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  • 1
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    Online Resource
    Life-Sustaining Procedures, Palliative Care Consultation, and Do-Not Resuscitate Status in Dying Patients With COPD in US Hospitals : 2010-2014
    SAGE Publications ; 2018
    In:  Journal of Palliative Care Vol. 33, No. 3 ( 2018-07), p. 159-166
    Details
    In: Journal of Palliative Care, SAGE Publications, Vol. 33, No. 3 ( 2018-07), p. 159-166
    Abstract: Little is known regarding the extent to which dying patients with chronic obstructive pulmonary disease (COPD) receive life-sustaining procedures and palliative care in US hospitals. We examined temporal trends and the impact of palliative care on the use of life-sustaining procedures in this population. Materials and Methods: A retrospective nationwide cohort analysis was performed using weighted National Inpatient Sample (NIS) data obtained from 2010 to 2014. Decedents ≥18 years of age at the time of death and with a principal diagnosis of COPD were included. We examined the receipt of life-sustaining procedures, defined as1 ventilation (intubation, mechanical ventilation, and noninvasive ventilation),2 vasopressor use (infusion and intravascular monitoring),3 nutrition (enteral and parenteral infusion of concentrated nutrition),4 dialysis, and5 cardiopulmonary resuscitation as well as palliative care consultation and do not resuscitate (DNR). We used compound annual growth rates (CAGRs) and the Rao-Scott correction of the χ2 statistic to determine the statistical significance of temporal trends of life-sustaining procedures, palliative care utilization, and DNR status. Results: Among 37 312 324 hospitalizations, 38 425 patients were examined. The CAGRs of life-sustaining procedures were 6.61% and −9.73% among patients who underwent multiple procedures and patients who did not undergo any procedure, respectively (both P 〈 .001). The CAGRs of palliative consultation and DNR were 5.25% and 36.62%, respectively (both P 〈 .001). Conclusions: Among adults with COPD dying in US hospitals between 2010 and 2014, the utilization of life-sustaining procedures, palliative care, and DNR status increased.
    Type of Medium: Online Resource
    ISSN: 0825-8597 , 2369-5293
    URL: Article
    DOI: 10.1177/0825859718777375
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2809167-X
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  • 2
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    Trends in the Utilization of Life-Sustaining Procedures and Palliative Care Consultation Among Dying Patients With Advanced Chronic Pancreas Illnesses in US Hospitals: 2005 to 2014
    SAGE Publications ; 2019
    In:  Journal of Palliative Care Vol. 34, No. 4 ( 2019-10), p. 232-240
    Details
    In: Journal of Palliative Care, SAGE Publications, Vol. 34, No. 4 ( 2019-10), p. 232-240
    Abstract: Pancreas cancer continues to carry a poor prognosis. Hospitalized patients with advanced chronic pancreatic illnesses increasingly receive palliative care due to its perceived clinical benefits. Meanwhile, a growing proportion of elderly patients are reportedly receiving life-sustaining procedures. Temporal trends in the utilization of life-sustaining procedures and palliative care consultation among dying patients with advanced chronic pancreatic illnesses in US hospitals were examined. Methods and Materials: A serial, cross-sectional analysis was carried out using the National Inpatient Sample Database. Decedents 18 years and older with a principal diagnosis of pancreas cancer or other advanced chronic pancreatic illnesses from 2005 through 2014. The compound annual growth rates (CAGRs) and Cochrane-Armitage correction of χ 2 statistic were used. The receipt of life-sustaining systemic procedures, intra-abdominal local procedures and surgeries, and palliative care consultation were examined. Multilevel multivariate logistic regressions were performed to examine the association of various procedures with the utilization of palliative care consultation. Results: Among 77 394 183 hospitalizations, 29 515 patients were examined. The CAGRs of systemic procedures, intra-abdominal procedures, surgeries, and palliative care were −4.19% ( P = .008), 2.17%, −1.40%, and 14.03% ( P 〈 .001), respectively. The receipt of systemic procedures (odds ratio [OR] = 2.40, 95% confidence interval [CI] , 2.08-2.74), local intra-abdominal procedures (OR = 1.46, 95% CI, 1.27-1.70), and surgeries (OR = 2.51, 95% CI, 2.07-3.05) was associated with palliative care consultation ( Ps 〈 .001). Conclusions: Among adults with pancreatic cancer or other advanced chronic pancreatic illnesses in the US hospitals from 2005 to 2014, the utilization of life-sustaining systemic procedures decreased while the prevalence of palliative care consultation increased.
