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  • 1
    Online Resource
    Online Resource
    Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank
    SAGE Publications ; 2022
    In:  Biomarker Insights Vol. 17 ( 2022-01), p. 117727192211372-
    Details
    In: Biomarker Insights, SAGE Publications, Vol. 17 ( 2022-01), p. 117727192211372-
    Abstract: Biobanks have been supporting longitudinal prospective and retrospective studies by providing standardized services for the acquisition, transport, processing, storage, and distribution of high-quality biological material and associated data. Here, we describe how the Dog Aging Project (DAP), a large-scale longitudinal study of the domestic dog ( Canis familiaris) with translational applications for humans, developed a biobank of canine biospecimens and associated data. Design and methods: This was accomplished by working with the Cornell Veterinary Biobank, the first biobank in the world to receive accreditation to ISO 20387:2018—General Requirements for Biobanking. The biobank research team was involved in the early collection stages of the DAP, contributing to the development of appropriate workflows and processing fit-for-purpose biospecimens. In support of a dynamic strategy for real-time adjustment of processes, a pilot phase was implemented to develop, test, and optimize the biospecimen workflows, followed by an early phase of collection, processing, and banking of specimens from DAP participants. Results: During the pilot and early phases of collection, the DAP Biobank stored 164 aliquots of whole blood, 273 aliquots of peripheral blood mononuclear cells, 130 aliquots of plasma, and 70 aliquots of serum, and extracted high molecular weight genomic DNA suitable for whole-genome sequencing from 109 whole blood specimens. These specimens, along with their associated preanalytical data, have been made available for distribution to researchers. Conclusion: We discuss the challenges and opportunities encountered during the implementation of the DAP Biobank, along with novel strategies for promoting biobanking sustainability such as partnering with a DAP quality assurance manager and a DAP marketing and communication specialist and developing a pilot grant structure to fund small innovative research projects.
    Type of Medium: Online Resource
    ISSN: 1177-2719 , 1177-2719
    URL: Article
    DOI: 10.1177/11772719221137217
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2256754-9
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  • 2
    Online Resource
    Online Resource
    2016 AHA/ACC Guideline on the Management of Patients with Lower Extremity Peripheral Artery Disease: Executive Summary
    SAGE Publications ; 2017
    In:  Vascular Medicine Vol. 22, No. 3 ( 2017-06), p. NP1-NP43
    Details
    In: Vascular Medicine, SAGE Publications, Vol. 22, No. 3 ( 2017-06), p. NP1-NP43
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    URL: Article
    DOI: 10.1177/1358863X17701592
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2027562-6
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  • 3
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    Online Resource
    Guidelines for the Safe Preparation of Sterile Compounds: Results of the ISMP Sterile Preparation Compounding Safety Summit of October 2011
    SAGE Publications ; 2013
    In:  Hospital Pharmacy Vol. 48, No. 4 ( 2013-04), p. 282-301
    Details
    In: Hospital Pharmacy, SAGE Publications, Vol. 48, No. 4 ( 2013-04), p. 282-301
    Abstract: Significant patient safety incidents related to sterile drug compounding have occurred for many years. Previous guidelines have focused on ensuring sterility, but serious compounding errors have occurred as well. National efforts are needed to identify and reduce the potential for such errors and their causative factors. In response, the Institute for Safe Medication Practices (ISMP) convened in October 2011 a summit of 60 invited experts in the field for the purpose of establishing by consensus guidelines, safe practices, and standard operating procedures needed to ensure the safe preparation of compounded sterile preparations, especially intravenous admixtures. The resulting guidelines were categorized into 14 core processes: policies and procedures, order entry and verification, drug storage, assembling products and supplies, compounding, drug conservation during drug shortages, preparation of source/bulk containers, technology/automation used, IV workflow software, automated IV compounding devices, quality control/final verification, product labeling, record keeping, and staff management. They were also classified into 3 levels: mandatory, standard, and recommendation. The guidelines presented in this article were felt to be applicable to any health care organization that prepares sterile compounded products. The consensus of the group was that adherence to these guidelines will improve the safety of sterile product compounding and reduce harmful errors in patients receiving these products. Incorporation of these guidelines into sterile compounding practices of health care organizations is an important component of improving patient safety.
