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  • SAGE Publications  (11)
  • 1
    Online Resource
    Online Resource
    Hepatocyte Transplantation for Glycogen Storage Disease Type Ib
    SAGE Publications ; 2007
    In:  Cell Transplantation Vol. 16, No. 6 ( 2007-07), p. 629-637
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 16, No. 6 ( 2007-07), p. 629-637
    Abstract: Glycogen storage disease type I (GSD-I) is a group of autosomal recessive disorders with an incidence of 1 in 100,000. The two major subtypes are GSD-Ia, caused by a deficiency of glucose-6-phosphatase (G6Pase), and GSD-Ib, caused by a deficiency of glucose-6-phosphate transporter (G6PT). We report that a substantial improvement was achieved following several infusions of hepatocytes in a patient with GSD-Ib. Hepatocytes were isolated from the unused cadaveric whole livers of two donors. At the first transplantation, approximately 2 × 109 cells (2% of the estimated recipient's total hepatocytes) were infused. Seven days later 1 × 109 (1% of liver mass) cryopreserved hepatocytes from the same donor were infused, and an additional 3 × 109 (3% of liver mass) cells from the second donor were infused 1 month after the second transplantation. After the hepatocyte transplantation, the patient showed no hypoglycemic symptoms despite the discontinuation of cornstarch meals. Liver biopsies on posttransplantation days 20 and 250 showed a normal level of glucose-6-phosphatase activity in presolubilization assay that was very low before transplantation. This was the first and successful clinical hepatocyte transplantation in Korea. In this study, hepatocyte transplantation allowed a normal diet in a patient with GSD-Ib, with substantial improvement in their quality of life. Hepatocyte transplantation might be an alternative to liver transplantation and dietary therapy in GSD-Ib.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/000000007783465019
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2020466-8
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  • 2
    Online Resource
    Online Resource
    Adult sail sign: radiographic and computed tomographic features
    SAGE Publications ; 2008
    In:  Acta Radiologica Vol. 49, No. 1 ( 2008-02), p. 37-40
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 49, No. 1 ( 2008-02), p. 37-40
    Abstract: Background: The sail sign is a well-known radiographic feature of the pediatric chest. This sign can be observed in an adult population as well, but for a different reason. Purpose: To investigate the sail sign appearing in adult chest radiography. Material and Methods: Based on two anecdotal adult cases in which frontal chest radiographs showed the sail sign, we prospectively screened radiographs of 10,238 patients to determine the incidence of the sail sign found in adults in their 40s or older. The cause of the sail sign was assessed using computed tomography (CT). Results: The sail sign was revealed in 10 (seven males, three females; median age 60.6 years) of 10,238 patients. Of these 10 patients with a sail sign on frontal radiographs, eight underwent CT. The frontal radiographs of these 10 patients showed a concave superior margin toward the lung in nine patients, a concave inferior margin in five, and a double-lined inferior margin in three. Lateral radiographs disclosed a focal opacity over the minor fissure in five of six patients, which was either fuzzy ( n = 4) or sharp ( n = 1) in its upper margin, and was sometimes double lined in the inferior margin ( n = 3). CT revealed the anterior mediastinal fat to be the cause of the radiographic sail sign, which stretched laterally from the mediastinum to insinuate into the minor fissure. Conclusion: The incidence of sail sign on adult chest radiographs is about 0.1%. The sign is specific enough to eliminate the need for more sophisticated imaging.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1080/02841850701675677
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2024579-8
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  • 3
    Online Resource
    Online Resource
    Degradation and Dynamic Properties of Poly(amide-co-imide)/Carbon Nanotube Composite Films
    SAGE Publications ; 2010
    In:  Polymers and Polymer Composites Vol. 18, No. 7 ( 2010-09), p. 381-390
    Details
    In: Polymers and Polymer Composites, SAGE Publications, Vol. 18, No. 7 ( 2010-09), p. 381-390
    Abstract: Poly(amide-imide) (PAI)/carbon nanotube (CNT) composite films were investigated through FT-IR spectroscopy, TGA, and DMTA measurements in order to understand the interrelationships of surface modification of CNTs, thermal imidization time, and thermal stability after they were prepared by solution mixing. Thermal stability and glass transition temperature were significantly improved when the PAI/CNT nanocomposites were filled with hydrogen peroxide treated CNTs (p-CNT) because the dispersion of p-CNTs and interfacial bonding between p-CNT particles and PAI molecules were improved. The imidization time of the PAI/p-CNT composite film needed for sufficient imidization reaction was reduced by about 3 hours compared with that of the pure PAI film, because p-CNTs have higher thermal conductivity than the pure PAI resin. They also showed the highest glass transition temperature among all PAI/CNT composites since p-CNTs have many hydrophilic functional groups which yield strong interaction with PAI molecules. It was found that the thermal imidization depended on the network structure which was generated by the crosslinking reaction and surface modification of CNTs.
