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  • SAGE Publications  (12)
  • 1
    Online Resource
    Online Resource
    Lactobacillus casei Extract Induces Apoptosis in Gastric Cancer by Inhibiting NF-κB and mTOR-Mediated Signaling
    SAGE Publications ; 2013
    In:  Integrative Cancer Therapies Vol. 12, No. 2 ( 2013-03), p. 165-173
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 12, No. 2 ( 2013-03), p. 165-173
    Abstract: Lactobacillus casei extract (LBX) has been reported to prevent gastric cancer, but the underlying mechanism remains unclear. The proliferation and cell death of gastric cancer KATO3 cells were examined after treatment with LBX for various times and at various doses. LBX inhibited the growth of gastric cancer cells and induced apoptosis by inactivating NF-κB promoter activity. Apoptosis induced by LBX, however, is not directly associated with the intrinsic mitochondrial pathway. Immunoblot analysis revealed that LBX decreased the expressions of NF-κB and IκB. The reduced NF-κB levels led to the decreased phosphorylation of mTOR signaling components, such as PI3K, Akt, and p70 S6 kinase. These results showed for the first time that LBX induced apoptosis in gastric cancer cells by inhibiting NF-κB and mTOR-mediated signaling.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735412442380
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2101248-9
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  • 2
    Online Resource
    Online Resource
    Diffusion-weighted MRI: usefulness for differentiating intrapancreatic accessory spleen and small hypervascular neuroendocrine tumor of the pancreas
    SAGE Publications ; 2014
    In:  Acta Radiologica Vol. 55, No. 10 ( 2014-12), p. 1157-1165
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 55, No. 10 ( 2014-12), p. 1157-1165
    Abstract: Image findings of intrapancreatic accessory spleen (IPAS) can closely resemble those of neuroendocrine tumor (NET) of the pancreas. Purpose To investigate the usefulness of diffusion-weighted imaging (DWI) for differentiating IPAS from small (≤3 cm) hypervascular NET of the pancreas. Material and Methods The visually assessed signal intensity of pancreatic lesions compared with the spleen on DWI ( b value of 1000 s/mm 2 ) and the apparent diffusion coefficient (ADC) values were compared in 25 patients with IPAS and 31 patients with small hypervascular NET. Two blinded radiologists independently rated their confidence in differentiating the two conditions and compared the diagnostic performance of contrast-enhanced magnetic resonance imaging (CE-MRI) alone with that of combined CE-MRI and DWI. Results The isointensity of the pancreatic lesions compared with the spleen on DWI was more frequently observed in IPAS than in NET (92% vs. 12.9%, P  〈  0.001). The mean ADC value was significantly lower in IPAS than in NET (0.90 × 10 −3 mm 2 /s vs. 1.44 × 10 −3 mm 2 /s, P  〈  0.001). The sensitivity and specificity of ADC quantification for differentiating the two conditions when using 1.07 × 10 −3 mm 2 /s as the cut-off value were 96% and 93.5%, respectively. For both readers, the area under the receiver operating characteristic curve and accuracy in differentiating the two conditions of combined CE-MRI and DWI were significantly greater than those of CE-MRI alone ( P ≤ 0.039). Conclusion Visual assessment of DWI and ADC quantification were useful in differentiating IPAS from small hypervascular NET of the pancreas.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185113513760
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2024579-8
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  • 3
    Online Resource
    Online Resource
    Asiatic Acid Derivatives Protect Primary Cultures of Rat Hepatocytes against Carbon Tetrachloride-Induced Injury via the Cellular Antioxidant System
    SAGE Publications ; 2009
    In:  Natural Product Communications Vol. 4, No. 6 ( 2009-06), p. 1934578X0900400-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 4, No. 6 ( 2009-06), p. 1934578X0900400-
    Abstract: We attempted to elucidate the hepatoprotective mechanism of two asiatic acid (AS) derivatives, 3β,23-dihydroxyurs-2-oxo-12-ene-28-oic acid (AS-10) and 3β,23-dihydroxyurs-12-ene-28-oic acid (AS-14), which exhibited significant protective activity against carbon tetrachloride (CCl 4 )-induced hepatotoxicity in primary cultures of rat hepatocytes. Our findings showed that AS-10 and AS-14 preserved the level of glutathione and the activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase. In addition, these compounds ameliorated lipid peroxidation, as demonstrated by a reduction in the production of malondialdehyde. Furthermore, AS-10 and AS-14 did not restore the reduced total GSH level by BSO, indicating that the hepatoprotective activities of these compounds may be involved, in part, by regulating GSH synthesis. From these results, we suggest that both AS-10 and AS-14 exerted their hepatoprotective activities against CCl 4 -induced injury by preserving the cellular antioxidative defense system.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X0900400605