    Type of Medium: Online Resource
    ISSN: 0018-5787 , 1945-1253
    URL: Article
    DOI: 10.1310/hpj4804-282
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2069227-4
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    The Role of Reported Affective Symptoms and Anxiety in Recovery Trajectories After Sport-Related Concussion
    SAGE Publications ; 2022
    In:  The American Journal of Sports Medicine Vol. 50, No. 8 ( 2022-07), p. 2258-2270
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 50, No. 8 ( 2022-07), p. 2258-2270
    Abstract: There is growing awareness and clinical interest in athletes with affective symptoms after sport-related concussion (SRC), as these symptoms may contribute to overall symptoms and represent a modifiable risk factor of longer recovery. However, evidence of their effects on the entire return-to-play (RTP) trajectory, particularly among women and men, is limited. Purpose/Hypothesis: To examine the relationship between affective symptom reporting and RTP progression after SRC among a cohort of Division 1 student-athletes. We hypothesized that those endorsing affective symptoms, specifically nervous-anxious symptoms, spend more time in RTP progression and recovery. Study Design: Cohort study; Level of evidence, 3. Methods: Using SRC data from the Ivy League–Big Ten Epidemiology of Concussion Study among varsity athletes through February 2020, we identified the 4 affective symptoms from the Sport Concussion Assessment Tool symptom inventory. We modeled the relationship between a 4-category affective symptom variable and time to symptom resolution, RTP, and RTP progression, adjusting for nonaffective symptom prevalence and concussion history. Cox regressions were used to estimate hazard ratios for time to event outcomes, and linear regressions were used to evaluate mean differences for continuous outcomes. Results: Among 2077 student-athletes (men, 63.5%) with SRC symptoms, affective symptom prevalence was 47.6% and 44.3% in women and men, respectively, and nervous-anxious prevalence was 24.2% and 22.5%, respectively. When comparing women with and without co-occurring affective symptoms, rates of symptom resolution and RTP were significantly lower in those with affective symptoms, and women with nervous-anxious symptoms spent significantly longer in RTP progression. When comparing men with and without co-occurring affective symptoms, rates of symptom resolution and RTP were significantly lower in those with co-occurring affective symptoms, and affective symptoms were not associated with time in RTP progression. Conclusion: Student-athletes with affective symptoms and nervous-anxious symptoms exhibited delayed clinical recovery and RTP timelines, particularly for time in RTP. Symptom prevalence and concussion history contributed to this; however, unmeasured confounding remains, as indicated by the poor model fit. This study motivates future work to explore affective symptoms and RTP timelines, considering anxiety and risk/protective factors over time.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/03635465221098112
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 5
    Online Resource
    Online Resource
    Distal Biceps Tendon Repair : A Cadaveric Analysis of Suture Anchor and Interference Screw Restoration of the Anatomic Footprint
    SAGE Publications ; 2009
    In:  The American Journal of Sports Medicine Vol. 37, No. 11 ( 2009-11), p. 2214-2221
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 37, No. 11 ( 2009-11), p. 2214-2221
    Abstract: Distal biceps tendon repair with interference screw or double suture-anchor fixation are 2 successful techniques performed with either 1- or 2-incision approaches. No study has examined the accuracy and quality of the repaired tendon footprint with these devices and approaches. Hypothesis A 2-incision approach will allow a more anatomic repair of the distal biceps footprint compared with a 1-incision anterior approach. Fixation technique will affect insertional footprint location and footprint contact area. Study Design Controlled laboratory study. Methods After randomization, 36 distal biceps repairs were performed on human cadaveric upper extremity specimens, with 1- or 2-incision approaches and with fixation devices of either two 5.5-mm suture anchors or an 8-mm interference screw. Native and repaired footprint areas and centroid location were calculated with a 3-dimensional digitizer. Results Interference screw repair had the smallest footprint area (135 mm 2 ) compared with suture anchor repair (197 mm 2 ) and the native tendon (259 mm 2 ) ( P = .013). The 2-incision approach repaired the footprint to a more posterior and anatomic position (2.5 mm) than a 1-incision approach ( P = .001). The fixation device did not affect footprint location significantly. Conclusion Suture anchor repair more closely re-creates the footprint area on the radial tuberosity of the native distal biceps tendon compared with the interference screw repair. A 2-incision approach more closely re-creates footprint position compared with the 1-incision approach. Clinical Relevance A 2-incision approach with double suture-anchor fixation may yield a more anatomic distal biceps repair based on reproduction of the footprint compared with a 1-incision approach.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546509337451
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 6
    Online Resource
    Online Resource
    Comparing Strategic Voting Under FPTP and PR
    SAGE Publications ; 2010
    In:  Comparative Political Studies Vol. 43, No. 1 ( 2010-01), p. 61-90
    Details
    In: Comparative Political Studies, SAGE Publications, Vol. 43, No. 1 ( 2010-01), p. 61-90
    Abstract: Based on recent work that suggests that voters in proportional representation (PR) systems have incentives to cast strategic votes, the authors hypothesize that levels of strategic voting are similar in both first-past-the-post (FPTP) and PR systems. Comparing vote intentions in majoritarian elections in the United States, Mexico, Britain, and Israel to PR elections in Israel and the Netherlands, the authors find that a substantial proportion of the voters desert their most preferred candidate or party and that patterns of strategic voting across FPTP and PR bear striking similarities. In every election, smaller parties tend to lose votes to major parties. Because there tend to be more small parties in PR systems, tactical voting is actually more common under PR than under FPTP. The findings suggest that whatever the electoral system, voters focus on the policy consequences of their behavior and which parties are likely to influence policy outcomes following the election.