    Type of Medium: Online Resource
    ISSN: 0967-3911 , 1478-2391
    URL: Article
    DOI: 10.1177/096739111001800704
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2099644-5
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  • 4
    Online Resource
    Online Resource
    Effectiveness of the sequential organ failure assessment, acute physiology and chronic health evaluation II, and simplified acute physiology score II prognostic scoring systems in paraquat-poisoned patients in the intensive care unit
    SAGE Publications ; 2017
    In:  Human & Experimental Toxicology Vol. 36, No. 5 ( 2017-05), p. 431-437
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 36, No. 5 ( 2017-05), p. 431-437
    Abstract: This study was conducted to assess the ability of the sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) II scoring systems, as well as the simplified acute physiology score (SAPS) II method to predict group mortality in intensive care unit (ICU) patients who were poisoned with paraquat. This will assist physicians with risk stratification. Material and methods: The medical records of 244 paraquat-poisoned patients admitted to the ICU from January 2010 to April 2015 were examined retrospectively. The SOFA, APACHE II, and SAPS II scores were calculated based on initial laboratory data in the emergency department and during the first 24 h of ICU admission. The probability of death was calculated for each patient based on the SOFA score, APACHE II score, and SAPS II. The ability of the SOFA score, APACHE II score, and SAPS II method to predict group mortality was assessed using a receiver operating characteristic (ROC) curve and calibration analyses. Results: A total of 219 patients (mean age, 63 years) were enrolled. Sensitivities, specificities, and accuracies were 58.5%, 86.1%, and 64.0% for the SOFA, respectively; 75.1%, 86.1%, and 77.6% for the APACHE II scoring systems, respectively; and 76.1%, 79.1%, and 76.7% for the SAPS II, respectively. The areas under the curve in the ROC curve analysis for the SOFA score, APACHE II scoring system, and SAPS II were 0.716, 0.850, and 0.835, respectively. Conclusion: The SOFA, APACHE II, and SAPS II had different capabilities to discriminate and estimate early in-hospital mortality of paraquat-poisoned patients. Our results show that although the SOFA and SAPS II are easier and more quickly calculated than APACHE II, the APACHE II is superior for predicting mortality. We recommend use of the APACHE II for outcome predictions and risk stratification in paraquat-poisoned patients in the ICU.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/0960327116657602
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1483723-7
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  • 5
    Online Resource
    Online Resource
    The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients
    SAGE Publications ; 2012
    In:  Palliative Medicine Vol. 26, No. 3 ( 2012-04), p. 275-282
    Details
    In: Palliative Medicine, SAGE Publications, Vol. 26, No. 3 ( 2012-04), p. 275-282
    Abstract: Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-α, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (β = 0.376, p = 0.002), severe pain intensity (β = 0.349, p = 0.004), and impaired performance status (β = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance.
