DOI: 10.1260/1369-4332.17.6.871
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2026561-X
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  • 9
    Online Resource
    Online Resource
    Robustness evaluation for rolling gaits of a six-strut tensegrity robot
    SAGE Publications ; 2021
    In:  International Journal of Advanced Robotic Systems Vol. 18, No. 1 ( 2021-01-01), p. 172988142199363-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 18, No. 1 ( 2021-01-01), p. 172988142199363-
    Abstract: Locomotive robots based on tensegrities have recently drawn much attention from various communities. A common strategy to realize long-distance locomotion is combining several basic gaits that are designed in advance. Considering the unavoidable uncertainties of the environment and the real locomotive system, selecting the gaits with high robustness is essential to the implementation of long-distance locomotion of tensegrity robots. However, no quantitative approach for robustness evaluation of rolling gaits is reported in recent research work. In this study, a practical and quantitative method is proposed for the robustness evaluation of rolling gaits of tensegrity robots. A mathematical model is built to describe the evaluation process, and the success rate of rolling is adopted as an indicator of robustness. Sensitivity analysis and robust evaluation are conducted on the rolling gaits of a typical six-strut tensegrity robot. Specifically, the sensitivities of the rolling gaits to five uncertain parameters (i.e. tendon stiffness, initial tendon prestress, the equivalent mass of nodes, actuation lengths of actuators, and slope of ground) are investigated and discussed in detail, and the robustness of the rolling gaits is evaluated by correlated random sampling. Experiments on a physical prototype of the six-strut tensegrity robot are carried out to verify the proposed concept and method.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.1177/1729881421993638
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2202393-8
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  • 10
    Online Resource
    Online Resource
    Diagnostic role of Gallium-68 DOTATOC and Gallium-68 DOTATATE PET in patients with neuroendocrine tumors: a meta-analysis
    SAGE Publications ; 2014
    In:  Acta Radiologica Vol. 55, No. 4 ( 2014-05), p. 389-398
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 55, No. 4 ( 2014-05), p. 389-398
    Abstract: Gallium-68 somatostatin receptor positron emission tomography (PET) has been used in the diagnosis of neuroendocrine tumors (NETs). The compounds often used in molecular imaging of NETs with PET are 68Ga-DOTATOC, 68Ga-DOTATATE, and 68Ga-DOTANOC. There is varying affinity to different somatostatin receptors. Purpose To systematically review and perform a meta-analysis of published data regarding the diagnostic role of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs. Material and Methods A comprehensive literature search of studies published through 30 April 2013 regarding 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs was performed using the PubMed/MEDLINE, Embase, and Scopus databases. Pooled sensitivity and specificity of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs were calculated. The area under the receiver-operating characteristic (ROC) curve was calculated to measure the accuracy of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs. Results Ten studies comprising 416 patients with NETs were included in this meta-analysis. The pooled sensitivity of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs calculated on a per-patient-based analysis was 93% (95% confidence interval [CI] 89–96%) and 96% (95% CI 91–99%). The pooled specificity of 68Ga-DOTATOC and 68Ga-DOTATATE PET in diagnosing NETs was 85% (95% CI 74–93%) and 100% (95% CI 82–100%). The area under the ROC curve of 68Ga-DOTATOC and 68Ga-DOTATATE PET was 0.96 and 0.98, respectively, on a per-patient-based analysis. Conclusion The molecular imaging agents 68Ga-DOTATOC and 68Ga-DOTATATE demonstrated high sensitivity and specificity in the diagnosis of NETs on PET scan. Although both are accurate tools in the diagnosis of NETs, 68Ga-DOTATATE PET may be more sensitive and specific than 68Ga-DOTATOC PET scan.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185113496679
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2024579-8
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