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  • SAGE Publications  (18)
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  • SAGE Publications  (18)
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  • 1
    Online Resource
    Online Resource
    Cardioprotective effects of alantolactone on isoproterenol-induced cardiac injury and cobalt chloride-induced cardiomyocyte injury
    SAGE Publications ; 2022
    In:  International Journal of Immunopathology and Pharmacology Vol. 36 ( 2022-01), p. 205873842110519-
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 36 ( 2022-01), p. 205873842110519-
    Abstract: Alantolactone (AL) is a compound extracted from the roots of Inula Racemosa that has shown beneficial effects in cardiovascular disease. However, the cardioprotective mechanism of AL against hypoxic/ischemic (H/I) injury is still unclear. This research aimed to determine AL’s ability to protect the heart against isoproterenol (ISO)-induced MI injury in vivo and cobalt chloride (CoCl 2 ) induced H/I injury in vitro. Methods Electrocardiography (ECG), lactate dehydrogenase (LDH), creatine kinase (CK), and cardiac troponin I (cTnI) assays in addition to histological analysis of the myocardium were used to investigate the effects of AL in vivo. Influences of AL on L-type Ca 2+ current (I Ca-L ) in isolated rat myocytes were observed by the patch-clamp technique. Furthermore, cell viability, apoptosis, oxidative stress injury, mitochondrial membrane potential, and intracellular Ca 2+ concentration were examined in vitro. Results The results indicated that AL treatment ameliorated the morphological and ECG changes associated with MI, and decreased levels of LDH, CK, and cTnI. Furthermore, pretreatment with AL elevated antioxidant enzyme activity and suppressed ROS production. AL prevented H/I-induced apoptosis, mitochondria damage, and calcium overload while reducing I Ca-L in a concentration and time dependent fashion. The 50% inhibiting concentration (IC 50 ) and maximal inhibitory effect (E max ) of AL were 17.29 μmol/L and 57.73 ± 1.05%, respectively. Conclusion AL attenuated MI-related injury by reducing oxidative stress, apoptosis, calcium overload, and mitochondria damage. These cardioprotective effects may be related to the direct inhibition of I Ca-L .
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/20587384211051993
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2505963-4
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  • 2
    Online Resource
    Online Resource
    A novel LOXHD1 variant in a Chinese couple with hearing loss
    SAGE Publications ; 2019
    In:  Journal of International Medical Research Vol. 47, No. 12 ( 2019-12), p. 6082-6090
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 47, No. 12 ( 2019-12), p. 6082-6090
    Abstract: To perform molecular diagnosis and genetic counseling in a young Chinese couple with congenital hearing loss. Methods Variant screening analysis was performed by PCR and direct Sanger sequencing or targeted next-generation sequencing of all known hearing loss genes. Novel variants were evaluated by PolyPhen2 and PROVEAN software tools to evaluate possible effects on protein function. Results We identified causative variants in the young couple: c.235delC (rs80338943)/c.299-300delAT (rs111033204) compound heterozygous variants of GJB2 in the husband and c.1828G 〉 A (p.Glu610Lys, rs535637788)/c.2825-2827delAGA compound heterozygous variants of LOXHD1 in the wife. The LOXHD1 c.1828G 〉 A variant has only previously been reported in a Mexican-American individual in the 1000 Genomes Project database. Using PolyPhen2 and PROVEAN, we speculated that the LOXHD1 variant c.1828G 〉 A is potentially pathogenic. Conclusion We carried out molecular diagnosis in a young couple with congenital hearing loss, and identified different disease-causing genes in the two individuals. The LOXHD1 variant c.1828G 〉 A present in the wife had not previously been reported in individuals with congenital hearing loss. We determined this to be a potential pathogenic variant, and a novel variant associated with hearing loss in a Chinese individual.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060519884197
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2082422-1
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  • 3
    Online Resource
    Online Resource
    Source identification of a vibrating plate using phase conjugation and interior boundary element method
    SAGE Publications ; 2024
    In:  Journal of Low Frequency Noise, Vibration and Active Control Vol. 43, No. 2 ( 2024-06), p. 880-892
    Details
    In: Journal of Low Frequency Noise, Vibration and Active Control, SAGE Publications, Vol. 43, No. 2 ( 2024-06), p. 880-892
    Abstract: Noise pollution is the most serious environmental pollution, which seriously affects people’s normal life and physical and mental health, as well as normal production work. Therefore, noise control is necessary, but before noise control, the first thing to do is to identify the location of the noise source, and the noise control work is meaningless when the noise cannot be identified. Flat plate structures are a fundamental part of complex ship structures, and their vibration, noise, and their interrelationships when excited by the outside world are receiving increasing attention. The core of the research in this paper is the identification of the sound source of the vibrating plate. A method combining phase conjugation with interior boundary element method is developed for the identification of the pressure and normal velocity distribution of a vibrating plate. An interior problem is formed by enclosing the phase conjugation array plane and the plate surface. The pressures at the array elements are phase-conjugated as the specified pressure boundary condition. The impedance relationship between the surface pressure and the surface normal velocity of the plate is utilized as a specified impedance boundary condition. The interior boundary element method is applied to solve the interior problem. The identification of the surface pressure and normal velocity distribution is studied numerically. The numerical results show that with the array located in the near field the proposed method achieves subwavelength focusing to identify the surface pressure and normal velocity distribution and clearly shows the response shapes.