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Inhibitory Effects of Stilbene Derivatives from Parthenocissus Tricuspidata on Adipocyte Differentiation and Pancreatic Lipase
    SAGE Publications ; 2013
    In:  Natural Product Communications Vol. 8, No. 10 ( 2013-10), p. 1934578X1300801-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 8, No. 10 ( 2013-10), p. 1934578X1300801-
    Abstract: Obesity, which is characterized by excessive fat accumulation, occurs by fat absorption by lipase and sequential fat accumulation in adipocytes through adipocyte differentiation. Thus, inhibition of pancreatic lipase activity and adipocyte differentiation would be crucial for the prevention and treatment of obesity. Investigation of anti-obesity compounds from Parthenocissus tricuspidata stems resulted in the isolation of nineteen compounds including five acetophenones, five flavonoids and nine stilbene derivatives. Among them, the stilbene derivatives showed the most potent anti-obesity effects. Stilbene monomers showed strong inhibitory activity on both adipocyte differentiation and pancreatic lipase, followed by stilbene dimer and trimer. Flavonoids showed mild inhibition on adipocyte differentiation, whereas acetophenones showed little effect in our assay system. Taken together, P. tricuspidata might be a new candidate for the development of obesity treatment.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1300801026
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    A sagittal reference line using the preoperative radiograph in total knee arthroplasty
    SAGE Publications ; 2020
    In:  Journal of Orthopaedic Surgery Vol. 28, No. 2 ( 2020-01-01), p. 230949902092414-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 28, No. 2 ( 2020-01-01), p. 230949902092414-
    Abstract: We evaluated the accuracy of a sagittal alignment of tibial component in total knee arthroplasty (TKA) with the sagittal reference line using the preoperative radiograph. Methods: We evaluated 151 patients who underwent primary TKA with posterior cruciate substituting type implant. For 75 patients, the sagittal reference line using preoperative radiograph (group A) was used, while for 76 patients the sagittal reference using intraoperative fibular shaft line (group B) was used. The parallel line (line S) to the anatomical axis of the tibia in the lateral plain radiograph was used as the sagittal reference. The distance from line S to proximal tibia cutting area and to skin surface 20 cm distal to the cutting area was measured in preoperative radiographs. Next, the distance to the extramedullary guide rod was applied intraoperatively, reflecting the results. The intraoperative fibular shaft line was determined using the connecting line between the tip of fibular head and the lateral malleolus. The postoperative tibial component slope angle and the difference to the target slope angle were compared. Results: The difference to the target angle was 1.8 ± 1.3° in group A, whereas the difference was 2.5 ± 1.4° in group B ( p = 0.04). The patients with difference within 3° to the target angle were 78.7% in group A and 61.8% in group B ( p = 0.024). Conclusion: The sagittal reference line using the preoperative lateral radiograph was helpful as a reference guide for the tibial slope in TKA.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499020924143
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2128854-9
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  • 6
    Online Resource
    Online Resource
    Open-wedge high tibial osteotomy in patients with discoid lateral meniscus
    SAGE Publications ; 2021
    In:  Journal of Orthopaedic Surgery Vol. 29, No. 2 ( 2021-05-01), p. 230949902110173-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 29, No. 2 ( 2021-05-01), p. 230949902110173-
    Abstract: There are concerns about the progression of the lateral osteoarthritis (OA) should be taken into account when high tibial osteotomy (HTO) is performed in patients with discoid lateral meniscus (LM). This study evaluated the clinical results of HTO in patients with discoid LM and elucidated factors affecting the results. Methods: This study evaluated 32 female patients with varus deformity and medial OA. Patients with discoid LM (8 patients) or without discoid LM (24 patients) underwent open-wedge HTO. The mean age was 53.5 years and the mean follow-up period was 35 months. Clinical results, including the Hospital for Special Surgery (HSS) score, Knee Society knee score (KS) and function score (FS), were evaluated. The progression of OA in the lateral compartment was also evaluated. Finally, we evaluated the factors affecting the clinical results and OA progression in the lateral compartment. Results: Between two groups, all clinical scores were not different (p = 0.964, 0.963, and 0.559, respectively). Three of eight patients (37.5%) in the discoid group developed OA in the lateral compartment, whereas 2 of 24 patients (8.3%) in the control group developed such; however, this was not significantly different (p = 0.085). In discoid group, patients with undercorrection has higher KS relative to patients with acceptable correction (p = 0.044). Other clinical results and OA change in the lateral compartment were not affected by evaluated factors. Conclusions: Patients who underwent open-wedge HTO showed the satisfactory clinical results and lateral OA progression regardless of the presence or absence discoid LM. However, when discoid LM was present, patients with undercorrection showed higher KS in comparison with patients with acceptable correction.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/23094990211017355
