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  • 1
    Online Resource
    Online Resource
    Adjustment Disorders and Suicidality
    SAGE Publications ; 1986
    In:  Psychological Reports Vol. 59, No. 2 ( 1986-10), p. 355-358
    Details
    In: Psychological Reports, SAGE Publications, Vol. 59, No. 2 ( 1986-10), p. 355-358
    Abstract: In this study two rating scales, the Echelle d'Evaluation de Risque Suicidaire and the Pierce-modified form of the Suicide Intent Scale, were administered to a group of 43 persons admitted to the general hospital of Padua for suicide attempts. The purpose of our study was to verify whether these tools could be considered useful in the assessment of severity of the attempts. The rating scales showed good concordance in identifying the adjustment disorder group as less dangerous for the seriousness of the attempt.
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.2466/pr0.1986.59.2.355
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1986
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
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  • 2
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    Hepatitis C treatment uptake and response among human immunodeficiency virus/hepatitis C virus-coinfected patients in a large integrated healthcare system
    SAGE Publications ; 2019
    In:  International Journal of STD & AIDS Vol. 30, No. 7 ( 2019-06), p. 689-695
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 30, No. 7 ( 2019-06), p. 689-695
    Abstract: U.S. guidelines recommend that patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) be prioritized for HCV treatment with direct-acting antiviral agents (DAAs), but the high cost of DAAs may contribute to disparities in treatment uptake and outcomes. We evaluated DAA initiation and effectiveness in HIV/HCV-coinfected patients in a U.S.-based healthcare system during October 2014–December 2017. Of 462 HIV/HCV-coinfected patients, 276 initiated DAAs (70% cumulative proportion treated over three years). Lower likelihood of DAA initiation was observed among patients with Medicare (government-sponsored insurance) versus commercial insurance (adjusted rate ratio [aRR] = 0.62, 95% CI = 0.46–0.84), patients with drug abuse diagnoses (aRR = 0.72, 95% CI = 0.54–0.97), patients with CD4 cell count 〈 200 cells/µl versus ≥500 (aRR = 0.45, 95% CI = 0.23–0.91), and patients without prior HCV treatment (aRR = 0.68, 95% CI = 0.48–0.97). There were no significant differences in DAA initiation by age, gender, race/ethnicity, socioeconomic status, HIV transmission risk, alcohol use, smoking, fibrosis level, HIV RNA levels, antiretroviral therapy use, hepatitis B infection, or number of outpatient visits. Ninety-five percent of patients achieved sustained virologic response (SVR). We found little evidence of sociodemographic disparities in DAA initiation among HIV/HCV-coinfected patients, and SVR rates were high. Efforts are needed to increase DAA uptake among coinfected Medicare enrollees, patients with drug abuse diagnoses, patients with low CD4 cell count, and patients receiving first-time HCV treatment.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1177/0956462419836520
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2009782-7
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  • 3
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    An Intensive Treatment with Mitoxantrone and Ifosfamide in Second-Line Therapy of Epithelial Ovarian Cancer
    SAGE Publications ; 1994
    In:  Tumori Journal Vol. 80, No. 6 ( 1994-12), p. 443-447
    Details
    In: Tumori Journal, SAGE Publications, Vol. 80, No. 6 ( 1994-12), p. 443-447
    Abstract: Both mitoxantrone (DHAD) and ifosfamide (IFO) have given promising results when administered as single agents in advanced ovarian cancer pretreated with platinum compounds. The aim of this I.T.M.O. group pilot trial was to evaluate, in a selected population of ovarian cancer patients, the efficacy and tolerability of the following intensive second-line regimen: DHAD, 12 mg/m 2 i.v., day 1; IFO, 4,000 mg/m 2 i.v., days 1 and 2; Mesna, 800 mg/m 2 i.v. t.i.d., days 1 and 2. Filgrastim (5 μg/kg/day i.m.) was given from day 6 to day 19 to reduce the expected neutropenia. Cycles were repeated every 21 days. Methods Nineteen platinum-pre-treated patients were enrolled and 14 were evaluated for tumor response; the disease of 5 patients was not measurable clinically or radiologically. Results Seven responses were observed (3 CRs), with a median response duration of 5 months. The median time to treatment failure and overall survival for all 19 patients was respectively 8 and 13 months. Anemia was observed in all of the treated patients (grade 3–4 in 9 cases). Only 6 of the 19 patients ended the five planned cycles of chemotherapy without any delay. Conclusions Although DHAD plus IFO induced a considerable number of objective responses, the limited response duration time to treatment failure, and overall survival as well as the reported side effects suggest that this is not a recommended regimen for the palliative treatment of ovarian cancer patients undergoing second-line chemotherapy.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089169408000607