    Type of Medium: Online Resource
    ISSN: 0010-4140 , 1552-3829
    URL: Article
    DOI: 10.1177/0010414009341717
    RVK:
    MA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 123009-8
    detail.hit.zdb_id: 1494061-9
    SSG: 3,6
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  • 7
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    Treatment of Lisfranc Fracture-Dislocations with Primary Partial Arthrodesis
    SAGE Publications ; 2012
    In:  Foot & Ankle International Vol. 33, No. 1 ( 2012-01), p. 50-56
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 33, No. 1 ( 2012-01), p. 50-56
    Abstract: Background: The optimal method of treatment for Lisfranc fracture-dislocations remains controversial, and the role of primary partial arthrodesis for combined osseous-ligamentous Lisfranc injuries is unclear. This study reviewed the outcomes of Lisfranc injuries treated by primary partial arthrodesis. Methods: Patients who underwent primary partial arthrodesis for a primarily ligamentous or combined osseous and ligamentous Lisfranc fracture-dislocation were reviewed retrospectively and assessed at followup according to radiographic, clinical and standardized patient-based outcomes. Twenty-five patients (12 ligamentous, 13 combined), median age of 46 (range, 20 to 73) years, were followed for an average of 42 (range, 24 to 96) months. Results: The average American Orthopedic Foot and Ankle Society (AOFAS) score was 81 points (scale 0 to 100), with patients in general losing points for mild pain, limitations of recreational activities, and fashionable footwear requirements. There was no statistical difference between ligamentous and combined injuries with regard to the physical or mental component scores on the SF-36. At latest followup, patients reported an average return to 85% of their preinjury activity level (range, 50% to 100%). Twenty-one patients (84%) expressed satisfaction with their outcome and at latest followup, the mean visual analog pain scale (VAS) score was 1.8 out of 10 (range, 0 to 8). Three patients showed radiographic signs of posttraumatic arthritis of adjacent joints. Conclusion: Treatment of both primarily ligamentous and combined osseous and ligamentous lisfranc injuries with primary partial arthrodesis produced good clinical and patient-based outcomes. Level of Evidence: III, Retrospective Comparative Study
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.3113/FAI.2012.0050
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2129503-7
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  • 8
    Online Resource
    Online Resource
    Predictors of Depressive Symptoms in Parents of Chronically Ill Children Admitted to the Pediatric Intensive Care Unit
    SAGE Publications ; 2011
    In:  American Journal of Hospice and Palliative Medicine® Vol. 28, No. 8 ( 2011-12), p. 556-563
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 28, No. 8 ( 2011-12), p. 556-563
    Abstract: Objective: To identify factors in the pediatric intensive care unit (PICU) patient population that may result in increased risk of depressive symptoms in their parents. Design: Six-month, prospective, observational study in a tertiary-level PICU on parents of chronically ill children admitted to PICU. Parents were assessed by background questionnaire and standardized depression scale. Results: Data was compared to various markers such as child’s diagnosis, admission reason, palliative care diagnosis type (ACT code), and course/length of disease. Incidence of depressive symptoms in parents was inversely correlated with duration of child’s chronic illness. Parents of children admitted for planned postoperative management were more likely to report depressive symptoms compared to parents of children admitted for acute changes in health. Conclusion: Parents of certain chronically ill children may benefit from routine screening for depression.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/1049909111403465
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2236674-X
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