    Type of Medium: Online Resource
    ISSN: 0825-8597 , 2369-5293
    URL: Article
    DOI: 10.1177/0825859719827313
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2809167-X
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  • 3
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    Porthole Extrusion Process Design for Magnesium-Alloy Bumper Back Beam by Using FE Analysis and Extrusion Limit Diagram
    SAGE Publications ; 2014
    In:  Advances in Mechanical Engineering Vol. 6 ( 2014-01-01), p. 120745-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 6 ( 2014-01-01), p. 120745-
    Abstract: In recent years, several studies with focus on developing state-of-the-art manufacturing technologies have been conducted to produce light vehicles by employing parts made of light materials such as aluminum and magnesium. Of such materials, magnesium has been found to pose numerous issues, because it cannot be deformed (plastic deformation) easily at low temperatures. Furthermore, oxidation on the surface of manganese occurs at high temperatures. This study analyzes the extrusion process for manufacturing magnesium bumper back beams used in vehicles, using finite element (FE) analysis. The properties of magnesium were determined through a compression test performed at high temperatures. And the temperature at which oxidation occurs at its surface was evaluated via an extrusion test. FE analysis was used to evaluate the extrusion load and temperature during the extrusion process, according to changes in initial material temperature and ram speed. Extrusion limit diagram of the extrusion process was derived based on the results of the FE analysis. Process conditions required to be established during the extrusion process were determined by using the derived extrusion limit diagram. The conditions were further validated by the extrusion test.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1155/2014/120745
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2501620-9
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  • 4
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    Serum oestradiol levels are inversely associated with C-reactive protein levels in premenopausal women, but not postmenopausal women
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 10 ( 2020-10), p. 030006052096122-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 10 ( 2020-10), p. 030006052096122-
    Abstract: Epidemiological studies on the association of serum oestradiol levels and inflammatory markers have reported inconsistent and conflicting results. Therefore, we investigated the association between serum oestradiol and high-sensitivity C-reactive protein (CRP) levels in women on the basis of their menopausal status. Methods This cross-sectional study examined the association between serum oestradiol and CRP levels on the basis of menopausal status in 151 premenopausal women aged 42.7 ± 6.7 years and 394 postmenopausal women aged 58.1 ± 6.7 years who participated in a health examination program. Multiple linear regression analysis was conducted using CRP levels as the dependent variable. Results Multiple linear regression analysis showed that serum oestradiol levels were inversely associated with CRP levels in premenopausal women (β coefficient = −0.298) after adjusting for age, body mass index, smoking, mean arterial pressure, and levels of fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, aspartate aminotransferase, and alanine aminotransferase. However, this association was not found in postmenopausal women after adjusting for the same confounding factors. Conclusions Serum oestradiol levels are inversely associated with CRP levels in premenopausal women, but not in postmenopausal women. Lower oestrogenic activity may at least partly contribute to the pathogenesis of chronic inflammation, particularly in premenopausal women.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520961228
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 5
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    Development of a test method and experimental study on cable unwinding
    SAGE Publications ; 2021
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 235, No. 15 ( 2021-08), p. 2653-2667
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 235, No. 15 ( 2021-08), p. 2653-2667
    Abstract: In addition to the textile industry, unwinding of cable or fiber is used in various fields such as electronics, communication, and guided weapons. The cable released from the package exhibit a complicated behavior, entailing a combination of rotational and translational motion. This causes problems such as entangling and fracture. Therefore, it is necessary to study boundary and adhesion conditions to prevent unwinding failure. In this study, an experimental device for the analysis of cable unwinding was developed, and unwinding behavior was analyzed experimentally under various unwinding conditions. The experimental device comprises a jig for high-speed camera measurements, control device, and cable unwinding device. Cable behavior was analyzed according to the unwinding velocity and the distance between the fiber package and the point where the fiber was released. In addition, unwinding behavior with respect of the tension acting on the cable was analyzed experimentally by applying the adhesive.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406220954498
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2024890-8
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  • 6
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    What Motivates Donors to Athletic Programs : A New Model of Donor Behavior
    SAGE Publications ; 2014
    In:  Nonprofit and Voluntary Sector Quarterly Vol. 43, No. 3 ( 2014-06), p. 523-546
    Details
    In: Nonprofit and Voluntary Sector Quarterly, SAGE Publications, Vol. 43, No. 3 ( 2014-06), p. 523-546
    Abstract: In the highly competitive college sport environment, many varsity sport programs have financial systems independent from the academic side of the university. These programs function on multimillion dollar budgets partially funded through ticket sales, licensed merchandise, and television rights. However, donations from alumni and boosters account for the most substantial portion of many athletic budgets. Fund-raising efforts in this environment have not had available models of donor behavior from which to streamline solicitation efforts. Using the Existence Relatedness Growth (ERG) Theory as a guide, this article fills this gap by reporting on the development and testing of an integrated model of college donor motives: A Model of Athletic Donor Motivation (MADOM). Using a sample of college sport donors ( N = 532), the results yield a psychometrically sound eight-factor measurement scale: A Scale of Athletic Donor Motivation (SADOM). Study implications and practical applications of the scale are discussed.