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 4
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    Online Resource
    Mammographic findings after reshaping with autoprosthesis in women undergoing contralateral breast reconstruction and mastectomy
    SAGE Publications ; 2016
    In:  Tumori Journal Vol. 102, No. 1 ( 2016-01), p. 77-83
    Details
    In: Tumori Journal, SAGE Publications, Vol. 102, No. 1 ( 2016-01), p. 77-83
    Abstract: Breast reduction and mastopexy combined with inferior dermo-lipo-glandular flap (autoprosthesis) gives good breast shape, long-term projection, and upper pole fullness. We assess the impact on breast oncologic surveillance compared to other techniques. Methods A total of 105 patients who underwent mastectomy and reconstruction were divided into 3 groups of 35 patients each: groups 1 and 2 include patients with contralateral breast symmetrization performed with and without autoprosthesis technique, respectively. Group 3 is a control group without contralateral breast reshaping. On mammography, edema, skin thickening, architectural distortion, and calcifications were recorded, as well as further diagnostic examinations, biopsies, and surgical treatments required. Results Statistically significant differences (p 〈 0.001) in the first follow-up mammography between groups 1 and 2 were stromal edema (6% vs 51%) and architectural distortion (74% vs 63%). The latest findings meant architectural distortion also have significant difference (p 〈 0.001) in the last mammography (79% vs 66%). Microcalcification has statistically significant difference (p 〈 0.001) in the latest postsurgical mammography, increased in group 1. Skin thickening had a similar course in either group. Mammography follow-up was not impaired in most cases notwithstanding the parenchyma distortion as compared with mammography after breast-conserving surgery. Four core biopsies were performed in both groups: 3 new breast cancers and 1 benign epithelial hyperplasia were found. Conclusions No difficulties were found impairing mammographic evaluation in patients treated with autoprosthesis as compared to other techniques.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.5301/tj.5000395
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 5
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    Within The Family
    SAGE Publications ; 1955
    In:  Exceptional Children Vol. 22, No. 3 ( 1955-12), p. 118-119
    Details
    In: Exceptional Children, SAGE Publications, Vol. 22, No. 3 ( 1955-12), p. 118-119
    Type of Medium: Online Resource
    ISSN: 0014-4029 , 2163-5560
    URL: Article
    DOI: 10.1177/001440295502200307
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1955
    detail.hit.zdb_id: 2066308-0
    SSG: 5,2
    SSG: 5,3
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  • 6
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    Online Resource
    Disparities in Initiation of Direct-Acting Antiviral Agents for Hepatitis C Virus Infection in an Insured Population
    SAGE Publications ; 2018
    In:  Public Health Reports Vol. 133, No. 4 ( 2018-07), p. 452-460
    Details
    In: Public Health Reports, SAGE Publications, Vol. 133, No. 4 ( 2018-07), p. 452-460
    Abstract: The cost of direct-acting antiviral agents (DAAs) for hepatitis C virus (HCV) infection may contribute to treatment disparities. However, few data exist on factors associated with DAA initiation. Methods: We conducted a retrospective cohort study of HCV-infected Kaiser Permanente Northern California members aged ≥18 during October 2014 to December 2016, using Poisson regression models to evaluate demographic, behavioral, and clinical factors associated with DAA initiation. Results: Of 14 790 HCV-infected patients aged ≥18 (median age, 60; interquartile range, 53-64), 6148 (42%) initiated DAAs. DAA initiation was less likely among patients who were non-Hispanic black (adjusted rate ratio [aRR] = 0.7; 95% confidence interval [CI] , 0.7-0.8), Hispanic (aRR = 0.8; 95% CI, 0.7-0.9), and of other minority races/ethnicities (aRR = 0.9; 95% CI, 0.8-1.0) than among non-Hispanic white people and among those with lowest compared with highest neighborhood deprivation index (ie, a marker of socioeconomic status) (aRR = 0.8; 95% CI, 0.7-0.8). Having maximum annual out-of-pocket health care costs 〉 $3000 compared with ≤$3000 (aRR = 0.9; 95% CI, 0.8-0.9) and having Medicare (aRR = 0.8; 95% CI, 0.8-0.9) or Medicaid (aRR = 0.7; 95% CI, 0.6-0.8) compared with private health insurance were associated with a lower likelihood of DAA initiation. Behavioral factors (eg, drug abuse diagnoses, alcohol use, and smoking) were also significantly associated with a lower likelihood of DAA initiation (all P 〈 .001). Clinical factors associated with a higher likelihood of DAA initiation were advanced liver fibrosis, HCV genotype 1, previous HCV treatment (all P 〈 .001), and HIV infection ( P = .007). Conclusions: Racial/ethnic and socioeconomic disparities exist in DAA initiation. Substance use may also influence patient or provider decision making about DAA initiation. Strategies are needed to ensure equitable access to DAAs, even in insured populations.