    Type of Medium: Online Resource
    ISSN: 1461-3484 , 2048-4046
    URL: Article
    DOI: 10.1177/14613484231205803
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2025887-2
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  • 4
    Online Resource
    Online Resource
    Roles of LINC01473 and CD74 in osteoblasts in multiple myeloma bone disease
    SAGE Publications ; 2022
    In:  Journal of Investigative Medicine Vol. 70, No. 5 ( 2022-06), p. 1301-1307
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 70, No. 5 ( 2022-06), p. 1301-1307
    Abstract: The suppression of osteoblast (OB) activity is partially responsible for multiple myeloma (MM) bone disease. Long non-coding RNAs (lncRNAs) play a vital role in bone formation and resorption. However, their functions in OBs from patients with MM have rarely been reported. Through high-throughput sequencing of OBs from patients with MM and healthy controls, we identified several lncRNAs and messenger RNAs (mRNAs) with different expression profile and validated them using quantitative real-time PCR. In total, 22 upregulated and 21 downregulated lncRNAs were found in OBs from patients with MM. Moreover, 18 upregulated protein-coding mRNAs were identified. The expression levels of LINC01473 and its associated co-expression mRNA, CD74, were higher in patients with MM than in healthy controls (p=0.047 and p=0.016, respectively). LINC01473 expression demonstrated a negative correlation with serum interleukin-2 and tumor necrosis factor α levels, whereas the expression of mRNA CD74 was positively associated with serum lactic dehydrogenase in patients with MM. Aberrant expression of lncRNAs and mRNAs was observed in OBs from patients with MM. This study identifies new promising targets for further research on imbalanced bone formation and resorption and MM immune escape.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-2021-002192
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Comparative Efficacy and Patient-Specific Moderating Factors of Nonsurgical Treatment Strategies for Frozen Shoulder: An Updated Systematic Review and Network Meta-analysis
    SAGE Publications ; 2021
    In:  The American Journal of Sports Medicine Vol. 49, No. 6 ( 2021-05), p. 1669-1679
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 49, No. 6 ( 2021-05), p. 1669-1679
    Abstract: Frozen shoulder is a common shoulder disorder characterized by pain and restriction. Various nonsurgical treatments have been reported, but there is no consensus about their comparative efficacy and the effects of moderators. Purpose: To compare the efficacy of different nonsurgical interventions and identify potential patient-specific moderating factors for frozen shoulder. Study Design: Systematic review and network meta-analysis. Methods: PubMed, Embase, Cochrane Library, and Web of Science databases were searched from their inception to February 18, 2019. The search was supplemented by manual review of relevant reference lists. Randomized controlled trials of participants with frozen shoulder that compared nonsurgical interventions were selected. Measured outcomes included pain, shoulder function in daily activities, and range of motion. Results: Of 3136 records identified, 92 trials were eligible, evaluating 32 nonsurgical interventions in 5946 patients. Intra-articular injection improved pain (pooled standardized mean difference [95% CI]: steroid injection, 1.68 [1.03-2.34] ; capsular distension, 2.68 [1.32-4.05]) and shoulder function (steroid injection, 2.16 [1.52-2.81] ; distension, 2.89 [1.71-4.06]) to a greater extent than placebo. Capsular distension and extracorporeal shockwave therapy showed the highest ranking for pain relief and functional improvement, respectively. Laser therapy also showed benefits for pain relief (3.02 [1.84-4.20] ) and functional improvement (3.66 [1.65-5.67]). Subgroup analyses by disease stages revealed that steroid injection combined with physical therapy provided more benefits during the freezing phase, whereas joint manipulation provided more benefits in the adhesive phase. Adjunctive therapies, female sex, and diabetes were also identified as moderators of effectiveness. Conclusion: Capsular distension is a highly recommended choice for treatment of frozen shoulder, contributing greatly to pain relief and functional improvement; steroid injection is also a prevailing effective intervention. Among new options, extracorporeal shockwave therapy and laser therapy show potential benefits for multiple outcomes. Individualized optimal intervention should be considered, given that treatment effect is moderated by factors including the disease stage, time of assessment, adjunctive therapies, female sex, and diabetes.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546520956293