    Type of Medium: Online Resource
    ISSN: 0899-7640 , 1552-7395
    URL: Article
    DOI: 10.1177/0899764012472065
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2029449-9
    SSG: 3,4
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  • 7
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    Cilostazol versus aspirin in ischemic stroke with cerebral microbleeds versus prior intracerebral hemorrhage
    SAGE Publications ; 2021
    In:  International Journal of Stroke Vol. 16, No. 9 ( 2021-12), p. 1019-1030
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 16, No. 9 ( 2021-12), p. 1019-1030
    Abstract: In PreventIon of CArdiovascular Events in Ischaemic Stroke Patients with High Risk of Cerebral HaemOrrhage (PICASSO), cilostazol versus aspirin was comparable for the end points of cerebral hemorrhage and major vascular events. However, underlying hemorrhage-prone lesions could modify the treatment effect. Aims We explored whether the safety and efficacy of cilostazol versus aspirin would differ between hemorrhage-prone lesions (multiple cerebral microbleeds vs. prior intracerebral hemorrhage). Methods In this post hoc analysis of PICASSO, we divided patients into the cerebral microbleeds and prior intracerebral hemorrhage subgroups. The primary safety end point was the first occurrence of cerebral hemorrhage. The primary efficacy end point was the composite of stroke, myocardial infarction, or vascular death. Results Of 1512 patients, 903 (59.7%) had multiple cerebral microbleeds and 609 (40.3%) had prior intracerebral hemorrhage. The cerebral hemorrhage risk was lower with cilostazol versus aspirin (0.12%/year vs. 1.49%/year; hazard ratio, 0.08 [95% confidence interval 0.01–0.60]; p = 0.015) in the cerebral microbleeds subgroup, but was not different (1.26%/year vs. 0.79%/year; hazards ratio 1.60 [0.52–4.90] ; p = 0.408) in the prior intracerebral hemorrhage subgroup. The interaction of treatment-by-subgroup was significant ( p interaction  = 0.011). For the composite of major vascular events, there was a trend toward a lower risk with cilostazol versus aspirin (3.56%/year vs. 5.53%/year; hazards ratio 0.64 [0.41–1.01]; p = 0.056) in the cerebral microbleeds subgroup, but was comparable (5.21%/year vs. 5.05%/year; hazards ratio 1.03 [0.63–1.67] ; p = 0.913) in the prior intracerebral hemorrhage subgroup without a significant treatment-by-subgroup interaction ( p interaction  = 0.165). Conclusions Cilostazol versus aspirin might be a better option in ischemic stroke with multiple cerebral microbleeds, but confirmatory trials are needed. Clinical Trial Registration URL: http://www.clinicaltrials.gov . NCT01013532.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493020941273
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2211666-7
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  • 8
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    Tinnitus and Its Association With Mental Health and Health-Related Quality of Life in an Older Population: A Nationwide Cross-Sectional Study
    SAGE Publications ; 2022
    In:  Journal of Applied Gerontology Vol. 41, No. 1 ( 2022-01), p. 181-186
    Details
    In: Journal of Applied Gerontology, SAGE Publications, Vol. 41, No. 1 ( 2022-01), p. 181-186
    Abstract: This study investigated the relationship of tinnitus with mental health and health-related quality of life (QoL) in older people. Data source included 5,129 community-dwelling men and women ≥60 years old from the Korean National Health and Nutrition Examination Survey. Tinnitus was categorized into three groups: normal, tolerable tinnitus, and annoying tinnitus. Mental health and health-related QoL were assessed according to three dimensions (depressive mood, psychological distress, and suicidal ideation) and five domains (impaired mobility, impaired self-care, impaired usual activities, pain/discomfort, and anxiety/depression). The odds ratios (ORs) and 95% confidence intervals (CIs) of mental health and health-related QoL were calculated using multiple logistic regression analyses. Annoying tinnitus was positively and independently associated with deteriorated mental health and health-related QoL, suggesting comprehensive care is needed in older people with annoying tinnitus.