    Type of Medium: Online Resource
    ISSN: 0033-3549 , 1468-2877
    URL: Article
    DOI: 10.1177/0033354918772059
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2017700-8
    SSG: 20,1
    SSG: 27
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  • 7
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    Implementation of the Liverpool Care Pathway (LCP) for the Dying Patient in the Inpatient Hospice Setting : Development and Preliminary Assessment of the Italian LCP Program
    SAGE Publications ; 2014
    In:  American Journal of Hospice and Palliative Medicine® Vol. 31, No. 1 ( 2014-02), p. 61-68
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 31, No. 1 ( 2014-02), p. 61-68
    Abstract: The Liverpool Care Pathway (LCP) is extensively used in hospices, but the literature on the process of implementation is scarce. Aim: Developing, piloting, and preliminarily assessing the LCP program within the inpatient hospice setting. Methods: This is a phase 0-1 study, according to the Medical Research Council (MRC) Framework, divided into three phases: literature review on LCP in hospice and development of the Italian version of the LCP program (LCP-I), development of a procedure for assessing the quality of the implementation process and assessing the feasibility of the implementation process, and piloting the procedure in 7 inpatient Italian hospices. Results: The LCP was implemented in all the hospices involved. A high proportion of physicians (50%-100%) and nurses (94%-100%) attended the self-education program. The self-implementation of the LCP-I program was completed in all hospices. The proportion of patients who died on LCP-I ranged between 35.6% and 89.1%. Professionals from 2 hospices reported a positive impact of the LCP-I. Conversely, professionals from 2 hospices did not recognize a positive impact of the program and did not agree to maintain the LCP-I in hospice. Finally, professionals from the other 3 hospices reported intermediate evaluations (1 stopped to use the LCP-I). Some weaknesses emerged from the external audits, related to the self-education and the self-implementation approach. Professionals required an external support from a trained palliative care team with reference to both phases. Conclusions: The LCP-I implementation within hospices is feasible, and the process of implementation is evaluable. Issues that occurred within the implementation process suggest the introduction of an external support from a trained palliative care team in implementing the LCP program.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/1049909113482355
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2236674-X
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  • 8
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    Online Resource
    Cardiac Response to Internally and Externally Elicited Stressful Imagery as a Function of Field Dependence
    SAGE Publications ; 1976
    In:  Perceptual and Motor Skills Vol. 42, No. 3_suppl ( 1976-06), p. 1295-1304
    Details
    In: Perceptual and Motor Skills, SAGE Publications, Vol. 42, No. 3_suppl ( 1976-06), p. 1295-1304
    Abstract: The present study investigated heart-rate response to internally and externally elicited stressful imagery as a function of field dependence. 40 female undergraduates were divided into five field-dependent groups. Both the internal and the external modes of presentation included a stimulus block followed by an image block. The internal-stimulus block was an internally elicited thought, while the external-stimulus block was a visually presented typewritten statement. Half of the Ss within each field-dependent group experienced the external mode and half experienced the internal mode. A tone served as the time-locked cue to signal the thoughts and the images. The results indicated that the internal mode produced significantly greater heart-rate response than the external mode, and there was a trend toward field-independent Ss reacting with higher heart rate to both modes. These findings and trends are discussed in terms of the importance of internally elicited cognitive activity in the experience of fear, the Lacey hypothesis of directional fractionation, and the relationship between field dependence and various autonomic and personality characteristics.