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 6
    Online Resource
    Online Resource
    Surgical Treatment of Spinal Metastatic Pheochromocytoma and Paraganglioma: A Single Institutional Cohort of 18 Patients
    SAGE Publications ; 2023
    In:  Global Spine Journal Vol. 13, No. 8 ( 2023-10), p. 2454-2462
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 13, No. 8 ( 2023-10), p. 2454-2462
    Abstract: Retrospective Cohort Study Objectives To describe surgeries and treatment outcomes of metastatic pheochromocytomas and paragangliomas (PPGLs) on the spine. Methods We reviewed a cohort of 18 patients with spinal PPGLs who were consecutively treated in our spinal center. Their clinical data was reviewed. The survival period and its relevant factors was then analyzed. Results The cohort included ten cases of pheochromocytomas and eight paragangliomas. The local pain and neurological deficits were the two most common symptoms. One third of the spinal PPGLs were diagnosed as functional tumors, arousing secondary hypertension. The imaging features were consistent with those of osteolytic lesions. The surgical strategies for the cohort included percutaneous vertebroplasty, neurological decompression and partial tumor resection, and total en-bloc resection. The postoperative courses were uneventful except 1 patient developed heart failure. The adjuvant therapies were implemented in 6 patients with 131I-MIBG, five with radiotherapy, two with chemotherapy, and 1 with target therapy. The median survival period was 39 months, and the overall survival rate of 1 year was 77.8% (14/18). The patients’ Karnofsky performance scores were positively correlated with the survival period ( P 〈 .05). Conclusion Surgery is indicated for intractable local pain and neurological impairment in the patients with spinal PPGLs. Palliative surgical strategies, including neurological decompression and partial tumor resection, could bring fair outcomes, especially for the patients in poor physical conditions.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682221087600
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 7
    Online Resource
    Online Resource
    Study on weak sound signal separation and pattern recognition under strong background noise in marine engineering
    SAGE Publications ; 2024
    In:  Journal of Low Frequency Noise, Vibration and Active Control Vol. 43, No. 2 ( 2024-06), p. 595-608
    Details
    In: Journal of Low Frequency Noise, Vibration and Active Control, SAGE Publications, Vol. 43, No. 2 ( 2024-06), p. 595-608
    Abstract: The extraction of weak acoustic signals under strong background noise is of great significance in the applications of target identification and localization. In this paper, the pulse signal with high randomness is set as the weak signal sound source, random noise and sine sound are used as the background noise. Under the condition of a signal-to-noise ratio of −20 dB, combined with blind source separation and neural network methods, the collected observation signals are subjected to weak sound signal separation and recognition research. The optimization method of centralization and scaling processing is used to eliminate the unfavorable influence of the uncertainty of the separated signal amplitude caused by the blind source separation method on the pattern recognition. The recognition result is verified by the combination of “weak impulse acoustic signal” and “random noise signal,” and the output vector (0.99 0.01 0.01) approaches (1 0 0), which is recognized as impulse acoustic signal. By combining blind source separation and neural network methods, the separation and identification of weak pulse signals under the condition of a signal-to-noise ratio of −20 dB can be achieved.
