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  • 1
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2006
    In:  Veterinary Pathology Vol. 43, No. 3 ( 2006-05), p. 374-377
    In: Veterinary Pathology, SAGE Publications, Vol. 43, No. 3 ( 2006-05), p. 374-377
    Kurzfassung: A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog. The animal presented with a large nonpainful swelling in the left submandibular region. A computed tomography scan detected an irregularly enhancing soft tissue mass that was closely associated with the left external ear canal and extended to the left wing of the atlas. On surgical exploration, the mass was intimately associated with the left mandibular salivary gland. Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology. The tumor was comprised of basaloid and low columnar epithelial cells, many glandular units formed by well-differentiated sebocytes, and multifocal regions of necrosis, mineralization, and hemorrhage. Salivary gland tumors with sebaceous differentiation are very rare in animals, with one previously reported case in a cat.
    Materialart: Online-Ressource
    ISSN: 0300-9858 , 1544-2217
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2006
    ZDB Id: 2106608-5
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: European Journal of Inflammation, SAGE Publications, Vol. 11, No. 3 ( 2013-09), p. 641-654
    Kurzfassung: Inflammatory bowel diseases (IBD) describe a group of complex intestinal disorders characterized by inflammation in the gastrointestinal tract. Current treatments for IBD include the use of antiinflammatory drugs; furthermore, recombinant lactic acid bacteria have been used as a therapeutic vehicle for anti-inflammatory agents in IBD models. Interleukin-10 (IL-10) is one of the most important anti-inflammatory cytokines; however, its oral administration is limited because it is quickly degraded in the gastrointestinal tract and systemic treatments have led to undesirable side effects. In this study, an engineered invasive strain of Lactococcus (L.) lactis producing Fibronectin Binding Protein A (FnBPA+), from Staphylococcus aureus capable of delivering, directly inside eukaryotic cells, an eukaryotic DNA expression vector containing the ORF coding for IL-10 of Mus musculus (pValac: il-10) was developed and its functionality was evaluated using in vitro and in vivo assays. Functionality of the plasmid and the invasive strain was demonstrated by transfection and invasiveness assays using cell cultures and in vivo in mice by fluorescence microscopy. TNBS inoculated mice that received this novel strain showed lower damage scores in their large intestines (at both macroscopic and microscopic levels), lower microbial translocation to liver, and increased anti-inflammatory/pro-inflammatory cytokine ratios compared to mice that received L. lactis FnBPA+ without the pValac: il-10 plasmid. The effectiveness was demonstrated of this novel DNA delivery therapeutic strategy in the prevention of inflammation using a murine model of colitis.
    Materialart: Online-Ressource
    ISSN: 2058-7392 , 2058-7392
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2584683-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 1996
    In:  Multiple Sclerosis Journal Vol. 2, No. 5 ( 1996-12), p. 251-251
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 2, No. 5 ( 1996-12), p. 251-251
    Materialart: Online-Ressource
    ISSN: 1352-4585 , 1477-0970
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1996
    ZDB Id: 2008225-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
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    SAGE Publications ; 2009
    In:  International Journal of Toxicology Vol. 28, No. 5 ( 2009-09), p. 368-381
    In: International Journal of Toxicology, SAGE Publications, Vol. 28, No. 5 ( 2009-09), p. 368-381
    Kurzfassung: Thyroid hormone (TH) disrupting compounds interfere with both thyroidal and extrathyroidal mechanisms to decrease circulating thyroxine (T 4 ). This research tested the hypothesis that serum T 4 concentrations of rodents exposed to a mixture of both TH synthesis inhibitors (pesticides) and stimulators of T 4 clearance in the liver (polyhalogenated aromatic hydrocarbons, PHAHs) could be best predicted by an integrated addition model. Female Long-Evans rats, 23 days of age, were dosed with dilutions of a mixture of 18 PHAHs (2 dioxins, 4 dibenzofurans, and 12 PCBs, including dioxin-like and non-dioxin like PCBs) and a mixture of 3 pesticides (thiram, pronamide, and mancozeb) for four consecutive days. Serum was collected 24 hours after the last exposure and T 4 concentrations were measured by radioimmunoassay. Animals exposed to the highest dose of the mixture experienced a 45% decrease in serum T 4 . Three additivity model predictions (dose addition, effect addition, and integrated addition) were generated based on single chemical data, and the results were compared. Effect addition overestimated the effect produced by the combination of all 21 chemicals. The results of the dose- and integrated-addition models were similar, and both provided better predictions than the effect-addition model. These results support the use of dose- and integrated additivity models in predicting the effects of complex mixtures.