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Preoperative planning using the picture archiving and communication system technique in high tibial osteotomy
    SAGE Publications ; 2017
    In:  Journal of Orthopaedic Surgery Vol. 25, No. 1 ( 2017-01-01), p. 230949901668470-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 25, No. 1 ( 2017-01-01), p. 230949901668470-
    Abstract: This study aimed to evaluate the accuracy of the picture archiving and communication system (PACS) method in order to select the correction angle and gap in open-wedge high tibial osteotomy (HTO) and clinical results of the patients. Material and methods: This retrospective study analyzed 27 consecutive patients (30 knees) underwent open-wedge HTO using the PACS method between April 2013 and March 2015. Full-length lower limb radiographs obtained preoperatively and at the final follow-up were used to the percentages of crossing points of the weight-bearing line and tibial plateau with respect to the medial border and mechanical femur-tibia angle. Preoperatively predicted and postoperatively measured wedge angles and gaps were compared. The clinical results were evaluated using the Hospital for Special Surgery (HSS) knee score and the Knee Society score. Results: At the 20.5 months (12–26.5) follow-up, the weight-bearing line on the tibial plateau was corrected from 17.3% to 61.3%, and the mechanical femur-tibia angle was corrected from 7.3° varus to 3.1° valgus. No significant difference in preoperative and postoperative measured values was observed ( p = 0.440 and p = 0.505). The mean HSS score increased from 66.7 to 88.8 ( p 〈 0.001). The knee score and function score of Knee Society increased from 62.0 to 88.7 ( p 〈 0.001) and from 60.2 to 91.7 ( p 〈 0.001), respectively. Conclusion: In open-wedge HTO, correction of angular deformity based on the PACS method could be an accurate correction method and the good clinical results could be obtained.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499016684701
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 8
    Online Resource
    Online Resource
    Feasibility of reduced-dose CT of the head and neck with iterative reconstruction: a phantom and prospective clinical study
    SAGE Publications ; 2019
    In:  Acta Radiologica Vol. 60, No. 11 ( 2019-11), p. 1457-1464
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 60, No. 11 ( 2019-11), p. 1457-1464
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185119830276
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024579-8
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  • 9
    Online Resource
    Online Resource
    Antifibrotic Constituents from Garcinia mangostana
    SAGE Publications ; 2011
    In:  Natural Product Communications Vol. 6, No. 9 ( 2011-09), p. 1934578X1100600-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 6, No. 9 ( 2011-09), p. 1934578X1100600-
    Abstract: From the CHCl 3 -soluble fraction of the fruits of Garcinia mangostana (Clusiaceae), six xanthone derivatives, α-mangostin (1), γ-mangostin (2), gartanin (3), deoxygartanin (4), 1-isomangstanin (5) and garcinone E (6), were isolated. All these compounds significantly inhibited HSC-T6 viability as assessed by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Among them, compounds 1 and 2, the most potent and major constituents of G. mangostana, inhibited HSC-T6 viability in dose- and time-dependent manners. In addition, compounds 1 and 2 significantly reduced collagen content, a pathological characteristic of liver fibrosis. Taken together, G. mangostana and its constituents might be beneficial for the treatment of liver fibrosis.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1100600915
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Anti-adipogenic Activity of Cordyceps militaris in 3T3-L1 Cells
    SAGE Publications ; 2011
    In:  Natural Product Communications Vol. 6, No. 12 ( 2011-12), p. 1934578X1100601-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 6, No. 12 ( 2011-12), p. 1934578X1100601-
    Abstract: Inhibition of adipocytes differentiation is suggested to be an important strategy for prevention and/or treatment of obesity. In our present study, Cordyceps militaris showed significant inhibitory activity on adipocyte differentiation in 3T3-L1 preadipocytes as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to the isolation of cordycepin (1), guanosine (2) and tryptophan (3) as active compounds. All the three compounds were more effective in the prevention of early stage of adipogenesis than in lipolysis. In addition, combinational treatment of three compounds significantly increased anti-adipogenic activity.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1100601213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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