    Type of Medium: Online Resource
    ISSN: 0031-5125 , 1558-688X
    URL: Article
    DOI: 10.2466/pms.1976.42.3c.1295
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1976
    detail.hit.zdb_id: 2066876-4
    SSG: 5,2
    SSG: 7,11
    SSG: 31
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  • 9
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    The role of abemaciclib in treatment of advanced breast cancer
    SAGE Publications ; 2018
    In:  Therapeutic Advances in Medical Oncology Vol. 10 ( 2018-01-01), p. 175883591877692-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 10 ( 2018-01-01), p. 175883591877692-
    Abstract: Until recently, the mainstay of treatment in the majority of hormone receptor (HR)-positive, human epidermal growth factor 2 receptor (HER2)-negative advanced breast cancer (ABC) has consisted of single-agent endocrine therapy (ET). However, as understanding of endocrine resistance has grown, newer targeted agents have come to the fore. Inhibition of cyclin-dependent kinase complexes 4 and 6 (CDK4/6) combined with ET has shown significant activity in HR+ HER2− ABC, with impressive results in terms of progression-free survival (PFS) when compared with ET alone. This review summarizes the seminal findings pertaining to CDK4/6 inhibition in this population, specifically focusing on abemaciclib, contrasted with palbociclib and ribociclib. Potential directions for future studies are discussed, as a way of addressing outstanding issues such as establishing optimal treatment sequencing and agent combinations, appropriate patient selection to derive maximal benefits, predictive biomarkers and the employment of CDK4/6 inhibition beyond the ABC setting.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835918776925
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2503443-1
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  • 10
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    Increasing Saving Behavior Through Age-Progressed Renderings of the Future Self
    SAGE Publications ; 2011
    In:  Journal of Marketing Research Vol. 48, No. SPL ( 2011-02), p. S23-S37
    Details
    In: Journal of Marketing Research, SAGE Publications, Vol. 48, No. SPL ( 2011-02), p. S23-S37
    Abstract: Many people fail to save what they will need for retirement. Research on excessive discounting of the future suggests that removing the lure of immediate rewards by precommitting to decisions or elaborating the value of future rewards both can make decisions more future oriented. The authors explore a third and complementary route, one that deals not with present and future rewards but with present and future selves. In line with research that shows that people may fail, because of a lack of belief or imagination, to identify with their future selves, the authors propose that allowing people to interact with age-progressed renderings of themselves will cause them to allocate more resources to the future. In four studies, participants interacted with realistic computer renderings of their future selves using immersive virtual reality hardware and interactive decision aids. In all cases, those who interacted with their virtual future selves exhibited an increased tendency to accept later monetary rewards over immediate ones.
    Type of Medium: Online Resource
    ISSN: 0022-2437 , 1547-7193
    URL: Article
    DOI: 10.1509/jmkr.48.SPL.S23
    RVK:
    QA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2066604-4
    detail.hit.zdb_id: 218319-5
    SSG: 3,2
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