    Materialart: Online-Ressource
    ISSN: 1091-5818 , 1092-874X
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2009
    ZDB Id: 1500682-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    In: Palliative Medicine, SAGE Publications, Vol. 34, No. 9 ( 2020-10), p. 1263-1273
    Kurzfassung: The 3 Wishes Project is a semistructured program that improves the quality of care for patients dying in the intensive care unit by eliciting and implementing wishes. This simple intervention honors the legacy of patients and eases family grief, forging human connections between family members and clinicians. Aim: To examine how the 3 Wishes Project enables collective patterns of compassion between patients, families, clinicians, and managerial leaders in the intensive care unit. Design: Using a qualitative descriptive approach, interviews and focus groups were used to collect data from family members of dying patients, clinicians, and institutional leaders. Unconstrained directed qualitative content analysis was performed using Organizational Compassion as the analytic framework. Setting/participants: Four North American intensive care units, participants were 74 family members of dying patients, 72 frontline clinicians, and 20 managerial leaders. Results: The policies and processes of the 3 Wishes Project exemplify organizational compassion by supporting individuals in the intensive care unit to collectively notice, feel, and respond to suffering. As an intervention that enables and empowers clinicians to engage in acts of kindness to enhance end-of-life care, the 3 Wishes Project is particularly well situated to encourage collective responses to suffering and promote compassion between patients, family members, and clinicians. Conclusions: Examining the 3 Wishes Project through the lens of organizational compassion reveals the potential of this program to cultivate the capacity for people to collectively notice, feel, and respond to suffering. Our data document multidirectional demonstrations of compassion between clinicians and family members, forging the type of human connections that may foster resilience.
    Materialart: Online-Ressource
    ISSN: 0269-2163 , 1477-030X
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2027566-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Online-Ressource
    SAGE Publications ; 1998
    In:  Journal of Fire Protection Engineering Vol. 9, No. 2 ( 1998-01-01), p. 14-35
    In: Journal of Fire Protection Engineering, SAGE Publications, Vol. 9, No. 2 ( 1998-01-01), p. 14-35
    Materialart: Online-Ressource
    ISSN: 1042-3915
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1998
    ZDB Id: 2098538-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    In: Breast Cancer: Basic and Clinical Research, SAGE Publications, Vol. 17 ( 2023-01), p. 117822342311664-
    Kurzfassung: Breast cancer is the most common non-cutaneous malignancy and the second leading cause of cancer mortality in the United States. Breast cancer is a heterogeneous disease; diagnosis at an early stage renders it potentially curable, whereas advanced metastatic disease carries a worse prognosis. Objectives: To investigate whether hepatic steatosis (HS) is associated with liver metastases in patients with newly diagnosed stage IV female breast cancer patients (either de novo metastatic breast cancer or recurrent metastatic breast cancer) using non-contrast computed tomography (CT) as a marker of HS. Design: Retrospective analysis. Methods: We retrospectively identified 168 patients with stage IV breast cancer with suitable imaging from a prospectively maintained oncologic database. Three radiologists manually defined hepatic regions of interest on non-contrast CT images, and attenuation data were extracted. HS was defined as a mean attenuation 〈 48 Hounsfield units. The frequency of hepatic metastatic disease was calculated for patient with and without HS. Relationships between HS and various patient (age, body mass index, race) and tumor (hormone receptor status, HER2 status, tumor grade) characteristics were also analyzed. Results: There were 4 patients with liver metastasis in the HS group (41 patients) versus 20 patients with liver metastases in the non-HS group (127 patients). The difference in frequencies of liver metastases among patients with (9.8%) versus without (15.7%) hepatic steatosis (odds ratio = 1.72 [0.53-7.39]) was not statistically significant ( P = .45). Body mass index was significantly higher ( P = .01) among patients with hepatic steatosis (32.2 ± 7.3 vs 28.8 ± 7.1 kg/m 2 ). Otherwise, there were no significant differences between patients with versus without HS with respect to regarding age, race, hormone receptor status, HER2 status, or tumor grade. Conclusion: The frequency of hepatic metastatic disease in patients with stage IV breast cancer is similar for steatotic and non-steatotic livers.