    Type of Medium: Online Resource
    ISSN: 0733-4648 , 1552-4523
    URL: Article
    DOI: 10.1177/0733464820966512
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2089028-X
    detail.hit.zdb_id: 155897-3
    SSG: 5,2
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  • 9
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    2,3,7,8-Tetrachlorodibenzo- p -Dioxin (TCDD) Induces Calcium Influx Through T-type Calcium Channel and Enhances Lysosomal Exocytosis and Insulin Secretion in INS-1 Cells
    SAGE Publications ; 2009
    In:  International Journal of Toxicology Vol. 28, No. 3 ( 2009-05), p. 151-161
    Details
    In: International Journal of Toxicology, SAGE Publications, Vol. 28, No. 3 ( 2009-05), p. 151-161
    Abstract: 2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) has been associated with diabetes in several epidemiological studies. However, the diabetogenic action of TCDD on pancreatic cells is unclear. Here, we investigated the direct toxic effects of TCDD on a rat insulin-secreting beta cell line. We found that TCDD enhances exocytosis of MTT formazan and lysosomal proteins such as β-hexosaminindase and Lamp-1. This TCDD-induced exocytosis was abrogated by T-type calcium channel blockers (mibefradil, flunarizine) but not by an aryl hydrocarbon receptor antagonist (α-naphtoflavone). Indeed, cytosolic calcium levels were increased by TCDD. Furthermore, TCDD stimulated insulin secretion, which was inhibited by flunarizine. Taken together, our results suggest that TCDD-induced calcium influx via T-type channels regulates vesicular trafficking, such as lysosomal and secretory granule exocytosis, and that TCDD might exert adverse effects on beta cells by continuous insulin release followed by beta cell exhaustion. This could contribute to the link between TCDD exposure and the risk of developing diabetes.
    Type of Medium: Online Resource
    ISSN: 1091-5818 , 1092-874X
    URL: Article
    DOI: 10.1177/1091581809336885
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 1500682-7
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  • 10
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    Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial
    SAGE Publications ; 2016
    In:  International Journal of Stroke Vol. 11, No. 4 ( 2016-06), p. 485-491
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 11, No. 4 ( 2016-06), p. 485-491
    Abstract: The antiplatelet effect of clopidogrel is reportedly influenced by cytochrome P450 2C19 (CYP2C19) polymorphisms. However, there is no data concerning the relationship between stroke recurrence and CYP2C19 polymorphisms in patients treated with clopidogrel for secondary prevention of ischemic stroke. Triflusal may be an alternative therapy for clopidogrel in patients with poor genotype. The Comparison of Triflusal and Clopidogrel Effects in Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping (MAESTRO) study will investigate the effect of antiplatelet agents based on CYP2C19 polymorphisms in secondary prevention of ischemic stroke. Sample size and design Assuming that 55% of patients belong to the poor genotype group, the required sample size is 1080 patients with at least 24 months of follow-up. This study is designed as a prospective, multicenter, randomized, parallel-group, open-label, and blind genotype trial. Patients who experience their first non-cardiogenic ischemic stroke within 30 days prior to screening are eligible. Patients received 300 mg triflusal twice a day or 75 mg clopidogrel once daily during the trial. The study is registered with ClinicalTrials.gov (NCT01174693). Study outcome The primary outcome is recurrent ischemic stroke or hemorrhagic stroke. Secondary outcomes consist of composite major vascular events including stroke, myocardial infarction, coronary revascularization, or vascular death. Discussion Personalized medicine may be essential for patients according to individual drug metabolism abilities. MAESTRO is the first prospective study designed to evaluate the effect of CYP2C19 polymorphism in secondary stroke prevention and will resolve several questions regarding preventive antiplatelet agents for recurrent stroke.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493015620804
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2211666-7
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