    Type of Medium: Online Resource
    ISSN: 1461-3484 , 2048-4046
    URL: Article
    DOI: 10.1177/14613484241226524
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2025887-2
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  • 8
    Online Resource
    Online Resource
    Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis
    SAGE Publications ; 2023
    In:  Cell Transplantation Vol. 32 ( 2023-01), p. 096368972311625-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 32 ( 2023-01), p. 096368972311625-
    Abstract: Glaucoma including primary open-angle glaucoma (POAG) results from elevations in intraocular pressure (IOP). An eye-localized renin-angiotensin system (RAS) has been implicated in IOP regulation, although its mechanism of action and contribution to glaucoma is poorly understood. Here, we detected significant increases in the levels of angiotensin II (ANGII) in aqueous humor samples from POAG patients. Moreover, we determined that the concentrations of ANGII were positively correlated with IOP, suggesting a role for elevated ANGII levels in eye pathogenesis. Functional investigations demonstrated that ANGII induces the expression of fibrosis-related genes of transformed and primary human trabecular meshwork cells (HTMCs) through the transcriptional upregulation of key fibrotic genes. Parallel experiments using a murine periocular conjunctival fornix injection model confirmed that ANGII induces the expression of fibrosis-related genes in trabecular meshwork (TM) cells in vivo along with increasing IOP. ANGII was revealed to function through increasing the levels of reactive oxygen species (ROS) via selectively upregulating NOX4, with NOX4 knockdown or inhibition with GLX351322 alleviating fibrotic changes induced by ANGII. We further show that ANGII activates Smad3, with both GLX351322 and an inhibitor of Smad3 (SIS3) decreasing the phosphorylation of Smad3 and dampening the ANGII-induced increases in fibrotic proteins. Moreover, NOX4 and Smad3 inhibitors also partially rescued the elevated IOP levels induced by ANGII. Our collective results therefore highlight ANGII as a biomarker and treatment target in POAG together with establishing a causal relationship between ANGII and up-regulation of the expression of fibrosis-related genes of TM cells via a NOX4/ROS axis in cooperation with TGFβ/Smad3 signaling.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897231162526
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2020466-8
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  • 9
    Online Resource
    Online Resource
    Automatic classification of tobacco leaves based on near infrared spectroscopy and nonnegative least squares
    SAGE Publications ; 2018
    In:  Journal of Near Infrared Spectroscopy Vol. 26, No. 2 ( 2018-04), p. 101-105
    Details
    In: Journal of Near Infrared Spectroscopy, SAGE Publications, Vol. 26, No. 2 ( 2018-04), p. 101-105
    Abstract: A nonnegative least squares classifier was proposed in this paper to classify near infrared spectral data. The method used near infrared spectral data of training samples to make up a data dictionary of the sparse representation. By adopting the nonnegative least squares sparse coding algorithm, the near infrared spectral data of test samples would be expressed via the sparsest linear combinations of the dictionary. The regression residual of the test sample of each class was computed, and finally it was assigned to the class with the minimum residual. The method was compared with the other classifying approaches, including the well-performing principal component analysis–linear discriminant analysis and principal component analysis–particle swarm optimization–support vector machine. Experimental results showed that the approach was faster and generally achieved a better prediction performance over compared methods. The method can accurately recognize different classes of tobacco leaves and it provides a new technology for quality evaluation of tobacco leaf in its purchasing activities.
    Type of Medium: Online Resource
    ISSN: 0967-0335 , 1751-6552
    URL: Article
    DOI: 10.1177/0967033518762617
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2021280-X
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  • 10
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    LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Respiratory Disease Vol. 15 ( 2021-01), p. 175346662110280-
    Details
    In: Therapeutic Advances in Respiratory Disease, SAGE Publications, Vol. 15 ( 2021-01), p. 175346662110280-
    Abstract: Chronic obstructive pulmonary disease (COPD) is a systemic disease. Several long non-coding RNAs (lncRNAs) have been identified to be aberrantly expressed in COPD patients. This study investigated the role of lncRNA cancer susceptibility candidate 2 (CASC2) in COPD, as well as its potential mechanism. Methods: Fifty smokers with COPD and another 50 smokers without COPD were recruited. Receiver operating characteristic curve was constructed to assess the diagnostic value of CASC2 in COPD patients. 16HBE cells were treated with cigarette smoke extract (CSE) to establish a cell model. qRT-PCR was used for the measurement of mRNA levels. The cell viability and apoptosis were detected by using Cell Counting Kit-8 and flow cytometry assay. Enzyme-linked immunosorbent assay was performed to detect the levels of proinflammatory cytokines. Luciferase reporter assay was performed for the target gene analysis. Results: Serum CASC2 was dramatically decreased in COPD patients compared with smokers without COPD, and was positively associated with FEV1 (forced expiratory volume in one second). Serum CASC2 was overexpressed in severe COPD patients, and had the diagnostic accuracy to distinguish COPD patients from smokers. CASC2 overexpression alleviated CSE-induced apoptosis and inflammation in 16HBE cells. CASC2 functions as a ceRNA of miR-18a-5p. Upregulation of miR-18a-5p reversed the influence of CASC2 on cell apoptosis and inflammation in 16HBE cells. IGF1 was the target gene of miR-18a-5p. Conclusion: CASC2 was downregulated in COPD patients and it might be a promising biomarker for the disease diagnosis. Overexpression of CASC2 might inhibit the bronchial epithelial cell apoptosis and inflammation via targeting miR-18a-5p/IGF1 axis. The reviews of this paper are available via the supplemental material section.
    Type of Medium: Online Resource
    ISSN: 1753-4666 , 1753-4666
    URL: Article
    DOI: 10.1177/17534666211028072
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2387506-9
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