    Type of Medium: Online Resource
    ISSN: 0269-2163 , 1477-030X
    URL: Article
    DOI: 10.1177/0269216311406991
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2027566-3
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  • 6
    Online Resource
    Online Resource
    Recovery Effect of a Rutin-Enriched Fraction Prepared From Forsythia koreana Flowers on Alloxan-Induced Pancreatic Islets in Zebrafish Larvae ( Danio rerio )
    SAGE Publications ; 2021
    In:  Natural Product Communications Vol. 16, No. 10 ( 2021-10), p. 1934578X2110437-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 16, No. 10 ( 2021-10), p. 1934578X2110437-
    Abstract: A simple method to prepare a high-content rutin fraction from Forsythia koreana flowers (HRFK) is described. Rutin, isolated for the first time from the flowers, was identified from spectroscopic data including nuclear magnetic resonance, mass spectrometry, and infrared. As a result of HPLC quantitative analysis, the content of rutin was found to be 80.0 ± 0.02% in HRFK. Our previous study reported that F koreana MeOH extract (FK) significantly recovered alloxan-induced pancreatic islets in zebrafish. However, HRFK as well as rutin exhibited an enhanced anti-diabetic effect compared to FK in our latest experiments. In conclusion, HRFK, as well as rutin and FK, have potential as anti-diabetic agents.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X211043731
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Combined Use of Multiple Computational Intracranial EEG Analysis Techniques for the Localization of Epileptogenic Zones in Lennox–Gastaut Syndrome
    SAGE Publications ; 2014
    In:  Clinical EEG and Neuroscience Vol. 45, No. 3 ( 2014-07), p. 169-178
    Details
    In: Clinical EEG and Neuroscience, SAGE Publications, Vol. 45, No. 3 ( 2014-07), p. 169-178
    Abstract: Traditionally, identification of epileptogenic zones primarily relied on visual inspection of intracranial electroencephalography (iEEG) recordings by experienced epileptologists; however, removal of epileptogenic zones identified by iEEG does not always guarantee favorable surgical outcomes. To confirm visual inspection results, and assist in making decisions about surgical resection areas, computational iEEG analysis methods have recently been used for the localization of epileptogenic zones. In this study, we have proposed a new approach for the localization of epileptogenic zones in Lennox–Gastaut syndrome (LGS), and have investigated whether the proposed approach could confirm surgical resection areas and predict seizure outcome before surgery. The proposed approach simultaneously used results of 2 iEEG analysis methods, directed transfer function (DTF) and time delay estimation, to enhance localization accuracy. This new combined method was applied to patients who became seizure-free after resective epilepsy surgery, as well as those who had unsuccessful surgery. A quantitative metric was also introduced that can measure how well the localized epileptogenic zones coincided with the surgical resection areas, with the aim of verifying whether the approach could confirm surgical resection areas determined by epileptologists. The estimated epileptogenic zones more strongly coincided with surgical resection areas in patients with successful, compared to those with unsuccessful surgical outcomes. Both qualitative and quantitative analyses showed that the combined use of 2 iEEG analyses resulted in a more accurate estimate of epileptogenic zones in LGS than the use of a single method. A combination of multiple iEEG analyses could not only enhance overall accuracy of localizing epileptogenic zones in LGS, but also has the potential to predict outcomes before resective surgery.
    Type of Medium: Online Resource
    ISSN: 1550-0594 , 2169-5202
    URL: Article
    DOI: 10.1177/1550059413495393
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2647038-X
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  • 8
    Online Resource
    Online Resource
    Review : Decreased tumour necrosis factor-beta production in TNFB*2 homozygote: an important predisposing factor of lupus nephritis in Koreans
    SAGE Publications ; 1997
    In:  Lupus Vol. 6, No. 7 ( 1997-09), p. 603-609
    Details
    In: Lupus, SAGE Publications, Vol. 6, No. 7 ( 1997-09), p. 603-609
