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  • SAGE Publications  (3)
  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2013
    In:  Annals of Otology, Rhinology & Laryngology Vol. 122, No. 2 ( 2013-02), p. 121-130
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 122, No. 2 ( 2013-02), p. 121-130
    Abstract: We investigated whether mouse bone marrow-derived clonal mesenchymal stem cells (BM-cMSCs) could promote vocal fold (VF) wound healing by using a xenograft animal model. Methods: Homogeneous BM-cMSCs isolated by a subfractionation culturing method from the bone marrow aspirates of green fluorescent protein transgenic mice were injected into the VFs of rabbits immediately after direct mechanical injury. Macroscopic, biomechanical (rheometric), histologic, immunohistochemical, and transcriptional evaluations were performed on the scarred VFs 1 to 3 months after injury. Engraftment of the implanted BM-cMSCs was determined by detection of green fluorescent protein cells in the recipient VF by confocal microscopy. Results: The BM-cMSC-treated VFs showed improved morphological properties and viscoelasticity as compared to control VFs injected with phosphate-buffered saline solution. Histologic and immunohistochemical evaluations showed less excessive collagen deposition and increased density of glycosaminoglycans in the BM-cMSC-treated VFs as compared to the control VFs at 3 months after injury (p = 0.003 and p = 0.037, respectively). BM-cMSC transplantation led to a significant attenuation of fibronectin (p = 0.036) and transforming growth factor β1 (p = 0.042) messenger RNA expression at 1 month after injury. Green fluorescent protein-expressing BM-cMSCs engrafted in recipient VFs were found at 1 month after implantation. Conclusions: BM-cMSCs appeared to survive in the injured xenogeneic VFs after transplantation for up to 1 month and favorably enhanced the wound healing of VFs after injury. We conclude that BM-cMSCs are a possible source of cell therapy for vocal fold regeneration.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2033055-8
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2020
    In:  Mobile Media & Communication Vol. 8, No. 3 ( 2020-09), p. 360-378
    In: Mobile Media & Communication, SAGE Publications, Vol. 8, No. 3 ( 2020-09), p. 360-378
    Abstract: Communication about crime and the places it occurs has been an important area of study for criminology, sociology, public policy, and media scholars. Where incidents used to be communicated through word of mouth, physical evidence, and news outlets, recent advances in crime tracking, mapping, and mobile media have dramatically changed how individuals are informed about crime. Many organizations have adopted mobile text alerts, and recent advances in augmented reality (AR) technologies have made it possible to overlay visuals about crime on top of users’ physical surroundings. How people make sense of this visual, individualized, and location-specific crime information, however, is largely unknown and complicated by the fact that mobile technologies are challenging to study in situ, as people move through and experience urban place. Within the AR literature, while existing research has started to look at the ways that AR can affect people’s experience of place, the precise ways that people perceive and integrate AR displays into their understanding of place are still largely unexplored. This empirical study reports findings from a project utilizing AR as an urban probe, where we took participants ( N = 57) around to places in a large metropolitan area in the United States and showed them visual AR crime information overlaid on the physical place where they were moving through. After seeing these urban probes, participants were asked what they noticed, remembered, and thought occurred in that place when shown AR crime information. The analysis draws on Lefebvre’s (1991) spatial triad to explain how people read places through the lens of AR, and also how they extrapolate, speculate, and make associations from AR information. Based on these findings, this study discusses the implications for mobile media scholars and their understanding of visual place-based communication, as well as for designers and policymakers considering the use of AR to communicate crime information.
    Type of Medium: Online Resource
    ISSN: 2050-1579 , 2050-1587
    RVK:
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2684519-2
    detail.hit.zdb_id: 2686704-7
    SSG: 24,1
    SSG: 3,4
    SSG: 3,5
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2012
    In:  Asian Cardiovascular and Thoracic Annals Vol. 20, No. 1 ( 2012-02), p. 36-41
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 20, No. 1 ( 2012-02), p. 36-41
    Abstract: Lung cancer, the leading cause of cancer-related death, still lacks reliable biomarkers. Apurinic/apyrimidinic endonuclease 1/Ref-1 is a multifunctional protein involved in the base excision repair of DNA damaged by oxidative stress or alkylating compounds, as well as in the regulation of multiple transcription factors. To validate apurinic/apyrimidinic endonuclease 1/Ref-1 as a biomarker for prediction of lung cancer recurrence, we studied 42 patients who received curative resection and mediastinal lymph node dissection for stage I non-small-cell lung cancer. They were divided into 2 groups based on recurrence, and compared by immunohistochemistry staining of paraffin-embedded tissues and Western blot analysis. Immunohistochemical staining showed a significant difference between the cytoplasm and nucleus in patients who had a recurrence compared to those with nonrecurrent adenocarcinoma. In Western blot analysis, the recurrent adenocarcinoma group showed increased expression of apurinic/apyrimidinic endonuclease 1/Ref-1 in cytoplasm, nucleus, and in total. This indicates that apurinic/apyrimidinic endonuclease 1/Ref-1 is unregulated in recurrent stage I adenocarcinoma. For clinical application as a prognostic marker for non-small-cell lung cancer, further investigation into the role of apurinic/apyrimidinic endonuclease 1/Ref-1 in carcinogenesis is needed in an expanded prospective study.
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2044527-1
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