    Materialart: Online-Ressource
    ISSN: 1178-2234 , 1178-2234
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2023
    ZDB Id: 2423804-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 1969
    In:  Canadian Psychiatric Association Journal Vol. 14, No. 1 ( 1969-02), p. 71-76
    In: Canadian Psychiatric Association Journal, SAGE Publications, Vol. 14, No. 1 ( 1969-02), p. 71-76
    Kurzfassung: A ten-week therapeutic trial with T.P.S.-23 (mesoridazine) was carried out on twelve cases of chronic childhood psychosis. Results showed an improvement in behaviour; the target symptoms most responsible for the differences in scores were anxiety, tension, emotional withdrawal and blunted affect. The clinical picture clearly deteriorated during the two-week period on placebo. There were no major untoward effects other than a case of acute hypotension in one patient, who had to be withdrawn from the trial (an 18-year old boy receiving the fixed maximum dose: 400 mg./day) and a case of preclinical, cellular type liver toxicity, whose origin cannot with certitude be attributed to mesoridazine.
    Materialart: Online-Ressource
    ISSN: 0008-4824
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1969
    ZDB Id: 2035338-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 1983
    In:  Environment and Planning A: Economy and Space Vol. 15, No. 9 ( 1983-09), p. 1219-1230
    In: Environment and Planning A: Economy and Space, SAGE Publications, Vol. 15, No. 9 ( 1983-09), p. 1219-1230
    Kurzfassung: A unified approach to deriving models of urban location, destination, mode, and route choice is illustrated, and an algorithm based on Evans's approach and the Lagrange multiplier procedure is proposed. By examining derivatives of the Lagrangian function, we show that the Newton—Raphson technique can be implemented for finding the optimal Lagrange multipliers for these models. Procedures for identifying values of generalized cost-function coefficients are studied.
    Materialart: Online-Ressource
    ISSN: 0308-518X , 1472-3409
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1983
    ZDB Id: 2039728-8
    ZDB Id: 750312-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Online-Ressource
    SAGE Publications ; 1999
    In:  Cell Transplantation Vol. 8, No. 1 ( 1999-01), p. 131-142
    In: Cell Transplantation, SAGE Publications, Vol. 8, No. 1 ( 1999-01), p. 131-142
    Kurzfassung: Adults rats were lesioned with 192-IgG-saporin, an immunotoxin that targets cholinergic neurons in the basal forebrain expressing the low-affinity nerve growth factor receptor (p75). One month later, rats received E30–35 porcine cholinergic neurons bilaterally into the hippocampus, and were tested in the Morris water maze and the passive avoidance task 4.5–6 months after transplantation (in two experiments, rats were retested in the water maze) followed by histological and cellular analyses. The 192-IgG-saporin-lesioned animals displayed clear cognitive deficits in the Morris water maze. In all experiments the lesioned animals had spatial probe deficits on day 5 testing. A large variance was found among the transplanted animals, with individual animals exhibiting improved performance, but little overall improvement when compared to lesion-alone animals as a group. The relationships between behavioral performance and graft cholinergic factors were established by histological analyses. Grafted animals exhibited an increase in cholinergic innervation of the dentate gyrus (DG) region of the dorsal hippocampus when compared to lesion-alone animals. There was a significant correlation between the level of cholinergic innervation in the dentate gyrus and spatial navigation performance (latency and spatial probe) in the Morris water maze task. These data provide evidence of memory and spatial deficits following cholinergic denervation, and of target-specific growth of xenogeneic cholinergic neurons into the hippocampus. The lack of a clear treatment (transplant) effect in the behavioral measures leads us to believe that functional restoration of cognitive function would require cholinergic reinnervation of both the hippocampus and the neocortex in this 192-IgG-saporin animal model.
    Materialart: Online-Ressource
    ISSN: 0963-6897 , 1555-3892
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1999
    ZDB Id: 2020466-8
    Standort Signatur Einschränkungen Verfügbarkeit
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