    Abstract: Low TNF production and its association with TNF gene restriction fragment length polymorphism (RFLP) was demonstrated in (NZW/NZB) F 1 mice. However, little is known about the significance of TNF production in association with TNF gene polymorphism in human SLE. This study was designed to evaluate the role of TNF production of peripheral blood mononuclear cells (PBMC) and its association with TNFB gene polymorphism in SLE, particularly lupus nephritis. TNFB gene polymorphism was defined by PCR- NcoI RFLP. TNF productions of phytohemagglutinin (PHA)- stimulated PBMC and T cells were examined by bioassay using L929 cell line and ELISA. The PBMC stimulated by PHA from patients with SLE ( n = 60) tended to secrete less amounts of TNF by bioassay (1032±184pg/ml vs 1524±224pg/ml, P=0.094), and TNF-β by ELISA ( P = 0.0082) than that from normal controls ( n = 38). The low TNF-α producer was more frequent in nephritis than non-nephritis (34.4% vs 7.1% respectively, P 〈 0.01). TNF-β also revealed similar results (53.1% vs 21.4%, P 〈 0.05). In SLE, mean production of TNF-β was decreased in TNFB*2 homozygote ( n=18) than that in TNFB*1 homozygote ( n = 9) (1126.3±145 pg/ml) vs 642 ± 118.4 pg/ml, respectively, P = 0.021), whereas TNF-α production showed little difference between the two groups (710.1 ± 56.4 vs 542.4 ± 71.1 pg/ml, respectively, P = 0.149). Our results demonstrate that decreased TNF production of PBMC, which was significantly associated with TNFB*2 homozygosity, could be an important predisposing factor of lupus nephritis in Koreans.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/096120339700600708
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
    detail.hit.zdb_id: 2008035-9
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  • 9
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    Intra-articular and meniscal pathology according to anterior cruciate ligament injury pattern: both-bundle tear or selective bundle tear
    SAGE Publications ; 2020
    In:  Acta Radiologica Vol. 61, No. 5 ( 2020-05), p. 644-650
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 61, No. 5 ( 2020-05), p. 644-650
    Abstract: Articular cartilage injury and meniscal tear are usually combined with anterior cruciate ligament injury. Purpose We investigated the incidence of cartilage injury and traumatic meniscal tear according to the type of combined anterior cruciate ligament tear (both-bundle versus selective bundle tear). Material and Methods This retrospective study included 103 patients diagnosed with anterior cruciate ligament tear after knee joint magnetic resonance imaging and who underwent knee joint arthroscopy. Two radiologists evaluated articular cartilage injuries and meniscal tear independently. We used the chi-square test to analyze the association between type of anterior cruciate ligament bundle tear and presence of cartilage or meniscal injury in each reader. Results Cartilage injury presented a significantly higher prevalence in both-bundle tear than did selective bundle tear in reader 1 ( P = 0.004). In reader 2, both-bundle tear had a tendency for higher risk of cartilage injury, but this was not statistically significant ( P = 0.178). In meniscal injury, there was a statistically significant increase in the risk of associated meniscal injury in both-bundle tear versus selective bundle anterior cruciate ligament injury ( P = 0.019 and 0.021). The risk of accompanying traumatic meniscal lesion was significantly higher in both-bundle tear ( P = 0.036 and 0.018). Conclusion The incidence of accompanying meniscal injury, especially traumatic tears, is higher in both-bundle anterior cruciate ligament tear than in selective bundle tear. There was no significant difference in incidence of cartilage injury between both-bundle tear and selective bundle tear, although one of two readers showed a higher incidence in both-bundle tear.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185119873117
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2024579-8
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  • 10
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    Compression and Relaxation Behavior of Dry Fiber Preforms for Resin Transfer Molding
    SAGE Publications ; 2010
    In:  Journal of Composite Materials Vol. 44, No. 15 ( 2010-07), p. 1801-1820
    Details
    In: Journal of Composite Materials, SAGE Publications, Vol. 44, No. 15 ( 2010-07), p. 1801-1820
    Abstract: Compression and relaxation behavior of various fiber preforms for resin transfer molding was investigated experimentally through compression, relaxation, and decompression procedures. A simple Maxwell model was used in order to predict the nonlinear compression and relaxation behavior, and numerical simulation was performed for a unit cell of the fiber preform by using the finite-element method. As the fiber volume fraction is larger than 0.4, compressive stresses acting on the woven fabric increased linearly with increasing fiber volume fraction. A typical hysteresis occurred due to relaxation behavior of the fiber preform during compression and decompression test. It was also found that numerical analysis yields slightly lower displacement field than experimental results under the same compressive force. However, experimental results were in good agreement with the analytic results obtained by considering the viscoelasticity of fiber preforms.
    Type of Medium: Online Resource
    ISSN: 0021-9983 , 1530-793X
    URL: Article
    DOI: 10.1177/0021998310369583
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 160490-9
    detail.hit.zdb_id: 2081924-9
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